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Livermore
Livermore
ZHEN

OrbiMed Advisors LLC

SEC CIK
0001055951
Latest filing
Aug 14, 2026

Holdings in Q2 2026

Holdings as of Jun 30, 2026, filed Aug 14, 2026. Long positions only; changes compare share counts with Q1 2026.

Institution overview
Positions
121
+14 vs. Q1 2026
Portfolio value
$5.28B
+$878.4M (+20.0%) vs. Q1 2026
Filed
Aug 14, 2026
SEC
Holdings of OrbiMed Advisors LLC in Q2 2026
SecurityClassSharesValue% of portfolioShare changeActionHistory
TRAWTraws Pharma, Inc.COM NEW1,203,260$1.01M<0.1%+597,729+98.7%AddedHistory
Viridian Therapeutics Inc92790CAB0NOTE 1.750% 5/1–$1.07M<0.1%–New–
Cogent Biosciences, Inc.19240QAA0NOTE 1.625%11/1–$1.23M<0.1%–––
EPRXEupraxia Pharmaceuticals Inc.COM269,000$1.78M<0.1%+269,000NewHistory
OVIDOvid Therapeutics Inc.COM747,000$2.01M<0.1%+747,000NewHistory
BLTEBelite Bio, IncSPONSORED ADS13,300$2.05M<0.1%+13,300NewHistory
EVMNEvommune, Inc.COM SHS161,000$2.14M<0.1%+161,000NewHistory
OCULOcular Therapeutix, IncCOM220,000$2.16M<0.1%+220,000NewHistory
NSPRInspireMD, Inc.COM3,133,405$2.19M<0.1%00.0%UnchangedHistory
CYTKCytokinetics IncCOM NEW25,800$2.20M<0.1%+25,800NewHistory
ACRSAclaris Therapeutics, Inc.COM421,500$2.23M<0.1%+421,500NewHistory
TARSTarsus Pharmaceuticals, Inc.COM35,581$2.24M<0.1%+35,581NewHistory
AGMBAgomAb Therapeutics NVSPONSORED ADS192,740$2.50M<0.1%+192,740NewHistory
RAPPRapport Therapeutics, Inc.COM76,616$3.19M0.1%+76,616NewHistory
TYRATyra Biosciences, Inc.COM102,000$3.26M0.1%+102,000NewHistory
AMLXAmylyx Pharmaceuticals, Inc.COM183,400$3.29M0.1%+183,400NewHistory
ACADAcadia Pharmaceuticals IncCOM137,000$3.47M0.1%+137,000NewHistory
NMRANeumora Therapeutics, Inc.COM2,139,882$3.64M0.1%+2,139,882NewHistory
AORTArtivion, Inc.COM175,000$3.93M0.1%+24,000+15.9%AddedHistory
PTCTPTC Therapeutics, Inc.COM49,100$4.01M0.1%00.0%UnchangedHistory
ATAIAtaiBeckley Inc.COM SHS797,500$4.20M0.1%+450,500+129.8%AddedHistory
Revolution Medicines, Inc.76155XAA8NOTE 0.500% 5/0–$4.38M0.1%–New–
PALIPalisade Bio, Inc.COM2,333,000$4.88M0.1%00.0%UnchangedHistory
ALNYAlnylam Pharmaceuticals, Inc.COM17,000$5.12M0.1%−102,000−85.7%ReducedHistory
PTGXProtagonist Therapeutics, IncCOM42,100$5.16M0.1%00.0%UnchangedHistory
IMAImageneBio, Inc.COM909,269$5.36M0.1%+530,713+140.2%AddedHistory
BCAXBicara Therapeutics Inc.COM191,100$5.67M0.1%−476,200−71.4%ReducedHistory
XLOXilio Therapeutics, Inc.COM592,300$5.67M0.1%+592,300NewHistory
Travere Therapeutics, Inc.89422GAB3NOTE 0.500% 5/1–$5.89M0.1%–New–
ALXOAlx Oncology Holdings IncCOM2,866,256$5.93M0.1%00.0%UnchangedHistory
DRUGBright Minds Biosciences Inc.COM NEW93,000$6.53M0.1%+53,000+132.5%AddedHistory
ZNTLZentalis Pharmaceuticals, Inc.COM1,390,576$6.74M0.1%+1,390,576NewHistory
ANROAlto Neuroscience, Inc.COM SHS257,852$6.80M0.1%+90,352+53.9%AddedHistory
PHVSPharvaris N.V.COM205,400$7.10M0.1%00.0%UnchangedHistory
ACETAdicet Bio, Inc.COM NEW844,787$7.30M0.1%−183,157−17.8%ReducedHistory
TECXTectonic Therapeutic, Inc.COM226,600$7.79M0.1%00.0%UnchangedHistory
JANXJanux Therapeutics, Inc.COM524,700$8.06M0.2%−458,900−46.7%ReducedHistory
KROSKeros Therapeutics, Inc.COM759,155$8.12M0.2%00.0%UnchangedHistory
TARAProtara Therapeutics, Inc.COM STK2,220,000$8.48M0.2%+2,220,000NewHistory
ERASErasca, Inc.COM495,900$9.08M0.2%+495,900NewHistory
LFSTLifeStance Health Group, Inc.COM947,400$10.1M0.2%+447,400+89.5%AddedHistory
SPRBSpruce Biosciences, Inc.COM NEW200,000$10.8M0.2%+200,000NewHistory
DNTHDianthus Therapeutics, Inc.COM115,000$11.2M0.2%+115,000NewHistory
RVMDRevolution Medicines, Inc.COM70,500$13.2M0.3%+18,500+35.6%AddedHistory
BIIBBiogen Inc.COM61,600$13.3M0.3%00.0%UnchangedHistory
TSHATaysha Gene Therapies, Inc.COM SHS2,000,000$13.6M0.3%+2,000,000NewHistory
TVTXTravere Therapeutics, Inc.COM253,000$14.4M0.3%+253,000NewHistory
MNPRMonopar TherapeuticsCOM NEW157,423$14.6M0.3%+157,423NewHistory
