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Ghost Tree Capital, LLC

SEC CIK
0001595851
Latest filing
Nov 14, 2024

Holdings in Q3 2024

Holdings as of Sep 30, 2024, filed Nov 14, 2024. Long positions only; changes compare share counts with Q2 2024.

Institution overview
Positions
51
−8 vs. Q2 2024
Portfolio value
$293.2M
+$5.86M (+2.0%) vs. Q2 2024
Filed
Nov 14, 2024
SEC
Holdings of Ghost Tree Capital, LLC in Q3 2024
SecurityClassSharesValue% of portfolioShare changeActionHistory
AMLXAmylyx Pharmaceuticals, Inc.COM325,000$1.05M0.4%+325,000NewHistory
ENGNenGene Therapeutics Inc.COM160,898$1.06M0.4%−259,433−61.7%ReducedHistory
LRMRLarimar Therapeutics, Inc.COM200,000$1.31M0.4%+200,000NewHistory
ATYRaTYR PHARMA INCCOM NEW800,000$1.41M0.5%00.0%UnchangedHistory
PRQRProQR Therapeutics N.V.SHS EURO887,700$1.62M0.6%−12,300−1.4%ReducedHistory
VRDNViridian Therapeutics, Inc.COM75,000$1.71M0.6%−512,708−87.2%ReducedHistory
SYRESpyre Therapeutics, Inc.COM NEW60,000$1.76M0.6%−190,237−76.0%ReducedHistory
SMMTSummit Therapeutics Inc.COM85,000$1.86M0.6%+85,000NewHistory
APLSApellis Pharmaceuticals, Inc.COM65,000$1.87M0.6%−70,000−51.9%ReducedHistory
CAPRCapricor Therapeutics, Inc.COM NEW125,000$1.90M0.6%+125,000NewHistory
NGNENeurogene Inc.COM50,000$2.10M0.7%−20,000−28.6%ReducedHistory
ABSIAbsci CorpCOM550,000$2.10M0.7%+550,000NewHistory
CRVSCorvus Pharmaceuticals, Inc.COM500,000$2.64M0.9%+500,000NewHistory
RGNXREGENXBIO Inc.COM265,000$2.78M0.9%+95,000+55.9%AddedHistory
TNYATenaya Therapeutics, Inc.COM1,500,000$2.90M1.0%+150,000+11.1%AddedHistory
SVRASavara IncCOM725,000$3.07M1.0%−325,876−31.0%ReducedHistory
NUVBNuvation Bio Inc.COM CL A1,350,000$3.09M1.1%+200,000+17.4%AddedHistory
BBOTBridgeBio Oncology Therapeutics, Inc.CL A ORD SHS300,000$3.13M1.1%00.0%UnchangedHistory
CRBPCorbus Pharmaceuticals Holdings, Inc.COM NEW160,000$3.30M1.1%−15,000−8.6%ReducedHistory
ARVNArvinas, Inc.COM145,000$3.57M1.2%+70,000+93.3%AddedHistory
DYNDyne Therapeutics, Inc.COM100,000$3.59M1.2%+100,000NewHistory
KRROKorro Bio, Inc.COM110,000$3.68M1.3%+10,000+10.0%AddedHistory
ANNXAnnexon, Inc.COM650,000$3.85M1.3%+340,000+109.7%AddedHistory
RYTMRhythm Pharmaceuticals, Inc.COM78,842$4.13M1.4%−38,546−32.8%ReducedHistory
TSHATaysha Gene Therapies, Inc.COM SHS2,150,000$4.32M1.5%+900,000+72.0%AddedHistory
BBIOBridgeBio Pharma, Inc.COM175,000$4.46M1.5%+35,000+25.0%AddedHistory
REPLReplimune Group, Inc.COM450,000$4.93M1.7%00.0%UnchangedHistory
EWTXEdgewise Therapeutics, Inc.COM195,000$5.20M1.8%+195,000NewHistory
INSMINSMED IncCOM PAR $.0175,000$5.47M1.9%+10,000+15.4%AddedHistory
IMVTImmunovant, Inc.COM215,000$6.13M2.1%−45,000−17.3%ReducedHistory
OLMAOlema Pharmaceuticals, Inc.COM535,000$6.39M2.2%−15,000−2.7%ReducedHistory
MLTXMoonLake ImmunotherapeuticsCLASS A ORD128,411$6.47M2.2%−171,589−57.2%ReducedHistory
PHATPhathom Pharmaceuticals, Inc.COM375,000$6.78M2.3%−225,000−37.5%ReducedHistory
RZLTRezolute, Inc.COM NEW1,474,995$7.15M2.4%+53,494+3.8%AddedHistory
TGTXTG Therapeutics, Inc.COM310,000$7.25M2.5%−190,000−38.0%ReducedHistory
SLNOSoleno Therapeutics IncCOM150,000$7.57M2.6%−150,000−50.0%ReducedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM150,000$7.67M2.6%−90,000−37.5%ReducedHistory
ASNDAscendis Pharma A/SSPONSORED ADR52,500$7.84M2.7%−34,221−39.5%ReducedHistory
JANXJanux Therapeutics, Inc.COM190,000$8.63M2.9%+140,000+280.0%AddedHistory
SNDXSyndax Pharmaceuticals IncCOM450,000$8.66M3.0%+100,000+28.6%AddedHistory
VKTXViking Therapeutics, Inc.COM140,000$8.86M3.0%+45,000+47.4%AddedHistory
PCVXVaxcyte, Inc.COM80,000$9.14M3.1%−70,000−46.7%ReducedHistory
ROIVRoivant Sciences Ltd.SHS800,000$9.23M3.1%−200,000−20.0%ReducedHistory
CGONCG Oncology, Inc.COM250,000$9.43M3.2%−10,000−3.8%ReducedHistory
CATXPerspective Therapeutics, Inc.COM NEW750,000$10.0M3.4%−175,000−18.9%ReducedHistory
TARSTarsus Pharmaceuticals, Inc.COM350,000$11.5M3.9%+115,000+48.9%AddedHistory
AXSMAxsome Therapeutics, Inc.COM135,000$12.1M4.1%−15,000−10.0%ReducedHistory
BPMCBlueprint Medicines CorpCOM140,000$12.9M4.4%+100,000+250.0%AddedHistory
NVONovo Nordisk A SADR110,000$13.1M4.5%+110,000NewHistory
SRPTSarepta Therapeutics, Inc.COM120,000$15.0M5.1%+65,000+118.2%AddedHistory
Biohaven LtdG1110E907CALL348,778$17.4M5.9%+348,778New–

