| Wellington Management Group LLP | 21,189,305 | $2.37 億 | 0.04% | – | – |
| Brown Capital Management LLC | 20,170,126 | $2.26 億 | 1.68% | – | – |
| Sarissa Capital Management LP | 16,390,000 | $1.83 億 | 17.56% | – | – |
| Vanguard Group Inc | 15,697,720 | $1.76 億 | 0.00% | – | – |
| BlackRock Inc. | 13,348,564 | $1.49 億 | 0.00% | – | – |
| Camber Capital Management LP | 7,500,000 | $8,385 萬 | 3.33% | – | – |
| State Street Corp | 7,380,026 | $8,251 萬 | 0.00% | – | – |
| Westfield Capital Management Co LP | 5,383,650 | $6,019 萬 | 0.37% | – | – |
| Credit Suisse AG | 3,707,830 | $4,145 萬 | 0.03% | – | – |
| Putnam Investments LLC | 3,348,532 | $3,744 萬 | 0.06% | – | – |
| Renaissance Technologies LLC | 3,140,753 | $3,511 萬 | 0.04% | – | – |
| Bridger Management, LLC | 2,852,414 | $3,189 萬 | 2.98% | – | – |
| Geode Capital Management, LLC | 2,776,343 | $3,104 萬 | 0.00% | – | – |
| New York State Common Retirement Fund | 2,369,882 | $2,650 萬 | 0.03% | – | – |
| Dimensional Fund Advisors LP | 1,944,699 | $2,174 萬 | 0.01% | – | – |
| UBS Asset Management Americas Inc | 1,856,086 | $2,075 萬 | 0.01% | – | – |
| Northern Trust Corp | 1,854,700 | $2,074 萬 | 0.00% | – | – |
| Norges Bank | 1,807,569 | $2,021 萬 | 0.00% | – | – |
| Goldman Sachs Group Inc | 1,581,236 | $1,768 萬 | 0.01% | – | – |
| D. E. Shaw & Co., Inc. | 1,521,040 | $1,701 萬 | 0.02% | – | – |
| HealthInvest Partners AB | 1,450,000 | $1,621 萬 | 12.91% | – | – |
| Nuveen Asset Management, LLC | 1,396,804 | $1,562 萬 | 0.00% | – | – |
| Charles Schwab Investment Management Inc | 1,189,795 | $1,330 萬 | 0.00% | – | – |
| JPMorgan Chase & Co | 1,159,775 | $1,297 萬 | 0.00% | – | – |
| Pictet Asset Management Ltd | 1,154,927 | $1,291 萬 | 0.02% | – | – |
| Park West Asset Management LLC | 1,112,383 | $1,244 萬 | 0.41% | – | – |
| Glenmede Trust Co NA | 1,100,301 | $1,230 萬 | 0.07% | – | – |
| Morgan Stanley | 1,004,793 | $1,123 萬 | 0.00% | – | – |
| Bank of New York Mellon Corp | 995,830 | $1,113 萬 | 0.00% | – | – |
| Millennium Management LLC | 983,457 | $1,100 萬 | 0.02% | – | – |
| Great Lakes Advisors, LLC | 977,173 | $1,093 萬 | 0.18% | – | – |
| LSV Asset Management | 973,999 | $1,089 萬 | 0.02% | – | – |
| Invesco Ltd. | 926,526 | $1,036 萬 | 0.00% | – | – |
| Islet Management, LP | 900,000 | $1,006 萬 | 0.51% | – | – |
| Deutsche Bank AG | 747,212 | $835.4 萬 | 0.00% | – | – |
| HealthCor Management, L.P. | 736,201 | $823.1 萬 | 0.31% | – | – |
| 13D Management LLC | 658,017 | $735.7 萬 | 2.73% | – | – |
| Wells Fargo & Company | 552,701 | $618.0 萬 | 0.00% | – | – |
| Teachers Retirement System of the State of Kentucky | 542,131 | $606.1 萬 | 0.06% | – | – |
| AQR Capital Management LLC | 540,473 | $604.2 萬 | 0.01% | – | – |
| Price Michael F | 520,000 | $581.4 萬 | 0.70% | – | – |
| Federated Hermes, Inc. | 487,388 | $544.9 萬 | 0.01% | – | – |
| Two Sigma Investments, LP | 461,587 | $516.1 萬 | 0.02% | – | – |
| Two Sigma Advisers, LP | 453,857 | $507.4 萬 | 0.01% | – | – |
| Barclays PLC | 442,401 | $494.6 萬 | 0.00% | – | – |
| Citigroup Inc | 436,107 | $487.6 萬 | 0.00% | – | – |
| Jupiter Asset Management Ltd | 435,529 | $486.9 萬 | 0.05% | – | – |
| Bank of America Corp | 419,548 | $469.0 萬 | 0.00% | – | – |
| Jefferies Group LLC | 394,640 | $441.2 萬 | 0.10% | – | – |
| Swiss National Bank | 347,500 | $388.5 萬 | 0.00% | – | – |
| BNP Paribas Arbitrage, SA | 335,242 | $374.8 萬 | 0.01% | – | – |
| Russell Investments Group, Ltd. | 323,857 | $361.8 萬 | 0.01% | – | – |
