| Vanguard Group Inc | 7,547,533 | $7.66 億 | 0.02% | – | – |
| BlackRock Inc. | 6,432,039 | $6.53 億 | 0.02% | – | – |
| Fred Alger Management, LLC | 5,778,060 | $5.87 億 | 1.54% | – | – |
| Wells Fargo & Company | 3,658,910 | $3.72 億 | 0.09% | – | – |
| JPMorgan Chase & Co | 3,286,004 | $3.34 億 | 0.05% | – | – |
| Sofinnova Investments, Inc. | 3,100,560 | $3.15 億 | 19.86% | – | – |
| FMR LLC | 2,565,629 | $2.61 億 | 0.02% | – | – |
| OrbiMed Advisors LLC | 2,195,900 | $2.23 億 | 2.10% | – | – |
| Ameriprise Financial Inc | 2,022,885 | $2.05 億 | 0.07% | – | – |
| State Street Corp | 1,909,243 | $1.94 億 | 0.01% | – | – |
| RTW Investments, LP | 1,712,234 | $1.74 億 | 2.71% | – | – |
| Invesco Ltd. | 1,645,261 | $1.67 億 | 0.04% | – | – |
| Millennium Management LLC | 1,629,702 | $1.65 億 | 0.23% | – | – |
| Gilder Gagnon Howe & Co LLC | 1,490,435 | $1.51 億 | 0.82% | – | – |
| Lord, Abbett & Co. LLC | 1,468,197 | $1.49 億 | 0.38% | – | – |
| Geode Capital Management, LLC | 1,325,018 | $1.35 億 | 0.02% | – | – |
| Macquarie Group Ltd | 1,264,272 | $1.28 億 | 0.18% | – | – |
| Marshall Wace, LLP | 1,174,013 | $1.19 億 | 0.63% | – | – |
| Credit Suisse AG | 1,139,704 | $1.16 億 | 0.09% | – | – |
| Jennison Associates LLC | 1,136,896 | $1.15 億 | 0.08% | – | – |
| Federated Hermes, Inc. | 1,087,890 | $1.10 億 | 0.21% | – | – |
| D. E. Shaw & Co., Inc. | 1,037,369 | $1.05 億 | 0.13% | – | – |
| Franklin Resources Inc | 1,026,262 | $1.04 億 | 0.04% | – | – |
| American Century Companies Inc | 1,011,269 | $1.03 億 | 0.08% | – | – |
| Norges Bank | 989,245 | $1.00 億 | 0.02% | – | – |
| Holocene Advisors, LP | 934,701 | $9,491 萬 | 0.61% | – | – |
| Goldman Sachs Group Inc | 897,212 | $9,110 萬 | 0.03% | – | – |
| Bank of New York Mellon Corp | 856,548 | $8,697 萬 | 0.02% | – | – |
| Northern Trust Corp | 852,296 | $8,654 萬 | 0.02% | – | – |
| Nuveen Asset Management, LLC | 800,833 | $8,132 萬 | 0.03% | – | – |
| Driehaus Capital Management LLC | 771,185 | $7,831 萬 | 1.16% | – | – |
| Charles Schwab Investment Management Inc | 740,364 | $7,518 萬 | 0.03% | – | – |
| Point72 Asset Management, L.P. | 737,682 | $7,490 萬 | 0.38% | – | – |
| Principal Financial Group Inc | 732,760 | $7,440 萬 | 0.05% | – | – |
| Janus Henderson Group PLC | 698,962 | $7,097 萬 | 0.03% | – | – |
| UBS Asset Management Americas Inc | 375,480 | $6,726 萬 | 0.03% | – | – |
| Citadel Advisors LLC | 653,325 | $6,634 萬 | 0.07% | – | – |
| Capital World Investors | 643,000 | $6,529 萬 | 0.01% | – | – |
| Two Sigma Investments, LP | 607,574 | $6,169 萬 | 0.19% | – | – |
| Loomis Sayles & Co L P | 596,008 | $6,052 萬 | 0.08% | – | – |
| Two Sigma Advisers, LP | 587,800 | $5,969 萬 | 0.16% | – | – |
| Hudson Executive Capital LP | 527,086 | $5,352 萬 | 3.32% | – | – |
| Eagle Asset Management Inc | 504,560 | $5,193 萬 | 0.23% | – | – |
| Kornitzer Capital Management Inc | 501,965 | $5,097 萬 | 0.82% | – | – |
| Allianz Asset Management GmbH | 471,630 | $4,789 萬 | 0.05% | – | – |
| Frontier Capital Management Co LLC | 444,550 | $4,514 萬 | 0.34% | – | – |
| Avidity Partners Management LP | 395,600 | $4,017 萬 | 1.12% | – | – |
| Bridger Management, LLC | 388,620 | $3,946 萬 | 3.68% | – | – |
| Amundi Asset Management US, Inc. | 365,927 | $3,716 萬 | 0.03% | – | – |
| Bank of America Corp | 357,316 | $3,628 萬 | 0.00% | – | – |
| Blue Water Life Science Advisors, LLC | 328,836 | $3,339 萬 | 16.31% | – | – |
| Hood River Capital Management LLC | 317,374 | $3,223 萬 | 1.04% | – | – |
