| Vivo Capital, LLC | 1,863,296 | $4,787 萬 | 1.68% | – | – |
| BlackRock Inc. | 1,559,488 | $4,006 萬 | 0.00% | – | – |
| Wellington Management Group LLP | 1,509,025 | $3,877 萬 | 0.01% | – | – |
| Eventide Asset Management, LLC | 1,373,000 | $3,527 萬 | 0.52% | – | – |
| FMR LLC | 1,347,970 | $3,463 萬 | 0.00% | – | – |
| Franklin Resources Inc | 1,287,661 | $3,308 萬 | 0.01% | – | – |
| Janus Henderson Group PLC | 1,133,772 | $2,912 萬 | 0.01% | – | – |
| Deerfield Management Company, L.P. (Series C) | 1,020,005 | $2,620 萬 | 0.55% | – | – |
| Polar Capital Holdings Plc | 1,007,055 | $2,587 萬 | 0.16% | – | – |
| Suvretta Capital Management, LLC | 959,892 | $2,466 萬 | 0.37% | – | – |
| Vanguard Group Inc | 929,481 | $2,388 萬 | 0.00% | – | – |
| Adage Capital Partners GP, L.L.C. | 805,000 | $2,068 萬 | 0.04% | – | – |
| Cormorant Asset Management, LP | 750,000 | $1,927 萬 | 0.55% | – | – |
| Nicholas Investment Partners, LP | 594,130 | $1,526 萬 | 1.06% | – | – |
| State Street Corp | 591,472 | $1,520 萬 | 0.00% | – | – |
| Pictet Asset Management Ltd | 565,729 | $1,453 萬 | 0.02% | – | – |
| Stonepine Capital Management, LLC | 422,310 | $1,085 萬 | 5.86% | – | – |
| Emerald Mutual Fund Advisers Trust | 416,212 | $1,069 萬 | 0.35% | – | – |
| Emerald Advisers, LLC | 397,283 | $1,021 萬 | 0.37% | – | – |
| Ra Capital Management, L.P. | 350,000 | $899.2 萬 | 0.14% | – | – |
| Geode Capital Management, LLC | 327,267 | $840.7 萬 | 0.00% | – | – |
| Ikarian Capital, LLC | 296,965 | $762.9 萬 | 1.14% | – | – |
| Sphera Funds Management Ltd. | 258,880 | $665.1 萬 | 0.61% | – | – |
| Northern Trust Corp | 228,670 | $587.5 萬 | 0.00% | – | – |
| Dimensional Fund Advisors LP | 228,625 | $587.3 萬 | 0.00% | – | – |
| Woodline Partners LP | 224,059 | $575.6 萬 | 0.13% | – | – |
| American Century Companies Inc | 218,163 | $560.5 萬 | 0.00% | – | – |
| Commodore Capital LP | 214,467 | $551.0 萬 | 2.19% | – | – |
| International Biotechnology Trust PLC | 214,533 | $548.6 萬 | 1.45% | – | – |
| Renaissance Technologies LLC | 153,428 | $394.2 萬 | 0.00% | – | – |
| Altium Capital Management LP | 128,130 | $329.2 萬 | 0.91% | – | – |
| Laurion Capital Management LP | 120,000 | $308.3 萬 | 0.04% | – | – |
| Bank of New York Mellon Corp | 110,504 | $283.9 萬 | 0.00% | – | – |
| EAM Investors, LLC | 106,777 | $274.3 萬 | 0.41% | – | – |
| Affinity Asset Advisors, LLC | 100,000 | $256.9 萬 | 1.26% | – | – |
| Marshall Wace North America L.P. | 98,178 | $252.3 萬 | 0.01% | – | – |
| Two Sigma Investments, LP | 80,673 | $207.2 萬 | 0.01% | – | – |
| Susquehanna International Group, LLP | 66,020 | $169.6 萬 | 0.00% | – | – |
| EAM Global Investors LLC | 64,603 | $166.0 萬 | 0.46% | – | – |
| DAFNA Capital Management LLC | 58,600 | $150.5 萬 | 0.36% | – | – |
| Goldman Sachs Group Inc | 54,599 | $140.3 萬 | 0.00% | – | – |
| Nuveen Asset Management, LLC | 83,090 | $129.7 萬 | 0.00% | – | – |
| Parametric Portfolio Associates LLC | 50,244 | $129.1 萬 | 0.00% | – | – |
| Tekla Capital Management LLC | 50,000 | $128.5 萬 | 0.04% | – | – |
| Silverarc Capital Management, LLC | 50,000 | $128.5 萬 | 0.72% | – | – |
| Jacobs Levy Equity Management, Inc | 47,681 | $122.5 萬 | 0.01% | – | – |
| Ensign Peak Advisors, Inc | 47,116 | $121.0 萬 | 0.00% | – | – |
| Charles Schwab Investment Management Inc | 46,897 | $120.5 萬 | 0.00% | – | – |
| Citadel Advisors LLC | 45,411 | $116.7 萬 | 0.00% | – | – |
