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VR Adviser, LLC

SEC CIK
0001615982
Latest filing
Aug 14, 2026

Holdings in Q4 2025

Holdings as of Dec 31, 2025, filed Feb 17, 2026. Long positions only; changes compare share counts with Q3 2025.

Institution overview
Positions
27
−6 vs. Q3 2025
Portfolio value
$2.02B
+$247.8M (+13.9%) vs. Q3 2025
Filed
Feb 17, 2026
SEC
Holdings of VR Adviser, LLC in Q4 2025
SecurityClassSharesValue% of portfolioShare changeActionHistory
CASIFCASI Pharmaceuticals, Inc.ORD SHS987,259$839.2K<0.1%00.0%UnchangedHistory
ARTVArtiva Biotherapeutics, Inc.COM1,609,569$6.91M0.3%00.0%UnchangedHistory
CGEMCullinan Therapeutics, Inc.COM1,379,965$14.3M0.7%00.0%UnchangedHistory
SRZNSurrozen, Inc.COM NEW632,931$14.3M0.7%00.0%UnchangedHistory
SEPNSepterna, Inc.COM610,808$17.0M0.8%00.0%UnchangedHistory
CBIOCrescent Biopharma, Inc.COM2,133,576$25.3M1.2%+745,712+53.7%AddedHistory
VORVor Biopharma Inc.COM NEW1,943,766$25.4M1.3%+1,443,800+288.8%AddedHistory
ZURAZura Bio LtdCLASS A ORD SHS5,345,115$28.0M1.4%+713,899+15.4%AddedHistory
HELPHelus Pharma Inc.COM NEW3,840,250$31.4M1.6%+3,840,250NewHistory
UPBUpstream Bio, Inc.COM1,169,298$31.7M1.6%00.0%UnchangedHistory
DNTHDianthus Therapeutics, Inc.COM1,000,000$41.2M2.0%+39,197+4.1%AddedHistory
DYNDyne Therapeutics, Inc.COM2,173,913$42.5M2.1%00.0%UnchangedHistory
ENGNenGene Therapeutics Inc.COM4,771,414$43.1M2.1%−275,000−5.4%ReducedHistory
ORICOric Pharmaceuticals, Inc.COM5,676,230$46.4M2.3%−920,655−14.0%ReducedHistory
ELVNEnliven Therapeutics, Inc.COM3,226,331$49.7M2.5%00.0%UnchangedHistory
JBIOJade Biosciences, Inc.COM NEW3,220,364$49.7M2.5%00.0%UnchangedHistory
MAZEMaze Therapeutics, Inc.COM1,548,569$64.2M3.2%+317,800+25.8%AddedHistory
CTMXCytomX Therapeutics, Inc.COM15,561,500$66.3M3.3%00.0%UnchangedHistory
ERASErasca, Inc.COM17,857,083$66.4M3.3%00.0%UnchangedHistory
COGTCogent Biosciences, Inc.COM2,000,000$71.0M3.5%−2,000,000−50.0%ReducedHistory
SVRASavara IncCOM13,740,375$82.9M4.1%+1,059,332+8.4%AddedHistory
OCULOcular Therapeutix, IncCOM7,315,547$88.8M4.4%−5,845,915−44.4%ReducedHistory
KALVKalVista Pharmaceuticals, Inc.COM6,728,985$108.7M5.4%00.0%UnchangedHistory
SYRESpyre Therapeutics, Inc.COM NEW3,685,448$120.7M6.0%+1,000,000+37.2%AddedHistory
VRDNViridian Therapeutics, Inc.COM3,882,709$120.8M6.0%00.0%UnchangedHistory
ORKAOruka Therapeutics, Inc.COM4,148,428$125.7M6.2%00.0%UnchangedHistory
APGEApogee Therapeutics, Inc.COM8,493,321$641.1M31.7%00.0%UnchangedHistory

Sold out since Q3 2025 (7)

Positions held at the end of Q3 2025 that are gone from this filing.

Positions of VR Adviser, LLC sold out since Q3 2025
SecurityClassShares in Q3 2025Value in Q3 2025% of portfolio in Q3 2025History
MTSRMetsera, Inc.COM3,750,662$196.3M11.0%History
CDTXCidara Therapeutics, Inc.COM NEW946,788$90.7M5.1%History
ABVXAbivax S.A.SPONSORED ADS576,729$49.0M2.8%History
ATXSAstria Therapeutics, Inc.COM2,457,348$17.9M1.0%History
PHVSPharvaris N.V.COM674,599$16.8M0.9%History
FRNMFreenome, Inc.CL A ORD SHS750,000$7.95M0.4%History
TENXTenax Therapeutics, Inc.COM NEW437,708$3.33M0.2%History