| Jun 11, 2025 (view filing) | Jun 9-10 | 2 days | Detheux MichelChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −16.8K | $10.03 | −$168.4K | −11.0%135.9K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jun 11, 2025 (view filing) | Jun 9-10 | 2 days | Detheux MichelChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −87.8K | $10.02 | −$879.8K | −100.0%0 after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jun 6, 2025 (view filing) | Jun 4-6 | 2 days | Detheux MichelChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −25.2K | $10.15 | −$255.9K | −15.6%135.9K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jun 6, 2025 (view filing) | Jun 4-6 | 2 days | Detheux MichelChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −131.6K | $10.15 | −$1.34M | −100.0%0 after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jun 6, 2025 (view filing) | Jun 4-6 | 2 days | Hallal DavidDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −114.7K | $10.15 | −$1.16M | −100.0%0 after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| May 16, 2025 (view filing) | May 14-15 | 2 days | EcoR1 Capital, LLC10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +4.96M | $7.80 | +$38.7M | +86.5%10.7M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| May 15, 2025 (view filing)5:34 PM ET | May 13 | 2 days | Gadicke Ansbert and 3 othersOther: Former 10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.03M | $8.06 | −$8.32M | −23.0%3.45M after | |
| May 15, 2025 (view filing)5:33 PM ET | May 13 | 2 days | MPM Bioventures 2018, L.P. and 2 othersOther: Former 10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −630.2K | $8.06 | −$5.08M | −23.0%2.11M after | Duplicate filingThe same trade also appears in an earlier filing, for example when the same people file twice or a fund and its partners each report it. Rankings and totals count only the earliest copy. |
| May 15, 2025 (view filing)5:32 PM ET | May 13 | 2 days | Evnin Luke and 8 othersOther: Former 10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −630.2K | $8.06 | −$5.08M | −23.0%2.11M after | |
| Nov 19, 2024 (view filing) | Nov 19 | Same day | Gall MatthewChief Financial Officer | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +5.00K | $7.73 | +$38.6K | +8.3%65.4K after | |
| May 14, 2024 (view filing)9:06 PM ET | May 10 | 4 days | RA Capital Healthcare Fund LP and 3 othersOther: Former 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +5.71M | $17.50 | +$100.0M | –5.71M after | DerivativeA trade in a derivative security (option, warrant, restricted stock unit and so on). The value is the derivative's own price times the quantity. |
| Oct 12, 2023 (view filing) | Oct 12 | Same day | Gall MatthewChief Financial Officer | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +5.00K | $8.37 | +$41.9K | +34.7%19.4K after | |
| Aug 25, 2023 (view filing)9:28 PM ET | Aug 23 | 2 days | Lewis Joseph and 3 othersOther: See remarks | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −350.0K | $16.26 | −$5.69M | −16.2%1.80M after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Jun 10, 2022 (view filing) | Jun 8-9 | 2 days | Hallal DavidDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −29.6K | $20.17 | −$597.2K | −100.0%0 after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average. |
| May 11, 2022 (view filing) | May 9-11 | 2 days | Davis Aaron I.Director | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −663.0K | $21.04 | −$14.0M | −23.5%2.15M after | 6 lotsThis row combines 6 trades of the same kind from one filing. The price is the value-weighted average. |
| May 2, 2022 (view filing) | Apr 28-May 2 | 4 days | Davis Aaron I.Director | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −375.0K | $27.32 | −$10.2M | −11.7%2.82M after | 5 lotsThis row combines 5 trades of the same kind from one filing. The price is the value-weighted average. |
| Apr 19, 2022 (view filing) | Apr 18 | 1 day | Detheux MichelChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −11.5K | $31.87 | −$366.5K | −30.5%26.3K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Mar 24, 2022 (view filing) | Mar 22-23 | 2 days | Davis Aaron I.Director | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +50.0K | $32.51 | +$1.63M | +1.6%3.19M after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average. |
