Siren, L.L.C.
- SEC CIK
- 0002005245
- Latest filing
- Aug 13, 2026
Holdings in Q3 2024
Holdings as of Sep 30, 2024, filed Nov 13, 2024. Long positions only.
- Positions
- 109
- No filing for Q2 2024
- Portfolio value
- $2.00B
- No filing for Q2 2024
Siren, L.L.C. did not file a 13F for Q2 2024, so these holdings cannot be compared with the previous quarter and changes are not shown.
| Security | Class | Shares | Value | % of portfolio | Share change | Action | History |
|---|---|---|---|---|---|---|---|
| KYMRKymera Therapeutics, Inc. | COM | 2,969,733 | $140.6M | 7.0% | – | – | History |
| ONCBeOne Medicines Ltd. | ADR | 563,314 | $126.5M | 6.3% | – | – | History |
| SRRKScholar Rock Holding Corp | COM | 11,259,438 | $90.2M | 4.5% | – | – | History |
| BCAXBicara Therapeutics Inc. | COM | 3,072,827 | $78.3M | 3.9% | – | – | History |
| ARGXArgenx SE | SPONSORED ADR | 143,647 | $77.9M | 3.9% | – | – | History |
| CRNXCrinetics Pharmaceuticals, Inc. | COM | 1,309,652 | $66.9M | 3.3% | – | – | History |
| Avidity Biosciences, Inc.05370A108 | COM | 1,440,736 | $66.2M | 3.3% | – | – | – |
| APLSApellis Pharmaceuticals, Inc. | COM | 2,167,224 | $62.5M | 3.1% | – | – | History |
| LXRXLexicon Pharmaceuticals, Inc. | COM NEW | 38,918,903 | $61.1M | 3.1% | – | – | History |
| IGMSIGM Biosciences, Inc. | COM | 3,330,422 | $55.1M | 2.8% | – | – | History |
| CNTACentessa Pharmaceuticals plc | SPONSORED ADS | 3,258,677 | $52.1M | 2.6% | – | – | History |
| ASNDAscendis Pharma A/S | SPONSORED ADR | 347,921 | $51.9M | 2.6% | – | – | History |
| SLNSilence Therapeutics plc | ADS | 2,831,770 | $51.5M | 2.6% | – | – | History |
| ARWRArrowhead Pharmaceuticals, Inc. | COM | 2,458,778 | $47.6M | 2.4% | – | – | History |
| WVEWave Life Sciences, Inc. | SHS | 5,721,172 | $46.9M | 2.3% | – | – | History |
| SWTXSpringWorks Therapeutics, Inc. | COM | 1,377,701 | $44.1M | 2.2% | – | – | History |
| DYNDyne Therapeutics, Inc. | COM | 1,134,664 | $40.8M | 2.0% | – | – | History |
| VERAVera Therapeutics, Inc. | CL A | 837,928 | $37.0M | 1.9% | – | – | History |
| NMRANeumora Therapeutics, Inc. | COM | 2,606,571 | $34.4M | 1.7% | – | – | History |
| PCVXVaxcyte, Inc. | COM | 299,991 | $34.3M | 1.7% | – | – | History |
| RVMDRevolution Medicines, Inc. | COM | 753,601 | $34.2M | 1.7% | – | – | History |
| MRUSMerus N.V. | COM | 682,201 | $34.1M | 1.7% | – | – | History |
| TBLATaboola.com Ltd. | ORD SHS | 9,969,495 | $33.5M | 1.7% | – | – | History |
| LBPHLongboard Pharmaceuticals, Inc. | COM | 903,227 | $30.1M | 1.5% | – | – | History |
| XENEXenon Pharmaceuticals Inc. | COM | 743,769 | $29.3M | 1.5% | – | – | History |
| CYTKCytokinetics Inc | COM NEW | 525,971 | $27.8M | 1.4% | – | – | History |
| KURAKura Oncology, Inc. | COM | 1,339,942 | $26.2M | 1.3% | – | – | History |
| RCUSArcus Biosciences, Inc. | COM | 1,612,077 | $24.6M | 1.2% | – | – | History |
| DNLIDenali Therapeutics Inc. | COM | 834,028 | $24.3M | 1.2% | – | – | History |