WATWaters CorpCOM40,300$15.1M0.3%+40,300NewHistory
EYPTEyePoint, Inc.COM NEW1,069,147$15.3M0.3%00.0%UnchangedHistory
ALMSAlumis Inc.COM548,163$15.4M0.3%00.0%UnchangedHistory
VERAVera Therapeutics, Inc.CL A369,596$15.9M0.3%00.0%UnchangedHistory
CRBPCorbus Pharmaceuticals Holdings, Inc.COM NEW1,737,287$16.3M0.3%00.0%UnchangedHistory
SYRESpyre Therapeutics, Inc.COM NEW186,145$16.5M0.3%+186,145NewHistory
DFTXDefinium Therapeutics, Inc.COM SHS365,400$17.2M0.3%−438,600−54.6%ReducedHistory
WHWKWhitehawk Therapeutics, Inc.COM3,934,296$18.0M0.3%−231,704−5.6%ReducedHistory
LXEOLexeo Therapeutics, Inc.COM3,947,850$18.4M0.3%+345,400+9.6%AddedHistory
BIOABioAge Labs, Inc.COM752,153$18.4M0.3%+40,342+5.7%AddedHistory
BCRXBiocryst Pharmaceuticals IncCOM1,852,000$18.5M0.4%+426,800+29.9%AddedHistory
HELPHelus Pharma Inc.COM NEW3,271,400$21.6M0.4%−561,443−14.6%ReducedHistory
ORICOric Pharmaceuticals, Inc.COM2,015,000$21.8M0.4%−678,929−25.2%ReducedHistory
AURAAura Biosciences, Inc.COM3,333,333$23.7M0.4%+3,333,333NewHistory
NPCENeuroPace IncCOM1,505,125$23.9M0.5%−591,402−28.2%ReducedHistory
SVRASavara IncCOM3,959,900$24.4M0.5%+3,324,900+523.6%AddedHistory
STROSutro Biopharma, Inc.COM SHS743,944$24.7M0.5%−57,200−7.1%ReducedHistory
URGNUroGen Pharma Ltd.COM676,187$24.9M0.5%−199,300−22.8%ReducedHistory
RLMDRelmada Therapeutics, Inc.COM3,631,195$25.1M0.5%−1,084,669−23.0%ReducedHistory
WSTWest Pharmaceutical Services IncCOM70,600$25.3M0.5%+70,600NewHistory
IRONDisc Medicine, Inc.COM357,535$26.2M0.5%−710,015−66.5%ReducedHistory
TRVITrevi Therapeutics, Inc.COM1,430,293$26.7M0.5%−1,024,107−41.7%ReducedHistory
KNSAKiniksa Pharmaceuticals International, plcORD SHS CL A420,600$26.9M0.5%+240,001+132.9%AddedHistory
AXSMAxsome Therapeutics, Inc.COM117,578$28.8M0.5%−96,343−45.0%ReducedHistory
0000000000Stock5,680,186$30.3M0.6%−530,713−8.5%Reduced–
KRYSKrystal Biotech, Inc.COM83,200$30.9M0.6%+14,100+20.4%AddedHistory
NKTRNektar TherapeuticsCOM NEW465,346$32.5M0.6%+190,346+69.2%AddedHistory
CMPXCompass Therapeutics, Inc.COM15,219,994$33.3M0.6%00.0%UnchangedHistory
FBRXForte Biosciences, Inc.COM NEW1,577,705$33.5M0.6%+380,750+31.8%AddedHistory
SNDXSyndax Pharmaceuticals IncCOM1,542,000$33.7M0.6%+579,700+60.2%AddedHistory
RYTMRhythm Pharmaceuticals, Inc.COM322,900$35.9M0.7%+8,800+2.8%AddedHistory
CRNXCrinetics Pharmaceuticals, Inc.COM999,000$37.4M0.7%00.0%UnchangedHistory
UPBUpstream Bio, Inc.COM5,693,589$39.4M0.7%00.0%UnchangedHistory
STTKShattuck Labs, Inc.COM6,306,127$43.8M0.8%00.0%UnchangedHistory
ELVElevance Health, Inc.Stock114,700$44.4M0.8%00.0%UnchangedHistory
PVLAPalvella Therapeutics, Inc.COM292,360$44.7M0.8%+157,760+117.2%AddedHistory
TMOThermo Fisher Scientific Inc.Stock90,700$45.5M0.9%+44,200+95.1%AddedHistory
CAICaris Life Sciences, Inc.COM2,806,811$50.0M0.9%00.0%UnchangedHistory
SYKStryker CorpStock159,100$50.1M0.9%−23,400−12.8%ReducedHistory
QTTBQ32 Bio Inc.COM4,127,987$52.6M1.0%+1,875,000+83.2%AddedHistory
BMYBristol Myers Squibb CoStock925,000$53.3M1.0%00.0%UnchangedHistory
ARQTArcutis Biotherapeutics, Inc.COM2,042,000$53.5M1.0%+2,042,000NewHistory
XENEXenon Pharmaceuticals Inc.COM892,471$53.9M1.0%−167,500−15.8%ReducedHistory
ODTXOdyssey Therapeutics, Inc.COMMON STOCK3,001,198$56.2M1.1%+3,001,198NewHistory
MLYSMineralys Therapeutics, Inc.COM2,110,300$56.9M1.1%+57,400+2.8%AddedHistory
ISRGIntuitive Surgical IncCOM NEW157,900$62.8M1.2%−50,800−24.3%ReducedHistory
BSXBoston Scientific CorpStock1,483,200$63.3M1.2%−898,900−37.7%ReducedHistory
COGTCogent Biosciences, Inc.COM1,681,300$65.1M1.2%+1,359,200+422.0%AddedHistory
HUMHumana IncStock164,100$65.2M1.2%+164,100NewHistory
ASNDAscendis Pharma A/SORD SHS244,456$65.2M1.2%+62,479+34.3%AddedHistory
SPRYARS Pharmaceuticals, Inc.COM8,288,510$66.4M1.3%00.0%UnchangedHistory
UNHUnitedHealth Group IncStock161,100$67.0M1.3%+161,100NewHistory

