Siren, L.L.C.
- SEC CIK
- 0002005245
- Latest filing
- Aug 13, 2026
Holdings in Q2 2025
Holdings as of Jun 30, 2025, filed Aug 13, 2025. Long positions only; changes compare share counts with Q1 2025.
- Positions
- 110
- −6 vs. Q1 2025
- Portfolio value
- $1.93B
- +$159.7M (+9.0%) vs. Q1 2025
| Security | Class | Shares | Value | % of portfolio | Share change | Action | History |
|---|---|---|---|---|---|---|---|
| SRRKScholar Rock Holding Corp | COM | 9,250,005 | $327.6M | 17.0% | 00.0% | Unchanged | History |
| KYMRKymera Therapeutics, Inc. | COM | 3,428,150 | $149.6M | 7.7% | +187,837+5.8% | Added | History |
| ONCBeOne Medicines Ltd. | ADR | 509,990 | $123.5M | 6.4% | +11,301+2.3% | Added | History |
| IRONDisc Medicine, Inc. | COM | 1,099,401 | $58.2M | 3.0% | +27,536+2.6% | Added | History |
| CRNXCrinetics Pharmaceuticals, Inc. | COM | 1,688,611 | $48.6M | 2.5% | 00.0% | Unchanged | History |
| BCAXBicara Therapeutics Inc. | COM | 5,216,969 | $48.5M | 2.5% | +1,949,886+59.7% | Added | History |
| DYNDyne Therapeutics, Inc. | COM | 4,836,437 | $46.0M | 2.4% | +2,118,450+77.9% | Added | History |
| CNTACentessa Pharmaceuticals plc | SPONSORED ADS | 3,460,029 | $45.5M | 2.4% | +500,000+16.9% | Added | History |
| MRUSMerus N.V. | COM | 853,467 | $44.9M | 2.3% | −190,000−18.2% | Reduced | History |
| APLSApellis Pharmaceuticals, Inc. | COM | 2,578,396 | $44.6M | 2.3% | 00.0% | Unchanged | History |
| ASNDAscendis Pharma A/S | SPONSORED ADR | 245,943 | $42.4M | 2.2% | −41,423−14.4% | Reduced | History |
| ARWRArrowhead Pharmaceuticals, Inc. | COM | 2,669,880 | $42.2M | 2.2% | 00.0% | Unchanged | History |
| EWTXEdgewise Therapeutics, Inc. | COM | 3,160,298 | $41.4M | 2.1% | +1,463,854+86.3% | Added | History |
| SLNOSoleno Therapeutics Inc | COM | 467,342 | $39.2M | 2.0% | −259,995−35.7% | Reduced | History |
| LXRXLexicon Pharmaceuticals, Inc. | COM NEW | 38,918,903 | $36.8M | 1.9% | 00.0% | Unchanged | History |
| TBLATaboola.com Ltd. | ORD SHS | 9,969,495 | $36.5M | 1.9% | 00.0% | Unchanged | History |
| SLDBSolid Biosciences Inc. | COM NEW | 7,415,905 | $36.1M | 1.9% | 00.0% | Unchanged | History |
| RVMDRevolution Medicines, Inc. | COM | 938,755 | $34.5M | 1.8% | +375,000+66.5% | Added | History |
| Avidity Biosciences, Inc.05370A108 | COM | 1,110,610 | $31.5M | 1.6% | 00.0% | Unchanged | – |
| RYTMRhythm Pharmaceuticals, Inc. | COM | 409,742 | $25.9M | 1.3% | +132,209+47.6% | Added | History |
| APGEApogee Therapeutics, Inc. | COM | 594,994 | $25.8M | 1.3% | 00.0% | Unchanged | History |
| STOKStoke Therapeutics, Inc. | COM | 2,247,347 | $25.5M | 1.3% | 00.0% | Unchanged | History |
| TSHATaysha Gene Therapies, Inc. | COM SHS | 11,014,737 | $25.4M | 1.3% | +4,500,000+69.1% | Added | History |
| XENEXenon Pharmaceuticals Inc. | COM | 812,761 | $25.4M | 1.3% | +80,000+10.9% | Added | History |
| WVEWave Life Sciences, Inc. | SHS | 3,696,322 | $24.0M | 1.2% | 00.0% | Unchanged | History |
