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Livermore
Livermore
ZHEN

OrbiMed Advisors LLC

SEC CIK
0001055951
Latest filing
Aug 14, 2026

Holdings in Q3 2023

Holdings as of Sep 30, 2023, filed Nov 14, 2023. Long positions only; changes compare share counts with Q2 2023.

Institution overview
Positions
120
+1 vs. Q2 2023
Portfolio value
$4.32B
−$816.9M (−15.9%) vs. Q2 2023
Filed
Nov 14, 2023
SEC
Holdings of OrbiMed Advisors LLC in Q3 2023
SecurityClassSharesValue% of portfolioShare changeActionHistory
OMICSingular Genomics Systems, Inc.COM540,697$206.0K<0.1%00.0%UnchangedHistory
HARPHarpoon Therapeutics, Inc.COM NEW62,121$250.3K<0.1%00.0%UnchangedConverted for a 1-for-10 splitHistory
ALTAltimmune, Inc.COM NEW100,000$260.0K<0.1%00.0%UnchangedHistory
XNCRXencor IncCOM19,142$385.7K<0.1%+19,142NewHistory
DMRADamora Therapeutics, Inc.COM924,788$665.4K<0.1%−2,909,449−75.9%ReducedHistory
CALCCalciMedica, Inc.COM NEW297,380$790.9K<0.1%00.0%UnchangedHistory
HRTXHeron Therapeutics, Inc.COM802,700$826.8K<0.1%00.0%UnchangedHistory
ELEVElevation Acquisition Group Inc.COM1,500,000$993.9K<0.1%00.0%UnchangedHistory
SYBXSynlogic, Inc.COM NEW401,998$1.13M<0.1%00.0%UnchangedConverted for a 1-for-15 splitHistory
TARAProtara Therapeutics, Inc.COM STK772,584$1.29M<0.1%00.0%UnchangedHistory
BOLTBolt Biotherapeutics, Inc.COM1,541,000$1.60M<0.1%00.0%UnchangedHistory
HLSQTessera Defense & Homeland Security Inc.COM4,553,489$1.60M<0.1%00.0%UnchangedHistory
BCABBioAtla, Inc.COM1,009,279$1.72M<0.1%−146,896−12.7%ReducedHistory
AFIBAcutus Medical, Inc.COM2,648,386$1.84M<0.1%00.0%UnchangedHistory
CMMBChemomab Therapeutics Ltd.SPONSORED ADS2,241,274$2.01M<0.1%00.0%UnchangedHistory
TDOCTeladoc Health, Inc.COM110,000$2.04M<0.1%+110,000NewHistory
KRTXKaruna Therapeutics, Inc.COM14,000$2.37M0.1%+14,000NewHistory
VIGLVigil Neuroscience, Inc.COM448,891$2.42M0.1%00.0%UnchangedHistory
EPIXESSA Pharma Inc.COM NEW842,366$2.60M0.1%−79,574−8.6%ReducedHistory
NXTCNextCure, Inc.COM2,711,013$3.50M0.1%00.0%UnchangedHistory
CUTRCutera IncCOM603,100$3.63M0.1%+216,000+55.8%AddedHistory
Ys Biopharma Co LtdG9845F109ORDINARY SHARES4,541,422$3.63M0.1%+242,957+5.7%Added–
RLAYRelay Therapeutics, Inc.COM501,966$4.22M0.1%+501,966NewHistory
MORFMorphic Holding, Inc.COM208,500$4.78M0.1%00.0%UnchangedHistory
CGEMCullinan Therapeutics, Inc.COM544,848$4.93M0.1%00.0%UnchangedHistory
ORICOric Pharmaceuticals, Inc.COM893,668$5.41M0.1%−274,800−23.5%ReducedHistory
NSPRInspireMD, Inc.COM1,860,405$6.08M0.1%00.0%UnchangedHistory
KVUEKenvue Inc.Stock312,404$6.27M0.1%+312,404NewHistory
KZRKezar Life Sciences, Inc.COM5,463,000$6.50M0.2%00.0%UnchangedHistory
PASGPassage BIO, Inc.COM10,124,576$6.66M0.2%00.0%UnchangedHistory
MLTXMoonLake ImmunotherapeuticsCLASS A ORD117,000$6.67M0.2%00.0%UnchangedHistory
GILDGilead Sciences, Inc.Stock100,000$7.49M0.2%00.0%UnchangedHistory
XFORX4 Pharmaceuticals, IncCOM7,133,515$7.78M0.2%00.0%UnchangedHistory
FUSNFusion Pharmaceuticals Inc.COM3,122,770$8.12M0.2%00.0%UnchangedHistory
IVVDInvivyd, Inc.COM5,270,400$8.96M0.2%00.0%UnchangedHistory
GDRXGoodRx Holdings, Inc.COM CL A1,595,000$8.98M0.2%−193,600−10.8%ReducedHistory
SGENSeagen Inc.COM42,600$9.04M0.2%+42,600NewHistory
CRVSCorvus Pharmaceuticals, Inc.COM6,943,654$10.1M0.2%00.0%UnchangedHistory
ARQTArcutis Biotherapeutics, Inc.COM1,914,479$10.2M0.2%00.0%UnchangedHistory
JBIOJade Biosciences, Inc.COM756,930$10.3M0.2%00.0%UnchangedHistory
REGNRegeneron Pharmaceuticals, Inc.COM13,500$11.1M0.3%00.0%UnchangedHistory
KNTEKinnate Biopharma Inc.COM8,009,729$11.2M0.3%00.0%UnchangedHistory
ACETAdicet Bio, Inc.COM8,322,140$11.4M0.3%00.0%UnchangedHistory
ARWRArrowhead Pharmaceuticals, Inc.COM433,651$11.7M0.3%+316,651+270.6%AddedHistory
VTYXVentyx Biosciences, Inc.COM340,384$11.8M0.3%−200,600−37.1%ReducedHistory
IMTXImmatics N.V.SHS1,050,200$12.2M0.3%+83,371+8.6%AddedHistory