| Mar 22, 2022 (view filing) | Mar 22 | Same day | Detheux MichelChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −18.4K | $34.17 | −$630.0K | −41.2%26.3K after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average. |
| Mar 18, 2022 (view filing)9:00 PM ET | Mar 17 | 1 day | Lewis Joseph and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −575.2K | $35.25 | −$20.3M | −15.5%3.14M after | |
| Mar 14, 2022 (view filing) | Mar 11 | 3 days | Lager Joanne JenkinsChief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.50K | $36.01 | −$126.0K | −100.0%0 after | |
| Mar 2, 2022 (view filing) | Mar 1 | 1 day | McGrath YvonneChief Scientific Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.0K | $36.76 | −$367.6K | −100.0%0 after | |
| Feb 24, 2022 (view filing) | Feb 23 | 1 day | Detheux MichelChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −14.5K | $34.34 | −$497.9K | −29.5%34.7K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Feb 14, 2022 (view filing) | Feb 11 | 3 days | Lager Joanne JenkinsChief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.50K | $35.85 | −$125.5K | −100.0%0 after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 26, 2022 (view filing) | Jan 25 | 1 day | Detheux MichelChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −14.5K | $35.68 | −$517.4K | −22.8%49.2K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 18, 2022 (view filing) | Jan 14 | 4 days | Lager Joanne JenkinsChief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.50K | $39.32 | −$137.6K | −100.0%0 after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 6, 2022 (view filing)4:13 PM ET | Jan 4-5 | 2 days | MPM Bioventures 2018, L.P. and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −146.7K | $42.58 | −$6.25M | −5.1%2.74M after | 5 lotsThis row combines 5 trades of the same kind from one filing. The price is the value-weighted average.Duplicate filingThe same trade also appears in an earlier filing, for example when the same people file twice or a fund and its partners each report it. Rankings and totals count only the earliest copy. |
| Jan 6, 2022 (view filing)4:12 PM ET | Jan 4-5 | 2 days | Evnin Luke and 8 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −146.7K | $42.58 | −$6.25M | −5.1%2.74M after | 5 lotsThis row combines 5 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 6, 2022 (view filing)4:12 PM ET | Jan 4-5 | 2 days | Gadicke Ansbert and 3 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −245.5K | $42.58 | −$10.5M | −5.2%4.48M after | 5 lotsThis row combines 5 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 5, 2022 (view filing)9:20 PM ET | Jan 3-4 | 2 days | Boxer Capital, LLC and 4 othersDirector, 10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −700.0K | $46.54 | −$32.6M | −100.0%0 after | 14 lotsThis row combines 14 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 4, 2022 (view filing) | Jan 3 | 1 day | Lager Joanne JenkinsChief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −7.00K | $51.90 | −$363.3K | −100.0%0 after | |
| Jan 4, 2022 (view filing) | Jan 3 | 1 day | Biniszkiewicz DetlevDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.50K | $51.90 | −$181.7K | −100.0%0 after | |
| Dec 28, 2021 (view filing) | Dec 27 | 1 day | Gall MatthewChief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −5.00K | $46.45 | −$232.3K | −25.7%14.4K after | |
| Dec 22, 2021 (view filing) | Dec 20-22 | 2 days | Detheux MichelChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −44.5K | $44.54 | −$1.98M | −41.1%63.7K after | 7 lotsThis row combines 7 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 22, 2021 (view filing) | Dec 20 | 2 days | Hallal DavidDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −50.0K | $43.57 | −$2.18M | −100.0%0 after | |
| Dec 17, 2021 (view filing) | Dec 17 | Same day | Lager Joanne JenkinsChief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −7.00K | $41.00 | −$287.0K | −100.0%0 after | |
| Dec 10, 2021 (view filing) | Dec 10 | Same day | Lager Joanne JenkinsChief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.50K | $34.50 | −$120.8K | −100.0%0 after | |