| Hillsdale Investment Management Inc. | 302,617 | $338.3 萬 | 0.28% | – | – |
| Rafferty Asset Management, LLC | 294,450 | $329.2 萬 | 0.02% | – | – |
| FMR LLC | 291,483 | $325.8 萬 | 0.00% | – | – |
| Alps Advisors Inc | 291,213 | $325.6 萬 | 0.03% | – | – |
| California Public Employees Retirement System | 291,024 | $325.4 萬 | 0.00% | – | – |
| Comerica Bank | 288,977 | $320.8 萬 | 0.02% | – | – |
| Citadel Advisors LLC | 285,774 | $319.5 萬 | 0.00% | – | – |
| Principal Financial Group Inc | 280,680 | $313.8 萬 | 0.00% | – | – |
| Jacobs Levy Equity Management, Inc | 280,544 | $313.6 萬 | 0.02% | – | – |
| Susquehanna International Group, LLP | 278,399 | $311.3 萬 | 0.00% | – | – |
| Assenagon Asset Management S.A. | 256,734 | $287.0 萬 | 0.01% | – | – |
| California State Teachers Retirement System | 240,626 | $269.0 萬 | 0.00% | – | – |
| State of New Jersey Common Pension Fund D | 232,635 | $260.1 萬 | 0.01% | – | – |
| Alliancebernstein L.P. | 225,221 | $251.8 萬 | 0.00% | – | – |
| Acadian Asset Management LLC | 224,636 | $251.1 萬 | 0.01% | – | – |
| Virginia Retirement Systems Et Al | 222,700 | $249.0 萬 | 0.02% | – | – |
| ClariVest Asset Management LLC | 221,185 | $247.3 萬 | 0.09% | – | – |
| Skandinaviska Enskilda Banken AB (publ) | 215,600 | $241.0 萬 | 0.02% | – | – |
| State of Wisconsin Investment Board | 214,800 | $240.1 萬 | 0.01% | – | – |
| Healthcare Value Capital, LLC | 200,000 | $223.6 萬 | 5.71% | – | – |
| Squarepoint Ops LLC | 192,592 | $215.3 萬 | 0.02% | – | – |
| Rhumbline Advisers | 191,987 | $214.6 萬 | 0.00% | – | – |
| Man Group plc | 186,226 | $208.2 萬 | 0.01% | – | – |
| ExodusPoint Capital Management, LP | 185,096 | $206.9 萬 | 0.04% | – | – |
| Parametric Portfolio Associates LLC | 182,431 | $204.0 萬 | 0.00% | – | – |
| Broderick Brian C | 152,100 | $170.1 萬 | 0.49% | – | – |
| Price T Rowe Associates Inc | 150,914 | $168.7 萬 | 0.00% | – | – |
| Junson Asset Management (Hong Kong) Ltd | 155,277 | $166.1 萬 | 0.69% | – | – |
| Prelude Capital Management, LLC | 140,338 | $156.9 萬 | 0.11% | – | – |
| Redwood Investment Management, LLC | 132,165 | $147.8 萬 | 0.28% | – | – |
| Voloridge Investment Management, LLC | 127,473 | $142.5 萬 | 0.01% | – | – |
| Sullivan, Bruyette, Speros & Blaney, LLC | 124,303 | $139.0 萬 | 0.06% | – | – |
| American International Group, Inc. | 122,973 | $137.5 萬 | 0.01% | – | – |
| HighTower Advisors, LLC | 114,480 | $128.0 萬 | 0.00% | – | – |
| AlphaCrest Capital Management LLC | 113,392 | $126.8 萬 | 0.07% | – | – |
| Mackay Shields LLC | 112,519 | $125.8 萬 | 0.01% | – | – |
| Artal Group S.A. | 110,532 | $123.6 萬 | 0.03% | – | – |
| Legal & General Group Plc | 108,968 | $121.8 萬 | 0.00% | – | – |
| Jennison Associates LLC | 106,282 | $118.8 萬 | 0.00% | – | – |
| Schroder Investment Management Group | 98,045 | $109.6 萬 | 0.00% | – | – |
| Manufacturers Life Insurance Company, The | 90,763 | $101.5 萬 | 0.00% | – | – |
| State Board of Administration of Florida Retirement System | 89,266 | $99.8 萬 | 0.00% | – | – |
| American Century Companies Inc | 88,882 | $99.4 萬 | 0.00% | – | – |
| Davide Leone & Partners Investment Co Ltd. | 87,677 | $98.0 萬 | 0.13% | – | – |
| Fisher Asset Management, LLC | 81,518 | $91.1 萬 | 0.00% | – | – |
| Caption Management, LLC | 78,900 | $88.3 萬 | 0.11% | – | – |
| Winton Group Ltd | 78,453 | $87.7 萬 | 0.05% | – | – |
| Cubist Systematic Strategies, LLC | 77,429 | $86.6 萬 | 0.01% | – | – |
