Upstream Bio, Inc.
UPB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0002022626
In the last 90 days, Upstream Bio, Inc. insiders filed 0 open-market purchases and 5 sales; 148 institutions reported holding it in 13F filings for Q2 2026, worth $350.1M in total; no superinvestor holds it.
Q2 2025 vs. Q1 2025
How the institutions holding Upstream Bio, Inc. changed between Q1 2025 and Q2 2025.
All holders in Q2 2025All holders in Q1 2025
| Measure | Q1 2025 | Q2 2025 | Change |
|---|---|---|---|
| Holders | 79 | 83 | +4 |
| Shares | 46.3M | 48.4M | +2.07M (+4.5%) |
| Value | $266.9M | $530.9M | +$264.0M (+98.9%) |
New holders (14)
Institutions that held Upstream Bio, Inc. at the end of Q2 2025 but not at the end of Q1 2025.
| Institution | Shares | Value | % of portfolio |
|---|---|---|---|
| Verition Fund Management LLC | 33,505 | $367.9K | 0.00% |
| American Century Companies Inc | 22,362 | $245.5K | 0.00% |
| Price T Rowe Associates Inc | 17,448 | $192.0K | 0.00% |
| Commonwealth Equity Services, LLC | 15,526 | $170.0K | 0.00% |
| Creative Planning | 14,030 | $154.1K | 0.00% |
| Manufacturers Life Insurance Company, The | 13,190 | $144.8K | 0.00% |
| Virtus Investment Advisers, Inc. | 8,134 | $89.3K | 0.03% |
| Caitong International Asset Management Co., Ltd | 224 | $2.46K | 0.00% |
| Clearstead Advisors, LLC | 163 | $1.79K | 0.00% |
| Russell Investments Group, Ltd. | 147 | $1.61K | 0.00% |
| Essential Partners LLC | 97 | $1.06K | 0.00% |
| Advisor Group Holdings, Inc. | 42 | $257 | 0.00% |
| Parallel Advisors, LLC | 2 | $22 | 0.00% |
| IFP Advisors, Inc | 1 | $11 | 0.00% |
Sold out (10)
Institutions that held Upstream Bio, Inc. at the end of Q1 2025 and filed for Q2 2025 without it.
| Institution | Shares, Q1 2025 | Value, Q1 2025 |
|---|---|---|
| Millennium Management LLC | 61,796 | $378.2K |
| EcoR1 Capital, LLC | 60,000 | $367.2K |
| Goldman Sachs Group Inc | 32,955 | $201.7K |
| Two Sigma Investments, LP | 21,789 | $133.3K |
| ADAR1 Capital Management, LLC | 15,000 | $91.8K |
| XTX Topco Ltd | 12,731 | $77.9K |
| Walleye Capital LLC | 10,000 | $61.2K |
| Corebridge Financial, Inc. | 8,533 | $52.2K |
| UMA Financial Services, Inc. | 69 | $423 |
| Principal Securities, Inc. | 12 | $197 |