| Dec 7, 2021 (view filing)6:36 PM ET | Dec 3-7 | 4 days | MPM Bioventures 2018, L.P. and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −49.8K | $33.73 | −$1.68M | −1.7%2.89M after | 9 lotsThis row combines 9 trades of the same kind from one filing. The price is the value-weighted average.Duplicate filingThe same trade also appears in an earlier filing, for example when the same people file twice or a fund and its partners each report it. Rankings and totals count only the earliest copy. |
| Dec 7, 2021 (view filing)6:35 PM ET | Dec 3-7 | 4 days | Evnin Luke and 8 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −49.8K | $33.73 | −$1.68M | −1.7%2.89M after | 9 lotsThis row combines 9 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 7, 2021 (view filing)6:33 PM ET | Dec 3-7 | 4 days | Gadicke Ansbert and 3 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −83.4K | $33.73 | −$2.81M | −1.7%4.73M after | 9 lotsThis row combines 9 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 2, 2021 (view filing)6:56 PM ET | Nov 30-Dec 2 | 2 days | MPM Bioventures 2018, L.P. and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −83.5K | $34.47 | −$2.88M | −2.8%2.94M after | 7 lotsThis row combines 7 trades of the same kind from one filing. The price is the value-weighted average.Duplicate filingThe same trade also appears in an earlier filing, for example when the same people file twice or a fund and its partners each report it. Rankings and totals count only the earliest copy. |
| Dec 2, 2021 (view filing)6:53 PM ET | Nov 30-Dec 2 | 2 days | Evnin Luke and 8 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −83.5K | $34.47 | −$2.88M | −2.8%2.94M after | 7 lotsThis row combines 7 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 2, 2021 (view filing)6:53 PM ET | Nov 30-Dec 2 | 2 days | Gadicke Ansbert and 3 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −139.8K | $34.47 | −$4.82M | −2.8%4.81M after | 7 lotsThis row combines 7 trades of the same kind from one filing. The price is the value-weighted average. |
| Nov 30, 2021 (view filing)4:57 PM ET | Nov 26-29 | 4 days | MPM Bioventures 2018, L.P. and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −23.0K | $35.18 | −$810.8K | −0.8%3.02M after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average.Duplicate filingThe same trade also appears in an earlier filing, for example when the same people file twice or a fund and its partners each report it. Rankings and totals count only the earliest copy. |
| Nov 30, 2021 (view filing)4:53 PM ET | Nov 26-29 | 4 days | Evnin Luke and 8 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −23.0K | $35.18 | −$810.8K | −0.8%3.02M after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average. |
| Nov 30, 2021 (view filing)4:49 PM ET | Nov 26-29 | 4 days | Gadicke Ansbert and 3 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −38.6K | $35.18 | −$1.36M | −0.8%4.95M after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average. |
| Nov 24, 2021 (view filing)6:38 PM ET | Nov 22-24 | 2 days | Gadicke Ansbert and 3 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −129.6K | $36.61 | −$4.74M | −2.5%4.99M after | 7 lotsThis row combines 7 trades of the same kind from one filing. The price is the value-weighted average. |
| Nov 24, 2021 (view filing)6:35 PM ET | Nov 22-24 | 2 days | MPM Bioventures 2018, L.P. and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −77.5K | $36.61 | −$2.84M | −2.5%3.04M after | 7 lotsThis row combines 7 trades of the same kind from one filing. The price is the value-weighted average.Duplicate filingThe same trade also appears in an earlier filing, for example when the same people file twice or a fund and its partners each report it. Rankings and totals count only the earliest copy. |
| Nov 24, 2021 (view filing)6:34 PM ET | Nov 22-24 | 2 days | Evnin Luke and 8 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −77.5K | $36.61 | −$2.84M | −2.5%3.04M after | 7 lotsThis row combines 7 trades of the same kind from one filing. The price is the value-weighted average. |
| Nov 24, 2021 (view filing) | Nov 23 | 1 day | Detheux MichelChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −14.5K | $36.08 | −$523.2K | −15.6%78.2K after | |
