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Ghost Tree Capital, LLC

SEC CIK
0001595851
Latest filing
Nov 14, 2024

Holdings in Q1 2023

Holdings as of Mar 31, 2023, filed May 15, 2023. Long positions only; changes compare share counts with Q4 2022.

Institution overview
Positions
52
+17 vs. Q4 2022
Portfolio value
$264.3M
+$30.1M (+12.9%) vs. Q4 2022
Filed
May 15, 2023
SEC
Holdings of Ghost Tree Capital, LLC in Q1 2023
SecurityClassSharesValue% of portfolioShare changeActionHistory
VNDAVanda Pharmaceuticals Inc.COM12,500$85.0K<0.1%+12,500NewHistory
BBIOBridgeBio Pharma, Inc.COM25,000$415.0K0.2%+25,000NewHistory
IMGNImmunoGen, Inc.COM124,977$480.0K0.2%+124,977NewHistory
KYNBKyntra Bio, Inc.COM26,500$494.0K0.2%+26,500NewHistory
KZRKezar Life Sciences, Inc.COM175,000$548.0K0.2%−164,907−48.5%ReducedHistory
SWTXSpringWorks Therapeutics, Inc.COM27,578$710.0K0.3%+27,578NewHistory
XFORX4 Pharmaceuticals, IncCOM850,000$740.0K0.3%−150,000−15.0%ReducedHistory
GERNGeron CorpCOM450,000$977.0K0.4%+450,000NewHistory
TARSTarsus Pharmaceuticals, Inc.COM80,000$1.01M0.4%00.0%UnchangedHistory
WHWKWhitehawk Therapeutics, Inc.COM150,000$1.09M0.4%+60,000+66.7%AddedHistory
FUSNFusion Pharmaceuticals Inc.COM350,000$1.32M0.5%+350,000NewHistory
RCUSArcus Biosciences, Inc.COM75,000$1.37M0.5%+75,000NewHistory
ALPNAlpine Immune Sciences, Inc.COM200,000$1.54M0.6%+200,000NewHistory
RXDXPrometheus Biosciences, Inc.COM15,000$1.61M0.6%+5,104+51.6%AddedHistory
Avidity Biosciences, Inc.05370A108COM125,000$1.92M0.7%+25,000+25.0%Added–
IRONDisc Medicine, Inc.COM100,000$2.12M0.8%+100,000NewHistory
Rain Oncology Inc.75082Q105COM250,000$2.19M0.8%+250,000New–
AMAMAmbrx Biopharma Cayman, Inc.SPONSORED ADS250,000$2.23M0.8%+250,000NewHistory
BCRXBiocryst Pharmaceuticals IncCOM275,000$2.29M0.9%+50,000+22.2%AddedHistory
ETNB89bio, Inc.COM200,000$3.05M1.2%+200,000NewHistory
KRTXKaruna Therapeutics, Inc.COM17,500$3.18M1.2%−22,500−56.3%ReducedHistory
ACRSAclaris Therapeutics, Inc.COM425,000$3.44M1.3%+425,000NewHistory
BMEABiomea Fusion, Inc.COM120,000$3.72M1.4%+120,000NewHistory
JBIOJade Biosciences, Inc.COM200,000$4.03M1.5%+65,000+48.1%AddedHistory
MLTXMoonLake ImmunotherapeuticsCLASS A ORD195,000$4.17M1.6%+195,000NewHistory
ISEEIVERIC bio, Inc.COM175,000$4.26M1.6%−275,000−61.1%ReducedHistory
VRDNViridian Therapeutics, Inc.COM175,000$4.45M1.7%+10,000+6.1%AddedHistory
PTGXProtagonist Therapeutics, IncCOM225,000$5.17M2.0%+225,000NewHistory
MRTXMirati Therapeutics, Inc.COM140,000$5.21M2.0%−60,000−30.0%ReducedHistory
FOLDAmicus Therapeutics, Inc.COM475,000$5.27M2.0%+475,000NewHistory
INCYIncyte CorpCOM75,000$5.42M2.1%+75,000NewHistory
COGTCogent Biosciences, Inc.COM550,000$5.93M2.2%−250,000−31.3%ReducedHistory
ATXSAstria Therapeutics, Inc.COM450,000$5.99M2.3%00.0%UnchangedHistory
IOVAIovance Biotherapeutics, Inc.COM1,000,000$6.11M2.3%−300,000−23.1%ReducedHistory
RETAReata Pharmaceuticals IncCL A70,000$6.36M2.4%−430,000−86.0%ReducedHistory
SNDXSyndax Pharmaceuticals IncCOM325,000$6.86M2.6%+175,000+116.7%AddedHistory
XENEXenon Pharmaceuticals Inc.COM200,000$7.16M2.7%+200,000NewHistory
MDGLMadrigal Pharmaceuticals, Inc.COM30,000$7.27M2.7%+10,000+50.0%AddedHistory
QUREuniQure N.V.SHS375,000$7.55M2.9%+375,000NewHistory
JNJJohnson & JohnsonStock50,000$7.75M2.9%+50,000NewHistory
RVNCRevance Therapeutics, Inc.COM250,000$8.05M3.0%−50,000−16.7%ReducedHistory
PFEPfizer IncStock200,000$8.16M3.1%+200,000NewHistory
SRPTSarepta Therapeutics, Inc.COM60,000$8.27M3.1%+5,000+9.1%AddedHistory
CTICCti Biopharma CorpCOM2,000,000$8.40M3.2%+150,000+8.1%AddedHistory
PCVXVaxcyte, Inc.COM225,000$8.43M3.2%+65,000+40.6%AddedHistory
VKTXViking Therapeutics, Inc.COM600,000$9.99M3.8%+300,000+100.0%AddedHistory
AKROAkero Therapeutics, Inc.COM275,000$10.5M4.0%+190,000+223.5%AddedHistory
APLSApellis Pharmaceuticals, Inc.COM164,620$10.9M4.1%−135,380−45.1%ReducedHistory
ASNDAscendis Pharma A/SSPONSORED ADR110,000$11.8M4.5%−20,000−15.4%ReducedHistory
AXSMAxsome Therapeutics, Inc.COM225,000$13.9M5.3%−10,000−4.3%ReducedHistory
AMLXAmylyx Pharmaceuticals, Inc.COM475,000$13.9M5.3%+125,000+35.7%AddedHistory
TGTXTG Therapeutics, Inc.COM1,100,000$16.5M6.3%+1,100,000NewHistory