| Susquehanna Fundamental Investments, LLC | 40,567 | $104.2 萬 | 0.02% | – | – |
| Birchview Capital, LP | 40,000 | $102.8 萬 | 0.61% | – | – |
| CSS LLC | 39,963 | $102.7 萬 | 0.06% | – | – |
| Marshall Wace, LLP | 37,443 | $96.2 萬 | 0.01% | – | – |
| Crawford Lake Capital Management, LLC | 36,730 | $94.4 萬 | 0.85% | – | – |
| New York State Common Retirement Fund | 33,659 | $86.5 萬 | 0.00% | – | – |
| Barclays PLC | 33,283 | $85.4 萬 | 0.00% | – | – |
| Boothbay Fund Management, LLC | 32,875 | $84.5 萬 | 0.05% | – | – |
| State of Wisconsin Investment Board | 31,900 | $82.0 萬 | 0.00% | – | – |
| Wells Fargo & Company | 30,309 | $77.9 萬 | 0.00% | – | – |
| Gainplan LLC | 30,000 | $77.2 萬 | 0.34% | – | – |
| Apis Capital Advisors, LLC | 30,000 | $77.1 萬 | 0.70% | – | – |
| Morgan Stanley | 29,815 | $76.6 萬 | 0.00% | – | – |
| California State Teachers Retirement System | 28,739 | $73.8 萬 | 0.00% | – | – |
| California Public Employees Retirement System | 27,700 | $71.2 萬 | 0.00% | – | – |
| LMR Partners LLP | 25,000 | $64.2 萬 | 0.02% | – | – |
| Citigroup Inc | 24,685 | $63.4 萬 | 0.00% | – | – |
| Squarepoint Ops LLC | 23,741 | $61.0 萬 | 0.01% | – | – |
| Rhumbline Advisers | 23,177 | $59.5 萬 | 0.00% | – | – |
| SG Americas Securities, LLC | 22,412 | $57.6 萬 | 0.00% | – | – |
| Teachers Retirement System of the State of Kentucky | 21,078 | $54.1 萬 | 0.01% | – | – |
| Qube Research & Technologies Ltd | 21,030 | $54.0 萬 | 0.01% | – | – |
| Pura Vida Investments, LLC | 20,257 | $52.0 萬 | 0.04% | – | – |
| Bank of America Corp | 19,196 | $49.3 萬 | 0.00% | – | – |
| Russell Investments Group, Ltd. | 18,705 | $48.0 萬 | 0.00% | – | – |
| Rafferty Asset Management, LLC | 18,299 | $47.0 萬 | 0.00% | – | – |
| STRS Ohio | 16,400 | $42.1 萬 | 0.00% | – | – |
| Massachusetts Financial Services Co | 13,757 | $35.3 萬 | 0.00% | – | – |
| Virtu Financial LLC | 13,262 | $34.1 萬 | 0.02% | – | – |
| Deutsche Bank AG | 12,475 | $32.0 萬 | 0.00% | – | – |
| American International Group, Inc. | 11,105 | $28.5 萬 | 0.00% | – | – |
| Manufacturers Life Insurance Company, The | 11,012 | $28.3 萬 | 0.00% | – | – |
| UBS Group AG | 10,776 | $27.7 萬 | 0.00% | – | – |
| Alpine Global Management, LLC | 10,000 | $25.7 萬 | 0.02% | – | – |
| Two Sigma Advisers, LP | 9,522 | $24.5 萬 | 0.00% | – | – |
| BNP Paribas Arbitrage, SA | 8,374 | $21.5 萬 | 0.00% | – | – |
| JPMorgan Chase & Co | 8,334 | $21.4 萬 | 0.00% | – | – |
| ProShare Advisors LLC | 8,318 | $21.4 萬 | 0.00% | – | – |
| Voya Investment Management LLC | 8,195 | $21.1 萬 | 0.00% | – | – |
| Boston Private Wealth LLC | 7,801 | $20.0 萬 | 0.00% | – | – |
| MetLife Investment Management | 6,130 | $15.7 萬 | 0.00% | – | – |
| Metropolitan Life Insurance Co | 5,038 | $12.9 萬 | 0.00% | – | – |
| Pinz Capital Management, LP | 4,518 | $11.6 萬 | 0.03% | – | – |
| Tower Research Capital LLC (TRC) | 3,684 | $9.50 萬 | 0.00% | – | – |
| Group One Trading, L.P. | 3,169 | $8.10 萬 | 0.00% | – | – |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,172 | $8.10 萬 | 0.00% | – | – |
| First Mercantile Trust Co | 1,845 | $4.70 萬 | 0.01% | – | – |
| Royal Bank of Canada | 1,788 | $4.60 萬 | 0.00% | – | – |
| FORA Capital, LLC | 1,791 | $4.60 萬 | 0.02% | – | – |
| Lindbrook Capital, LLC | 1,800 | $4.60 萬 | 0.01% | – | – |
| Legal & General Group Plc | 1,666 | $4.30 萬 | 0.00% | – | – |