Options (8)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of OrbiMed Advisors LLC in Q2 2026
SecurityClassPutsCalls
State Street SPDR S&P Biotech ETF78464A870ETF$47.5M–
ABVXAbivax S.A.SPONSORED ADS–$26.7M
PTGXProtagonist Therapeutics, IncCOM–$18.4M
RVMDRevolution Medicines, Inc.COM–$9.36M
PVLAPalvella Therapeutics, Inc.COM–$6.11M
UNHUnitedHealth Group IncStock–$4.16M
ELVElevance Health, Inc.Stock–$3.87M
SLSSELLAS Life Sciences Group, Inc.COM NEW$1.37M–

Sold out since Q1 2026 (20)

Positions held at the end of Q1 2026 that are gone from this filing.

Positions of OrbiMed Advisors LLC sold out since Q1 2026
SecurityClassShares in Q1 2026Value in Q1 2026% of portfolio in Q1 2026History
MYGNMyriad Genetics IncCOM–$122.9M2.8%History
PFEPfizer IncStock1,946,500$54.7M1.2%History
DHRDanaher CorpStock265,800$50.4M1.1%History
RCELAVITA Medical, Inc.COM544,895$42.5M1.0%History
ESPREsperion Therapeutics, Inc.COM10,570,300$29.0M0.7%History
BTSGBrightSpring Health Services, Inc.COM497,800$21.2M0.5%History
AMGNAmgen IncStock39,900$14.0M0.3%History
ALHCAlignment Healthcare, Inc.COM791,000$13.9M0.3%History
REGNRegeneron Pharmaceuticals, Inc.COM14,700$11.4M0.3%History
CARLCarlsmed, Inc.COM1,252,600$11.3M0.3%History
GILDGilead Sciences, Inc.Stock59,600$8.31M0.2%History
HRTXHeron Therapeutics, Inc.COM9,816,940$7.85M0.2%History
AVTXAvalo Therapeutics, Inc.COM NEW475,165$7.09M0.2%History
CMPSCOMPASS Pathways plcSPONSORED ADS1,150,646$6.36M0.1%History
ADCTADC Therapeutics SASHS1,318,026$4.94M0.1%History
CGEMCullinan Therapeutics, Inc.COM243,006$3.45M0.1%History
JBIOJade Biosciences, Inc.COM NEW185,011$2.60M0.1%History
CCCCC4 Therapeutics, Inc.COM STK856,353$2.25M0.1%History
KALVKalVista Pharmaceuticals, Inc.COM94,400$1.90M<0.1%History
VTGNVistagen Therapeutics, Inc.COM3,060,000$1.75M<0.1%History