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Spyre Therapeutics, Inc.

SYRE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001636282

In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 6 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.

Four kinds of short-selling data, each measuring something different:

  • Short interest: shares sold short and not yet bought back, as of a settlement date. FINRA publishes it twice a month, about eight business days after the settlement date.
  • Daily short volume: shares sold short each day in off-exchange trades reported to FINRA. It counts trades, not open positions, and is published the next day.
  • Fails-to-deliver: shares not delivered by the settlement date. The SEC publishes them twice a month, about two weeks late.
  • ATS (dark pool) volume: weekly volume on alternative trading systems and other off-exchange venues. FINRA publishes it two to four weeks after the week.

More in the glossary.

Short interest

Shares sold short and not yet bought back, from FINRA, on every settlement date in the last two years.

Short interest
11.6M
Shares, settlement Oct 30, 2026
Change
−887.9K
−7.1% vs. Oct 15, 2026
Days to cover
12.69
Short interest ÷ average daily volume
Average daily volume
915.4K
Shares, as reported by FINRA
Short interest by settlement date
Oct 31, 2024: 8,250,593 sharesNov 15, 2024: 8,040,536 sharesNov 29, 2024: 8,859,758 sharesDec 13, 2024: 9,620,365 sharesDec 31, 2024: 9,940,874 sharesJan 15, 2025: 10,003,304 sharesJan 31, 2025: 10,235,934 sharesFeb 14, 2025: 9,923,952 sharesFeb 28, 2025: 10,022,703 sharesMar 14, 2025: 10,767,640 sharesMar 31, 2025: 11,358,696 sharesApr 15, 2025: 11,749,883 sharesApr 30, 2025: 12,553,112 sharesMay 15, 2025: 12,296,733 sharesMay 30, 2025: 12,090,208 sharesJun 13, 2025: 12,592,074 sharesJun 30, 2025: 13,486,500 sharesJul 15, 2025: 13,602,876 sharesJul 31, 2025: 12,879,446 sharesAug 15, 2025: 13,187,699 sharesAug 29, 2025: 14,087,087 sharesSep 15, 2025: 13,780,763 sharesSep 30, 2025: 14,459,688 sharesOct 15, 2025: 13,390,470 sharesOct 31, 2025: 12,407,305 sharesNov 14, 2025: 12,464,842 sharesNov 28, 2025: 11,157,711 sharesDec 15, 2025: 11,818,159 sharesDec 31, 2025: 11,636,998 sharesJan 15, 2026: 10,069,741 sharesJan 30, 2026: 9,980,496 sharesFeb 13, 2026: 9,862,924 sharesFeb 27, 2026: 9,985,198 sharesMar 13, 2026: 9,997,086 sharesMar 31, 2026: 10,435,737 sharesApr 15, 2026: 11,672,747 sharesApr 30, 2026: 12,221,682 sharesMay 15, 2026: 12,417,051 sharesMay 29, 2026: 12,627,576 sharesJun 15, 2026: 12,616,535 sharesJun 30, 2026: 13,640,183 sharesJul 15, 2026: 12,508,710 sharesJul 31, 2026: 12,143,879 sharesAug 14, 2026: 11,755,434 sharesAug 31, 2026: 11,859,975 sharesSep 15, 2026: 12,129,443 sharesSep 30, 2026: 12,844,608 sharesOct 15, 2026: 12,505,491 sharesOct 30, 2026: 11,617,573 shares
Short interest in SYRE by settlement date
Settlement dateShort interestChangeChange %Avg. daily volumeDays to cover
Oct 30, 202611.6M−887.9K−7.1%915.4K12.69
Oct 15, 202612.5M−339.1K−2.6%1.70M7.34
Sep 30, 202612.8M+715.2K+5.9%1.44M8.89
Sep 15, 202612.1M+269.5K+2.3%1.05M11.58
Aug 31, 202611.9M+104.5K+0.9%1.22M9.69
Aug 14, 202611.8M−388.4K−3.2%736.8K15.95
Jul 31, 202612.1M−364.8K−2.9%898.5K13.52
Jul 15, 202612.5M−1.13M−8.3%1.39M9.03
Jun 30, 202613.6M+1.02M+8.1%2.46M5.56
Jun 15, 202612.6M−11.0K−0.1%1.17M10.83
May 29, 202612.6M+210.5K+1.7%816.2K15.47
May 15, 202612.4M+195.4K+1.6%1.19M10.44
Apr 30, 202612.2M+548.9K+4.7%1.22M10.04
Apr 15, 202611.7M+1.24M+11.9%1.59M7.35
Mar 31, 202610.4M+438.7K+4.4%909.1K11.48
Mar 13, 202610.0M+11.9K+0.1%714.8K13.99
Feb 27, 20269.99M+122.3K+1.2%803.7K12.42
Feb 13, 20269.86M−117.6K−1.2%663.2K14.87
Jan 30, 20269.98M−89.2K−0.9%492.0K20.29
Jan 15, 202610.1M−1.57M−13.5%724.8K13.89
Dec 31, 202511.6M−181.2K−1.5%827.6K14.06
Dec 15, 202511.8M+660.4K+5.9%852.2K13.87
Nov 28, 202511.2M−1.31M−10.5%611.0K18.26
Nov 14, 202512.5M+57.5K+0.5%618.5K20.15
Oct 31, 202512.4M−983.2K−7.3%1.04M11.89
Oct 15, 202513.4M−1.07M−7.4%1.46M9.19
Sep 30, 202514.5M+678.9K+4.9%795.1K18.19
Sep 15, 202513.8M−306.3K−2.2%483.0K28.53
Aug 29, 202514.1M+899.4K+6.8%480.0K29.35
Aug 15, 202513.2M+308.3K+2.4%432.4K30.50
Jul 31, 202512.9M−723.4K−5.3%551.7K23.35
Jul 15, 202513.6M+116.4K+0.9%588.2K23.13
Jun 30, 202513.5M+894.4K+7.1%795.6K16.95
Jun 13, 202512.6M+501.9K+4.2%461.5K27.28
May 30, 202512.1M−206.5K−1.7%364.0K33.21
May 15, 202512.3M−256.4K−2.0%592.7K20.75
Apr 30, 202512.6M+803.2K+6.8%587.1K21.38
Apr 15, 202511.7M+391.2K+3.4%1.02M11.52
Mar 31, 202511.4M+591.1K+5.5%645.1K17.61
Mar 14, 202510.8M+744.9K+7.4%669.4K16.08
Feb 28, 202510.0M+98.8K+1.0%623.3K16.08
Feb 14, 20259.92M−312.0K−3.1%581.6K17.06
Jan 31, 202510.2M+232.6K+2.3%611.0K16.75
Jan 15, 202510.0M+62.4K+0.6%554.1K18.05
Dec 31, 20249.94M+320.5K+3.3%499.9K19.88
Dec 13, 20249.62M+760.6K+8.6%488.9K19.68
Nov 29, 20248.86M+819.2K+10.2%925.9K9.57
Nov 15, 20248.04M−210.1K−2.6%542.1K14.83
Oct 31, 20248.25M−162.9K−1.9%359.7K22.94

