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Livermore
Livermore
ZHEN

EcoR1 Capital, LLC

SEC CIK
0001587114
Latest filing
Aug 14, 2026

Holdings in Q4 2021

Holdings as of Dec 31, 2021, filed Feb 14, 2022. Long positions only; changes compare share counts with Q3 2021.

Institution overview
Positions
75
+6 vs. Q3 2021
Portfolio value
$3.12B
+$292.2M (+10.3%) vs. Q3 2021
Filed
Feb 14, 2022
SEC
Holdings of EcoR1 Capital, LLC in Q4 2021
SecurityClassSharesValue% of portfolioShare changeActionHistory
PRTAProthena Corp Public Ltd CoSHS11,284,280$557.4M17.8%00.0%UnchangedHistory
ANABAnaptysbio, IncCOM7,521,024$261.4M8.4%00.0%UnchangedHistory
RCUSArcus Biosciences, Inc.COM5,523,358$223.5M7.2%+400,999+7.8%AddedHistory
XNCRXencor IncCOM4,906,106$196.8M6.3%00.0%UnchangedHistory
APLSApellis Pharmaceuticals, Inc.COM4,033,882$190.7M6.1%+4,033,882NewHistory
MORFMorphic Holding, Inc.COM3,951,566$187.2M6.0%00.0%UnchangedHistory
LKFTLakefront Biotherapeutics NVSPON ADR2,224,403$122.6M3.9%+665,654+42.7%AddedHistory
NUVBNuvation Bio Inc.COM CL A13,896,543$118.1M3.8%+185,026+1.3%AddedHistory
ALECAlector, Inc.COM4,994,970$103.1M3.3%00.0%UnchangedHistory
PTGXProtagonist Therapeutics, IncCOM2,639,706$90.3M2.9%+1,195,906+82.8%AddedHistory
CRSPCRISPR Therapeutics AGNAMEN AKT1,077,483$81.7M2.6%+1,077,483NewHistory
GRTSGritstone bio, Inc.COM6,012,232$77.3M2.5%+451,484+8.1%AddedHistory
ACADAcadia Pharmaceuticals IncCOM3,060,593$71.4M2.3%+3,060,593NewHistory
Avidity Biosciences, Inc.05370A108COM2,759,505$65.6M2.1%00.0%Unchanged–
ITOSiTeos Therapeutics, Inc.COM1,303,157$60.7M1.9%00.0%UnchangedHistory
RLAYRelay Therapeutics, Inc.COM1,779,084$54.6M1.7%+393,808+28.4%AddedHistory
KURAKura Oncology, Inc.COM3,724,437$52.1M1.7%00.0%UnchangedHistory
ORICOric Pharmaceuticals, Inc.COM3,468,944$51.0M1.6%00.0%UnchangedHistory
TSVT2seventy bio, Inc.COMMON STOCK1,917,063$49.1M1.6%+1,917,063NewHistory
AVIRAtea Pharmaceuticals, Inc.COM5,376,134$48.1M1.5%+5,376,134NewHistory
DSGNDesign Therapeutics, Inc.COM2,152,997$46.1M1.5%+289,899+15.6%AddedHistory
SAGESage Therapeutics, Inc.COM940,636$40.0M1.3%+940,636NewHistory
JANXJanux Therapeutics, Inc.COM1,411,975$27.9M0.9%00.0%UnchangedHistory
PRDSPardes Biosciences, Inc.COM1,597,139$26.1M0.8%+1,597,139NewHistory
VTYXVentyx Biosciences, Inc.COM1,300,000$25.8M0.8%+1,300,000NewHistory
EWTXEdgewise Therapeutics, Inc.COM1,279,175$19.5M0.6%00.0%UnchangedHistory
OVIDOvid Therapeutics Inc.COM6,082,200$19.5M0.6%00.0%UnchangedHistory
AKUSAkouos, Inc.COM1,975,984$16.8M0.5%00.0%UnchangedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM590,169$16.8M0.5%+590,169NewHistory
ALNYAlnylam Pharmaceuticals, Inc.COM98,146$16.6M0.5%+98,146NewHistory
SLDBSolid Biosciences Inc.COM9,202,702$16.1M0.5%00.0%UnchangedHistory
HALOHalozyme Therapeutics, Inc.COM392,000$15.8M0.5%+392,000NewHistory
LEGNLegend Biotech CorpSPONSORED ADS307,594$14.3M0.5%+307,594NewHistory
TNGXTango Therapeutics, Inc.COM1,300,000$14.2M0.5%00.0%UnchangedHistory
ERASErasca, Inc.COM700,000$10.9M0.3%00.0%UnchangedHistory
ARVNArvinas, Inc.COM130,300$10.7M0.3%+130,300NewHistory
CNTACentessa Pharmaceuticals plcSPONSORED ADS882,176$9.93M0.3%+127,631+16.9%AddedHistory
IMVTImmunovant, Inc.COM1,140,819$9.72M0.3%00.0%UnchangedHistory
VYGRVoyager Therapeutics, Inc.COM3,557,507$9.64M0.3%+3,111,515+697.7%AddedHistory
NRIXNurix Therapeutics, Inc.COM309,540$8.96M0.3%−817,100−72.5%ReducedHistory
LENZLENZ Therapeutics, Inc.COM688,900$8.56M0.3%+688,900NewHistory
SPRYARS Pharmaceuticals, Inc.COM1,060,010$7.06M0.2%−124,700−10.5%ReducedHistory
CCCCC4 Therapeutics, Inc.COM STK200,000$6.44M0.2%00.0%UnchangedHistory
FLACFrazier Lifesciences Acquisition CorpCL A SHS587,615$5.73M0.2%00.0%UnchangedHistory
AMTIApplied Molecular Transport Inc.COM400,000$5.59M0.2%+400,000NewHistory
KRONKronos Bio, Inc.COM387,357$5.26M0.2%00.0%UnchangedHistory
JYACJiya Acquisition Corp.COM CL A500,000$4.88M0.2%00.0%UnchangedHistory
NGNENeurogene Inc.COM860,619$4.15M0.1%00.0%UnchangedHistory
OBIOOrchestra BioMed Holdings, Inc.ORD SHS400,000$4.03M0.1%00.0%UnchangedHistory
ACIUAC Immune SASHS749,585$3.71M0.1%−1,666−0.2%ReducedHistory
VERVVerve Therapeutics, Inc.COM100,000$3.69M0.1%00.0%UnchangedHistory
KNTEKinnate Biopharma Inc.COM175,000$3.10M0.1%00.0%UnchangedHistory
DYNDyne Therapeutics, Inc.COM215,000$2.56M0.1%00.0%UnchangedHistory
MLTXMoonLake ImmunotherapeuticsCOM CL A200,000$1.98M0.1%00.0%UnchangedHistory
5 01 Acquisition Corp33836P105COM CL A200,000$1.97M0.1%00.0%Unchanged–
BCLS Acquisition CorpG0904B105COM CL A200,000$1.96M0.1%00.0%Unchanged–
Eucrates Biomedical Acqu CorG3141W106SHS200,000$1.95M0.1%00.0%Unchanged–
ADVMAdverum Biotechnologies, Inc.COM1,046,700$1.84M0.1%+1,046,700NewHistory
ARYDARYA Sciences Acquisition Corp IVCL A150,000$1.49M<0.1%00.0%UnchangedHistory
PMVPPMV Pharmaceuticals, Inc.COM50,000$1.16M<0.1%00.0%UnchangedHistory
CRBUCaribou Biosciences, Inc.COM75,000$1.13M<0.1%00.0%UnchangedHistory
ALGSAligos Therapeutics, Inc.COM91,044$1.08M<0.1%+91,044NewHistory
RPTXRepare Therapeutics Inc.COM50,000$1.05M<0.1%00.0%UnchangedHistory
Turmeric Acquisition CorpG9127T108CL A100,000$982.0K<0.1%00.0%Unchanged–
VTVTvTv Therapeutics Inc.CL A834,333$830.0K<0.1%+834,333NewHistory
GLUEMonte Rosa Therapeutics, Inc.COM37,593$768.0K<0.1%+37,593NewHistory
BOLTBolt Biotherapeutics, Inc.COM150,000$735.0K<0.1%00.0%UnchangedHistory
PCVXVaxcyte, Inc.COM20,800$495.0K<0.1%+20,800NewHistory
Omega Alpha SpacG6749V107CL A50,000$489.0K<0.1%00.0%Unchanged–
Nuvation Bio Inc.67080N119*W EXP 07/07/202963,333––00.0%Unchanged–
Eucrates Biomedical Acqu CorG3141W122*W EXP 10/23/20266,666––00.0%Unchanged–
Frazier Lifesciences Acqu CoG3710A113*W EXP 11/30/20266,665––00.0%Unchanged–
Turmeric Acquisition CorpG9127T124*W EXP 10/08/20233,333––00.0%Unchanged–
CareMax, Inc.14171W111*W EXP 06/08/202100,000––00.0%Unchanged–
Surrozen, Inc.86889P117*W EXP 08/01/20366,665––00.0%Unchanged–

