| FMR LLC | 9,179,469 | $2.60 億 | 0.02% | – | – |
| BlackRock Inc. | 5,223,546 | $1.48 億 | 0.00% | – | – |
| Avoro Capital Advisors LLC | 4,000,000 | $1.13 億 | 1.95% | – | – |
| EcoR1 Capital, LLC | 3,692,637 | $1.04 億 | 4.67% | – | – |
| Vanguard Group Inc | 3,328,408 | $9,409 萬 | 0.00% | – | – |
| State Street Corp | 2,833,650 | $8,011 萬 | 0.00% | – | – |
| Ameriprise Financial Inc | 2,474,145 | $6,994 萬 | 0.02% | – | – |
| Holocene Advisors, LP | 2,241,352 | $6,336 萬 | 0.41% | – | – |
| Foresite Capital Management IV, LLC | 1,849,947 | $5,230 萬 | 6.26% | – | – |
| Invesco Ltd. | 1,695,212 | $4,792 萬 | 0.01% | – | – |
| Wellington Management Group LLP | 1,687,618 | $4,771 萬 | 0.01% | – | – |
| Victory Capital Management Inc | 1,671,574 | $4,726 萬 | 0.05% | – | – |
| BVF Inc | 1,635,112 | $4,623 萬 | 1.73% | – | – |
| Eventide Asset Management, LLC | 1,617,573 | $4,573 萬 | 0.68% | – | – |
| Citadel Advisors LLC | 1,435,217 | $4,057 萬 | 0.04% | – | – |
| Geode Capital Management, LLC | 1,087,457 | $3,074 萬 | 0.00% | – | – |
| RTW Investments, LP | 1,081,912 | $3,059 萬 | 0.48% | – | – |
| Boxer Capital, LLC | 1,050,289 | $2,969 萬 | 1.01% | – | – |
| Goldman Sachs Group Inc | 1,044,008 | $2,951 萬 | 0.01% | – | – |
| Candriam Luxembourg S.C.A. | 929,277 | $2,915 萬 | 0.24% | – | – |
| Eagle Asset Management Inc | 845,190 | $2,479 萬 | 0.11% | – | – |
| Dimensional Fund Advisors LP | 819,092 | $2,310 萬 | 0.01% | – | – |
| Franklin Resources Inc | 741,764 | $2,097 萬 | 0.01% | – | – |
| Suvretta Capital Management, LLC | 732,415 | $2,071 萬 | 0.31% | – | – |
| Sphera Funds Management Ltd. | 717,751 | $2,029 萬 | 1.86% | – | – |
| Northern Trust Corp | 716,413 | $2,025 萬 | 0.00% | – | – |
| Rock Springs Capital Management LP | 710,035 | $2,007 萬 | 0.44% | – | – |
| HHLR Advisors, Ltd.大師高瓴 HHLR | 650,000 | $1,838 萬 | 0.18% | – | – |
| Two Sigma Advisers, LP | 633,400 | $1,791 萬 | 0.05% | – | – |
| Two Sigma Investments, LP | 608,283 | $1,720 萬 | 0.05% | – | – |
| Artal Group S.A. | 600,000 | $1,696 萬 | 0.36% | – | – |
| Ghost Tree Capital, LLC | 600,000 | $1,696 萬 | 4.75% | – | – |
| VR Adviser, LLC | 575,000 | $1,626 萬 | 1.76% | – | – |
| Acuta Capital Partners, LLC | 536,820 | $1,518 萬 | 5.47% | – | – |
| Vivo Capital, LLC | 525,262 | $1,485 萬 | 0.52% | – | – |
| Commodore Capital LP | 521,555 | $1,474 萬 | 5.87% | – | – |
| Charles Schwab Investment Management Inc | 443,227 | $1,253 萬 | 0.00% | – | – |
| Farallon Capital Management, L.L.C. | 400,000 | $1,131 萬 | 0.06% | – | – |
| Affinity Asset Advisors, LLC | 365,000 | $1,032 萬 | 5.06% | – | – |
| Polar Capital Holdings Plc | 350,000 | $989.5 萬 | 0.06% | – | – |
| D. E. Shaw & Co., Inc. | 347,190 | $981.5 萬 | 0.01% | – | – |
| Millennium Management LLC | 325,104 | $919.1 萬 | 0.01% | – | – |
| UBS Asset Management Americas Inc | 299,976 | $848.0 萬 | 0.00% | – | – |
| Bank of New York Mellon Corp | 298,342 | $843.4 萬 | 0.00% | – | – |
| Nuveen Asset Management, LLC | 289,919 | $819.6 萬 | 0.00% | – | – |
| Asymmetry Capital Management, L.P. | 277,468 | $784.4 萬 | 4.06% | – | – |
| Tekla Capital Management LLC | 273,463 | $773.1 萬 | 0.27% | – | – |
| Sio Capital Management, LLC | 213,471 | $603.5 萬 | 1.26% | – | – |
| Verition Fund Management LLC | 195,085 | $551.5 萬 | 0.10% | – | – |
| AXA S.A. | 176,411 | $498.7 萬 | 0.02% | – | – |
| Citigroup Inc | 143,054 | $404.4 萬 | 0.00% | – | – |
