| Redmile Group, LLC | 4,351,644 | $1.95 億 | 2.75% | – | – |
| Vanguard Group Inc | 3,948,062 | $1.77 億 | 0.00% | – | – |
| Franklin Resources Inc | 3,840,734 | $1.72 億 | 0.07% | – | – |
| BlackRock Inc. | 3,485,003 | $1.56 億 | 0.00% | – | – |
| Alliancebernstein L.P. | 1,992,706 | $8,935 萬 | 0.04% | – | – |
| State Street Corp | 1,859,037 | $8,336 萬 | 0.00% | – | – |
| ArrowMark Colorado Holdings LLC | 1,610,683 | $7,222 萬 | 0.54% | – | – |
| OrbiMed Advisors LLC | 1,380,900 | $6,192 萬 | 0.58% | – | – |
| New Leaf Venture Partners, L.L.C. | 1,209,571 | $5,424 萬 | 12.62% | – | – |
| Price T Rowe Associates Inc | 1,168,268 | $5,239 萬 | 0.01% | – | – |
| Consonance Capital Management LP | 993,912 | $4,457 萬 | 4.75% | – | – |
| Avoro Capital Advisors LLC | 893,000 | $4,004 萬 | 0.69% | – | – |
| FMR LLC | 800,457 | $3,589 萬 | 0.00% | – | – |
| Pictet Asset Management Ltd | 739,481 | $3,316 萬 | 0.04% | – | – |
| Geode Capital Management, LLC | 704,063 | $3,157 萬 | 0.00% | – | – |
| Alkeon Capital Management LLC | 670,975 | $3,009 萬 | 0.11% | – | – |
| Goldman Sachs Group Inc | 620,541 | $2,783 萬 | 0.01% | – | – |
| Wells Fargo & Company | 548,990 | $2,462 萬 | 0.01% | – | – |
| Deerfield Management Company, L.P. (Series C) | 528,585 | $2,370 萬 | 0.50% | – | – |
| SV Health Investors, LLC | 449,951 | $2,018 萬 | 7.56% | – | – |
| Nicholas Investment Partners, LP | 446,674 | $2,003 萬 | 1.40% | – | – |
| Northern Trust Corp | 439,191 | $1,969 萬 | 0.00% | – | – |
| Janus Henderson Group PLC | 426,077 | $1,911 萬 | 0.01% | – | – |
| Invesco Ltd. | 407,203 | $1,826 萬 | 0.00% | – | – |
| Polar Capital Holdings Plc | 400,000 | $1,794 萬 | 0.11% | – | – |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 379,256 | $1,701 萬 | 0.07% | – | – |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 348,620 | $1,563 萬 | 4.68% | – | – |
| Eversept Partners, LP | 345,717 | $1,550 萬 | 1.27% | – | – |
| Kornitzer Capital Management Inc | 344,760 | $1,546 萬 | 0.25% | – | – |
| Suvretta Capital Management, LLC | 336,808 | $1,510 萬 | 0.22% | – | – |
| Norges Bank | 324,868 | $1,457 萬 | 0.00% | – | – |
| Emerald Mutual Fund Advisers Trust | 319,202 | $1,431 萬 | 0.48% | – | – |
| Tekla Capital Management LLC | 307,703 | $1,380 萬 | 0.47% | – | – |
| Farallon Capital Management, L.L.C. | 300,000 | $1,345 萬 | 0.07% | – | – |
| Emerald Advisers, LLC | 285,846 | $1,282 萬 | 0.46% | – | – |
| UBS Asset Management Americas Inc | 285,801 | $1,282 萬 | 0.01% | – | – |
| Charles Schwab Investment Management Inc | 270,384 | $1,213 萬 | 0.00% | – | – |
| Capital World Investors | 270,000 | $1,211 萬 | 0.00% | – | – |
| American Century Companies Inc | 263,359 | $1,181 萬 | 0.01% | – | – |
| Hudson Bay Capital Management LP | 230,000 | $1,031 萬 | 0.15% | – | – |
| Hood River Capital Management LLC | 229,040 | $1,027 萬 | 0.33% | – | – |
| Opaleye Management Inc. | 222,000 | $995.4 萬 | 1.46% | – | – |
| Candriam Luxembourg S.C.A. | 176,655 | $968.4 萬 | 0.08% | – | – |
| Wellington Management Group LLP | 202,478 | $907.9 萬 | 0.00% | – | – |
| GW&K Investment Management, LLC | 202,078 | $906.1 萬 | 0.08% | – | – |
| Artal Group S.A. | 200,000 | $896.8 萬 | 0.19% | – | – |
| Cormorant Asset Management, LP | 200,000 | $896.8 萬 | 0.26% | – | – |
| Bank of New York Mellon Corp | 181,514 | $813.9 萬 | 0.00% | – | – |
| Deutsche Bank AG | 179,314 | $804.0 萬 | 0.00% | – | – |
| Alyeska Investment Group, L.P. | 167,932 | $753.0 萬 | 0.10% | – | – |