| ERASErasca, Inc. | COM | 8,857,179 | $24.2M | 1.2% | – | – | History |
| CGEMCullinan Therapeutics, Inc. | COM | 1,211,357 | $20.3M | 1.0% | – | – | History |
| TNGXTango Therapeutics, Inc. | COM | 2,603,897 | $20.1M | 1.0% | – | – | History |
| SLDBSolid Biosciences Inc. | COM NEW | 2,749,041 | $19.2M | 1.0% | – | – | History |
| PRTAProthena Corp Public Ltd Co | SHS | 1,099,840 | $18.4M | 0.9% | – | – | History |
| NAMSNewAmsterdam Pharma Co N.V. | ORDINARY SHARES | 920,564 | $15.3M | 0.8% | – | – | History |
| BHVNBiohaven Ltd. | COM | 283,540 | $14.2M | 0.7% | – | – | History |
| KRROKorro Bio, Inc. | COM | 418,833 | $14.0M | 0.7% | – | – | History |
| APLTApplied Therapeutics, Inc. | COM | 1,633,768 | $13.9M | 0.7% | – | – | History |
| GOSSGossamer Bio, Inc. | COM | 13,281,610 | $13.1M | 0.7% | – | – | History |
| TILInstil Bio, Inc. | COM NEW | 192,433 | $13.0M | 0.6% | – | – | History |
| EWTXEdgewise Therapeutics, Inc. | COM | 404,113 | $10.8M | 0.5% | – | – | History |
| IOVAIovance Biotherapeutics, Inc. | COM | 1,106,040 | $10.4M | 0.5% | – | – | History |
| ORICOric Pharmaceuticals, Inc. | COM | 1,007,575 | $10.3M | 0.5% | – | – | History |
| IONSIonis Pharmaceuticals Inc | COM | 250,000 | $10.0M | 0.5% | – | – | History |
| TSHATaysha Gene Therapies, Inc. | COM SHS | 4,879,875 | $9.81M | 0.5% | – | – | History |
| MSFTMicrosoft Corp | Stock | 22,000 | $9.46M | 0.5% | – | – | History |
| RNACCartesian Therapeutics, Inc. | COM NEW | 572,236 | $9.22M | 0.5% | – | – | History |
| SLRNACELYRIN, Inc. | COM | 1,729,665 | $8.53M | 0.4% | – | – | History |
| PHATPhathom Pharmaceuticals, Inc. | COM | 460,753 | $8.33M | 0.4% | – | – | History |
| SEERSeer, Inc. | COM CL A | 4,000,000 | $7.88M | 0.4% | – | – | History |
| RAPPRapport Therapeutics, Inc. | COM | 384,197 | $7.87M | 0.4% | – | – | History |
| NGNENeurogene Inc. | COM | 175,898 | $7.38M | 0.4% | – | – | History |
| GBIOGeneration Bio Co. | COM | 2,982,733 | $7.37M | 0.4% | – | – | History |
| IHSIHS Holding Ltd | ORD SHS | 2,357,520 | $7.05M | 0.4% | – | – | History |
| CRWDCrowdStrike Holdings, Inc. | Stock | 25,000 | $7.01M | 0.4% | – | – | History |
| VIGLVigil Neuroscience, Inc. | COM | 1,991,038 | $6.77M | 0.3% | – | – | History |
| FHTXFoghorn Therapeutics Inc. | COM | 720,720 | $6.71M | 0.3% | – | – | History |
| NOWServiceNow, Inc. | Stock | 7,500 | $6.71M | 0.3% | – | – | History |
| AMZNAmazon Com Inc | Stock | 34,750 | $6.47M | 0.3% | – | – | History |
| BIOABioAge Labs, Inc. | COM | 300,000 | $6.24M | 0.3% | – | – | History |
| NVDANVIDIA Corp | Stock | 48,932 | $5.94M | 0.3% | – | – | History |
| SYRSSyros Pharmaceuticals, Inc. | COM NEW | 2,587,372 | $5.56M | 0.3% | – | – | History |
| NVCRNovoCure Ltd | ORD SHS | 350,884 | $5.48M | 0.3% | – | – | History |
| LXEOLexeo Therapeutics, Inc. | COM | 603,435 | $5.46M | 0.3% | – | – | History |
