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Ghost Tree Capital, LLC

SEC CIK
0001595851
Latest filing
Nov 14, 2024

Holdings in Q4 2023

Holdings as of Dec 31, 2023, filed Feb 14, 2024. Long positions only; changes compare share counts with Q3 2023.

Institution overview
Positions
44
−14 vs. Q3 2023
Portfolio value
$173.7M
−$32.8M (−15.9%) vs. Q3 2023
Filed
Feb 14, 2024
SEC
Holdings of Ghost Tree Capital, LLC in Q4 2023
SecurityClassSharesValue% of portfolioShare changeActionHistory
AXSMAxsome Therapeutics, Inc.COM165,000$13.1M7.6%+55,000+50.0%AddedHistory
BHVNBiohaven Ltd.COM275,000$11.8M6.8%+275,000NewHistory
SRPTSarepta Therapeutics, Inc.COM100,000$9.64M5.6%+60,000+150.0%AddedHistory
AMAMAmbrx Biopharma, Inc.COM475,000$6.76M3.9%−50,000−9.5%ReducedHistory
ROIVRoivant Sciences Ltd.SHS600,000$6.74M3.9%+536,000+837.5%AddedHistory
VRDNViridian Therapeutics, Inc.COM300,000$6.53M3.8%+25,000+9.1%AddedHistory
KRYSKrystal Biotech, Inc.COM50,000$6.20M3.6%−30,000−37.5%ReducedHistory
GPCRStructure Therapeutics Inc.SPONSORED ADS150,000$6.11M3.5%+95,000+172.7%AddedHistory
TARSTarsus Pharmaceuticals, Inc.COM300,000$6.08M3.5%−100,000−25.0%ReducedHistory
ARGXArgenx SESPONSORED ADR15,000$5.71M3.3%+12,500+500.0%AddedHistory
ALNYAlnylam Pharmaceuticals, Inc.COM27,500$5.26M3.0%+27,500NewHistory
BBIOBridgeBio Pharma, Inc.COM125,000$5.05M2.9%+50,000+66.7%AddedHistory
MLTXMoonLake ImmunotherapeuticsCLASS A ORD80,000$4.83M2.8%−250,000−75.8%ReducedHistory
JBIOJade Biosciences, Inc.COM210,000$4.75M2.7%+8,803+4.4%AddedHistory
SLNOSoleno Therapeutics IncCOM112,385$4.52M2.6%+112,385NewHistory
PCVXVaxcyte, Inc.COM70,000$4.40M2.5%−70,000−50.0%ReducedHistory
TGTXTG Therapeutics, Inc.COM250,000$4.27M2.5%−750,000−75.0%ReducedHistory
EYPTEyePoint, Inc.COM NEW165,000$3.81M2.2%−160,000−49.2%ReducedHistory
TSHATaysha Gene Therapies, Inc.COM SHS2,100,000$3.72M2.1%+775,000+58.5%AddedHistory
DCPHDeciphera Pharmaceuticals, Inc.COM225,000$3.63M2.1%−100,000−30.8%ReducedHistory
SVRASavara IncCOM750,000$3.52M2.0%+750,000NewHistory
PHATPhathom Pharmaceuticals, Inc.COM385,241$3.52M2.0%−9,759−2.5%ReducedHistory
MDGLMadrigal Pharmaceuticals, Inc.COM15,000$3.47M2.0%−42,500−73.9%ReducedHistory
CABACabaletta Bio, Inc.COM150,000$3.40M2.0%+150,000NewHistory
REPLReplimune Group, Inc.COM400,000$3.37M1.9%+400,000NewHistory
RVNCRevance Therapeutics, Inc.COM375,000$3.30M1.9%+25,000+7.1%AddedHistory
PTGXProtagonist Therapeutics, IncCOM125,000$2.87M1.6%−275,000−68.8%ReducedHistory
ATXSAstria Therapeutics, Inc.COM335,000$2.57M1.5%+35,000+11.7%AddedHistory
ASNDAscendis Pharma A/SSPONSORED ADR20,000$2.52M1.5%−65,000−76.5%ReducedHistory
ARVNArvinas, Inc.COM59,250$2.44M1.4%+59,250NewHistory
CRNXCrinetics Pharmaceuticals, Inc.COM65,000$2.31M1.3%−36,443−35.9%ReducedHistory
PMVPPMV Pharmaceuticals, Inc.COM725,000$2.25M1.3%+19,119+2.7%AddedHistory
NTRANatera, Inc.COM35,000$2.19M1.3%+35,000NewHistory
CBAYCymaBay Therapeutics, Inc.COM90,000$2.13M1.2%+90,000NewHistory
KALVKalVista Pharmaceuticals, Inc.COM130,036$1.59M0.9%+30,036+30.0%AddedHistory
ACADAcadia Pharmaceuticals IncCOM50,000$1.57M0.9%−30,000−37.5%ReducedHistory
MRNSMarinus Pharmaceuticals, Inc.COM NEW135,000$1.47M0.8%+135,000NewHistory
INBXInhibrx Biosciences, Inc.COM35,000$1.33M0.8%00.0%UnchangedHistory
COGTCogent Biosciences, Inc.COM195,000$1.15M0.7%−455,000−70.0%ReducedHistory
QUREuniQure N.V.SHS165,000$1.12M0.6%−50,000−23.3%ReducedHistory
CYTKCytokinetics IncCOM NEW10,000$834.9K0.5%−80,000−88.9%ReducedHistory
CATXPerspective Therapeutics, Inc.COM1,600,000$643.2K0.4%+1,600,000NewHistory
BLUEbluebird bio, Inc.COM465,000$641.7K0.4%+465,000NewHistory
VRNAVerona Pharma plcSPONSORED ADS30,000$596.4K0.3%−15,000−33.3%ReducedHistory

