EcoR1 Capital, LLC
- SEC CIK
- 0001587114
- Latest filing
- Aug 14, 2026
Holdings in Q2 2025
Holdings as of Jun 30, 2025, filed Aug 14, 2025. Long positions only; changes compare share counts with Q1 2025.
- Positions
- 36
- −8 vs. Q1 2025
- Portfolio value
- $1.68B
- +$3.51M (+0.2%) vs. Q1 2025
| Security | Class | Shares | Value | % of portfolio | Share change | Action | History |
|---|---|---|---|---|---|---|---|
| ZYMEZymeworks Inc. | COM | 22,970,388 | $288.3M | 17.1% | +5,710,840+33.1% | Added | History |
| APLSApellis Pharmaceuticals, Inc. | COM | 11,895,808 | $205.9M | 12.2% | 00.0% | Unchanged | History |
| JAZZJazz Pharmaceuticals plc | SHS USD | 1,706,469 | $181.1M | 10.7% | 00.0% | Unchanged | History |
| ANABAnaptysbio, Inc | COM | 7,880,094 | $174.9M | 10.4% | 00.0% | Unchanged | History |
| CRNXCrinetics Pharmaceuticals, Inc. | COM | 4,288,120 | $123.3M | 7.3% | 00.0% | Unchanged | History |
| ITOSiTeos Therapeutics, Inc. | COM | 10,688,978 | $106.6M | 6.3% | +10,688,978 | New | History |
| CRSPCRISPR Therapeutics AG | NAMEN AKT | 1,389,276 | $67.6M | 4.0% | 00.0% | Unchanged | History |
| QUREuniQure N.V. | SHS | 3,988,971 | $55.6M | 3.3% | 00.0% | Unchanged | History |
| TNGXTango Therapeutics, Inc. | COM | 10,630,736 | $54.4M | 3.2% | 00.0% | Unchanged | History |
| XNCRXencor Inc | COM | 6,144,767 | $48.3M | 2.9% | 00.0% | Unchanged | History |
| IMNMImmunome Inc. | COM | 4,079,415 | $37.9M | 2.3% | 00.0% | Unchanged | History |
| JANXJanux Therapeutics, Inc. | COM | 1,469,818 | $34.0M | 2.0% | 00.0% | Unchanged | History |
| LKFTLakefront Biotherapeutics NV | SPON ADR | 1,036,945 | $29.0M | 1.7% | +881,939+569.0% | Added | History |
| ETONEton Pharmaceuticals, Inc. | COM | 2,030,544 | $28.9M | 1.7% | +91,256+4.7% | Added | History |
| KURAKura Oncology, Inc. | COM | 4,200,000 | $24.2M | 1.4% | +1,559,702+59.1% | Added | History |
| AKROAkero Therapeutics, Inc. | COM | 440,000 | $23.5M | 1.4% | 00.0% | Unchanged | History |
| MDGLMadrigal Pharmaceuticals, Inc. | COM | 75,000 | $22.7M | 1.3% | 00.0% | Unchanged | History |
| NGNENeurogene Inc. | COM | 1,271,342 | $19.0M | 1.1% | 00.0% | Unchanged | History |
| VRNAVerona Pharma plc | SPONSORED ADS | 200,000 | $18.9M | 1.1% | +200,000 | New | History |
| TECXTectonic Therapeutic, Inc. | COM | 935,121 | $18.6M | 1.1% | 00.0% | Unchanged | History |
| ORICOric Pharmaceuticals, Inc. | COM | 1,618,068 | $16.4M | 1.0% | −1,800,000−52.7% | Reduced | History |
| ALKSAlkermes plc. | SHS | 500,000 | $14.3M | 0.8% | +500,000 | New | History |
| Avidity Biosciences, Inc.05370A108 | COM | 500,000 | $14.2M | 0.8% | −57,576−10.3% | Reduced | – |