| MLTXMoonLake Immunotherapeutics | CLASS A ORD | 508,267 | $24.0M | 1.2% | +508,267 | New | History |
| SEPNSepterna, Inc. | COM | 2,202,514 | $23.3M | 1.2% | 00.0% | Unchanged | History |
| NAMSNewAmsterdam Pharma Co N.V. | ORDINARY SHARES | 1,194,240 | $21.6M | 1.1% | −717,790−37.5% | Reduced | History |
| TRVITrevi Therapeutics, Inc. | COM | 3,938,793 | $21.5M | 1.1% | +1,075,000+37.5% | Added | History |
| TNGXTango Therapeutics, Inc. | COM | 3,364,814 | $17.2M | 0.9% | +799,472+31.2% | Added | History |
| AKROAkero Therapeutics, Inc. | COM | 318,647 | $17.0M | 0.9% | +318,647 | New | History |
| SLNSilence Therapeutics plc | ADS | 2,911,438 | $16.9M | 0.9% | +121,605+4.4% | Added | History |
| AVBPArriVent BioPharma, Inc. | COM | 700,000 | $15.2M | 0.8% | +700,000 | New | History |
| BCYCBicycle Therapeutics PLC | SPONSORED ADS | 2,012,752 | $14.0M | 0.7% | +200,000+11.0% | Added | History |
| RCUSArcus Biosciences, Inc. | COM | 1,612,077 | $13.1M | 0.7% | 00.0% | Unchanged | History |
| IHSIHS Holding Ltd | ORD SHS | 2,357,520 | $13.1M | 0.7% | 00.0% | Unchanged | History |
| AMZNAmazon Com Inc | Stock | 56,500 | $12.4M | 0.6% | 00.0% | Unchanged | History |
| DNLIDenali Therapeutics Inc. | COM | 821,513 | $11.5M | 0.6% | 00.0% | Unchanged | History |
| ERASErasca, Inc. | COM | 8,757,249 | $11.1M | 0.6% | 00.0% | Unchanged | History |
| ORICOric Pharmaceuticals, Inc. | COM | 1,007,575 | $10.2M | 0.5% | 00.0% | Unchanged | History |
| RELYRemitly Global, Inc. | COM | 515,449 | $9.67M | 0.5% | +25,000+5.1% | Added | History |
| PCVXVaxcyte, Inc. | COM | 295,543 | $9.61M | 0.5% | 00.0% | Unchanged | History |
| CRWDCrowdStrike Holdings, Inc. | Stock | 18,500 | $9.42M | 0.5% | −6,500−26.0% | Reduced | History |
| CGEMCullinan Therapeutics, Inc. | COM | 1,193,410 | $8.99M | 0.5% | 00.0% | Unchanged | History |
| GOOGLAlphabet Inc. | Stock | 50,703 | $8.93M | 0.5% | 00.0% | Unchanged | History |
| UPBUpstream Bio, Inc. | COM | 788,450 | $8.66M | 0.4% | 00.0% | Unchanged | History |
| SEERSeer, Inc. | COM CL A | 4,000,000 | $8.56M | 0.4% | 00.0% | Unchanged | History |
| MSFTMicrosoft Corp | Stock | 16,150 | $8.03M | 0.4% | −12,350−43.3% | Reduced | History |
| NVDANVIDIA Corp | Stock | 49,985 | $7.90M | 0.4% | +5,553+12.5% | Added | History |
| IONQIonQ, Inc. | COM | 170,000 | $7.30M | 0.4% | 00.0% | Unchanged | History |
| TSMTaiwan Semiconductor Manufacturing Co Ltd | ADR | 30,500 | $6.91M | 0.4% | +2,000+7.0% | Added | History |
| GOSSGossamer Bio, Inc. | COM | 5,208,968 | $6.41M | 0.3% | 00.0% | Unchanged | History |
| CRMSalesforce, Inc. | Stock | 22,600 | $6.16M | 0.3% | +8,000+54.8% | Added | History |
| COGTCogent Biosciences, Inc. | COM | 854,379 | $6.13M | 0.3% | +854,379 | New | History |
| RNACCartesian Therapeutics, Inc. | COM NEW | 563,272 | $5.85M | 0.3% | 00.0% | Unchanged | History |
| VERAVera Therapeutics, Inc. | CL A | 247,216 | $5.82M | 0.3% | −500,000−66.9% | Reduced | History |
