EcoR1 Capital, LLC
- SEC CIK
- 0001587114
- Latest filing
- Aug 14, 2026
Holdings in Q4 2025
Holdings as of Dec 31, 2025, filed Feb 17, 2026. Long positions only; changes compare share counts with Q3 2025.
- Positions
- 28
- −2 vs. Q3 2025
- Portfolio value
- $2.18B
- +$102.6M (+4.9%) vs. Q3 2025
| Security | Class | Shares | Value | % of portfolio | Share change | Action | History |
|---|---|---|---|---|---|---|---|
| ZYMEZymeworks Inc. | COM | 22,970,388 | $604.8M | 27.7% | 00.0% | Unchanged | History |
| ANABAnaptysbio, Inc | COM | 7,880,094 | $382.0M | 17.5% | 00.0% | Unchanged | History |
| JAZZJazz Pharmaceuticals plc | SHS USD | 1,706,469 | $290.1M | 13.3% | 00.0% | Unchanged | History |
| CRNXCrinetics Pharmaceuticals, Inc. | COM | 4,288,120 | $199.6M | 9.1% | 00.0% | Unchanged | History |
| CNTACentessa Pharmaceuticals plc | SPONSORED ADS | 3,115,000 | $77.9M | 3.6% | +2,565,000+466.4% | Added | History |
| CRSPCRISPR Therapeutics AG | NAMEN AKT | 1,389,276 | $72.9M | 3.3% | 00.0% | Unchanged | History |
| MBXMBX Biosciences, Inc. | COM | 2,123,604 | $67.0M | 3.1% | 00.0% | Unchanged | History |
| IMNMImmunome Inc. | COM | 2,855,590 | $61.3M | 2.8% | −1,223,825−30.0% | Reduced | History |
| ORICOric Pharmaceuticals, Inc. | COM | 6,728,116 | $55.0M | 2.5% | 00.0% | Unchanged | History |
| LKFTLakefront Biotherapeutics NV | SPON ADR | 1,667,119 | $54.5M | 2.5% | 00.0% | Unchanged | History |
| XNCRXencor Inc | COM | 3,251,112 | $49.8M | 2.3% | −2,893,655−47.1% | Reduced | History |
| BBOTBridgeBio Oncology Therapeutics, Inc. | COM NEW | 2,823,126 | $35.3M | 1.6% | 00.0% | Unchanged | History |
| ETONEton Pharmaceuticals, Inc. | COM | 2,030,544 | $34.3M | 1.6% | 00.0% | Unchanged | History |
| CGONCG Oncology, Inc. | COM | 772,000 | $32.1M | 1.5% | +772,000 | New | History |
| ZBIOZenas BioPharma, Inc. | COM | 789,500 | $28.7M | 1.3% | +789,500 | New | History |
| NGNENeurogene Inc. | COM | 1,271,342 | $26.2M | 1.2% | 00.0% | Unchanged | History |
| GPCRStructure Therapeutics Inc. | SPONSORED ADS | 334,380 | $23.3M | 1.1% | +334,380 | New | History |
| PCVXVaxcyte, Inc. | COM | 450,000 | $20.8M | 1.0% | +450,000 | New | History |
| AQSTAquestive Therapeutics, Inc. | COM | 2,625,000 | $17.0M | 0.8% | 00.0% | Unchanged | History |
| VYGRVoyager Therapeutics, Inc. | COM | 4,002,847 | $15.7M | 0.7% | +3,332,544+497.2% | Added | History |
| ATRAAtara Biotherapeutics, Inc. | COM NEW | 573,183 | $10.4M | 0.5% | 00.0% | Unchanged | History |
| MNKDMannkind Corp | COM NEW | 1,660,000 | $9.41M | 0.4% | +1,660,000 | New | History |
| EOLSEvolus, Inc. | COM | 675,000 | $4.49M | 0.2% | +675,000 | New | History |
| IBIOiBio, Inc. | COM NEW | 2,228,000 | $4.30M | 0.2% | +2,228,000 | New | History |
| MREOMereo BioPharma Group plc | SPON ADS | 7,856,466 | $3.27M | 0.2% | +7,856,466 | New | History |
| CAMPCamp4 Therapeutics Corp | COM | 325,000 | $1.99M | 0.1% | +325,000 | New | History |
| Surrozen, Inc.86889P117 | *W EXP 08/01/203 | 4,444 | $100 | <0.1% | −62,221−93.3% | Reduced | – |
| Nuvation Bio Inc.67080N119 | *W EXP 07/07/202 | 963,333 | – | – | 00.0% | Unchanged | – |
Options (2)
Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.
Sold out since Q3 2025 (11)
Positions held at the end of Q3 2025 that are gone from this filing.
| Security | Class | Shares in Q3 2025 | Value in Q3 2025 | % of portfolio in Q3 2025 | History |
|---|---|---|---|---|---|
| QUREuniQure N.V. | SHS | 3,988,971 | $232.8M | 11.2% | History |
| TNGXTango Therapeutics, Inc. | COM | 10,630,736 | $89.3M | 4.3% | History |
| APLSApellis Pharmaceuticals, Inc. | COM | 3,447,156 | $78.0M | 3.8% | History |
| MDGLMadrigal Pharmaceuticals, Inc. | COM | 75,000 | $34.4M | 1.7% | History |
| Avidity Biosciences, Inc.05370A108 | COM | 765,000 | $33.3M | 1.6% | – |
| ALKSAlkermes plc. | SHS | 500,000 | $15.0M | 0.7% | History |
| MTSRMetsera, Inc. | COM | 271,529 | $14.2M | 0.7% | History |
| PRMEPrime Medicine, Inc. | COM | 1,543,326 | $8.55M | 0.4% | History |
| KURAKura Oncology, Inc. | COM | 872,500 | $7.72M | 0.4% | History |
| PEPGPepGen Inc. | COM | 800,000 | $3.70M | 0.2% | History |
| CMPSCOMPASS Pathways plc | SPONSORED ADS | 265,137 | $1.52M | 0.1% | History |