| Aug 18, 2026 (view filing)4:08 PM ET | Aug 18 | Same day | Zaderej Karen L.Director | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +10.6K | $4.93 | +$52.3K | +27.5%49.1K after | |
| Jul 2, 2026 (view filing)4:03 PM ET | Jun 30 | 2 days | Ribeiro RamiroChief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −4.88K | $15.01 | −$73.2K | −100.0%0 after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 20, 2026 (view filing) | Apr 17 | 3 days | Ribeiro RamiroChief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.44K | $15.00 | −$36.6K | −100.0%0 after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 16, 2026 (view filing) | Mar 16 | Same day | Duker Jay S.President and CEO | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +1.50K | $13.15 | +$19.7K | +1.5%100.7K after | |
| Mar 5, 2026 (view filing) | Mar 4 | 1 day | Ribeiro RamiroChief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.44K | $17.87 | −$43.6K | −100.0%0 after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 18, 2026 (view filing) | Feb 17 | 1 day | Ribeiro RamiroChief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.44K | $15.00 | −$36.6K | −100.0%0 after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jan 7, 2026 (view filing) | Jan 5 | 2 days | Ribeiro RamiroChief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −42.5K | $17.10 | −$727.5K | −100.0%0 after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 8, 2025 (view filing)4:03 PM ET | Dec 4 | 4 days | Cormorant Asset Management, LP and 2 othersOther: Former 10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −60.0K | $15.70 | −$942.2K | −0.7%8.27M after | |
| Dec 5, 2025 (view filing) | Dec 4 | 1 day | Lurker NancyDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −9.30K | $15.11 | −$140.5K | −4.3%206.5K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 1, 2025 (view filing) | Nov 26-28 | 5 days | Lurker NancyDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −700 | $14.95 | −$10.5K | −0.3%215.8K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Nov 12, 2025 (view filing) | Nov 11 | 1 day | Ribeiro RamiroChief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.72K | $11.61 | −$31.6K | −100.0%0 after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| May 19, 2025 (view filing) | May 16-19 | 3 days | Zaderej Karen L.Director | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +10.0K | $5.90 | +$59.0K | +37.7%36.5K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| May 15, 2025 (view filing) | May 14-15 | 1 day | Zaderej Karen L.Director | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +10.0K | $5.45 | +$54.5K | +60.6%26.5K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Aug 21, 2024 (view filing) | Aug 20 | 1 day | Dicicco Wendy FDirector | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +2.57K | $7.79 | +$20.0K | +34.7%9.97K after | |
| Aug 21, 2024 (view filing) | Aug 21 | Same day | Ando GoranDirector | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +5.00K | $7.95 | +$39.8K | +61.3%13.2K after | |
| Aug 21, 2024 (view filing) | Aug 19 | 2 days | Zaderej Karen L.Director | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +12.5K | $7.98 | +$99.8K | +312.5%16.5K after | |
| Aug 20, 2024 (view filing) | Aug 16 | 4 days | Lurker NancyDirector | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +3.17K | $7.88 | +$25.0K | +3.4%97.6K after | |
| Jul 16, 2024 (view filing) | Jul 12 | 4 days | Guyer David RDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −11.6K | $10.06 | −$116.9K | −86.3%1.85K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jun 4, 2024 (view filing) | Jun 3 | 1 day | Guyer David RDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −11.6K | $10.30 | −$119.7K | −75.9%3.70K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| May 16, 2024 (view filing) | May 14 | 2 days | Guyer David RDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −11.6K | $12.65 | −$147.1K | −67.7%5.55K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| May 8, 2024 (view filing)4:23 PM ET | May 6 | 2 days | Cormorant Asset Management, LP and 2 others10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +850.0K | $11.86 | +$10.1M | +11.4%8.32M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Apr 22, 2024 (view filing)4:00 PM ET | Apr 18 | 4 days | Cormorant Asset Management, LP and 2 others10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +581.8K | $18.03 | +$10.5M | +8.4%7.47M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Feb 5, 2024 (view filing) | Feb 2 | 3 days | Jones David ScottSVP & Chief Commercial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −209 | $28.49 | −$5.95K | −0.5%38.0K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jan 30, 2024 (view filing) | Jan 26 | 4 days | Paggiarino Dario A.Chief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −49.3K | $25.66 | −$1.27M | −57.5%36.5K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jan 29, 2024 (view filing) | Jan 26 | 3 days | Jones David ScottSVP & Chief Commercial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −26.0K | $25.38 | −$660.4K | −40.7%38.0K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jan 29, 2024 (view filing) | Jan 25 | 4 days | Paggiarino Dario A.Chief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −600 | $25.00 | −$15.0K | −1.6%36.5K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jan 26, 2024 (view filing) | Jan 24-25 | 2 days | Jones David ScottSVP & Chief Commercial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −11.9K | $25.01 | −$297.6K | −23.9%38.0K after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jan 25, 2024 (view filing) | Jan 23-24 | 2 days | Paggiarino Dario A.Chief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −16.4K | $25.01 | −$409.8K | −31.0%36.5K after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 25, 2024 (view filing) | Jan 23-24 | 2 days | Lurker NancyExecutive Vice Chair | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −35.0K | $24.98 | −$874.2K | −20.5%135.4K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jan 24, 2024 (view filing) | Jan 22-23 | 2 days | Jones David ScottSVP & Chief Commercial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −35.1K | $22.68 | −$795.3K | −48.0%38.0K after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 16, 2024 (view filing) | Jan 11 | 5 days | Ocumension TherapeuticsDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.91M | $19.45 | −$37.2M | −95.0%100.2K after | Duplicate filingThe same trade also appears in an earlier filing, for example when the same people file twice or a fund and its partners each report it. Rankings and totals count only the earliest copy. |