Options (1)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of EcoR1 Capital, LLC in Q4 2021
SecurityClassPutsCalls
GRTSGritstone bio, Inc.COM–$3.95M

Sold out since Q3 2021 (14)

Positions held at the end of Q3 2021 that are gone from this filing.

Positions of EcoR1 Capital, LLC sold out since Q3 2021
SecurityClassShares in Q3 2021Value in Q3 2021% of portfolio in Q3 2021History
MRTXMirati Therapeutics, Inc.COM464,298$82.1M2.9%History
STTKShattuck Labs, Inc.COM3,709,072$75.6M2.7%History
DRNADicerna Pharmaceuticals IncCOM1,249,812$25.2M0.9%History
BLUEbluebird bio, Inc.COM802,507$15.3M0.5%History
ODTOdonate Therapeutics, Inc.COM3,727,261$10.8M0.4%History
CRVSCorvus Pharmaceuticals, Inc.COM2,081,077$10.1M0.4%History
KRSAKorsana Biosciences, Inc.COM1,606,276$4.93M0.2%History
FS Development Corp II30318F100COM CL A371,014$3.69M0.1%–
IGMSIGM Biosciences, Inc.COM38,030$2.50M0.1%History
FMTXForma Therapeutics Holdings, Inc.SHS90,141$2.09M0.1%History
BCABBioAtla, Inc.COM50,000$1.47M0.1%History
MGTXMeiraGTx Holdings plcCOM94,819$1.25M<0.1%History
SRRKScholar Rock Holding CorpCOM8,208$271.0K<0.1%History
ALPNAlpine Immune Sciences, Inc.COM7,001$75.0K<0.1%History