| Wellington Management Group LLP | 19,003,480 | $1.54 億 | 0.03% | – | – |
| Ra Capital Management, L.P. | 18,417,458 | $1.49 億 | 2.25% | – | – |
| BlackRock Inc. | 16,305,586 | $1.32 億 | 0.00% | – | – |
| Vanguard Group Inc | 14,307,139 | $1.16 億 | 0.00% | – | – |
| FMR LLC | 13,534,350 | $1.10 億 | 0.01% | – | – |
| Redmile Group, LLC | 9,688,066 | $7,847 萬 | 1.11% | – | – |
| OrbiMed Advisors LLC | 9,131,822 | $7,397 萬 | 0.70% | – | – |
| State Street Corp | 9,023,479 | $7,309 萬 | 0.00% | – | – |
| Clearbridge Investments, LLC | 6,108,685 | $4,948 萬 | 0.04% | – | – |
| Ameriprise Financial Inc | 5,595,683 | $4,532 萬 | 0.02% | – | – |
| Adage Capital Partners GP, L.L.C. | 4,500,000 | $3,645 萬 | 0.07% | – | – |
| Morgan Stanley | 4,203,979 | $3,405 萬 | 0.01% | – | – |
| Geode Capital Management, LLC | 3,516,791 | $2,849 萬 | 0.00% | – | – |
| Deutsche Bank AG | 2,994,172 | $2,425 萬 | 0.01% | – | – |
| Two Sigma Advisers, LP | 2,947,918 | $2,388 萬 | 0.07% | – | – |
| Goldman Sachs Group Inc | 2,595,999 | $2,103 萬 | 0.01% | – | – |
| Two Sigma Investments, LP | 2,560,629 | $2,074 萬 | 0.06% | – | – |
| Millennium Management LLC | 2,242,301 | $1,816 萬 | 0.03% | – | – |
| Northern Trust Corp | 2,096,792 | $1,698 萬 | 0.00% | – | – |
| Renaissance Technologies LLC | 1,863,340 | $1,509 萬 | 0.02% | – | – |
| Lombard Odier Asset Management (Switzerland) SA | 1,849,772 | $1,498 萬 | 1.00% | – | – |
| Compagnie Lombard Odier SCmA | 1,849,772 | $1,498 萬 | 0.33% | – | – |
| D. E. Shaw & Co., Inc. | 1,831,244 | $1,483 萬 | 0.02% | – | – |
| Charles Schwab Investment Management Inc | 1,437,600 | $1,165 萬 | 0.00% | – | – |
| QVT Financial LP | 1,375,900 | $1,115 萬 | 0.78% | – | – |
| Panagora Asset Management Inc | 1,212,909 | $982.5 萬 | 0.06% | – | – |
| Wells Fargo & Company | 1,103,795 | $894.2 萬 | 0.00% | – | – |
| Nuveen Asset Management, LLC | 910,771 | $737.7 萬 | 0.00% | – | – |
| Pinnacle Associates Ltd | 878,058 | $711.2 萬 | 0.14% | – | – |
| Primecap Management Co | 846,127 | $685.4 萬 | 0.00% | – | – |
| Bank of New York Mellon Corp | 809,799 | $655.9 萬 | 0.00% | – | – |
| Pura Vida Investments, LLC | 804,192 | $651.4 萬 | 0.45% | – | – |
| Bank of America Corp | 779,151 | $631.2 萬 | 0.00% | – | – |
| Farallon Capital Management, L.L.C. | 750,000 | $607.5 萬 | 0.03% | – | – |
| Silverarc Capital Management, LLC | 729,364 | $590.8 萬 | 3.31% | – | – |
| Consonance Capital Management LP | 703,790 | $570.1 萬 | 0.61% | – | – |
| Citigroup Inc | 611,917 | $495.7 萬 | 0.00% | – | – |
| Rhenman & Partners Asset Management AB | 550,000 | $445.5 萬 | 0.31% | – | – |
| Federated Hermes, Inc. | 538,755 | $436.4 萬 | 0.01% | – | – |
| Marshall Wace, LLP | 523,087 | $423.7 萬 | 0.02% | – | – |
| Blair William & Co | 515,800 | $417.8 萬 | 0.02% | – | – |
| Voya Investment Management LLC | 509,856 | $413.0 萬 | 0.01% | – | – |
| Barclays PLC | 429,654 | $348.1 萬 | 0.00% | – | – |
| Swiss National Bank | 428,400 | $347.0 萬 | 0.00% | – | – |
| Allianz Asset Management GmbH | 393,240 | $318.6 萬 | 0.00% | – | – |
| Rafferty Asset Management, LLC | 377,762 | $306.0 萬 | 0.02% | – | – |
| CM Management, LLC | 375,000 | $303.8 萬 | 2.26% | – | – |
| California Public Employees Retirement System | 349,000 | $282.7 萬 | 0.00% | – | – |
| California State Teachers Retirement System | 289,325 | $234.4 萬 | 0.00% | – | – |
| Alliancebernstein L.P. | 287,864 | $233.2 萬 | 0.00% | – | – |
