| BlackRock Inc. | 16,244,464 | $6,319 萬 | 0.00% | – | – |
| Perceptive Advisors LLC | 15,711,334 | $6,112 萬 | 0.81% | – | – |
| State Street Corp | 12,930,224 | $5,030 萬 | 0.00% | – | – |
| Point72 Asset Management, L.P. | 11,785,115 | $4,584 萬 | 0.23% | – | – |
| Avidity Partners Management LP | 9,544,200 | $3,713 萬 | 1.04% | – | – |
| Vanguard Group Inc | 9,166,199 | $3,566 萬 | 0.00% | – | – |
| Third Point LLC大師第三點資本 | 7,601,115 | $2,957 萬 | 0.20% | – | – |
| Laurion Capital Management LP | 6,493,876 | $2,526 萬 | 0.34% | – | – |
| Boxer Capital, LLC | 6,205,882 | $2,414 萬 | 0.82% | – | – |
| Vivo Capital, LLC | 5,817,459 | $2,263 萬 | 0.80% | – | – |
| Great Point Partners LLC | 4,755,000 | $1,850 萬 | 3.82% | – | – |
| Citadel Advisors LLC | 4,362,638 | $1,697 萬 | 0.02% | – | – |
| Millennium Management LLC | 4,282,349 | $1,666 萬 | 0.02% | – | – |
| Morgan Stanley | 4,074,031 | $1,585 萬 | 0.00% | – | – |
| Mizuho Markets Americas LLC | 3,778,651 | $1,470 萬 | 7.20% | – | – |
| Goldman Sachs Group Inc | 3,094,985 | $1,204 萬 | 0.00% | – | – |
| Geode Capital Management, LLC | 2,875,705 | $1,119 萬 | 0.00% | – | – |
| Deutsche Bank AG | 2,801,077 | $1,090 萬 | 0.01% | – | – |
| Kennedy Capital Management, Inc. | 2,021,056 | $786.2 萬 | 0.16% | – | – |
| Northern Trust Corp | 1,914,035 | $744.4 萬 | 0.00% | – | – |
| Mangrove Partners | 1,573,543 | $612.1 萬 | 0.66% | – | – |
| Adage Capital Partners GP, L.L.C. | 1,500,000 | $583.5 萬 | 0.01% | – | – |
| Eversept Partners, LP | 1,373,119 | $534.1 萬 | 0.44% | – | – |
| Two Sigma Advisers, LP | 1,368,004 | $532.2 萬 | 0.01% | – | – |
| Invesco Ltd. | 1,318,527 | $512.9 萬 | 0.00% | – | – |
| Charles Schwab Investment Management Inc | 1,109,108 | $431.5 萬 | 0.00% | – | – |
| Woodline Partners LP | 996,495 | $387.6 萬 | 0.09% | – | – |
| Verition Fund Management LLC | 980,338 | $381.4 萬 | 0.07% | – | – |
| Ikarian Capital, LLC | 936,615 | $364.4 萬 | 0.54% | – | – |
| Norges Bank | 891,200 | $346.7 萬 | 0.00% | – | – |
| Schonfeld Strategic Advisors LLC | 869,430 | $338.1 萬 | 0.04% | – | – |
| Citigroup Inc | 826,283 | $321.4 萬 | 0.00% | – | – |
| Parkman Healthcare Partners LLC | 824,475 | $320.7 萬 | 0.77% | – | – |
| Maven Securities LTD | 798,036 | $309.2 萬 | 0.29% | – | – |
| Knott David M | 762,000 | $296.4 萬 | 1.29% | – | – |
| Cormorant Asset Management, LP | 750,000 | $291.8 萬 | 0.08% | – | – |
| AXA S.A. | 744,203 | $289.5 萬 | 0.01% | – | – |
| Nomura Holdings Inc | 700,000 | $274.1 萬 | 0.02% | – | – |
| Panagora Asset Management Inc | 699,605 | $272.1 萬 | 0.02% | – | – |
| Rafferty Asset Management, LLC | 665,924 | $259.0 萬 | 0.02% | – | – |
| Bank of New York Mellon Corp | 647,669 | $252.0 萬 | 0.00% | – | – |
| Assenagon Asset Management S.A. | 642,892 | $250.1 萬 | 0.01% | – | – |
| ClariVest Asset Management LLC | 627,601 | $244.2 萬 | 0.09% | – | – |
| Nuveen Asset Management, LLC | 615,835 | $239.5 萬 | 0.00% | – | – |
| Ghost Tree Capital, LLC | 600,000 | $233.4 萬 | 0.65% | – | – |
| Two Sigma Investments, LP | 595,817 | $231.8 萬 | 0.01% | – | – |
| UBS Group AG | 482,880 | $187.9 萬 | 0.00% | – | – |
| Gilder Gagnon Howe & Co LLC | 481,808 | $187.4 萬 | 0.01% | – | – |
| SG Americas Securities, LLC | 467,182 | $181.7 萬 | 0.01% | – | – |
| DAFNA Capital Management LLC | 394,561 | $153.5 萬 | 0.36% | – | – |
| California Public Employees Retirement System | 350,800 | $136.5 萬 | 0.00% | – | – |