| MBXMBX Biosciences, Inc. | COM | 1,149,794 | $13.1M | 0.8% | −109,479−8.7% | Reduced | History |
| VYGRVoyager Therapeutics, Inc. | COM | 3,917,546 | $12.2M | 0.7% | 00.0% | Unchanged | History |
| PCRXPacira BioSciences, Inc. | COM | 457,471 | $10.9M | 0.6% | +457,471 | New | History |
| REPLReplimune Group, Inc. | COM | 850,341 | $7.90M | 0.5% | 00.0% | Unchanged | History |
| MTSRMetsera, Inc. | COM | 271,529 | $7.72M | 0.5% | +221,529+443.1% | Added | History |
| ADAPYAdaptimmune Therapeutics PLC | SPONDS ADR | 27,404,070 | $6.57M | 0.4% | 00.0% | Unchanged | History |
| DAWNDay One Biopharmaceuticals, Inc. | Stock | 862,068 | $5.60M | 0.3% | 00.0% | Unchanged | History |
| HLVXHilleVax, Inc. | COM | 2,420,243 | $4.82M | 0.3% | +2,420,243 | New | History |
| ATRAAtara Biotherapeutics, Inc. | COM NEW | 573,183 | $4.42M | 0.3% | 00.0% | Unchanged | History |
| WHWKWhitehawk Therapeutics, Inc. | COM | 1,091,417 | $2.04M | 0.1% | −990,583−47.6% | Reduced | History |
| MGNXMacrogenics Inc | COM | 1,602,717 | $1.94M | 0.1% | +1,602,717 | New | History |
| Nuvation Bio Inc.67080N119 | *W EXP 07/07/202 | 963,333 | – | – | 00.0% | Unchanged | – |
| Surrozen, Inc.86889P117 | *W EXP 08/01/203 | 66,665 | – | – | 00.0% | Unchanged | – |
Options (1)
Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.
| Security | Class | Puts | Calls |
|---|---|---|---|
| QUREuniQure N.V. | SHS | – | $1.88M |
Sold out since Q1 2025 (14)
Positions held at the end of Q1 2025 that are gone from this filing.
| Security | Class | Shares in Q1 2025 | Value in Q1 2025 | % of portfolio in Q1 2025 | History |
|---|---|---|---|---|---|
| PRTAProthena Corp Public Ltd Co | SHS | 11,584,280 | $143.4M | 8.5% | History |
| SRPTSarepta Therapeutics, Inc. | COM | 1,292,386 | $82.5M | 4.9% | History |
| BEAMBeam Therapeutics Inc. | COM | 526,685 | $10.3M | 0.6% | History |
| DNAGinkgo Bioworks Holdings, Inc. | CL A NEW | 1,462,328 | $8.34M | 0.5% | History |
| BCYCBicycle Therapeutics PLC | SPONSORED ADS | 910,000 | $7.73M | 0.5% | History |
| VERVVerve Therapeutics, Inc. | COM | 1,250,000 | $5.71M | 0.3% | History |
| SLDBSolid Biosciences Inc. | COM NEW | 744,450 | $2.75M | 0.2% | History |
| KROSKeros Therapeutics, Inc. | COM | 187,500 | $1.91M | 0.1% | History |
| RLAYRelay Therapeutics, Inc. | COM | 641,426 | $1.68M | 0.1% | History |
| KLRSKalaris Therapeutics, Inc. | COM | 201,718 | $1.62M | 0.1% | History |
| PRMEPrime Medicine, Inc. | COM | 700,000 | $1.39M | 0.1% | History |
| TCRXTScan Therapeutics, Inc. | COM | 662,833 | $914.7K | 0.1% | History |
| ALGSAligos Therapeutics, Inc. | COM NEW | 88,569 | $730.7K | <0.1% | History |
| UPBUpstream Bio, Inc. | COM | 60,000 | $367.2K | <0.1% | History |