| PDDPDD Holdings Inc. | SPONSORED ADS | 40,401 | $5.45M | 0.3% | – | – | History |
| KLRSKalaris Therapeutics, Inc. | COM | 6,597,167 | $5.33M | 0.3% | – | – | History |
| BDTXBlack Diamond Therapeutics, Inc. | COM | 1,046,517 | $4.55M | 0.2% | – | – | History |
| ANROAlto Neuroscience, Inc. | COM SHS | 391,406 | $4.48M | 0.2% | – | – | History |
| DTDynatrace, Inc. | Stock | 82,729 | $4.42M | 0.2% | – | – | History |
| IONQIonQ, Inc. | COM | 500,000 | $4.37M | 0.2% | – | – | History |
| TSMTaiwan Semiconductor Manufacturing Co Ltd | ADR | 25,000 | $4.34M | 0.2% | – | – | History |
| AGENAgenus Inc | COM NEW | 775,000 | $4.25M | 0.2% | – | – | History |
| DDOGDatadog, Inc. | CL A COM | 32,925 | $3.79M | 0.2% | – | – | History |
| ADCTADC Therapeutics SA | SHS | 1,163,461 | $3.66M | 0.2% | – | – | History |
| SESea Ltd | SPONSORD ADS | 37,500 | $3.54M | 0.2% | – | – | History |
| OVIDOvid Therapeutics Inc. | COM | 2,850,000 | $3.36M | 0.2% | – | – | History |
| RGNXREGENXBIO Inc. | COM | 284,000 | $2.98M | 0.1% | – | – | History |
| EDUNew Oriental Education & Technology Group Inc. | SPON ADR | 38,500 | $2.92M | 0.1% | – | – | History |
| QCOMQualcomm Inc | Stock | 15,000 | $2.55M | 0.1% | – | – | History |
| HOOKHOOKIPA Pharma Inc. | COM | 566,640 | $2.44M | 0.1% | – | – | History |
| TRMLTourmaline Bio, Inc. | COM | 91,426 | $2.35M | 0.1% | – | – | History |
| SGMTSagimet Biosciences Inc. | COM SER A | 724,771 | $2.01M | 0.1% | – | – | History |
| PCORProcore Technologies, Inc. | COM | 32,300 | $1.99M | 0.1% | – | – | History |
| BEKEKE Holdings Inc. | SPONSORED ADS | 100,000 | $1.99M | 0.1% | – | – | History |
| VVisa Inc. | Stock | 7,000 | $1.92M | 0.1% | – | – | History |
| GRTSGritstone bio, Inc. | COM | 3,318,093 | $1.92M | 0.1% | – | – | History |
| GOOGLAlphabet Inc. | Stock | 11,000 | $1.82M | 0.1% | – | – | History |
| OXYOccidental Petroleum Corp | Stock | 35,000 | $1.80M | 0.1% | – | – | History |
| FROGJFrog Ltd | Stock | 61,000 | $1.77M | 0.1% | – | – | History |
| OMGAOmega Therapeutics, Inc. | COMMON STOCK | 1,323,530 | $1.61M | 0.1% | – | – | History |
| NTRANatera, Inc. | COM | 12,594 | $1.60M | 0.1% | – | – | History |
| PANWPalo Alto Networks Inc | Stock | 4,500 | $1.54M | 0.1% | – | – | History |
| PYPLPayPal Holdings, Inc. | Stock | 15,000 | $1.17M | 0.1% | – | – | History |
| ESTCElastic N.V. | ORD SHS | 13,000 | $997.9K | <0.1% | – | – | History |
| INTCIntel Corp | Stock | 40,000 | $938.4K | <0.1% | – | – | History |
| METAMeta Platforms, Inc. | Stock | 1,500 | $858.7K | <0.1% | – | – | History |
| KRONKronos Bio, Inc. | COM | 842,954 | $842.9K | <0.1% | – | – | History |
| TERNTerns Pharmaceuticals, Inc. | COM | 100,000 | $834.0K | <0.1% | – | – | History |
| RBRKRubrik, Inc. | Stock | 25,000 | $803.8K | <0.1% | – | – | History |
| Achilles Therapeutics PLC00449L102 | SPONSORED ADS | 755,375 | $770.5K | <0.1% | – | – | – |
Options (3)
Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.