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Ghost Tree Capital, LLC

SEC CIK
0001595851
Latest filing
Nov 14, 2024

Holdings in Q3 2022

Holdings as of Sep 30, 2022, filed Nov 14, 2022. Long positions only; changes compare share counts with Q2 2022.

Institution overview
Positions
35
+6 vs. Q2 2022
Portfolio value
$244.9M
+$99.5M (+68.4%) vs. Q2 2022
Filed
Nov 14, 2022
SEC
Holdings of Ghost Tree Capital, LLC in Q3 2022
SecurityClassSharesValue% of portfolioShare changeActionHistory
APLSApellis Pharmaceuticals, Inc.COM275,000$18.8M7.7%+50,000+22.2%AddedHistory
RETAReata Pharmaceuticals IncCL A725,000$18.2M7.4%+725,000NewHistory
RLMDRelmada Therapeutics, Inc.COM425,000$15.7M6.4%+175,000+70.0%AddedHistory
AMLXAmylyx Pharmaceuticals, Inc.COM550,000$15.5M6.3%+550,000NewHistory
AXSMAxsome Therapeutics, Inc.COM300,000$13.4M5.5%+75,000+33.3%AddedHistory
MRTXMirati Therapeutics, Inc.COM175,000$12.2M5.0%+65,000+59.1%AddedHistory
SRPTSarepta Therapeutics, Inc.COM110,000$12.2M5.0%−20,000−15.4%ReducedHistory
CTICCti Biopharma CorpCOM2,000,000$11.6M4.8%+1,200,000+150.0%AddedHistory
VRDNViridian Therapeutics, Inc.COM535,000$11.0M4.5%−65,000−10.8%ReducedHistory
RVNCRevance Therapeutics, Inc.COM390,000$10.5M4.3%+390,000NewHistory
ASNDAscendis Pharma A/SSPONSORED ADR95,000$9.81M4.0%+20,000+26.7%AddedHistory
COGTCogent Biosciences, Inc.COM600,000$8.95M3.7%−300,000−33.3%ReducedHistory
PCVXVaxcyte, Inc.COM360,000$8.64M3.5%+35,000+10.8%AddedHistory
ISEEIVERIC bio, Inc.COM463,700$8.32M3.4%−36,300−7.3%ReducedHistory
KRTXKaruna Therapeutics, Inc.COM30,000$6.75M2.8%−15,000−33.3%ReducedHistory
BCRXBiocryst Pharmaceuticals IncCOM525,000$6.62M2.7%+200,000+61.5%AddedHistory
ALTAltimmune, Inc.COM NEW435,000$5.55M2.3%+435,000NewHistory
FOLDAmicus Therapeutics, Inc.COM500,000$5.22M2.1%−500,000−50.0%ReducedHistory
SNDXSyndax Pharmaceuticals IncCOM200,000$4.81M2.0%−25,000−11.1%ReducedHistory
HZNPHorizon Therapeutics Public Ltd CoSHS75,000$4.64M1.9%−25,000−25.0%ReducedHistory
KZRKezar Life Sciences, Inc.COM525,000$4.52M1.8%+75,000+16.7%AddedHistory
ATXSAstria Therapeutics, Inc.COM500,000$4.52M1.8%+500,000NewHistory
BPMCBlueprint Medicines CorpCOM65,000$4.28M1.7%+65,000NewHistory
WHWKWhitehawk Therapeutics, Inc.COM200,000$2.83M1.2%+50,000+33.3%AddedHistory
ITCIIntra-Cellular Therapies, Inc.COM60,000$2.79M1.1%+60,000NewHistory
JBIOJade Biosciences, Inc.COM150,000$2.49M1.0%+150,000NewHistory
MLTXMoonLake ImmunotherapeuticsCLASS A ORD300,000$2.33M1.0%00.0%UnchangedHistory
RAPTRAPT Therapeutics, Inc.COM90,000$2.17M0.9%−75,000−45.5%ReducedHistory
TCDATricida, Inc.COM200,000$2.10M0.9%+200,000NewHistory
TARSTarsus Pharmaceuticals, Inc.COM120,000$2.05M0.8%00.0%UnchangedHistory
DSGNDesign Therapeutics, Inc.COM100,000$1.67M0.7%−175,000−63.6%ReducedHistory
MDGLMadrigal Pharmaceuticals, Inc.COM25,000$1.63M0.7%+25,000NewHistory
RYTMRhythm Pharmaceuticals, Inc.COM65,000$1.59M0.7%+65,000NewHistory
BIIBBiogen Inc.COM3,750$1.00M0.4%+3,750NewHistory
SYRESpyre Therapeutics, Inc.COM1,000,000$526.0K0.2%+75,000+8.1%AddedHistory

Options (9)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Ghost Tree Capital, LLC in Q3 2022
SecurityClassPutsCalls
State Street SPDR S&P Biotech ETF78464A870ETF$39.7M–
RLMDRelmada Therapeutics, Inc.COM$18.5M–
DICEDICE Therapeutics, Inc.COM–$14.2M
AMLXAmylyx Pharmaceuticals, Inc.COM$14.1M–
SGENSeagen Inc.COM–$6.84M
AXSMAxsome Therapeutics, Inc.COM–$6.69M
TCDATricida, Inc.COM–$5.24M
RETAReata Pharmaceuticals IncCL A–$5.03M
ISEEIVERIC bio, Inc.COM–$1.10M

Sold out since Q2 2022 (6)

Positions held at the end of Q2 2022 that are gone from this filing.

Positions of Ghost Tree Capital, LLC sold out since Q2 2022
SecurityClassShares in Q2 2022Value in Q2 2022% of portfolio in Q2 2022History
SGENSeagen Inc.COM35,000$6.19M4.3%History
MRUSMerus N.V.COM250,000$5.66M3.9%History
ARVNArvinas, Inc.COM110,000$4.63M3.2%History
NMTR9 Meters Biopharma, Inc.COM1,800,000$469.0K0.3%History
DICEDICE Therapeutics, Inc.COM30,000$466.0K0.3%History
ALNYAlnylam Pharmaceuticals, Inc.COM1,900$277.0K0.2%History