| ADBEAdobe Inc. | Stock | 15,051 | $5.82M | 0.3% | −4,247−22.0% | Reduced | History |
| SIONSionna Therapeutics, Inc. | COM | 325,000 | $5.64M | 0.3% | 00.0% | Unchanged | History |
| PDDPDD Holdings Inc. | SPONSORED ADS | 52,901 | $5.54M | 0.3% | 00.0% | Unchanged | History |
| SGMTSagimet Biosciences Inc. | COM SER A | 724,771 | $5.52M | 0.3% | 00.0% | Unchanged | History |
| SYRESpyre Therapeutics, Inc. | COM NEW | 368,598 | $5.52M | 0.3% | 00.0% | Unchanged | History |
| PCRXPacira BioSciences, Inc. | COM | 225,000 | $5.38M | 0.3% | +225,000 | New | History |
| NOWServiceNow, Inc. | Stock | 5,126 | $5.27M | 0.3% | −4,000−43.8% | Reduced | History |
| KRROKorro Bio, Inc. | COM | 418,833 | $5.23M | 0.3% | 00.0% | Unchanged | History |
| DDOGDatadog, Inc. | CL A COM | 38,425 | $5.16M | 0.3% | −9,000−19.0% | Reduced | History |
| AGENAgenus Inc | COM NEW | 1,064,250 | $4.86M | 0.3% | +564,250+112.9% | Added | History |
| FROGJFrog Ltd | Stock | 107,116 | $4.70M | 0.2% | −24,500−18.6% | Reduced | History |
| RAPPRapport Therapeutics, Inc. | COM | 378,469 | $4.30M | 0.2% | 00.0% | Unchanged | History |
| TILInstil Bio, Inc. | COM NEW | 203,933 | $4.25M | 0.2% | 00.0% | Unchanged | History |
| DTDynatrace, Inc. | Stock | 75,229 | $4.15M | 0.2% | −12,500−14.2% | Reduced | History |
| WHWKWhitehawk Therapeutics, Inc. | COM | 2,082,000 | $3.89M | 0.2% | 00.0% | Unchanged | History |
| EDUNew Oriental Education & Technology Group Inc. | SPON ADR | 72,000 | $3.88M | 0.2% | −7,500−9.4% | Reduced | History |
| IGMSIGM Biosciences, Inc. | COM | 3,255,826 | $3.65M | 0.2% | 00.0% | Unchanged | History |
| FHTXFoghorn Therapeutics Inc. | COM | 720,720 | $3.39M | 0.2% | 00.0% | Unchanged | History |
| VIGLVigil Neuroscience, Inc. | COM | 411,191 | $3.27M | 0.2% | −1,555,873−79.1% | Reduced | History |
| NMRANeumora Therapeutics, Inc. | COM | 4,358,283 | $3.20M | 0.2% | 00.0% | Unchanged | History |
| PRQRProQR Therapeutics N.V. | SHS EURO | 1,552,183 | $3.17M | 0.2% | 00.0% | Unchanged | History |
| NBISNebius Group N.V. | Stock | 51,000 | $2.82M | 0.1% | −89,000−63.6% | Reduced | History |
| BDTXBlack Diamond Therapeutics, Inc. | COM | 1,046,517 | $2.60M | 0.1% | 00.0% | Unchanged | History |
| LXEOLexeo Therapeutics, Inc. | COM | 603,435 | $2.43M | 0.1% | 00.0% | Unchanged | History |
| PANWPalo Alto Networks Inc | Stock | 11,500 | $2.35M | 0.1% | 00.0% | Unchanged | History |
| QCOMQualcomm Inc | Stock | 14,000 | $2.23M | 0.1% | 00.0% | Unchanged | History |
| WKWorkiva Inc | COM CL A | 28,000 | $1.92M | 0.1% | +10,500+60.0% | Added | History |
| ELDNEledon Pharmaceuticals, Inc. | COM | 690,170 | $1.87M | 0.1% | 00.0% | Unchanged | History |
| BEKEKE Holdings Inc. | SPONSORED ADS | 105,000 | $1.86M | 0.1% | 00.0% | Unchanged | History |
| HUBSHubSpot Inc | COM | 3,000 | $1.67M | 0.1% | +3,000 | New | History |
| UNHUnitedHealth Group Inc | Stock | 5,076 | $1.58M | 0.1% | +5,076 | New | History |