Fails-to-deliver

Shares that weren't delivered by the settlement date, from the SEC, for the last 30 dates with fails. The price is the previous day's closing price published by the SEC.

Fails-to-deliver in SYRE by settlement date
Settlement dateSharesPriceValue
Oct 14, 2026363$80.45$29.2K
Oct 13, 2026466$85.90$40.0K
Oct 9, 20263,534$79.90$282.4K
Oct 7, 202663$80.11$5.05K
Oct 5, 2026269$93.19$25.1K
Sep 24, 2026788$88.17$69.5K
Sep 21, 20265,660$90.25$510.8K
Sep 18, 202627$92.68$2.50K
Sep 14, 20269$90.60$815.4
Sep 10, 202624,790$86.93$2.15M
Aug 26, 20264,795$107.36$514.8K
Aug 17, 20265,549$103.63$575.0K
Aug 11, 20262,448$105.33$257.8K
Jul 22, 2026961$102.70$98.7K
Jul 21, 20264,468$97.33$434.9K
Jul 20, 2026821$100.23$82.3K
Jul 17, 20262,395$94.12$225.4K
Jul 16, 202656$102.07$5.72K
Jul 7, 20266,039$88.74$535.9K
Jun 30, 20266,600$90.16$595.1K
Jun 29, 20264,555$87.89$400.3K
Jun 26, 20265,392$88.67$478.1K
Jun 22, 2026207,327$88.34$18.3M
Jun 18, 20262,977$87.49$260.5K
Jun 17, 202674$83.41$6.17K
Jun 16, 20263$83.58$250.74
Jun 15, 2026514$80.79$41.5K
Jun 11, 20261,753$75.08$131.6K
Jun 5, 20266$78.48$470.88
Jun 3, 202673$69.16$5.05K

