Skip to main content
Livermore
Livermore
ZHEN

EcoR1 Capital, LLC

SEC CIK
0001587114
Latest filing
Aug 14, 2026

Holdings in Q2 2023

Holdings as of Jun 30, 2023, filed Aug 14, 2023. Long positions only; changes compare share counts with Q1 2023.

Institution overview
Positions
51
−7 vs. Q1 2023
Portfolio value
$3.79B
+$690.0M (+22.2%) vs. Q1 2023
Filed
Aug 14, 2023
SEC
Holdings of EcoR1 Capital, LLC in Q2 2023
SecurityClassSharesValue% of portfolioShare changeActionHistory
PRTAProthena Corp Public Ltd CoSHS11,584,280$791.0M20.9%00.0%UnchangedHistory
APLSApellis Pharmaceuticals, Inc.COM5,451,647$496.6M13.1%00.0%UnchangedHistory
SRPTSarepta Therapeutics, Inc.COM3,660,798$419.2M11.1%+661,345+22.0%AddedHistory
LKFTLakefront Biotherapeutics NVSPON ADR5,756,268$234.0M6.2%+1,511,623+35.6%AddedHistory
MORFMorphic Holding, Inc.COM3,846,964$220.5M5.8%−20.0%ReducedHistory
RVMDRevolution Medicines, Inc.COM7,198,700$192.6M5.1%+1,846,517+34.5%AddedHistory
ANABAnaptysbio, IncCOM7,521,024$153.0M4.0%00.0%UnchangedHistory
ACADAcadia Pharmaceuticals IncCOM5,991,479$143.5M3.8%00.0%UnchangedHistory
XNCRXencor IncCOM5,282,516$131.9M3.5%00.0%UnchangedHistory
ZYMEZymeworks Inc.COM13,437,473$116.1M3.1%+3,350,000+33.2%AddedHistory
BPMCBlueprint Medicines CorpCOM1,798,300$113.7M3.0%+1,798,300NewHistory
ARVNArvinas, Inc.COM4,017,788$99.7M2.6%+300,000+8.1%AddedHistory
SWTXSpringWorks Therapeutics, Inc.COM3,460,208$90.7M2.4%00.0%UnchangedHistory
KURAKura Oncology, Inc.COM5,806,871$61.4M1.6%−831,500−12.5%ReducedHistory
RLAYRelay Therapeutics, Inc.COM4,163,824$52.3M1.4%00.0%UnchangedHistory
JAZZJazz Pharmaceuticals plcSHS USD368,411$45.7M1.2%+368,411NewHistory
VYGRVoyager Therapeutics, Inc.COM3,851,507$44.1M1.2%00.0%UnchangedHistory
CNTACentessa Pharmaceuticals plcSPONSORED ADS5,618,779$34.8M0.9%00.0%UnchangedHistory
EWTXEdgewise Therapeutics, Inc.COM3,493,194$27.1M0.7%00.0%UnchangedHistory
ORICOric Pharmaceuticals, Inc.COM3,418,068$26.5M0.7%00.0%UnchangedHistory
AVIRAtea Pharmaceuticals, Inc.COM6,995,861$26.2M0.7%+811,000+13.1%AddedHistory
NUVBNuvation Bio Inc.COM CL A13,896,543$25.0M0.7%00.0%UnchangedHistory
ALECAlector, Inc.COM4,056,548$24.4M0.6%00.0%UnchangedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM1,330,263$24.0M0.6%00.0%UnchangedHistory
ALLOAllogene Therapeutics, Inc.COM4,488,200$22.3M0.6%00.0%UnchangedHistory
LENZLENZ Therapeutics, Inc.COM8,538,446$22.2M0.6%00.0%UnchangedHistory
OVIDOvid Therapeutics Inc.COM6,117,400$20.1M0.5%00.0%UnchangedHistory
NGMNGM Biopharmaceuticals IncCOM6,435,518$16.7M0.4%00.0%UnchangedHistory
TNGXTango Therapeutics, Inc.COM4,047,114$13.4M0.4%−154,300−3.7%ReducedHistory
TCRXTScan Therapeutics, Inc.COM5,000,000$12.5M0.3%+5,000,000NewHistory
GBIOGeneration Bio Co.COM2,046,867$11.3M0.3%+90,288+4.6%AddedHistory
THRDThird Harmonic Bio, Inc.COM2,088,780$10.0M0.3%+286,658+15.9%AddedHistory
PHATPhathom Pharmaceuticals, Inc.COM700,000$10.0M0.3%+700,000NewHistory
DYNDyne Therapeutics, Inc.COM798,701$8.99M0.2%−1,523,683−65.6%ReducedHistory
PRMEPrime Medicine, Inc.COM600,000$8.79M0.2%00.0%UnchangedHistory
ZNTLZentalis Pharmaceuticals, Inc.COM300,000$8.46M0.2%+300,000NewHistory
JANXJanux Therapeutics, Inc.COM452,590$5.37M0.1%−3,385,896−88.2%ReducedHistory
PRLDPrelude Therapeutics IncCOM1,157,452$5.21M0.1%+1,157,452NewHistory
PRQRProQR Therapeutics N.V.SHS EURO2,980,016$4.83M0.1%+77,301+2.7%AddedHistory
HOOKHOOKIPA Pharma Inc.COM4,595,024$4.04M0.1%+2,121,535+85.8%AddedHistory
ALGSAligos Therapeutics, Inc.COM3,948,360$3.83M0.1%00.0%UnchangedHistory
ALLKAllakos Inc.COM748,900$3.27M0.1%+748,900NewHistory
SYRESpyre Therapeutics, Inc.COM5,000,000$2.25M0.1%+5,000,000NewHistory
TPSTTempest Therapeutics, Inc.COM1,123,434$1.43M<0.1%+92,166+8.9%AddedHistory
FDMT4D Molecular Therapeutics, Inc.COM66,978$1.21M<0.1%+66,978NewHistory
PSTXPoseida Therapeutics, Inc.COM676,296$1.19M<0.1%−1,973,704−74.5%ReducedHistory
KRONKronos Bio, Inc.COM326,780$562.1K<0.1%00.0%UnchangedHistory
Nuvation Bio Inc.67080N119*W EXP 07/07/202963,333––00.0%Unchanged–
CareMax, Inc.14171W111*W EXP 06/08/202100,000––00.0%Unchanged–
Surrozen, Inc.86889P117*W EXP 08/01/20366,665––00.0%Unchanged–
NAMSWNewAmsterdam Pharma Co N.V.*W EXP 11/22/20266,665––00.0%UnchangedHistory

