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Xilio Therapeutics, Inc.

XLO
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001840233

No open-market purchases or sales by Xilio Therapeutics, Inc. insiders were filed in the last 90 days; 27 institutions reported holding it in 13F filings for Q2 2026, worth $32.6M in total; no superinvestor holds it.

Q4 2025 vs. Q3 2025

How the institutions holding Xilio Therapeutics, Inc. changed between Q3 2025 and Q4 2025.

All holders in Q4 2025All holders in Q3 2025

13F holders of XLO: Q3 2025 compared with Q4 2025
MeasureQ3 2025Of which not filed for Q4 2025Q4 2025Change
Holders36137+2
Shares22.1M1.48M39.7M+19.2M (+93.1%)
Value$18.6M$1.24M$25.4M+$8.06M (+46.4%)

1 institution that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so the changes leave them out.

New holders (11)

Institutions that held Xilio Therapeutics, Inc. at the end of Q4 2025 but not at the end of Q3 2025.

Institutions new to XLO in Q4 2025
InstitutionSharesValue% of portfolio
Frazier Life Sciences Management, L.P.5,915,091$3.79M0.10%
Point72 Asset Management, L.P.4,000,000$2.56M0.00%
Sio Capital Management, LLC2,134,537$1.37M0.23%
StemPoint Capital LP2,030,028$1.30M0.22%
Empery Asset Management, LP1,183,040$757.4K0.67%
Ghisallo Capital Management LLC1,113,222$712.7K0.03%
Citadel Advisors LLC436,216$279.3K0.00%
Velan Capital Investment Management LP170,000$108.8K0.06%
Gsa Capital Partners LLP147,966$95.0K0.01%
Stonepine Capital Management, LLC126,270$80.8K0.06%
Jane Street Group, LLC42,080$26.9K0.00%

Sold out (9)

Institutions that held Xilio Therapeutics, Inc. at the end of Q3 2025 and filed for Q4 2025 without it.

Institutions that sold out of XLO in Q4 2025
InstitutionShares, Q3 2025Value, Q3 2025
Squarepoint Ops LLC328,794$277.1K
Trustees of Columbia University in the City of New York249,635$210.4K
Balyasny Asset Management LLC198,859$167.6K
Two Sigma Securities, LLC32,130$27.1K
Two Sigma Advisers, LP29,689$25.0K
Aptus Capital Advisors, LLC25,000$21.1K
SevenBridge Financial Group, LLC25,000$19.3K
Federation des caisses Desjardins du Quebec3,300$2.78K
Citigroup Inc258$217

Not filed for Q4 2025 yet (1)

Institutions that held Xilio Therapeutics, Inc. at the end of Q3 2025 and haven't filed a 13F for Q4 2025. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding XLO in Q3 2025 that haven't filed for Q4 2025
InstitutionShares, Q3 2025Value, Q3 2025
Takeda Pharmaceutical Co Ltd1,475,121$1.24M