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Ghost Tree Capital, LLC

SEC CIK
0001595851
Latest filing
Nov 14, 2024

Holdings in Q1 2022

Holdings as of Mar 31, 2022, filed May 16, 2022. Long positions only; changes compare share counts with Q4 2021.

Institution overview
Positions
39
−4 vs. Q4 2021
Portfolio value
$201.8M
−$59.3M (−22.7%) vs. Q4 2021
Filed
May 16, 2022
SEC
Holdings of Ghost Tree Capital, LLC in Q1 2022
SecurityClassSharesValue% of portfolioShare changeActionHistory
PYXSPyxis Oncology, Inc.COMMON STOCK75,000$303.0K0.2%−220,000−74.6%ReducedHistory
LRMRLarimar Therapeutics, Inc.COM100,000$405.0K0.2%−125,000−55.6%ReducedHistory
PRDSPardes Biosciences, Inc.COM85,000$614.0K0.3%+35,000+70.0%AddedHistory
SYRESpyre Therapeutics, Inc.COM686,599$1.58M0.8%+686,599NewHistory
VTGNVistagen Therapeutics, Inc.COM NEW1,315,154$1.63M0.8%−684,846−34.2%ReducedHistory
MRTXMirati Therapeutics, Inc.COM20,000$1.64M0.8%−10,000−33.3%ReducedHistory
CYPHCypherpunk Technologies Inc.COM993,714$1.74M0.9%−356,286−26.4%ReducedHistory
STSASatsuma Pharmaceuticals, Inc.COM473,562$1.80M0.9%−430,663−47.6%ReducedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM85,000$1.87M0.9%−33,344−28.2%ReducedHistory
NMTR9 Meters Biopharma, Inc.COM3,250,000$1.95M1.0%00.0%UnchangedHistory
TARSTarsus Pharmaceuticals, Inc.COM120,000$2.02M1.0%−50,000−29.4%ReducedHistory
ACRSAclaris Therapeutics, Inc.COM125,000$2.15M1.1%−200,000−61.5%ReducedHistory
WHWKWhitehawk Therapeutics, Inc.COM150,000$2.55M1.3%−50,000−25.0%ReducedHistory
RLMDRelmada Therapeutics, Inc.COM100,000$2.70M1.3%−100,000−50.0%ReducedHistory
XENEXenon Pharmaceuticals Inc.COM100,000$3.06M1.5%00.0%UnchangedHistory
RCKTRocket Pharmaceuticals, Inc.COM200,000$3.17M1.6%−225,000−52.9%ReducedHistory
DSGNDesign Therapeutics, Inc.COM200,000$3.23M1.6%+65,000+48.1%AddedHistory
ZNTLZentalis Pharmaceuticals, Inc.COM80,000$3.69M1.8%00.0%UnchangedHistory
VRNAVerona Pharma plcSPONSORED ADS750,000$3.74M1.9%00.0%UnchangedHistory
SRPTSarepta Therapeutics, Inc.COM50,000$3.91M1.9%−50,000−50.0%ReducedHistory
AXSMAxsome Therapeutics, Inc.COM94,500$3.91M1.9%+94,500NewHistory
SNDXSyndax Pharmaceuticals IncCOM225,000$3.91M1.9%−75,000−25.0%ReducedHistory
BCYCBicycle Therapeutics PLCSPONSORED ADS100,000$4.39M2.2%+100,000NewHistory
RAPTRAPT Therapeutics, Inc.COM250,000$5.50M2.7%−100,000−28.6%ReducedHistory
BCRXBiocryst Pharmaceuticals IncCOM350,000$5.69M2.8%+350,000NewHistory
CTICCti Biopharma CorpCOM1,300,000$6.07M3.0%+100,000+8.3%AddedHistory
KZRKezar Life Sciences, Inc.COM400,000$6.65M3.3%+150,000+60.0%AddedHistory
PCVXVaxcyte, Inc.COM300,000$7.25M3.6%+50,000+20.0%AddedHistory
ARVNArvinas, Inc.COM110,000$7.40M3.7%00.0%UnchangedHistory
ISEEIVERIC bio, Inc.COM450,000$7.57M3.8%−175,000−28.0%ReducedHistory
KRTXKaruna Therapeutics, Inc.COM60,000$7.61M3.8%+60,000NewHistory
VRDNViridian Therapeutics, Inc.COM466,403$8.62M4.3%−33,597−6.7%ReducedHistory
CLDXCelldex Therapeutics, Inc.COM NEW300,000$10.2M5.1%−50,000−14.3%ReducedHistory
SRRASierra Oncology, Inc.COM NEW325,000$10.4M5.2%+75,000+30.0%AddedHistory
FOLDAmicus Therapeutics, Inc.COM1,100,000$10.4M5.2%+600,000+120.0%AddedHistory
MRUSMerus N.V.COM400,000$10.6M5.2%+50,000+14.3%AddedHistory
APLSApellis Pharmaceuticals, Inc.COM250,000$12.7M6.3%−75,000−23.1%ReducedHistory
COGTCogent Biosciences, Inc.COM1,700,000$12.7M6.3%00.0%UnchangedHistory
ASNDAscendis Pharma A/SSPONSORED ADR140,000$16.4M8.1%−50,000−26.3%ReducedHistory

Options (3)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of Ghost Tree Capital, LLC in Q1 2022
SecurityClassPutsCalls
SPYSPDR S&P 500 ETF TrustETF$225.8M–
State Street SPDR S&P Biotech ETF78464A870ETF–$27.0M
AXSMAxsome Therapeutics, Inc.COM$6.21M–

Sold out since Q4 2021 (9)

Positions held at the end of Q4 2021 that are gone from this filing.

Positions of Ghost Tree Capital, LLC sold out since Q4 2021
SecurityClassShares in Q4 2021Value in Q4 2021% of portfolio in Q4 2021History
ALNYAlnylam Pharmaceuticals, Inc.COM30,000$5.09M1.9%History
CMPSCOMPASS Pathways plcSPONSORED ADS210,000$4.64M1.8%History
Bellus Health Inc New07987C204COM NEW450,000$3.62M1.4%–
KURAKura Oncology, Inc.COM225,000$3.15M1.2%History
GHRSGH Research PLCORDINARY SHARES100,000$2.33M0.9%History
GBTGlobal Blood Therapeutics, Inc.COM60,000$1.76M0.7%History
IMUXImmunic, Inc.COM165,000$1.58M0.6%History
RETAReata Pharmaceuticals IncCL A55,000$1.45M0.6%History
CABACabaletta Bio, Inc.COM135,000$512.0K0.2%History