| FMR LLC | 7,685,259 | $6.15 億 | 0.05% | – | – |
| ARK Investment Management LLC大師方舟投資 | 4,779,104 | $3.83 億 | 0.76% | – | – |
| Temasek Holdings (Private) Ltd | 3,406,013 | $2.73 億 | 1.07% | – | – |
| Vanguard Group Inc | 3,233,410 | $2.59 億 | 0.01% | – | – |
| BlackRock Inc. | 3,091,811 | $2.47 億 | 0.01% | – | – |
| Redmile Group, LLC | 2,532,523 | $2.03 億 | 2.86% | – | – |
| MWG Management Limited | 2,362,635 | $1.89 億 | 91.90% | – | – |
| HHLR Advisors, Ltd.大師高瓴 HHLR | 2,072,679 | $1.66 億 | 1.64% | – | – |
| State Street Corp | 1,218,271 | $9,751 萬 | 0.01% | – | – |
| Casdin Capital, LLC | 818,820 | $6,554 萬 | 1.95% | – | – |
| SC China Holding Ltd | 796,089 | $6,372 萬 | 4.73% | – | – |
| Goldman Sachs Group Inc | 734,217 | $5,877 萬 | 0.02% | – | – |
| Alphabet Inc. | 640,792 | $5,129 萬 | 2.07% | – | – |
| Geode Capital Management, LLC | 596,405 | $4,774 萬 | 0.01% | – | – |
| Victory Capital Management Inc | 593,605 | $4,751 萬 | 0.05% | – | – |
| Farallon Capital Management, L.L.C. | 592,481 | $4,742 萬 | 0.25% | – | – |
| Bellevue Group AG | 566,821 | $4,537 萬 | 0.48% | – | – |
| Perceptive Advisors LLC | 537,635 | $3,783 萬 | 0.50% | – | – |
| Northern Trust Corp | 402,757 | $3,224 萬 | 0.01% | – | – |
| JPMorgan Chase & Co | 354,488 | $2,837 萬 | 0.00% | – | – |
| Norges Bank | 309,382 | $2,476 萬 | 0.01% | – | – |
| Monashee Investment Management LLC | 268,820 | $2,152 萬 | 3.31% | – | – |
| CVI Holdings, LLC | 268,820 | $2,152 萬 | 1.51% | – | – |
| Voloridge Investment Management, LLC | 244,641 | $1,958 萬 | 0.14% | – | – |
| Sumitomo Mitsui Trust Holdings, Inc. | 229,401 | $1,836 萬 | 0.01% | – | – |
| Nikko Asset Management Americas, Inc. | 229,401 | $1,836 萬 | 0.09% | – | – |
| University of Texas/Texas Am Investment Managment Co | 224,390 | $1,796 萬 | 10.54% | – | – |
| Charles Schwab Investment Management Inc | 219,692 | $1,759 萬 | 0.01% | – | – |
| Morgan Stanley | 208,195 | $1,666 萬 | 0.00% | – | – |
| Pictet Asset Management Ltd | 192,157 | $1,538 萬 | 0.02% | – | – |
| Millennium Management LLC | 194,295 | $1,484 萬 | 0.02% | – | – |
| Cormorant Asset Management, LP | 171,775 | $1,375 萬 | 0.40% | – | – |
| Bank of New York Mellon Corp | 171,468 | $1,373 萬 | 0.00% | – | – |
| Nuveen Asset Management, LLC | 169,130 | $1,354 萬 | 0.00% | – | – |
| Citadel Advisors LLC | 157,317 | $1,259 萬 | 0.01% | – | – |
| Gilder Gagnon Howe & Co LLC | 143,900 | $1,152 萬 | 0.06% | – | – |
| Ergoteles LLC | 116,855 | $935.3 萬 | 0.29% | – | – |
| California Public Employees Retirement System | 103,223 | $826.2 萬 | 0.01% | – | – |
| Hamilton Lane Advisors LLC | 98,761 | $790.5 萬 | 2.58% | – | – |
| Bamco Inc | 98,017 | $784.5 萬 | 0.02% | – | – |
| Granahan Investment Management Inc | 96,591 | $773.1 萬 | 0.16% | – | – |
| Capital Advisors Inc | 77,233 | $618.2 萬 | 0.20% | – | – |
| Lord, Abbett & Co. LLC | 72,445 | $579.8 萬 | 0.01% | – | – |
| Reynders McVeigh Capital Management, LLC | 67,452 | $539.9 萬 | 0.36% | – | – |
| California State Teachers Retirement System | 60,165 | $481.6 萬 | 0.01% | – | – |
| Deutsche Bank AG | 57,567 | $460.8 萬 | 0.00% | – | – |
| State of Wisconsin Investment Board | 57,100 | $457.0 萬 | 0.01% | – | – |
| Federated Hermes, Inc. | 53,388 | $427.3 萬 | 0.01% | – | – |
| Price T Rowe Associates Inc | 51,823 | $414.8 萬 | 0.00% | – | – |
| Alliancebernstein L.P. | 50,100 | $401.0 萬 | 0.00% | – | – |
| Citigroup Inc | 45,965 | $367.9 萬 | 0.00% | – | – |
