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Livermore
Livermore
ZHEN

Affinity Asset Advisors, LLC

SEC CIK
0001773195
Latest filing
Aug 13, 2026

Holdings in Q4 2025

Holdings as of Dec 31, 2025, filed Feb 13, 2026. Long positions only; changes compare share counts with Q3 2025.

Institution overview
Positions
86
0 vs. Q3 2025
Portfolio value
$1.39B
+$316.9M (+29.5%) vs. Q3 2025
Filed
Feb 13, 2026
SEC
Holdings of Affinity Asset Advisors, LLC in Q4 2025
SecurityClassSharesValue% of portfolioShare changeActionHistory
Rocket Pharmaceuticals, Inc.77313F114*W EXP 09/02/20275,000$1.82K<0.1%00.0%Unchanged–
ADGMAdagio Medical Holdings, Inc.COM80,000$83.2K<0.1%00.0%UnchangedHistory
QTTBQ32 Bio Inc.COM27,777$92.2K<0.1%00.0%UnchangedHistory
XFORX4 Pharmaceuticals, IncCOM NEW145,000$580.0K<0.1%+145,000NewHistory
FRNMFreenome, Inc.CL A ORD SHS50,000$651.5K<0.1%−300,000−85.7%ReducedHistory
MGNXMacrogenics IncCOM484,308$779.7K0.1%+484,308NewHistory
CATXPerspective Therapeutics, Inc.COM NEW300,000$825.0K0.1%00.0%UnchangedHistory
Cogent Biosciences, Inc.19240QAA0NOTE 1.625%11/1–$1.18M0.1%–New–
QUREuniQure N.V.SHS50,000$1.20M0.1%−250,000−83.3%ReducedHistory
CMPSCOMPASS Pathways plcSPONSORED ADS200,000$1.38M0.1%00.0%UnchangedHistory
KZRKezar Life Sciences, Inc.COM229,076$1.44M0.1%+229,076NewHistory
RAREUltragenyx Pharmaceutical Inc.COM75,000$1.73M0.1%+75,000NewHistory
GERNGeron CorpCOM1,500,000$1.98M0.1%00.0%UnchangedHistory
EPRXEupraxia Pharmaceuticals Inc.COM300,000$2.27M0.2%00.0%UnchangedHistory
OBIOOrchestra BioMed Holdings, Inc.COM572,804$2.38M0.2%−154,468−21.2%ReducedHistory
AVRAnteris Technologies Global Corp.COM486,684$2.43M0.2%+36,684+8.2%AddedHistory
OACCUOaktree Acquisition Corp. III Life SciencesUNIT 10/04/2029250,000$2.65M0.2%00.0%UnchangedHistory
MRSNMersana Therapeutics, Inc.COMMON STOCK100,000$2.89M0.2%+100,000NewHistory
AVBPArriVent BioPharma, Inc.COM150,000$3.02M0.2%+150,000NewHistory
BLTEBelite Bio, IncSPONSORED ADS20,000$3.20M0.2%+20,000NewHistory
AMGNAmgen IncStock10,000$3.27M0.2%+10,000NewHistory
CRNXCrinetics Pharmaceuticals, Inc.COM75,000$3.49M0.3%00.0%UnchangedHistory
NXTCNextCure, Inc.COM NEW247,294$3.51M0.3%+55,412+28.9%AddedHistory
IBIOiBio, Inc.COM NEW2,057,200$3.97M0.3%+2,057,200NewHistory
ARWRArrowhead Pharmaceuticals, Inc.COM70,000$4.65M0.3%+70,000NewHistory
DNTHDianthus Therapeutics, Inc.COM115,000$4.74M0.3%−147,100−56.1%ReducedHistory
PRQRProQR Therapeutics N.V.SHS EURO2,454,278$4.96M0.4%−1,145,722−31.8%ReducedHistory
IMVTImmunovant, Inc.COM200,000$5.08M0.4%−100,000−33.3%ReducedHistory
CLYMClimb Bio, Inc.COM1,300,000$5.20M0.4%00.0%UnchangedHistory
AVDLAvadel Pharmaceuticals PLCStock250,000$5.39M0.4%+250,000NewHistory
RZLTRezolute, Inc.COM NEW2,351,144$5.55M0.4%+251,144+12.0%AddedHistory
NAMSWNewAmsterdam Pharma Co N.V.*W EXP 11/22/202245,000$5.63M0.4%00.0%UnchangedHistory
ENGNenGene Therapeutics Inc.COM643,370$5.81M0.4%+566,370+735.5%AddedHistory
VRCAVerrica Pharmaceuticals Inc.COM SHS707,338$5.88M0.4%+707,338NewHistory
ASNDAscendis Pharma A/SSPONSORED ADR30,000$6.40M0.5%+30,000NewHistory
Celcuity Inc.15102KAA8NOTE 2.750% 8/0–$6.52M0.5%–––
KPTIKaryopharm Therapeutics Inc.COM NEW889,575$6.55M0.5%+889,575NewHistory
SGMTSagimet Biosciences Inc.COM SER A1,148,245$6.80M0.5%+798,245+228.1%AddedHistory
RCUSArcus Biosciences, Inc.COM300,000$7.15M0.5%+300,000NewHistory
VRDNViridian Therapeutics, Inc.COM250,000$7.78M0.6%00.0%UnchangedHistory
