| Capital World Investors | 6,506,829 | $7.47 億 | 0.14% | – | – |
| Capital Research Global Investors | 6,347,530 | $7.29 億 | 0.18% | – | – |
| RiverVest Venture Management LLC | 4,887,932 | $5.61 億 | 86.41% | – | – |
| Wellington Management Group LLP | 3,456,204 | $3.97 億 | 0.07% | – | – |
| BlackRock Inc. | 3,420,351 | $3.93 億 | 0.01% | – | – |
| Vanguard Group Inc | 3,286,450 | $3.77 億 | 0.01% | – | – |
| Redmile Group, LLC | 2,419,418 | $2.78 億 | 3.91% | – | – |
| Capital International Investors | 2,277,026 | $2.61 億 | 0.07% | – | – |
| NEA Management Company, LLC | 2,164,704 | $2.48 億 | 5.61% | – | – |
| State Street Corp | 892,725 | $1.02 億 | 0.01% | – | – |
| Baker Bros. Advisors LP | 703,050 | $8,070 萬 | 0.35% | – | – |
| Janus Henderson Group PLC | 547,434 | $6,284 萬 | 0.03% | – | – |
| Alliancebernstein L.P. | 510,750 | $5,862 萬 | 0.03% | – | – |
| Geode Capital Management, LLC | 504,651 | $5,792 萬 | 0.01% | – | – |
| Pictet Asset Management Ltd | 389,638 | $4,472 萬 | 0.05% | – | – |
| FMR LLC | 360,629 | $4,139 萬 | 0.00% | – | – |
| ArrowMark Colorado Holdings LLC | 351,639 | $4,036 萬 | 0.30% | – | – |
| Eventide Asset Management, LLC | 317,000 | $3,639 萬 | 0.54% | – | – |
| Northern Trust Corp | 306,403 | $3,517 萬 | 0.01% | – | – |
| Rock Springs Capital Management LP | 305,706 | $3,509 萬 | 0.77% | – | – |
| Goldman Sachs Group Inc | 232,146 | $2,665 萬 | 0.01% | – | – |
| Charles Schwab Investment Management Inc | 216,187 | $2,481 萬 | 0.01% | – | – |
| Tekla Capital Management LLC | 163,645 | $1,878 萬 | 0.65% | – | – |
| Capital International Inc | 157,858 | $1,812 萬 | 0.17% | – | – |
| Natixis | 153,041 | $1,757 萬 | 0.06% | – | – |
| Fairmount Funds Management LLC | 147,662 | $1,695 萬 | 7.14% | – | – |
| Samsara BioCapital, LLC | 146,259 | $1,679 萬 | 3.38% | – | – |
| Handelsbanken Fonder AB | 140,900 | $1,617 萬 | 0.09% | – | – |
| Two Sigma Investments, LP | 138,216 | $1,586 萬 | 0.05% | – | – |
| Nuveen Asset Management, LLC | 135,304 | $1,553 萬 | 0.00% | – | – |
| Norges Bank | 134,225 | $1,541 萬 | 0.00% | – | – |
| Point72 Asset Management, L.P. | 119,900 | $1,376 萬 | 0.07% | – | – |
| Jennison Associates LLC | 111,292 | $1,277 萬 | 0.01% | – | – |
| Morgan Stanley | 107,538 | $1,234 萬 | 0.00% | – | – |
| Bank of New York Mellon Corp | 102,306 | $1,174 萬 | 0.00% | – | – |
| Voloridge Investment Management, LLC | 91,727 | $1,053 萬 | 0.08% | – | – |
| Gilder Gagnon Howe & Co LLC | 90,957 | $1,044 萬 | 0.06% | – | – |
| Candriam Luxembourg S.C.A. | 68,951 | $927.2 萬 | 0.08% | – | – |
| Invesco Ltd. | 79,390 | $911.2 萬 | 0.00% | – | – |
| Citadel Advisors LLC | 72,186 | $828.6 萬 | 0.01% | – | – |
| D. E. Shaw & Co., Inc. | 67,165 | $770.9 萬 | 0.01% | – | – |
| California Public Employees Retirement System | 65,389 | $750.5 萬 | 0.01% | – | – |
| Dimensional Fund Advisors LP | 60,634 | $696.0 萬 | 0.00% | – | – |
| Swiss National Bank | 60,000 | $688.7 萬 | 0.00% | – | – |
| Deutsche Bank AG | 58,156 | $667.4 萬 | 0.00% | – | – |
| Barclays PLC | 54,780 | $628.7 萬 | 0.01% | – | – |
| Two Sigma Advisers, LP | 47,400 | $544.1 萬 | 0.01% | – | – |
| Moneta Group Investment Advisors LLC | 44,564 | $511.5 萬 | 0.27% | – | – |
| Teachers Retirement System of the State of Kentucky | 44,115 | $506.4 萬 | 0.05% | – | – |
| Allianz Asset Management GmbH | 41,102 | $471.8 萬 | 0.00% | – | – |
| California State Teachers Retirement System | 39,540 | $453.8 萬 | 0.01% | – | – |