| Barclays PLC | 136,202 | $385.2 萬 | 0.00% | – | – |
| Swiss National Bank | 125,900 | $355.9 萬 | 0.00% | – | – |
| Pura Vida Investments, LLC | 124,240 | $351.2 萬 | 0.24% | – | – |
| California Public Employees Retirement System | 122,976 | $347.7 萬 | 0.00% | – | – |
| Alliancebernstein L.P. | 119,918 | $339.0 萬 | 0.00% | – | – |
| Assenagon Asset Management S.A. | 118,200 | $334.2 萬 | 0.02% | – | – |
| Rafferty Asset Management, LLC | 112,942 | $319.3 萬 | 0.02% | – | – |
| Wells Fargo & Company | 106,193 | $300.2 萬 | 0.00% | – | – |
| Lombard Odier Asset Management (Switzerland) SA | 104,293 | $294.8 萬 | 0.20% | – | – |
| Compagnie Lombard Odier SCmA | 104,293 | $294.8 萬 | 0.07% | – | – |
| SG Americas Securities, LLC | 98,812 | $279.3 萬 | 0.02% | – | – |
| California State Teachers Retirement System | 94,414 | $266.9 萬 | 0.00% | – | – |
| Schonfeld Strategic Advisors LLC | 84,702 | $239.5 萬 | 0.03% | – | – |
| State of Wisconsin Investment Board | 84,300 | $238.3 萬 | 0.01% | – | – |
| Sofinnova Investments, Inc. | 83,164 | $235.1 萬 | 0.15% | – | – |
| Bank of America Corp | 82,415 | $232.9 萬 | 0.00% | – | – |
| Bailard, Inc. | 81,934 | $231.6 萬 | 0.09% | – | – |
| Silverarc Capital Management, LLC | 80,000 | $226.2 萬 | 1.27% | – | – |
| Connacht Asset Management LP | 77,501 | $219.1 萬 | 1.72% | – | – |
| Altrinsic Global Advisors LLC | 70,000 | $197.9 萬 | 0.06% | – | – |
| State of New Jersey Common Pension Fund D | 69,696 | $197.0 萬 | 0.01% | – | – |
| Rhumbline Advisers | 67,592 | $191.1 萬 | 0.00% | – | – |
| DekaBank Deutsche Girozentrale | 67,000 | $177.9 萬 | 0.01% | – | – |
| Integral Health Asset Management, LLC | 60,000 | $169.6 萬 | 0.48% | – | – |
| UBS Group AG | 57,999 | $164.0 萬 | 0.00% | – | – |
| Bellevue Group AG | 58,000 | $164.0 萬 | 0.02% | – | – |
| New York State Common Retirement Fund | 55,900 | $158.0 萬 | 0.00% | – | – |
| Erste Asset Management GmbH | 58,000 | $154.3 萬 | 0.04% | – | – |
| JPMorgan Chase & Co | 53,526 | $151.4 萬 | 0.00% | – | – |
| DAFNA Capital Management LLC | 51,800 | $146.4 萬 | 0.35% | – | – |
| Aaron Wealth Advisors | 51,792 | $146.4 萬 | 0.54% | – | – |
| Aviva PLC | 48,073 | $135.9 萬 | 0.01% | – | – |
| Squarepoint Ops LLC | 45,429 | $128.4 萬 | 0.01% | – | – |
| Thrivent Financial for Lutherans | 45,127 | $127.5 萬 | 0.00% | – | – |
| Deutsche Bank AG | 44,992 | $127.1 萬 | 0.00% | – | – |
| Credit Suisse AG | 42,102 | $119.0 萬 | 0.00% | – | – |
| Algert Global LLC | 39,598 | $111.9 萬 | 0.36% | – | – |
| Parametric Portfolio Associates LLC | 37,531 | $106.1 萬 | 0.00% | – | – |
| American International Group, Inc. | 36,482 | $103.1 萬 | 0.00% | – | – |
| Ensign Peak Advisors, Inc | 35,339 | $99.9 萬 | 0.00% | – | – |
| Manufacturers Life Insurance Company, The | 35,227 | $99.6 萬 | 0.00% | – | – |
| Chartwell Investment Partners, LLC | 34,518 | $97.6 萬 | 0.03% | – | – |
| Russell Investments Group, Ltd. | 32,016 | $90.4 萬 | 0.00% | – | – |
| Price T Rowe Associates Inc | 31,746 | $89.7 萬 | 0.00% | – | – |
| HighVista Strategies LLC | 30,212 | $85.4 萬 | 0.63% | – | – |
| Voya Investment Management LLC | 27,754 | $78.5 萬 | 0.00% | – | – |
| Quantitative Systematic Strategies LLC | 27,621 | $78.1 萬 | 0.12% | – | – |
| AlphaCrest Capital Management LLC | 27,500 | $77.7 萬 | 0.04% | – | – |
| Principal Financial Group Inc | 26,045 | $73.7 萬 | 0.00% | – | – |