MBXMBX Biosciences, Inc.COM250,000$7.88M0.6%+85,000+51.5%AddedHistory
RVMDRevolution Medicines, Inc.COM100,000$7.96M0.6%00.0%UnchangedHistory
STROSutro Biopharma, Inc.COM SHS748,382$8.66M0.6%+673,110+894.2%AddedConverted for a 1-for-10 splitHistory
TNGXTango Therapeutics, Inc.COM1,000,000$8.86M0.6%+1,000,000NewHistory
ZURAZura Bio LtdCLASS A ORD SHS1,813,671$9.50M0.7%+539,320+42.3%AddedHistory
CLDXCelldex Therapeutics, Inc.COM NEW350,000$9.51M0.7%+50,000+16.7%AddedHistory
NAMSNewAmsterdam Pharma Co N.V.ORDINARY SHARES275,000$9.65M0.7%00.0%UnchangedHistory
Travere Therapeutics, Inc.89422GAA5NOTE 2.250% 3/0–$9.99M0.7%–––
JBIOJade Biosciences, Inc.COM NEW714,956$11.0M0.8%+649,639+994.6%AddedHistory
TVTXTravere Therapeutics, Inc.COM300,000$11.5M0.8%−200,000−40.0%ReducedHistory
OVIDOvid Therapeutics Inc.COM7,150,000$11.7M0.8%+4,500,000+169.8%AddedHistory
COGTCogent Biosciences, Inc.COM350,000$12.4M0.9%+350,000NewHistory
VERAVera Therapeutics, Inc.CL A250,000$12.7M0.9%−53,330−17.6%ReducedHistory
ERASErasca, Inc.COM3,900,000$14.5M1.0%−385,787−9.0%ReducedHistory
ESTAEstablishment Labs Holdings Inc.COM200,000$14.6M1.0%−110,000−35.5%ReducedHistory
CNTACentessa Pharmaceuticals plcSPONSORED ADS600,552$15.0M1.1%−506,610−45.8%ReducedHistory
PTGXProtagonist Therapeutics, IncCOM172,125$15.0M1.1%−48,475−22.0%ReducedHistory
SVRASavara IncCOM2,797,153$16.9M1.2%+1,297,153+86.5%AddedHistory
MDGLMadrigal Pharmaceuticals, Inc.COM31,131$18.1M1.3%−83,869−72.9%ReducedHistory
TSHATaysha Gene Therapies, Inc.COM SHS3,300,000$18.1M1.3%+300,000+10.0%AddedHistory
NRIXNurix Therapeutics, Inc.COM967,620$18.4M1.3%00.0%UnchangedHistory
AVTXAvalo Therapeutics, Inc.COM NEW1,051,054$19.1M1.4%+44,837+4.5%AddedHistory
Omeros Corp682143AK8NOTE 9.500% 6/1–$19.4M1.4%–––
CGEMCullinan Therapeutics, Inc.COM1,932,106$20.0M1.4%+1,668,289+632.4%AddedHistory
ANABAnaptysbio, IncCOM444,692$21.6M1.5%+444,692NewHistory
TERNTerns Pharmaceuticals, Inc.COM550,000$22.2M1.6%+550,000NewHistory
ORKAOruka Therapeutics, Inc.COM802,342$24.3M1.7%−156,838−16.4%ReducedHistory
BBIOBridgeBio Pharma, Inc.COM320,000$24.5M1.8%+255,000+392.3%AddedHistory
MLYSMineralys Therapeutics, Inc.COM730,000$26.5M1.9%−20,000−2.7%ReducedHistory
TRVITrevi Therapeutics, Inc.COM2,150,172$26.9M1.9%−649,828−23.2%ReducedHistory
FBRXForte Biosciences, Inc.COM NEW989,490$27.0M1.9%+989,490NewHistory
ALKSAlkermes plc.SHS1,000,000$28.0M2.0%−250,000−20.0%ReducedHistory
LXEOLexeo Therapeutics, Inc.COM3,200,000$31.8M2.3%−670,527−17.3%ReducedHistory
NUVLNuvalent, Inc.COM322,633$32.5M2.3%−61,784−16.1%ReducedHistory
ACLXArcellx, Inc.COMMON STOCK523,725$34.1M2.5%+23,725+4.7%AddedHistory
ROIVRoivant Sciences Ltd.SHS1,700,000$36.9M2.7%+900,000+112.5%AddedHistory
TEVATeva Pharmaceutical Industries LtdSPONSORED ADS1,400,000$43.7M3.1%00.0%UnchangedHistory
WVEWave Life Sciences, Inc.SHS2,700,000$45.9M3.3%+600,000+28.6%AddedHistory
SYRESpyre Therapeutics, Inc.COM NEW1,432,591$46.9M3.4%+13,292+0.9%AddedHistory
CYTKCytokinetics IncCOM NEW800,000$50.8M3.7%+450,000+128.6%AddedHistory
PRAXPraxis Precision Medicines, Inc.COM NEW185,000$54.5M3.9%+185,000NewHistory
XENEXenon Pharmaceuticals Inc.COM1,250,000$56.0M4.0%−150,000−10.7%ReducedHistory
VTYXVentyx Biosciences, Inc.COM6,484,558$58.6M4.2%+2,560,143+65.2%AddedHistory
ABVXAbivax S.A.SPONSORED ADS505,000$68.1M4.9%+145,000+40.3%AddedHistory
INSMINSMED IncCOM PAR $.01450,000$78.3M5.6%00.0%UnchangedHistory
APGEApogee Therapeutics, Inc.COM1,234,926$93.2M6.7%+61,500+5.2%AddedHistory