| Soleus Capital Management, L.P. | 336,442 | $130.9 萬 | 0.24% | – | – |
| J. Goldman & Co LP | 332,577 | $129.4 萬 | 0.08% | – | – |
| Claraphi Advisory Network, LLC | 318,190 | $123.8 萬 | 0.34% | – | – |
| Integral Health Asset Management, LLC | 300,000 | $116.7 萬 | 0.33% | – | – |
| Swiss National Bank | 293,900 | $114.3 萬 | 0.00% | – | – |
| Telemetry Investments, L.L.C. | 289,435 | $112.6 萬 | 1.27% | – | – |
| California State Teachers Retirement System | 260,134 | $101.2 萬 | 0.00% | – | – |
| State of Wisconsin Investment Board | 232,200 | $90.3 萬 | 0.00% | – | – |
| Rhumbline Advisers | 228,432 | $88.9 萬 | 0.00% | – | – |
| Bank of America Corp | 218,065 | $84.8 萬 | 0.00% | – | – |
| Monashee Investment Management LLC | 200,000 | $77.8 萬 | 0.12% | – | – |
| UBS Asset Management Americas Inc | 184,720 | $71.9 萬 | 0.00% | – | – |
| Fred Alger Management, LLC | 177,220 | $68.9 萬 | 0.00% | – | – |
| Mackay Shields LLC | 174,666 | $68.0 萬 | 0.00% | – | – |
| Alliancebernstein L.P. | 147,500 | $57.4 萬 | 0.00% | – | – |
| Credit Suisse AG | 142,151 | $55.4 萬 | 0.00% | – | – |
| New York State Common Retirement Fund | 140,623 | $54.7 萬 | 0.00% | – | – |
| Boothbay Fund Management, LLC | 136,324 | $53.0 萬 | 0.03% | – | – |
| Maverick Capital Ltd大師Maverick 資本 | 128,972 | $50.2 萬 | 0.00% | – | – |
| Parametric Portfolio Associates LLC | 117,614 | $45.8 萬 | 0.00% | – | – |
| Wells Fargo & Company | 116,355 | $45.3 萬 | 0.00% | – | – |
| Virtu Financial LLC | 111,399 | $43.3 萬 | 0.03% | – | – |
| Jane Street Group, LLC | 104,229 | $40.6 萬 | 0.00% | – | – |
| American International Group, Inc. | 100,545 | $39.1 萬 | 0.00% | – | – |
| Manufacturers Life Insurance Company, The | 100,077 | $38.9 萬 | 0.00% | – | – |
| Voya Investment Management LLC | 80,310 | $31.2 萬 | 0.00% | – | – |
| Principal Financial Group Inc | 74,815 | $29.1 萬 | 0.00% | – | – |
| ProShare Advisors LLC | 69,833 | $27.2 萬 | 0.00% | – | – |
| Susquehanna International Group, LLP | 67,741 | $26.4 萬 | 0.00% | – | – |
| Virtus ETF Advisers LLC | 67,781 | $26.4 萬 | 0.11% | – | – |
| JPMorgan Chase & Co | 64,936 | $25.3 萬 | 0.00% | – | – |
| Quantitative Systematic Strategies LLC | 63,103 | $24.5 萬 | 0.04% | – | – |
| DekaBank Deutsche Girozentrale | 55,000 | $19.4 萬 | 0.00% | – | – |
| Legal & General Group Plc | 49,321 | $19.2 萬 | 0.00% | – | – |
| Raymond James & Associates | 48,371 | $18.8 萬 | 0.00% | – | – |
| Bayesian Capital Management, LP | 46,000 | $17.9 萬 | 0.04% | – | – |
| Windsor Creek Advisors, LLC | 45,000 | $17.5 萬 | 0.07% | – | – |
| State Board of Administration of Florida Retirement System | 42,525 | $16.5 萬 | 0.00% | – | – |
| MetLife Investment Management | 41,078 | $16.0 萬 | 0.00% | – | – |
| BNP Paribas Arbitrage, SA | 38,248 | $14.9 萬 | 0.00% | – | – |
| Arizona State Retirement System | 37,446 | $14.6 萬 | 0.00% | – | – |
| Diversified Trust Co | 33,507 | $13.0 萬 | 0.01% | – | – |
| Metropolitan Life Insurance Co | 33,106 | $12.9 萬 | 0.00% | – | – |
| AlphaCentric Advisors LLC | 30,000 | $11.7 萬 | 0.04% | – | – |
| Capital Investment Advisors, LLC | 28,125 | $10.9 萬 | 0.00% | – | – |
| Kovack Advisors, Inc. | 28,000 | $10.9 萬 | 0.01% | – | – |
| E Fund Management Co., Ltd. | 27,713 | $10.8 萬 | 0.01% | – | – |
| Amalgamated Bank | 26,937 | $10.5 萬 | 0.00% | – | – |
| Dimensional Fund Advisors LP | 24,085 | $9.40 萬 | 0.00% | – | – |