| BIOABioAge Labs, Inc. | COM | 382,406 | $1.58M | 0.1% | 00.0% | Unchanged | History |
| GTLBGitlab Inc. | CLASS A COM | 35,000 | $1.58M | 0.1% | +35,000 | New | History |
| TRMLTourmaline Bio, Inc. | COM | 91,426 | $1.46M | 0.1% | 00.0% | Unchanged | History |
| RCKTRocket Pharmaceuticals, Inc. | COM | 591,263 | $1.45M | 0.1% | 00.0% | Unchanged | History |
| TSLATesla, Inc. | Stock | 4,000 | $1.27M | 0.1% | −5,000−55.6% | Reduced | History |
| BIRKBirkenstock Holding plc | COM SHS | 25,000 | $1.23M | 0.1% | +25,000 | New | History |
| SAILSailPoint, Inc. | COM | 50,000 | $1.14M | 0.1% | −45,000−47.4% | Reduced | History |
| SEMRSEMrush Holdings, Inc. | CL A COM | 125,000 | $1.13M | 0.1% | 00.0% | Unchanged | History |
| PRMBPrimo Brands Corp | CLASS A COM SHS | 37,500 | $1.11M | 0.1% | +37,500 | New | History |
| CLBTCellebrite DI Ltd. | ORDINARY SHARES | 60,000 | $960.0K | <0.1% | +60,000 | New | History |
| GBIOGeneration Bio Co. | COM | 2,968,925 | $950.4K | <0.1% | 00.0% | Unchanged | History |
| KLRSKalaris Therapeutics, Inc. | COM | 282,586 | $754.5K | <0.1% | 00.0% | Unchanged | History |
| HOOKHOOKIPA Pharma Inc. | COM | 566,640 | $711.1K | <0.1% | 00.0% | Unchanged | History |
Sold out since Q1 2025 (21)
Positions held at the end of Q1 2025 that are gone from this filing.
| Security | Class | Shares in Q1 2025 | Value in Q1 2025 | % of portfolio in Q1 2025 | History |
|---|---|---|---|---|---|
| BPMCBlueprint Medicines Corp | COM | 726,167 | $64.3M | 3.6% | History |
| PRTAProthena Corp Public Ltd Co | SHS | 1,283,555 | $15.9M | 0.9% | History |
| SMMTSummit Therapeutics Inc. | COM | 695,000 | $13.4M | 0.8% | History |
| MTSRMetsera, Inc. | COM | 150,000 | $4.08M | 0.2% | History |
| LPLALPL Financial Holdings Inc. | COM | 7,500 | $2.45M | 0.1% | History |
| MRVLMarvell Technology, Inc. | COM | 36,808 | $2.27M | 0.1% | History |
| SAROStandardAero, Inc. | COM | 56,855 | $1.51M | 0.1% | History |
| BILLBILL Holdings, Inc. | Stock | 28,500 | $1.31M | 0.1% | History |
| PYPLPayPal Holdings, Inc. | Stock | 20,000 | $1.30M | 0.1% | History |
| PEGAPegasystems Inc | COM | 16,500 | $1.15M | 0.1% | History |
| MDBMongoDB, Inc. | CL A | 5,500 | $964.7K | 0.1% | History |
| NKENIKE, Inc. | Stock | 15,000 | $952.2K | 0.1% | History |
| INTCIntel Corp | Stock | 40,000 | $908.4K | 0.1% | History |
| INFAInformatica Inc. | COM CL A | 50,000 | $872.5K | <0.1% | History |
| BABoeing Co | Stock | 5,000 | $852.8K | <0.1% | History |
| BASECouchbase, Inc. | COM | 49,850 | $785.1K | <0.1% | History |
| KRONKronos Bio, Inc. | COM | 842,954 | $695.4K | <0.1% | History |
| RACEFerrari N.V. | COM | 1,500 | $636.4K | <0.1% | History |
| USBUS Bancorp DE | COM NEW | 12,500 | $527.8K | <0.1% | History |
| OXYOccidental Petroleum Corp | Stock | 10,000 | $493.6K | <0.1% | History |
| GDSGDS Holdings Ltd | SPONSORED ADS | 12,500 | $316.6K | <0.1% | History |