TSBXTurnstone Biologics Corp.COM3,099,265$12.2M0.3%+3,099,265NewHistory
VSTMVerastem, Inc.COM NEW1,529,115$12.4M0.3%00.0%UnchangedHistory
RYTMRhythm Pharmaceuticals, Inc.COM583,642$13.4M0.3%+583,642NewHistory
ALXOAlx Oncology Holdings IncCOM2,871,000$13.8M0.3%00.0%UnchangedHistory
IMAImageneBio, Inc.COM3,186,166$13.8M0.3%00.0%UnchangedHistory
QUREuniQure N.V.SHS2,064,455$13.9M0.3%00.0%UnchangedHistory
SRRKScholar Rock Holding CorpCOM2,033,789$14.4M0.3%+1,298,144+176.5%AddedHistory
ARGXArgenx SESPONSORED ADR32,600$16.0M0.4%00.0%UnchangedHistory
AKROAkero Therapeutics, Inc.COM350,000$17.7M0.4%+150,500+75.4%AddedHistory
SNDXSyndax Pharmaceuticals IncCOM1,284,000$18.6M0.4%−1,246,240−49.3%ReducedHistory
ABCLAbCellera Biologics Inc.COM4,180,768$19.2M0.4%00.0%UnchangedHistory
RAPTRAPT Therapeutics, Inc.COM1,244,945$20.7M0.5%−6,125−0.5%ReducedHistory
VERAVera Therapeutics, Inc.CL A1,518,115$20.8M0.5%−238,685−13.6%ReducedHistory
NMRANeumora Therapeutics, Inc.COM1,500,000$21.2M0.5%+1,500,000NewHistory
IOVAIovance Biotherapeutics, Inc.COM4,707,458$21.4M0.5%00.0%UnchangedHistory
TELATELA Bio, Inc.COM2,835,542$22.7M0.5%00.0%UnchangedHistory
Gracell Biotechnologies Inc38406L103SPONSORED ADS9,308,726$26.8M0.6%+275,000+3.0%Added–
APGEApogee Therapeutics, Inc.COM1,427,901$30.4M0.7%+1,427,901NewHistory
HZNPHorizon Therapeutics Public Ltd CoSHS266,400$30.8M0.7%−50,000−15.8%ReducedHistory
ICLRIcon PLCCOM132,200$32.6M0.8%+132,200NewHistory
XENEXenon Pharmaceuticals Inc.COM958,793$32.8M0.8%−137,207−12.5%ReducedHistory
JANXJanux Therapeutics, Inc.COM3,317,927$33.4M0.8%+481,541+17.0%AddedHistory
PRLDPrelude Therapeutics IncCOM10,909,256$33.7M0.8%00.0%UnchangedHistory
AMGNAmgen IncStock127,300$34.2M0.8%00.0%UnchangedHistory
SPRYARS Pharmaceuticals, Inc.COM9,240,887$34.9M0.8%+500,000+5.7%AddedHistory
UNHUnitedHealth Group IncStock70,000$35.3M0.8%−174,000−71.3%ReducedHistory
THRDThird Harmonic Bio, Inc.COM5,779,071$36.9M0.9%00.0%UnchangedHistory
MDGLMadrigal Pharmaceuticals, Inc.COM253,309$37.0M0.9%−68,260−21.2%ReducedHistory
TERNTerns Pharmaceuticals, Inc.COM7,619,135$38.3M0.9%00.0%UnchangedHistory
NPCENeuroPace IncCOM4,012,281$39.0M0.9%00.0%UnchangedHistory
SCPHscPharmaceuticals Inc.COM5,559,528$39.6M0.9%00.0%UnchangedHistory
RPTXRepare Therapeutics Inc.COM3,322,488$40.1M0.9%00.0%UnchangedHistory
PMVPPMV Pharmaceuticals, Inc.COM6,563,077$40.3M0.9%00.0%UnchangedHistory
NTRANatera, Inc.COM920,581$40.7M0.9%−53,000−5.4%ReducedHistory
CMPXCompass Therapeutics, Inc.COM22,362,850$44.1M1.0%00.0%UnchangedHistory
0000000000Stock12,048,773$45.1M1.0%+153,121+1.3%Added–
ALPNAlpine Immune Sciences, Inc.COM4,081,592$46.7M1.1%00.0%UnchangedHistory
NBIXNeurocrine Biosciences IncStock415,900$46.8M1.1%−73,100−14.9%ReducedHistory
THRXTheseus Pharmaceuticals, Inc.COM17,713,600$47.6M1.1%+479,932+2.8%AddedHistory
APLSApellis Pharmaceuticals, Inc.COM1,260,500$47.9M1.1%+350,300+38.5%AddedHistory
KROSKeros Therapeutics, Inc.COM1,514,734$48.3M1.1%00.0%UnchangedHistory
SIBNSI-BONE, Inc.COM2,292,531$48.7M1.1%00.0%UnchangedHistory
ABBVAbbVie Inc.Stock330,000$49.2M1.1%+330,000NewHistory
PCVXVaxcyte, Inc.COM1,007,148$51.3M1.2%00.0%UnchangedHistory
RCMR1 RCM Inc.COM3,441,000$51.9M1.2%00.0%UnchangedHistory
SLRNACELYRIN, Inc.COM5,326,302$54.2M1.3%00.0%UnchangedHistory
VRTXVertex Pharmaceuticals IncStock165,400$57.5M1.3%00.0%UnchangedHistory
RYZBRayzeBio, Inc.COM2,622,909$58.2M1.3%+2,622,909NewHistory
VRNAVerona Pharma plcSPONSORED ADS3,777,778$61.6M1.4%00.0%UnchangedHistory
SRPTSarepta Therapeutics, Inc.COM529,200$64.1M1.5%−124,800−19.1%ReducedHistory
CICigna GroupStock231,500$66.2M1.5%+70,500+43.8%AddedHistory
APLMApollomics Inc.CL A SHS17,993,635$67.4M1.6%+17,331,074+2,615.8%AddedHistory
TMOThermo Fisher Scientific Inc.Stock143,800$72.8M1.7%−19,000−11.7%ReducedHistory
SYKStryker CorpStock269,000$73.5M1.7%−2,400−0.9%ReducedHistory