Options (3)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Ghost Tree Capital, LLC in Q3 2024
SecurityClassPutsCalls
State Street SPDR S&P Biotech ETF78464A870ETF$29.6M–
CRBPCorbus Pharmaceuticals Holdings, Inc.COM NEW$4.54M–
INSMINSMED IncCOM PAR $.01–$3.65M

Sold out since Q2 2024 (18)

Positions held at the end of Q2 2024 that are gone from this filing.

Positions of Ghost Tree Capital, LLC sold out since Q2 2024
SecurityClassShares in Q2 2024Value in Q2 2024% of portfolio in Q2 2024History
BHVNBiohaven Ltd.COM490,000$17.0M5.9%History
ALNYAlnylam Pharmaceuticals, Inc.COM22,500$5.47M1.9%History
ACADAcadia Pharmaceuticals IncCOM225,000$3.66M1.3%History
CABACabaletta Bio, Inc.COM370,899$2.77M1.0%History
CYTKCytokinetics IncCOM NEW33,200$1.80M0.6%History
ELEVElevation Acquisition Group Inc.COM600,000$1.62M0.6%History
KRYSKrystal Biotech, Inc.COM8,500$1.56M0.5%History
WVEWave Life Sciences, Inc.SHS200,000$998.0K0.3%History
ARWRArrowhead Pharmaceuticals, Inc.COM35,000$909.6K0.3%History
SGMTSagimet Biosciences Inc.COM SER A225,000$769.5K0.3%History
ITCIIntra-Cellular Therapies, Inc.COM10,000$684.9K0.2%History
MGNXMacrogenics IncCOM150,000$637.5K0.2%History
PMVPPMV Pharmaceuticals, Inc.COM375,000$607.5K0.2%History
PTCTPTC Therapeutics, Inc.COM19,000$581.0K0.2%History
RVNCRevance Therapeutics, Inc.COM225,000$578.3K0.2%History
NTLAIntellia Therapeutics, Inc.COM25,000$559.5K0.2%History
ANTXAN2 Therapeutics, Inc.COM219,331$471.6K0.2%History
CTMXCytomX Therapeutics, Inc.COM300,000$366.0K0.1%History