| Westwood Management Corp | 290,100 | $2,946 萬 | 2.60% | – | – |
| Wellington Management Group LLP | 283,596 | $2,880 萬 | 0.01% | – | – |
| Thrivent Financial for Lutherans | 280,582 | $2,849 萬 | 0.06% | – | – |
| Assenagon Asset Management S.A. | 277,652 | $2,819 萬 | 0.14% | – | – |
| Voloridge Investment Management, LLC | 258,149 | $2,621 萬 | 0.19% | – | – |
| Armistice Capital, LLC | 248,000 | $2,518 萬 | 0.81% | – | – |
| Pura Vida Investments, LLC | 247,644 | $2,515 萬 | 1.74% | – | – |
| Morgan Stanley | 243,232 | $2,470 萬 | 0.00% | – | – |
| Voya Investment Management LLC | 228,433 | $2,320 萬 | 0.05% | – | – |
| Schroder Investment Management Group | 224,675 | $2,281 萬 | 0.03% | – | – |
| Balyasny Asset Management LLC | 222,274 | $2,257 萬 | 0.14% | – | – |
| Ally Bridge Group (NY) LLC | 218,000 | $2,214 萬 | 5.36% | – | – |
| Renaissance Technologies LLC | 213,900 | $2,172 萬 | 0.03% | – | – |
| Deutsche Bank AG | 192,504 | $1,955 萬 | 0.01% | – | – |
| California Public Employees Retirement System | 180,145 | $1,829 萬 | 0.01% | – | – |
| Agf Investments Inc. | 170,073 | $1,727 萬 | 0.14% | – | – |
| Fuller & Thaler Asset Management, Inc. | 169,828 | $1,724 萬 | 0.12% | – | – |
| Eagle Health Investments LP | 168,394 | $1,710 萬 | 6.94% | – | – |
| Swiss National Bank | 165,800 | $1,684 萬 | 0.01% | – | – |
| Moore Capital Management, LP | 165,618 | $1,682 萬 | 0.33% | – | – |
| Lombard Odier Asset Management (Switzerland) SA | 163,278 | $1,658 萬 | 1.11% | – | – |
| Compagnie Lombard Odier SCmA | 163,278 | $1,658 萬 | 0.37% | – | – |
| Iron Triangle Partners LP | 150,000 | $1,523 萬 | 1.94% | – | – |
| HWG Holdings LP | 148,794 | $1,511 萬 | 9.09% | – | – |
| Tygh Capital Management, Inc. | 147,445 | $1,497 萬 | 2.12% | – | – |
| Alliancebernstein L.P. | 141,917 | $1,441 萬 | 0.01% | – | – |
| Parkman Healthcare Partners LLC | 139,893 | $1,421 萬 | 3.42% | – | – |
| Thornburg Investment Management Inc | 131,398 | $1,334 萬 | 0.15% | – | – |
| Schonfeld Strategic Advisors LLC | 130,961 | $1,330 萬 | 0.18% | – | – |
| Lisanti Capital Growth, LLC | 130,043 | $1,321 萬 | 1.69% | – | – |
| Sectoral Asset Management Inc | 128,850 | $1,308 萬 | 0.99% | – | – |
| Prudential Financial Inc | 127,346 | $1,293 萬 | 0.02% | – | – |
| Foresite Capital Management III, LLC | 127,305 | $1,293 萬 | 11.35% | – | – |
| Adage Capital Partners GP, L.L.C. | 125,000 | $1,269 萬 | 0.03% | – | – |
| Castleark Management LLC | 117,589 | $1,194 萬 | 0.43% | – | – |
| California State Teachers Retirement System | 114,205 | $1,160 萬 | 0.02% | – | – |
| Atika Capital Management LLC | 112,000 | $1,137 萬 | 1.19% | – | – |
| Panagora Asset Management Inc | 111,094 | $1,128 萬 | 0.06% | – | – |
| Moody Aldrich Partners LLC | 110,290 | $1,120 萬 | 1.62% | – | – |
| Envestnet Asset Management Inc | 105,196 | $1,068 萬 | 0.01% | – | – |
| State of Wisconsin Investment Board | 105,100 | $1,067 萬 | 0.02% | – | – |
| Lagoda Investment Management, L.P. | 103,325 | $1,049 萬 | 5.24% | – | – |
| WCM Investment Management, LLC | 100,575 | $1,021 萬 | 0.03% | – | – |
| Mirae Asset Global Investments Co., Ltd. | 99,880 | $1,014 萬 | 0.04% | – | – |
| Rhumbline Advisers | 92,033 | $934.5 萬 | 0.01% | – | – |
| Parametric Portfolio Associates LLC | 91,454 | $928.6 萬 | 0.01% | – | – |
| Putnam Investments LLC | 85,442 | $867.5 萬 | 0.01% | – | – |
| Barclays PLC | 82,978 | $842.5 萬 | 0.01% | – | – |
