| Ra Capital Management, L.P. | 6,412,228 | $8.26 億 | 12.46% | – | – |
| Artisan Partners Limited Partnership | 6,046,890 | $7.79 億 | 1.01% | – | – |
| FMR LLC | 5,375,013 | $6.93 億 | 0.06% | – | – |
| Price T Rowe Associates Inc | 5,073,336 | $6.54 億 | 0.07% | – | – |
| Baker Bros. Advisors LP | 3,540,270 | $4.56 億 | 1.98% | – | – |
| Wellington Management Group LLP | 3,492,333 | $4.50 億 | 0.08% | – | – |
| Janus Henderson Group PLC | 3,167,312 | $4.08 億 | 0.19% | – | – |
| Westfield Capital Management Co LP | 1,867,693 | $2.41 億 | 1.50% | – | – |
| Eventide Asset Management, LLC | 1,698,648 | $2.19 億 | 3.24% | – | – |
| Vivo Capital, LLC | 1,664,242 | $2.14 億 | 7.54% | – | – |
| Lone Pine Capital LLC大師孤松資本 | 1,436,981 | $1.85 億 | 0.67% | – | – |
| Farallon Capital Management, L.L.C. | 1,000,000 | $1.29 億 | 0.67% | – | – |
| Spyglass Capital Management LLC | 971,105 | $1.25 億 | 3.30% | – | – |
| Invesco Ltd. | 734,292 | $9,464 萬 | 0.03% | – | – |
| Franklin Resources Inc | 732,375 | $9,439 萬 | 0.04% | – | – |
| Massachusetts Financial Services Co | 711,045 | $9,164 萬 | 0.03% | – | – |
| Sofinnova Investments, Inc. | 521,923 | $6,727 萬 | 4.24% | – | – |
| Victory Capital Management Inc | 518,396 | $6,681 萬 | 0.07% | – | – |
| OrbiMed Advisors LLC | 505,159 | $6,511 萬 | 0.61% | – | – |
| Alliancebernstein L.P. | 479,342 | $6,178 萬 | 0.03% | – | – |
| TimesSquare Capital Management, LLC | 466,300 | $6,010 萬 | 0.51% | – | – |
| BlackRock Inc. | 460,287 | $5,932 萬 | 0.00% | – | – |
| Eversept Partners, LP | 311,867 | $4,019 萬 | 3.29% | – | – |
| Brown Advisory Inc | 302,422 | $3,898 萬 | 0.07% | – | – |
| Candriam Luxembourg S.C.A. | 240,671 | $3,856 萬 | 0.32% | – | – |
| New York State Common Retirement Fund | 276,377 | $3,562 萬 | 0.04% | – | – |
| Bank of New York Mellon Corp | 262,814 | $3,387 萬 | 0.01% | – | – |
| SEI Investments Co | 262,392 | $3,383 萬 | 0.09% | – | – |
| Deutsche Bank AG | 243,261 | $3,135 萬 | 0.02% | – | – |
| Rock Springs Capital Management LP | 233,500 | $3,009 萬 | 0.66% | – | – |
| American Century Companies Inc | 199,383 | $2,570 萬 | 0.02% | – | – |
| Neuberger Berman Group LLC | 190,900 | $2,460 萬 | 0.02% | – | – |
| Marshall Wace North America L.P. | 176,712 | $2,278 萬 | 0.09% | – | – |
| Loomis Sayles & Co L P | 172,584 | $2,224 萬 | 0.03% | – | – |
| FIL Ltd | 171,883 | $2,215 萬 | 0.03% | – | – |
| Thrivent Financial for Lutherans | 165,961 | $2,139 萬 | 0.05% | – | – |
| Ghost Tree Capital, LLC | 135,000 | $1,740 萬 | 4.88% | – | – |
| Tekla Capital Management LLC | 118,336 | $1,525 萬 | 0.52% | – | – |
| Citadel Advisors LLC | 114,915 | $1,481 萬 | 0.02% | – | – |
| TD Asset Management Inc | 104,995 | $1,353 萬 | 0.02% | – | – |
| California Public Employees Retirement System | 103,376 | $1,332 萬 | 0.01% | – | – |
| Baillie Gifford & Co | 102,294 | $1,318 萬 | 0.01% | – | – |
| Putnam Investments LLC | 100,816 | $1,299 萬 | 0.02% | – | – |
| Cormorant Asset Management, LP | 100,000 | $1,289 萬 | 0.37% | – | – |
| Berylson Capital Partners, LLC | 92,325 | $1,190 萬 | 2.90% | – | – |
| Lakewood Capital Management, LP | 81,450 | $1,050 萬 | 0.45% | – | – |
| First Manhattan Co | 79,508 | $1,025 萬 | 0.04% | – | – |
| ARS Investment Partners, LLC | 75,068 | $967.5 萬 | 1.12% | – | – |
| Goldman Sachs Group Inc | 72,833 | $938.7 萬 | 0.00% | – | – |
| Westpac Banking Corp | 72,589 | $935.5 萬 | 0.10% | – | – |