| Rhumbline Advisers | 282,692 | $229.0 萬 | 0.00% | – | – |
| State of Wisconsin Investment Board | 282,000 | $228.4 萬 | 0.00% | – | – |
| Squarepoint Ops LLC | 273,526 | $221.6 萬 | 0.02% | – | – |
| Raymond James & Associates | 268,789 | $217.7 萬 | 0.00% | – | – |
| Principal Financial Group Inc | 259,564 | $210.2 萬 | 0.00% | – | – |
| Credit Suisse AG | 254,556 | $206.1 萬 | 0.00% | – | – |
| Parametric Portfolio Associates LLC | 231,884 | $187.8 萬 | 0.00% | – | – |
| UBS Group AG | 230,543 | $186.7 萬 | 0.00% | – | – |
| Citadel Advisors LLC | 216,480 | $175.3 萬 | 0.00% | – | – |
| Employees Retirement System of Texas | 208,100 | $168.6 萬 | 0.02% | – | – |
| Kercheville Advisors, LLC | 193,755 | $155.7 萬 | 0.78% | – | – |
| Truist Financial Corp | 191,593 | $155.2 萬 | 0.00% | – | – |
| Birchview Capital, LP | 190,000 | $153.9 萬 | 0.91% | – | – |
| SG Americas Securities, LLC | 188,392 | $152.6 萬 | 0.01% | – | – |
| Royal Bank of Canada | 179,161 | $145.2 萬 | 0.00% | – | – |
| New York State Common Retirement Fund | 160,100 | $129.7 萬 | 0.00% | – | – |
| Fernwood Investment Management, LLC | 151,340 | $122.6 萬 | 0.45% | – | – |
| Susquehanna International Group, LLP | 146,077 | $118.3 萬 | 0.00% | – | – |
| UBS Asset Management Americas Inc | 145,395 | $117.8 萬 | 0.00% | – | – |
| AQR Capital Management LLC | 135,348 | $109.6 萬 | 0.00% | – | – |
| American International Group, Inc. | 111,795 | $90.6 萬 | 0.00% | – | – |
| Manufacturers Life Insurance Company, The | 108,361 | $87.8 萬 | 0.00% | – | – |
| Los Angeles Capital Management LLC | 98,348 | $79.7 萬 | 0.00% | – | – |
| Susquehanna Fundamental Investments, LLC | 97,109 | $78.7 萬 | 0.01% | – | – |
| ExodusPoint Capital Management, LP | 96,140 | $77.9 萬 | 0.02% | – | – |
| Twin Focus Capital Partners, LLC | 94,068 | $76.2 萬 | 0.22% | – | – |
| Monarch Partners Asset Management LLC | 92,780 | $75.2 萬 | 0.11% | – | – |
| Advisor Group Holdings, Inc. | 91,906 | $74.5 萬 | 0.00% | – | – |
| Stifel Financial Corp | 86,691 | $70.3 萬 | 0.00% | – | – |
| Baxter Bros Inc | 86,800 | $70.3 萬 | 0.12% | – | – |
| Price T Rowe Associates Inc | 83,786 | $67.9 萬 | 0.00% | – | – |
| BNP Paribas Arbitrage, SA | 78,396 | $63.5 萬 | 0.00% | – | – |
| ProShare Advisors LLC | 78,178 | $63.3 萬 | 0.00% | – | – |
| State Board of Administration of Florida Retirement System | 77,227 | $62.6 萬 | 0.00% | – | – |
| Qube Research & Technologies Ltd | 74,588 | $60.4 萬 | 0.01% | – | – |
| Tudor Investment Corp Et Al | 74,072 | $60.0 萬 | 0.01% | – | – |
| MetLife Investment Management | 73,698 | $59.7 萬 | 0.01% | – | – |
| JPMorgan Chase & Co | 72,478 | $58.7 萬 | 0.00% | – | – |
| Gotham Asset Management, LLC | 66,040 | $53.5 萬 | 0.02% | – | – |
| DekaBank Deutsche Girozentrale | 62,000 | $49.6 萬 | 0.00% | – | – |
| Envestnet Asset Management Inc | 60,308 | $48.8 萬 | 0.00% | – | – |
| Thrivent Financial for Lutherans | 58,026 | $47.0 萬 | 0.00% | – | – |
| AXA S.A. | 56,400 | $45.7 萬 | 0.00% | – | – |
| Arizona State Retirement System | 54,590 | $44.2 萬 | 0.00% | – | – |
| Engineers Gate Manager LP | 54,600 | $44.2 萬 | 0.02% | – | – |
| PFS Investments Inc. | 51,600 | $41.8 萬 | 0.01% | – | – |
| HRT Financial LP | 51,578 | $41.7 萬 | 0.00% | – | – |
| Janney Montgomery Scott LLC | 50,212 | $40.7 萬 | 0.00% | – | – |
| Metropolitan Life Insurance Co | 48,893 | $39.6 萬 | 0.01% | – | – |
| Invesco Ltd. | 48,782 | $39.5 萬 | 0.00% | – | – |
