| Vanguard Group Inc | 4,250,754 | $7,596 萬 | 0.00% | – | – |
| BlackRock Inc. | 3,563,969 | $6,369 萬 | 0.00% | – | – |
| Bank of America Corp | 2,660,101 | $4,754 萬 | 0.01% | – | – |
| Woodline Partners LP | 2,157,039 | $3,855 萬 | 0.85% | – | – |
| PFM Health Sciences, LP | 2,067,684 | $3,695 萬 | 1.29% | – | – |
| Loomis Sayles & Co L P | 1,910,100 | $3,413 萬 | 0.04% | – | – |
| Morgan Stanley | 1,743,482 | $3,116 萬 | 0.00% | – | – |
| William Blair Investment Management, LLC | 1,637,872 | $2,927 萬 | 0.09% | – | – |
| Ameriprise Financial Inc | 1,591,132 | $2,843 萬 | 0.01% | – | – |
| Schroder Investment Management Group | 1,411,454 | $2,522 萬 | 0.03% | – | – |
| Rice Hall James & Associates, LLC | 1,398,066 | $2,498 萬 | 0.81% | – | – |
| Citigroup Inc | 1,173,166 | $2,096 萬 | 0.02% | – | – |
| Granahan Investment Management Inc | 1,159,309 | $2,072 萬 | 0.44% | – | – |
| C WorldWide Group Holding A/S | 1,156,142 | $2,066 萬 | 0.20% | – | – |
| Fred Alger Management, LLC | 983,365 | $1,757 萬 | 0.05% | – | – |
| Clearbridge Investments, LLC | 957,898 | $1,712 萬 | 0.01% | – | – |
| Levin Capital Strategies, L.P. | 913,884 | $1,633 萬 | 1.75% | – | – |
| State Street Corp | 835,459 | $1,493 萬 | 0.00% | – | – |
| Novo Holdings A/S | 788,410 | $1,409 萬 | 0.58% | – | – |
| Rhenman & Partners Asset Management AB | 750,000 | $1,340 萬 | 0.93% | – | – |
| Deutsche Bank AG | 702,413 | $1,255 萬 | 0.01% | – | – |
| Geode Capital Management, LLC | 697,287 | $1,246 萬 | 0.00% | – | – |
| Pinnacle Associates Ltd | 688,487 | $1,230 萬 | 0.23% | – | – |
| Principal Financial Group Inc | 529,366 | $946.0 萬 | 0.01% | – | – |
| Deerfield Management Company, L.P. (Series C) | 494,216 | $883.2 萬 | 0.19% | – | – |
| Rubric Capital Management LP | 480,402 | $858.5 萬 | 0.51% | – | – |
| Atika Capital Management LLC | 480,000 | $857.8 萬 | 0.89% | – | – |
| Northern Trust Corp | 452,761 | $809.1 萬 | 0.00% | – | – |
| Frontier Capital Management Co LLC | 432,373 | $772.7 萬 | 0.06% | – | – |
| Candriam Luxembourg S.C.A. | 576,495 | $748.1 萬 | 0.06% | – | – |
| Highland Capital Management Fund Advisors, L.P. | 396,998 | $709.4 萬 | 1.89% | – | – |
| Nuveen Asset Management, LLC | 361,945 | $646.8 萬 | 0.00% | – | – |
| Integral Health Asset Management, LLC | 350,000 | $625.5 萬 | 1.79% | – | – |
| Granite Investment Partners, LLC | 338,985 | $605.8 萬 | 0.20% | – | – |
| Charles Schwab Investment Management Inc | 298,801 | $534.0 萬 | 0.00% | – | – |
| DAFNA Capital Management LLC | 275,840 | $492.9 萬 | 1.17% | – | – |
| Norges Bank | 245,226 | $438.2 萬 | 0.00% | – | – |
| Altrinsic Global Advisors LLC | 240,000 | $428.9 萬 | 0.14% | – | – |
| Two Sigma Investments, LP | 233,029 | $416.4 萬 | 0.01% | – | – |
| Renaissance Technologies LLC | 227,510 | $406.6 萬 | 0.01% | – | – |
| Goldman Sachs Group Inc | 219,121 | $391.6 萬 | 0.00% | – | – |
| Voya Investment Management LLC | 217,738 | $389.0 萬 | 0.01% | – | – |
| Bank of New York Mellon Corp | 213,846 | $382.2 萬 | 0.00% | – | – |
| Jacobs Levy Equity Management, Inc | 200,228 | $357.8 萬 | 0.03% | – | – |
| Macquarie Group Ltd | 193,067 | $345.0 萬 | 0.00% | – | – |
| FMR LLC | 186,480 | $333.3 萬 | 0.00% | – | – |
| Allianz Asset Management GmbH | 152,580 | $272.7 萬 | 0.00% | – | – |
| RE Advisers Corp | 151,638 | $271.0 萬 | 0.06% | – | – |
| Voloridge Investment Management, LLC | 141,732 | $253.3 萬 | 0.02% | – | – |
| Endurance Wealth Management, Inc. | 127,600 | $228.0 萬 | 0.27% | – | – |