| Allianz Asset Management GmbH | 119,641 | $536.5 萬 | 0.01% | – | – |
| Jacobs Levy Equity Management, Inc | 111,983 | $502.1 萬 | 0.04% | – | – |
| International Biotechnology Trust PLC | 100,000 | $448.4 萬 | 1.19% | – | – |
| Citigroup Inc | 99,868 | $447.8 萬 | 0.00% | – | – |
| Dimensional Fund Advisors LP | 98,974 | $445.3 萬 | 0.00% | – | – |
| Sunesis Advisors, LLC | 96,299 | $431.8 萬 | 3.45% | – | – |
| Barclays PLC | 90,367 | $405.1 萬 | 0.00% | – | – |
| Man Group plc | 88,866 | $398.5 萬 | 0.02% | – | – |
| Swiss National Bank | 84,600 | $379.3 萬 | 0.00% | – | – |
| Millennium Management LLC | 82,757 | $371.1 萬 | 0.01% | – | – |
| Rafferty Asset Management, LLC | 77,263 | $346.4 萬 | 0.02% | – | – |
| Russell Investments Group, Ltd. | 73,347 | $328.7 萬 | 0.01% | – | – |
| Nuveen Asset Management, LLC | 161,564 | $322.3 萬 | 0.00% | – | – |
| California Public Employees Retirement System | 71,012 | $318.4 萬 | 0.00% | – | – |
| Moody Aldrich Partners LLC | 63,423 | $284.4 萬 | 0.41% | – | – |
| Logos Global Management LP | 62,000 | $278.0 萬 | 0.27% | – | – |
| Rhenman & Partners Asset Management AB | 60,000 | $269.0 萬 | 0.19% | – | – |
| California State Teachers Retirement System | 58,217 | $261.0 萬 | 0.00% | – | – |
| New York State Common Retirement Fund | 54,606 | $244.9 萬 | 0.00% | – | – |
| State of Wisconsin Investment Board | 51,900 | $232.7 萬 | 0.00% | – | – |
| State of New Jersey Common Pension Fund D | 48,005 | $215.3 萬 | 0.01% | – | – |
| Rhumbline Advisers | 43,754 | $196.2 萬 | 0.00% | – | – |
| UBS Group AG | 41,061 | $184.2 萬 | 0.00% | – | – |
| Hennion & Walsh Asset Management, Inc. | 40,723 | $182.6 萬 | 0.11% | – | – |
| Parametric Portfolio Associates LLC | 40,434 | $181.3 萬 | 0.00% | – | – |
| Silverarc Capital Management, LLC | 39,765 | $178.3 萬 | 1.00% | – | – |
| DekaBank Deutsche Girozentrale | 36,400 | $148.9 萬 | 0.00% | – | – |
| Atom Investors LP | 30,934 | $138.7 萬 | 0.26% | – | – |
| Bank of Montreal | 30,146 | $133.9 萬 | 0.00% | – | – |
| Credit Suisse AG | 28,951 | $129.7 萬 | 0.00% | – | – |
| Mackay Shields LLC | 28,200 | $126.4 萬 | 0.01% | – | – |
| Aviva PLC | 27,707 | $124.2 萬 | 0.01% | – | – |
| Schonfeld Strategic Advisors LLC | 27,096 | $121.5 萬 | 0.02% | – | – |
| Susquehanna International Group, LLP | 26,630 | $119.4 萬 | 0.00% | – | – |
| TD Asset Management Inc | 24,982 | $112.0 萬 | 0.00% | – | – |
| JPMorgan Chase & Co | 23,535 | $105.5 萬 | 0.00% | – | – |
| American International Group, Inc. | 22,495 | $100.9 萬 | 0.00% | – | – |
| Legal & General Group Plc | 22,310 | $100.1 萬 | 0.00% | – | – |
| Manufacturers Life Insurance Company, The | 22,280 | $99.9 萬 | 0.00% | – | – |
| Principal Financial Group Inc | 20,877 | $93.7 萬 | 0.00% | – | – |
| Nomura Holdings Inc | 20,500 | $92.0 萬 | 0.01% | – | – |
| Voya Investment Management LLC | 20,262 | $90.9 萬 | 0.00% | – | – |
| Morgan Stanley | 19,298 | $86.5 萬 | 0.00% | – | – |
| ProShare Advisors LLC | 18,285 | $82.0 萬 | 0.00% | – | – |
| Jefferies Group LLC | 17,827 | $79.9 萬 | 0.02% | – | – |
| Edmonds Duncan Registered Investment Advisors, LLC | 17,747 | $79.6 萬 | 0.26% | – | – |
| Squarepoint Ops LLC | 17,511 | $78.5 萬 | 0.01% | – | – |
| Erste Asset Management GmbH | 18,300 | $76.0 萬 | 0.02% | – | – |
| State Board of Administration of Florida Retirement System | 16,219 | $72.7 萬 | 0.00% | – | – |
| Victory Capital Management Inc | 16,056 | $72.0 萬 | 0.00% | – | – |