Options (2)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of EcoR1 Capital, LLC in Q2 2023
SecurityClassPutsCalls
JNJJohnson & JohnsonStock–$281.4M
KURAKura Oncology, Inc.COM–$5.29M

Sold out since Q1 2023 (16)

Positions held at the end of Q1 2023 that are gone from this filing.

Positions of EcoR1 Capital, LLC sold out since Q1 2023
SecurityClassShares in Q1 2023Value in Q1 2023% of portfolio in Q1 2023History
KYMRKymera Therapeutics, Inc.COM796,093$23.6M0.8%History
ACETAdicet Bio, Inc.COM3,560,700$20.5M0.7%History
KDNYChinook Therapeutics, Inc.COM445,550$10.3M0.3%History
BEAMBeam Therapeutics Inc.COM198,591$6.08M0.2%History
ARQTArcutis Biotherapeutics, Inc.COM415,322$4.57M0.1%History
MGNXMacrogenics IncCOM619,192$4.44M0.1%History
CGEMCullinan Therapeutics, Inc.COM246,410$2.52M0.1%History
BDTXBlack Diamond Therapeutics, Inc.COM1,191,094$2.25M0.1%History
SURFSurface Oncology, Inc.COM3,082,959$2.15M0.1%History
ERASErasca, Inc.COM678,441$2.04M0.1%History
Eucrates Biomedical Acqu CorG3141W106SHS200,000$2.03M0.1%–
Gracell Biotechnologies Inc38406L103SPONSORED ADS798,948$1.49M<0.1%–
RNACCartesian Therapeutics, Inc.COM200,000$278.0K<0.1%History
CYTCyteir Therapeutics, Inc.COM43,823$79.8K<0.1%History
ITOSiTeos Therapeutics, Inc.COM1,300$17.7K<0.1%History
Eucrates Biomedical Acqu CorG3141W122*W EXP 10/23/20266,666–––