Options (7)

Puts and calls in the same filing. Amounts are the market value of the underlying shares, which is what 13F reports.

Option positions of OrbiMed Advisors LLC in Q3 2023
SecurityClassPutsCalls
AZNAstraZeneca PLCSPONSORED ADR–$16.9M
SGENSeagen Inc.COM–$10.6M
KVUEKenvue Inc.Stock–$5.02M
DXCMDexcom IncCOM–$4.67M
MRTXMirati Therapeutics, Inc.COM–$4.36M
APLSApellis Pharmaceuticals, Inc.COM–$2.95M
IMTXImmatics N.V.SHS–$1.45M

Sold out since Q2 2023 (13)

Positions held at the end of Q2 2023 that are gone from this filing.

Positions of OrbiMed Advisors LLC sold out since Q2 2023
SecurityClassShares in Q2 2023Value in Q2 2023% of portfolio in Q2 2023History
BMYBristol Myers Squibb CoStock1,488,000$95.2M1.9%History
Vectivbio Hldg AGH9060V101ORD SHS5,156,561$87.7M1.7%–
EWEdwards Lifesciences CorpStock515,000$48.6M0.9%History
ZBHZimmer Biomet Holdings, Inc.Stock245,000$35.7M0.7%History
TVTXTravere Therapeutics, Inc.COM2,118,100$32.5M0.6%History
TSVT2seventy bio, Inc.COMMON STOCK2,391,628$24.2M0.5%History
MRSNMersana Therapeutics, Inc.COM7,214,937$23.7M0.5%History
FOLDAmicus Therapeutics, Inc.COM1,856,400$23.3M0.5%History
DBTXDecibel Therapeutics, Inc.COM4,945,192$19.0M0.4%History
BridgeBio Pharma, Inc.10806XAD4NOTE 2.250% 2/0–$9.27M0.2%–
GHRSGH Research PLCORDINARY SHARES736,315$8.74M0.2%History
ALKSAlkermes plc.SHS151,400$4.74M0.1%History
RVNCRevance Therapeutics, Inc.COM100,000$2.53M<0.1%History