| Millennium Management LLC | 69,010 | $889.4 萬 | 0.01% | – | – |
| Ensign Peak Advisors, Inc | 66,882 | $862.0 萬 | 0.02% | – | – |
| Ikarian Capital, LLC | 62,090 | $800.1 萬 | 1.19% | – | – |
| California State Teachers Retirement System | 58,799 | $757.8 萬 | 0.01% | – | – |
| Driehaus Capital Management LLC | 52,389 | $675.2 萬 | 0.10% | – | – |
| Ameriprise Financial Inc | 48,037 | $619.1 萬 | 0.00% | – | – |
| Comerica Bank | 44,091 | $582.3 萬 | 0.03% | – | – |
| JPMorgan Chase & Co | 44,488 | $573.3 萬 | 0.00% | – | – |
| Geode Capital Management, LLC | 43,463 | $560.1 萬 | 0.00% | – | – |
| Rice Hall James & Associates, LLC | 40,173 | $517.7 萬 | 0.17% | – | – |
| Henry James International Management, Inc. | 35,484 | $457.3 萬 | 1.38% | – | – |
| Point72 Asset Management, L.P. | 35,000 | $451.1 萬 | 0.02% | – | – |
| Allianz Asset Management GmbH | 32,225 | $415.3 萬 | 0.00% | – | – |
| Mirae Asset Global Investments Co., Ltd. | 31,786 | $409.6 萬 | 0.01% | – | – |
| Liberty Mutual Group Asset Management Inc. | 30,281 | $390.3 萬 | 0.24% | – | – |
| Morgan Stanley | 28,007 | $361.0 萬 | 0.00% | – | – |
| Q Global Advisors, LLC | 27,064 | $348.8 萬 | 1.33% | – | – |
| Hennion & Walsh Asset Management, Inc. | 25,047 | $322.8 萬 | 0.19% | – | – |
| Raymond James & Associates | 24,103 | $310.6 萬 | 0.00% | – | – |
| State Street Corp | 23,917 | $308.2 萬 | 0.00% | – | – |
| DAFNA Capital Management LLC | 23,237 | $299.5 萬 | 0.71% | – | – |
| Parkwood LLC | 21,210 | $273.4 萬 | 0.48% | – | – |
| DekaBank Deutsche Girozentrale | 21,270 | $272.5 萬 | 0.01% | – | – |
| Schroder Investment Management Group | 21,057 | $271.4 萬 | 0.00% | – | – |
| State of Wisconsin Investment Board | 20,646 | $266.1 萬 | 0.01% | – | – |
| Matisse Capital | 20,190 | $260.2 萬 | 0.75% | – | – |
| Affinity Asset Advisors, LLC | 20,000 | $257.8 萬 | 1.26% | – | – |
| Parametric Portfolio Associates LLC | 19,945 | $257.1 萬 | 0.00% | – | – |
| Stenahm Asset Managment Ltd | 19,400 | $250.0 萬 | 1.76% | – | – |
| Tudor Investment Corp Et Al | 18,862 | $243.1 萬 | 0.05% | – | – |
| Silverarc Capital Management, LLC | 18,694 | $240.9 萬 | 1.35% | – | – |
| Ergoteles LLC | 18,547 | $239.0 萬 | 0.07% | – | – |
| Hamilton Lane Advisors LLC | 18,519 | $238.7 萬 | 0.78% | – | – |
| Evolutionary Tree Capital Management, LLC | 16,764 | $216.1 萬 | 1.28% | – | – |
| Bellevue Group AG | 15,500 | $199.8 萬 | 0.02% | – | – |
| Erste Asset Management GmbH | 14,000 | $180.1 萬 | 0.04% | – | – |
| Advisors Asset Management, Inc. | 13,780 | $177.6 萬 | 0.03% | – | – |
| International Biotechnology Trust PLC | 13,800 | $177.5 萬 | 0.47% | – | – |
| Chicago Partners Investment Group LLC | 11,141 | $151.1 萬 | 0.12% | – | – |
| Bank of America Corp | 10,907 | $140.6 萬 | 0.00% | – | – |
| Values First Advisors, Inc. | 10,339 | $133.2 萬 | 0.98% | – | – |
| AMP Capital Investors Ltd | 10,220 | $131.7 萬 | 0.01% | – | – |
| Athanor Capital, LP | 9,779 | $126.0 萬 | 0.05% | – | – |
| Mackenzie Financial Corp | 9,660 | $124.5 萬 | 0.00% | – | – |
| Duality Advisers, LP | 9,394 | $121.1 萬 | 0.11% | – | – |
| Handelsbanken Fonder AB | 9,300 | $119.9 萬 | 0.01% | – | – |
| Atria Investments LLC | 9,212 | $118.7 萬 | 0.03% | – | – |
| Susquehanna International Group, LLP | 9,026 | $116.3 萬 | 0.00% | – | – |
| Envestnet Asset Management Inc | 9,020 | $116.2 萬 | 0.00% | – | – |
| Qube Research & Technologies Ltd | 9,016 | $116.2 萬 | 0.02% | – | – |