| New York State Common Retirement Fund | 45,650 | $365.4 萬 | 0.00% | – | – |
| Wells Fargo & Company | 45,634 | $365.3 萬 | 0.00% | – | – |
| Rhumbline Advisers | 43,701 | $349.8 萬 | 0.00% | – | – |
| Swiss National Bank | 39,700 | $317.8 萬 | 0.00% | – | – |
| Evolutionary Tree Capital Management, LLC | 38,966 | $311.9 萬 | 1.84% | – | – |
| UBS Group AG | 38,529 | $308.4 萬 | 0.00% | – | – |
| Renaissance Technologies LLC | 38,100 | $305.0 萬 | 0.00% | – | – |
| Pathway Capital Management, LP | 37,399 | $299.3 萬 | 16.59% | – | – |
| Squarepoint Ops LLC | 36,817 | $294.7 萬 | 0.03% | – | – |
| Two Sigma Investments, LP | 34,076 | $272.7 萬 | 0.01% | – | – |
| Rafferty Asset Management, LLC | 33,854 | $271.0 萬 | 0.02% | – | – |
| Euclidean Capital LLC | 31,131 | $249.2 萬 | 0.83% | – | – |
| Brevan Howard Capital Management LP | 30,000 | $240.1 萬 | 1.60% | – | – |
| Jane Street Group, LLC | 27,510 | $220.2 萬 | 0.01% | – | – |
| Russell Investments Group, Ltd. | 27,380 | $219.0 萬 | 0.00% | – | – |
| Jump Financial, LLC | 27,338 | $218.8 萬 | 0.20% | – | – |
| Ensign Peak Advisors, Inc | 27,034 | $216.4 萬 | 0.00% | – | – |
| Susquehanna International Group, LLP | 26,657 | $213.4 萬 | 0.00% | – | – |
| Vontobel Holding Ltd. | 25,914 | $207.4 萬 | 0.02% | – | – |
| Myriad Asset Management Ltd. | 25,200 | $201.7 萬 | 0.21% | – | – |
| Legal & General Group Plc | 25,195 | $201.6 萬 | 0.00% | – | – |
| Laurion Capital Management LP | 25,000 | $200.1 萬 | 0.03% | – | – |
| Credit Suisse AG | 23,801 | $190.5 萬 | 0.00% | – | – |
| American International Group, Inc. | 23,254 | $186.1 萬 | 0.01% | – | – |
| Virtu Financial LLC | 22,256 | $178.1 萬 | 0.13% | – | – |
| Manufacturers Life Insurance Company, The | 22,220 | $177.8 萬 | 0.00% | – | – |
| State of New Jersey Common Pension Fund D | 22,136 | $177.2 萬 | 0.01% | – | – |
| Tower Research Capital LLC (TRC) | 21,565 | $172.6 萬 | 0.03% | – | – |
| DC Investments Management, LLC | 21,010 | $168.2 萬 | 4.17% | – | – |
| Advisory Research Inc | 20,309 | $162.6 萬 | 0.11% | – | – |
| Principal Financial Group Inc | 20,218 | $161.8 萬 | 0.00% | – | – |
| DekaBank Deutsche Girozentrale | 21,300 | $161.3 萬 | 0.01% | – | – |
| Bank of America Corp | 19,940 | $159.6 萬 | 0.00% | – | – |
| ProShare Advisors LLC | 18,707 | $149.7 萬 | 0.00% | – | – |
| UBS Asset Management Americas Inc | 18,151 | $145.3 萬 | 0.00% | – | – |
| Trexquant Investment LP | 17,878 | $143.1 萬 | 0.13% | – | – |
| Voya Investment Management LLC | 17,480 | $139.9 萬 | 0.00% | – | – |
| Parametric Portfolio Associates LLC | 17,064 | $136.6 萬 | 0.00% | – | – |
| Prosight Management, LP | 17,000 | $136.1 萬 | 1.11% | – | – |
| Cubist Systematic Strategies, LLC | 16,953 | $135.7 萬 | 0.02% | – | – |
| MetLife Investment Management | 15,372 | $123.0 萬 | 0.01% | – | – |
| Koss-Olinger Consulting, LLC | 15,000 | $120.1 萬 | 0.20% | – | – |
| State Board of Administration of Florida Retirement System | 14,845 | $118.8 萬 | 0.00% | – | – |
| Bank Julius Baer & Co. Ltd, Zurich | 13,268 | $106.2 萬 | 0.01% | – | – |
| Advisor Group Holdings, Inc. | 12,998 | $103.9 萬 | 0.00% | – | – |
| Allianz Asset Management GmbH | 12,290 | $98.4 萬 | 0.00% | – | – |
| Migdal Insurance & Financial Holdings Ltd. | 11,596 | $92.8 萬 | 0.01% | – | – |
| Brandywine Managers, LLC | 11,067 | $88.6 萬 | 1.18% | – | – |
| SG Americas Securities, LLC | 10,946 | $87.6 萬 | 0.01% | – | – |