| Two Sigma Advisers, LP | 121,600 | $217.3 萬 | 0.01% | – | – |
| New York State Common Retirement Fund | 119,450 | $213.5 萬 | 0.00% | – | – |
| Eqis Capital Management, Inc. | 118,382 | $211.5 萬 | 0.16% | – | – |
| Royce & Associates LP | 117,650 | $210.2 萬 | 0.01% | – | – |
| Parametric Portfolio Associates LLC | 111,876 | $199.9 萬 | 0.00% | – | – |
| Caption Management, LLC | 93,808 | $167.6 萬 | 0.22% | – | – |
| DCF Advisers, LLC | 92,500 | $165.3 萬 | 0.84% | – | – |
| Swiss National Bank | 91,000 | $162.6 萬 | 0.00% | – | – |
| Citadel Advisors LLC | 87,840 | $157.0 萬 | 0.00% | – | – |
| Stifel Financial Corp | 85,379 | $152.6 萬 | 0.00% | – | – |
| Jacob Asset Management of New York LLC | 83,100 | $148.5 萬 | 0.57% | – | – |
| Morgens Waterfall Vintiadis & Co Inc | 80,000 | $143.0 萬 | 0.79% | – | – |
| California Public Employees Retirement System | 75,400 | $134.7 萬 | 0.00% | – | – |
| Millennium Management LLC | 74,850 | $133.8 萬 | 0.00% | – | – |
| Cubist Systematic Strategies, LLC | 72,413 | $129.4 萬 | 0.02% | – | – |
| Envestnet Asset Management Inc | 70,439 | $125.9 萬 | 0.00% | – | – |
| Tri Locum Partners LP | 68,472 | $122.4 萬 | 0.39% | – | – |
| Cushing Asset Management, LP | 68,236 | $121.9 萬 | 0.14% | – | – |
| PDT Partners, LLC | 62,143 | $111.0 萬 | 0.08% | – | – |
| Alliancebernstein L.P. | 59,100 | $105.6 萬 | 0.00% | – | – |
| Dimensional Fund Advisors LP | 57,095 | $102.0 萬 | 0.00% | – | – |
| California State Teachers Retirement System | 55,344 | $98.9 萬 | 0.00% | – | – |
| State of Wisconsin Investment Board | 52,400 | $93.6 萬 | 0.00% | – | – |
| Russell Investments Group, Ltd. | 51,172 | $91.4 萬 | 0.00% | – | – |
| Credit Suisse AG | 48,949 | $87.4 萬 | 0.00% | – | – |
| Barclays PLC | 47,735 | $85.3 萬 | 0.00% | – | – |
| Rhumbline Advisers | 46,182 | $82.5 萬 | 0.00% | – | – |
| UBS Asset Management Americas Inc | 42,076 | $75.2 萬 | 0.00% | – | – |
| Raymond James & Associates | 41,748 | $74.6 萬 | 0.00% | – | – |
| Knights of Columbus Asset Advisors LLC | 40,956 | $73.2 萬 | 0.07% | – | – |
| SG Americas Securities, LLC | 40,895 | $73.1 萬 | 0.00% | – | – |
| Vontobel Holding Ltd. | 40,000 | $71.5 萬 | 0.01% | – | – |
| Maverick Capital Ltd大師Maverick 資本 | 38,526 | $68.8 萬 | 0.01% | – | – |
| Tudor Investment Corp Et Al | 37,989 | $67.9 萬 | 0.01% | – | – |
| Thompson Investment Management, Inc. | 32,405 | $57.9 萬 | 0.09% | – | – |
| Quantitative Systematic Strategies LLC | 31,619 | $56.5 萬 | 0.09% | – | – |
| ExodusPoint Capital Management, LP | 31,559 | $56.4 萬 | 0.01% | – | – |
| Wrapmanager Inc | 30,155 | $53.9 萬 | 0.15% | – | – |
| Price T Rowe Associates Inc | 28,053 | $50.1 萬 | 0.00% | – | – |
| SEI Investments Co | 28,052 | $49.2 萬 | 0.00% | – | – |
| Truist Financial Corp | 26,909 | $48.1 萬 | 0.00% | – | – |
| HighTower Advisors, LLC | 24,781 | $44.1 萬 | 0.00% | – | – |
| Natixis Advisors, L.P. | 24,447 | $43.6 萬 | 0.00% | – | – |
| JPMorgan Chase & Co | 24,274 | $43.4 萬 | 0.00% | – | – |
| LPL Financial LLC | 23,638 | $42.2 萬 | 0.00% | – | – |
| Hanseatic Management Services Inc | 22,197 | $39.7 萬 | 0.79% | – | – |
| Manufacturers Life Insurance Company, The | 21,760 | $38.9 萬 | 0.00% | – | – |
| American International Group, Inc. | 21,381 | $38.2 萬 | 0.00% | – | – |
| Hennion & Walsh Asset Management, Inc. | 20,394 | $36.4 萬 | 0.02% | – | – |
| State Board of Administration of Florida Retirement System | 18,871 | $33.7 萬 | 0.00% | – | – |
