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Livermore
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Upstream Bio, Inc.

UPB
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0002022626

In the last 90 days, Upstream Bio, Inc. insiders filed 0 open-market purchases and 5 sales; 148 institutions reported holding it in 13F filings for Q2 2026, worth $350.1M in total; no superinvestor holds it.

Q4 2024 vs. Q3 2024

How the institutions holding Upstream Bio, Inc. changed between Q3 2024 and Q4 2024.

All holders in Q4 2024All holders in Q3 2024

13F holders of UPB: Q3 2024 compared with Q4 2024
MeasureQ3 2024Q4 2024Change
Holders070+70
Shares042.1M+42.1M
Value$0$690.1M+$690.1M

New holders (70)

Institutions that held Upstream Bio, Inc. at the end of Q4 2024 but not at the end of Q3 2024.

Institutions new to UPB in Q4 2024
InstitutionSharesValue% of portfolio
FMR LLC7,176,187$118.0M0.01%
OrbiMed Advisors LLC5,693,589$93.6M1.94%
Decheng Capital LLC3,285,293$54.0M11.58%
TCG Crossover Management, LLC2,801,763$44.9M4.38%
Enavate Sciences GP, LLC2,459,703$40.4M29.04%
Bain Capital Life Sciences Investors, LLC2,295,322$37.7M4.44%
VR Adviser, LLC2,295,319$37.7M2.59%
Samsara BioCapital, LLC2,217,146$36.4M5.00%
Omega Fund Management, LLC2,036,293$33.5M21.71%
Wellington Management Group LLP1,583,154$25.6M0.00%
BlackRock, Inc.1,117,800$18.4M0.00%
Alliancebernstein L.P.1,111,337$18.3M0.01%
Norges Bank1,000,000$16.4M0.00%
Deep Track Capital, LP1,000,000$16.4M0.62%
Vanguard Group Inc915,021$15.0M0.00%
Siren, L.L.C.800,000$13.2M0.58%
Nantahala Capital Management, LLC600,000$9.86M0.69%
Woodline Partners LP526,511$8.66M0.06%
Geode Capital Management, LLC363,269$5.97M0.00%
Balyasny Asset Management LLC301,152$4.95M0.01%
Great Point Partners LLC300,000$4.93M2.32%
Marshall Wace, LLP290,734$4.78M0.01%
State Street Corp247,187$4.06M0.00%
Lynx1 Capital Management LP240,042$3.95M1.48%
Citadel Advisors LLC180,000$2.96M0.00%
UBS Group AG161,512$2.66M0.00%
Northern Trust Corp143,721$2.36M0.00%
Charles Schwab Investment Management Inc135,323$2.22M0.00%
Alyeska Investment Group, L.P.85,000$1.40M0.01%
Moody Aldrich Partners LLC74,773$1.23M0.23%
EcoR1 Capital, LLC60,000$986.4K0.04%
JPMorgan Chase & Co47,792$785.7K0.00%
Soros Fund Management LLCSuperinvestorSoros Fund Management46,350$762.0K0.01%
Jane Street Group, LLC45,549$748.8K0.00%
Goldman Sachs Group Inc44,490$731.4K0.00%
Alps Advisors Inc43,340$712.5K0.00%
Morgan Stanley43,163$709.6K0.00%
Verition Fund Management LLC37,379$614.5K0.00%
Bank of New York Mellon Corp36,913$606.8K0.00%
Barclays PLC27,017$444.2K0.00%
Citigroup Inc26,504$435.7K0.00%
Nuveen Asset Management, LLC22,586$371.3K0.00%
Rhumbline Advisers16,721$274.9K0.00%
Invesco Ltd.15,602$256.5K0.00%
Deutsche Bank AG14,851$244.2K0.00%
Bank of America Corp13,963$229.6K0.00%
Davidson Kempner Capital Management LP12,500$205.3K0.00%
MetLife Investment Management11,034$181.4K0.00%
Walleye Capital LLC10,000$164.4K0.00%
Sandia Investment Management LP10,000$164.4K0.31%
Mirae Asset Global ETFs Holdings Ltd.9,828$161.6K0.00%
Wells Fargo & Company9,047$148.7K0.00%
Corebridge Financial, Inc.8,660$142.4K0.00%
SG Americas Securities, LLC7,590$125.0K0.00%
STRS Ohio3,200$52.6K0.00%
Tower Research Capital LLC (TRC)2,846$46.8K0.00%
Ameritas Investment Partners, Inc.1,822$30.0K0.00%
Legal & General Group Plc1,734$28.5K0.00%
US Bancorp1,660$27.3K0.00%
BNP Paribas Arbitrage, SA1,511$24.8K0.00%
California State Teachers Retirement System1,290$21.2K0.00%
Royal Bank of Canada1,282$21.0K0.00%
Amalgamated Bank594$10.0K0.00%
Sterling Capital Management LLC249$4.09K0.00%
R Squared Ltd160$2.63K0.00%
Aster Capital Management (DIFC) Ltd134$2.20K0.00%
Caitong International Asset Management Co., Ltd44$7230.00%
Advisor Group Holdings, Inc.17$2790.00%
Principal Securities, Inc.12$1970.00%
National Bank of Canada7$1150.00%

Sold out (0)

Institutions that held Upstream Bio, Inc. at the end of Q3 2024 and filed for Q4 2024 without it.

None.