Daily short volume

Off-exchange short-sale volume, not short interest: shares sold short each day in trades reported to FINRA, for the last 30 trading days.

The short volume ratio isn't a sentiment gauge: market makers sell short to fill buy orders and to hedge, so short sales are usually about half of off-exchange volume.

Off-exchange short volume in SYRE by trade date
Trade dateShort volumeShort exemptOff-exchange volumeShort volume ratio
Nov 11, 2026204,1720407,38350.1%
Nov 10, 2026222,9111,421348,92963.9%
Nov 9, 2026239,26414,835517,20346.3%
Nov 6, 2026273,23016,387443,90361.6%
Nov 5, 2026412,906249456,18490.5%
Nov 4, 2026380,53540575,00166.2%
Nov 3, 2026160,4520204,62878.4%
Nov 2, 2026195,9330255,25276.8%
Oct 30, 2026169,0940284,96759.3%
Oct 29, 2026110,18171203,35254.2%
Oct 28, 2026191,4930288,02366.5%
Oct 27, 2026268,7430434,94061.8%
Oct 26, 2026196,6442,718309,40963.6%
Oct 23, 2026150,7370185,68281.2%
Oct 22, 2026149,8740228,46665.6%
Oct 21, 2026180,3953,758300,76760.0%
Oct 20, 2026435,2582,800645,92767.4%
Oct 19, 2026348,45975535,46365.1%
Oct 16, 2026347,5450417,66383.2%
Oct 15, 2026226,6840499,40345.4%
Oct 14, 2026323,4910625,65851.7%
Oct 13, 2026334,3072,217587,19156.9%
Oct 12, 2026230,7490312,62273.8%
Oct 9, 2026334,5670518,28564.6%
Oct 8, 2026394,33001,002,83539.3%
Oct 7, 2026729,18611,4941,303,70555.9%
Oct 6, 20261,113,89314,3672,107,47352.9%
Oct 5, 2026166,9630222,95674.9%
Oct 2, 2026312,1420422,66373.9%
Oct 1, 2026429,1844,000739,28958.1%

ATS (dark pool) volume

Weekly volume on alternative trading systems (ATS) and other off-exchange (OTC) venues, from FINRA, for the last 12 weeks. ATS share is ATS volume ÷ (ATS + OTC volume), not a share of all trading.

Weekly ATS and OTC volume in SYRE
Week ofTierATS sharesATS tradesOther OTC sharesOther OTC tradesATS share
Oct 5, 2026T23,485,81263,1462,553,61011,65757.7%
Sep 28, 2026T22,260,49246,486882,5289,69071.9%
Sep 21, 2026T21,625,62739,173865,1377,48865.3%
Sep 14, 2026T21,635,23947,376998,7707,64362.1%
Sep 7, 2026T21,169,85530,147377,5235,89875.6%
Aug 31, 2026T21,844,76943,5921,201,84410,87060.6%
Aug 24, 2026T22,237,41150,7361,295,70914,84363.3%
Aug 17, 2026T21,471,60758,452966,5158,00760.4%
Aug 10, 2026T21,127,08560,081476,77016,58470.3%
Aug 3, 2026T21,196,71537,881424,5946,94773.8%
Jul 27, 2026T21,592,34737,571671,1367,11570.3%
Jul 20, 2026T21,147,58633,118461,6516,95671.3%