| Citigroup Inc | 38,806 | $445.4 萬 | 0.00% | – | – |
| State of Wisconsin Investment Board | 35,300 | $405.2 萬 | 0.01% | – | – |
| Ikarian Capital, LLC | 31,700 | $363.9 萬 | 0.54% | – | – |
| JPMorgan Chase & Co | 29,465 | $338.2 萬 | 0.00% | – | – |
| Caption Management, LLC | 29,236 | $335.6 萬 | 0.43% | – | – |
| Rhumbline Advisers | 28,703 | $329.5 萬 | 0.00% | – | – |
| Handelsinvest Investeringsforvaltning | 28,000 | $321.4 萬 | 0.39% | – | – |
| Bank of America Corp | 27,697 | $317.9 萬 | 0.00% | – | – |
| Rafferty Asset Management, LLC | 26,867 | $308.4 萬 | 0.02% | – | – |
| UBS Asset Management Americas Inc | 25,887 | $297.1 萬 | 0.00% | – | – |
| Cormorant Asset Management, LP | 25,000 | $287.0 萬 | 0.08% | – | – |
| Mutual of America Capital Management LLC | 24,688 | $283.4 萬 | 0.03% | – | – |
| New York State Common Retirement Fund | 23,700 | $272.0 萬 | 0.00% | – | – |
| Millennium Management LLC | 20,978 | $240.8 萬 | 0.00% | – | – |
| Credit Suisse AG | 20,749 | $238.2 萬 | 0.00% | – | – |
| Bellevue Group AG | 18,500 | $212.3 萬 | 0.02% | – | – |
| Legal & General Group Plc | 18,109 | $207.9 萬 | 0.00% | – | – |
| Russell Investments Group, Ltd. | 18,013 | $206.7 萬 | 0.00% | – | – |
| State of New Jersey Common Pension Fund D | 17,384 | $199.5 萬 | 0.01% | – | – |
| DekaBank Deutsche Girozentrale | 17,790 | $194.4 萬 | 0.01% | – | – |
| Principal Financial Group Inc | 16,639 | $191.0 萬 | 0.00% | – | – |
| Ensign Peak Advisors, Inc | 16,020 | $183.9 萬 | 0.00% | – | – |
| International Biotechnology Trust PLC | 15,700 | $180.1 萬 | 0.48% | – | – |
| American International Group, Inc. | 15,283 | $175.4 萬 | 0.01% | – | – |
| Manufacturers Life Insurance Company, The | 15,217 | $174.7 萬 | 0.00% | – | – |
| Cornerstone Partners Capital Management, LLC | 14,445 | $165.8 萬 | 0.42% | – | – |
| ProShare Advisors LLC | 14,273 | $163.8 萬 | 0.01% | – | – |
| Davide Leone & Partners Investment Co Ltd. | 14,253 | $163.6 萬 | 0.22% | – | – |
| Price T Rowe Associates Inc | 13,324 | $152.9 萬 | 0.00% | – | – |
| Hamilton Lane Advisors LLC | 12,318 | $141.4 萬 | 0.46% | – | – |
| Voya Investment Management LLC | 11,527 | $132.3 萬 | 0.00% | – | – |
| Aviva PLC | 10,699 | $122.8 萬 | 0.01% | – | – |
| MetLife Investment Management | 10,559 | $121.2 萬 | 0.01% | – | – |
| SG Americas Securities, LLC | 10,281 | $118.0 萬 | 0.01% | – | – |
| Strategic Wealth Advisors Group, LLC | 10,186 | $116.9 萬 | 0.06% | – | – |
| State Board of Administration of Florida Retirement System | 10,056 | $115.4 萬 | 0.00% | – | – |
| Mackay Shields LLC | 9,900 | $113.6 萬 | 0.01% | – | – |
| Parametric Portfolio Associates LLC | 9,692 | $111.2 萬 | 0.00% | – | – |
| Blair William & Co | 9,459 | $108.6 萬 | 0.00% | – | – |
| Prudential Financial Inc | 8,911 | $102.3 萬 | 0.00% | – | – |
| Victory Capital Management Inc | 8,668 | $99.5 萬 | 0.00% | – | – |
| AQR Capital Management LLC | 8,408 | $96.5 萬 | 0.00% | – | – |
| STRS Ohio | 8,400 | $96.4 萬 | 0.00% | – | – |
| ExodusPoint Capital Management, LP | 8,168 | $93.8 萬 | 0.02% | – | – |
| Royal Bank of Canada | 8,068 | $92.5 萬 | 0.00% | – | – |
| SEI Investments Co | 6,289 | $88.0 萬 | 0.00% | – | – |
| Arizona State Retirement System | 7,642 | $87.7 萬 | 0.01% | – | – |
| Metropolitan Life Insurance Co | 7,109 | $81.6 萬 | 0.01% | – | – |
| Legal Advantage Investments, Inc. | 7,000 | $80.3 萬 | 0.60% | – | – |