| Jan 16, 2024 (view filing) | Jan 11 | 5 days | Liu YeDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock, $0.001 par value | −1.91M | $19.45 | −$37.2M | −95.0%100.2K after | |
| Jan 11, 2024 (view filing)4:00 PM ET | Jan 9-11 | 2 days | Cormorant Asset Management, LP and 2 others10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +855.0K | $19.94 | +$17.1M | +14.2%6.89M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jan 10, 2024 (view filing) | Jan 8 | 2 days | Paggiarino Dario A.Chief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −22.9K | $21.13 | −$484.2K | −38.6%36.5K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 15, 2023 (view filing) | Dec 13 | 2 days | Paggiarino Dario A.Chief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.46K | $20.00 | −$29.2K | −5.4%25.7K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 12, 2023 (view filing)4:52 PM ET | Dec 8 | 4 days | Cormorant Asset Management, LP and 2 others10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +588.2K | $17.00 | +$10.0M | +10.8%6.04M after | |
| Dec 11, 2023 (view filing) | Dec 4 | 7 days | Pine Michael CraigChief Corp Dev.&Strat. Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −46.0K | $21.97 | −$1.01M | −91.4%4.34K after | AmendedAn amended filing (for example Form 4/A or 13F-HR/A) that corrects or adds to an earlier filing.2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 7, 2023 (view filing) | Dec 5-6 | 2 days | Ocumension TherapeuticsDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.00M | $19.51 | −$19.5M | −33.2%2.01M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.Duplicate filingThe same trade also appears in an earlier filing, for example when the same people file twice or a fund and its partners each report it. Rankings and totals count only the earliest copy. |
| Dec 7, 2023 (view filing) | Dec 5-6 | 2 days | Liu YeDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock, $0.001 par value | −1.00M | $19.51 | −$19.5M | −33.2%2.01M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 6, 2023 (view filing)4:39 PM ET | Dec 4 | 2 days | Cormorant Asset Management, LP and 2 others10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +1.92M | $21.82 | +$41.9M | +54.3%5.45M after | 17 lotsThis row combines 17 trades of the same kind from one filing. The price is the value-weighted average. |
| Dec 6, 2023 (view filing) | Dec 4 | 2 days | Paggiarino Dario A.Chief Medical Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −30.6K | $22.00 | −$673.8K | −54.4%25.7K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 6, 2023 (view filing) | Dec 4 | 2 days | Lurker NancyExecutive Vice Chair | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −20.0K | $20.76 | −$415.2K | −10.5%170.6K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Sep 6, 2023 (view filing)7:10 PM ET | Sep 1 | 5 days | EW Healthcare Partners, L.P. and 3 others10% Owner, Other: See footnotes 1 and 3 | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock, $0.001 par value | −20.0K | $9.90 | −$198.0K | −0.6%3.49M after | AmendedAn amended filing (for example Form 4/A or 13F-HR/A) that corrects or adds to an earlier filing. |
| Sep 1, 2023 (view filing)4:51 PM ET | Aug 30-31 | 2 days | EW Healthcare Partners, L.P. and 3 others10% Owner, Other: See footnotes 1 and 6 | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock, $0.001 par value | −139.5K | $10.54 | −$1.47M | −3.8%3.51M after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average. |
| Aug 30, 2023 (view filing)5:46 PM ET | Aug 28-29 | 2 days | EW Healthcare Partners, L.P. and 3 others10% Owner, Other: See footnotes 1 and 4 | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock, $0.001 par value | −148.7K | $11.14 | −$1.66M | −3.9%3.65M after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Aug 30, 2023 (view filing)5:32 PM ET | Aug 24-25 | 6 days | EW Healthcare Partners, L.P. and 3 others10% Owner, Other: See footnotes 1 and 6 | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock, $0.001 par value | −223.9K | $11.11 | −$2.49M | −5.6%3.80M after | AmendedAn amended filing (for example Form 4/A or 13F-HR/A) that corrects or adds to an earlier filing.4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average. |
| Aug 24, 2023 (view filing)5:30 PM ET | Aug 22-23 | 2 days | EW Healthcare Partners, L.P. and 3 others10% Owner, Other: See footnotes 1 and 2 | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock, $0.001 par value | −167.9K | $13.49 | −$2.26M | −4.0%4.02M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| May 31, 2023 (view filing) | May 30 | 1 day | Liu YeDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.Common Stock, $0.001 par value | −1 | $6.00 | −$6 | 0.0%3.01M after | |
| Mar 15, 2022 (view filing) | Mar 14 | 1 day | Pine Michael CraigChief Corp Dev.&Strat. Officer | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +1.00K | $12.21 | +$12.2K | New position1.00K after | |
| Nov 17, 2021 (view filing) | Nov 15 | 2 days | Lurker NancyPresident & CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.0K | $20.15 | −$201.5K | −8.8%103.5K after | |