Options (7)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Ghost Tree Capital, LLC in Q4 2023
SecurityClassPutsCalls
iShares Russell 2000 ETF464287655ETF–$50.2M
State Street SPDR S&P Biotech ETF78464A870ETF$26.8M$22.3M
MLTXMoonLake ImmunotherapeuticsCLASS A ORD–$15.1M
CYTKCytokinetics IncCOM NEW–$6.68M
APLSApellis Pharmaceuticals, Inc.COM–$5.99M
AMLXAmylyx Pharmaceuticals, Inc.COM–$2.94M
RVMDRevolution Medicines, Inc.COM$2.15M–

Sold out since Q3 2023 (26)

Positions held at the end of Q3 2023 that are gone from this filing.

Positions of Ghost Tree Capital, LLC sold out since Q3 2023
SecurityClassShares in Q3 2023Value in Q3 2023% of portfolio in Q3 2023History
ALPNAlpine Immune Sciences, Inc.COM664,132$7.60M3.7%History
AKROAkero Therapeutics, Inc.COM115,000$5.82M2.8%History
IMVTImmunovant, Inc.COM130,000$4.99M2.4%History
AMLXAmylyx Pharmaceuticals, Inc.COM215,000$3.94M1.9%History
XENEXenon Pharmaceuticals Inc.COM98,951$3.38M1.6%History
SNDXSyndax Pharmaceuticals IncCOM200,000$2.90M1.4%History
IMGNImmunoGen, Inc.COM175,000$2.78M1.3%History
Morphosys AG617760202SPONSORED ADS400,000$2.69M1.3%–
MRTXMirati Therapeutics, Inc.COM60,000$2.61M1.3%History
VKTXViking Therapeutics, Inc.COM225,000$2.49M1.2%History
FOLDAmicus Therapeutics, Inc.COM175,000$2.13M1.0%History
KRTXKaruna Therapeutics, Inc.COM12,500$2.11M1.0%History
SLRNACELYRIN, Inc.COM200,000$2.03M1.0%History
ZNTLZentalis Pharmaceuticals, Inc.COM100,000$2.01M1.0%History
LEGNLegend Biotech CorpSPONSORED ADS22,500$1.51M0.7%History
RCUSArcus Biosciences, Inc.COM75,000$1.35M0.7%History
TVTXTravere Therapeutics, Inc.COM150,000$1.34M0.6%History
VTYXVentyx Biosciences, Inc.COM35,000$1.22M0.6%History
WHWKWhitehawk Therapeutics, Inc.COM250,000$1.21M0.6%History
BMEABiomea Fusion, Inc.COM65,000$894.4K0.4%History
FUSNFusion Pharmaceuticals Inc.COM243,287$632.5K0.3%History
ABOSAcumen Pharmaceuticals, Inc.COM150,000$622.5K0.3%History
ETNB89bio, Inc.COM30,000$463.2K0.2%History
Avidity Biosciences, Inc.05370A108COM65,000$414.7K0.2%–
Rain Oncology Inc.75082Q105COM325,000$280.1K0.1%–
MRSNMersana Therapeutics, Inc.COM61,250$77.8K<0.1%History