Options (9)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Affinity Asset Advisors, LLC in Q4 2025
SecurityClassPutsCalls
State Street SPDR S&P Biotech ETF78464A870ETF$182.9M–
iShares Tr464287556ISHARES BIOTECH–$67.5M
AMGNAmgen IncStock–$44.2M
State Street Health Care Select Sector SPDR ETF81369Y209ETF–$38.7M
QUREuniQure N.V.SHS–$19.1M
SMMTSummit Therapeutics Inc.COM$6.12M–
ABUSArbutus Biopharma CorpCOM–$2.51M
LENZLENZ Therapeutics, Inc.COM$1.60M–
FBRXForte Biosciences, Inc.COM NEW–$610.8K

Sold out since Q3 2025 (22)

Positions held at the end of Q3 2025 that are gone from this filing.

Positions of Affinity Asset Advisors, LLC sold out since Q3 2025
SecurityClassShares in Q3 2025Value in Q3 2025% of portfolio in Q3 2025History
VRNAVerona Pharma plcSPONSORED ADS625,000$66.7M6.2%History
SPYSPDR S&P 500 ETF TrustETF84,490$56.3M5.2%History
MRUSMerus N.V.COM285,769$26.9M2.5%History
SLNOSoleno Therapeutics IncCOM200,000$13.5M1.3%History
Karyopharm Therapeutics Inc.48576UAA4NOTE 3.000%10/1–$12.5M1.2%–
ELVNEnliven Therapeutics, Inc.COM400,000$8.19M0.8%History
TARSTarsus Pharmaceuticals, Inc.COM125,000$7.43M0.7%History
AKBAAkebia Therapeutics, Inc.COM2,450,000$6.69M0.6%History
MNPRMonopar TherapeuticsCOM NEW79,483$6.49M0.6%History
PCVXVaxcyte, Inc.COM125,000$4.50M0.4%History
INSPInspire Medical Systems, Inc.COM50,000$3.71M0.3%History
JAZZJazz Pharmaceuticals plcSHS USD25,000$3.29M0.3%History
AUTLAutolus Therapeutics plcSPON ADS1,750,000$2.85M0.3%History
OCULOcular Therapeutix, IncCOM239,000$2.79M0.3%History
OLMAOlema Pharmaceuticals, Inc.COM250,000$2.45M0.2%History
ATXSAstria Therapeutics, Inc.COM300,000$2.18M0.2%History
UTHRUnited Therapeutics CorpCOM5,000$2.10M0.2%History
MISTMilestone Pharmaceuticals Inc.COM666,666$1.33M0.1%History
CNTXContext Therapeutics Inc.COM402,653$390.1K<0.1%History
RPTXRepare Therapeutics Inc.COM200,000$352.0K<0.1%History
CBIOCrescent Biopharma, Inc.COM17,998$214.0K<0.1%History
SPRYARS Pharmaceuticals, Inc.COM2,500$25.1K<0.1%History