Options (6)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Ghost Tree Capital, LLC in Q1 2023
SecurityClassPutsCalls
RETAReata Pharmaceuticals IncCL A–$27.3M
State Street SPDR S&P Biotech ETF78464A870ETF–$22.9M
SRPTSarepta Therapeutics, Inc.COM–$17.2M
APLSApellis Pharmaceuticals, Inc.COM–$3.42M
ALTAltimmune, Inc.COM NEW–$1.69M
ETNB89bio, Inc.COM–$1.52M

Sold out since Q4 2022 (7)

Positions held at the end of Q4 2022 that are gone from this filing.

Positions of Ghost Tree Capital, LLC sold out since Q4 2022
SecurityClassShares in Q4 2022Value in Q4 2022% of portfolio in Q4 2022History
Invesco QQQ Trust Series I46090E103ETF50,000$13.3M5.7%–
SGENSeagen Inc.COM85,000$10.9M4.7%History
PRVBProvention Bio, Inc.COM400,000$4.23M1.8%History
RAPTRAPT Therapeutics, Inc.COM125,000$2.48M1.1%History
BPMCBlueprint Medicines CorpCOM20,000$876.0K0.4%History
DSGNDesign Therapeutics, Inc.COM82,853$850.0K0.4%History
SYRESpyre Therapeutics, Inc.COM800,000$360.0K0.2%History