| Vanguard Group Inc | 8,140,893 | $12.4 億 | 0.03% | – | – |
| FMR LLC | 6,700,633 | $10.2 億 | 0.09% | – | – |
| SB Investment Advisers (UK) Ltd | 6,180,530 | $9.43 億 | 1.63% | – | – |
| BlackRock Inc. | 5,404,455 | $8.25 億 | 0.02% | – | – |
| Morgan Stanley | 4,425,636 | $6.76 億 | 0.10% | – | – |
| Clearbridge Investments, LLC | 3,050,021 | $4.66 億 | 0.35% | – | – |
| Viking Global Investors LP大師維京全球投資 | 2,918,223 | $4.45 億 | 1.33% | – | – |
| Jennison Associates LLC | 2,728,671 | $4.17 億 | 0.30% | – | – |
| Fred Alger Management, LLC | 2,637,489 | $4.03 億 | 1.05% | – | – |
| Nuveen Asset Management, LLC | 2,308,652 | $3.52 億 | 0.11% | – | – |
| Capital Research Global Investors | 2,037,754 | $3.11 億 | 0.08% | – | – |
| Coatue Management LLC大師Coatue | 2,018,453 | $3.08 億 | 1.69% | – | – |
| Franklin Resources Inc | 1,811,191 | $2.76 億 | 0.11% | – | – |
| Capital International Investors | 1,780,354 | $2.72 億 | 0.07% | – | – |
| Credit Suisse AG | 1,753,445 | $2.68 億 | 0.20% | – | – |
| Temasek Holdings (Private) Ltd | 1,613,007 | $2.46 億 | 0.96% | – | – |
| Price T Rowe Associates Inc | 1,540,884 | $2.35 億 | 0.02% | – | – |
| Wells Fargo & Company | 1,415,571 | $2.16 億 | 0.05% | – | – |
| Goldman Sachs Group Inc | 1,387,150 | $2.12 億 | 0.06% | – | – |
| Bamco Inc | 1,139,548 | $1.74 億 | 0.43% | – | – |
| Massachusetts Financial Services Co | 1,124,017 | $1.72 億 | 0.05% | – | – |
| Geode Capital Management, LLC | 1,071,117 | $1.64 億 | 0.03% | – | – |
| Bank of America Corp | 1,061,083 | $1.62 億 | 0.02% | – | – |
| Allianz Asset Management GmbH | 1,060,601 | $1.62 億 | 0.16% | – | – |
| State Street Corp | 994,245 | $1.52 億 | 0.01% | – | – |
| OrbiMed Advisors LLC | 977,400 | $1.49 億 | 1.41% | – | – |
| Invesco Ltd. | 927,218 | $1.42 億 | 0.04% | – | – |
| Alliancebernstein L.P. | 731,512 | $1.12 億 | 0.05% | – | – |
| ARK Investment Management LLC大師方舟投資 | 703,250 | $1.07 億 | 0.21% | – | – |
| Norges Bank | 699,198 | $1.07 億 | 0.02% | – | – |
| Polar Capital Holdings Plc | 694,468 | $1.06 億 | 0.66% | – | – |
| RTW Investments, LP | 609,774 | $9,308 萬 | 1.45% | – | – |
| Chevy Chase Trust Holdings, Inc. | 568,148 | $8,673 萬 | 0.31% | – | – |
| Suvretta Capital Management, LLC | 561,690 | $8,574 萬 | 1.27% | – | – |
| Northern Trust Corp | 443,704 | $6,773 萬 | 0.01% | – | – |
| Eagle Asset Management Inc | 423,441 | $6,648 萬 | 0.29% | – | – |
| Charles Schwab Investment Management Inc | 423,384 | $6,463 萬 | 0.02% | – | – |
| Frontier Capital Management Co LLC | 402,341 | $6,142 萬 | 0.46% | – | – |
| Senator Investment Group LP | 400,000 | $6,106 萬 | 1.26% | – | – |
| JPMorgan Chase & Co | 370,323 | $5,653 萬 | 0.01% | – | – |
| Ardevora Asset Management LLP | 347,622 | $5,306 萬 | 0.79% | – | – |
| Millennium Management LLC | 347,062 | $5,298 萬 | 0.07% | – | – |
| FIL Ltd | 346,725 | $5,293 萬 | 0.06% | – | – |
| Thrivent Financial for Lutherans | 333,796 | $5,095 萬 | 0.11% | – | – |
| Hitchwood Capital Management LP | 320,000 | $4,885 萬 | 1.74% | – | – |
| Fiera Capital Corp | 314,831 | $4,806 萬 | 0.14% | – | – |
| Manufacturers Life Insurance Company, The | 313,823 | $4,791 萬 | 0.04% | – | – |
| Railway Pension Investments Ltd | 307,978 | $4,701 萬 | 0.43% | – | – |
| Bellevue Group AG | 302,866 | $4,623 萬 | 0.49% | – | – |
| Bank of New York Mellon Corp | 296,075 | $4,520 萬 | 0.01% | – | – |
| Deutsche Bank AG | 295,901 | $4,517 萬 | 0.02% | – | – |
| Royal Bank of Canada | 288,667 | $4,407 萬 | 0.01% | – | – |
| First Trust Advisors LP | 288,569 | $4,405 萬 | 0.05% | – | – |
| Westwood Management Corp | 287,430 | $4,388 萬 | 3.87% | – | – |
| Mirae Asset Global Investments Co., Ltd. | 273,140 | $4,169 萬 | 0.14% | – | – |
| D. E. Shaw & Co., Inc. | 268,702 | $4,102 萬 | 0.05% | – | – |
| TimesSquare Capital Management, LLC | 265,225 | $4,049 萬 | 0.35% | – | – |
| Pictet Asset Management Ltd | 249,791 | $3,813 萬 | 0.05% | – | – |
| Chicago Capital, LLC | 249,682 | $3,811 萬 | 1.61% | – | – |
| Citadel Advisors LLC | 246,531 | $3,763 萬 | 0.04% | – | – |
| Janus Henderson Group PLC | 236,862 | $3,616 萬 | 0.02% | – | – |
| Rhenman & Partners Asset Management AB | 225,000 | $3,435 萬 | 2.39% | – | – |
| HealthCor Management, L.P. | 219,300 | $3,348 萬 | 1.25% | – | – |
| American Century Companies Inc | 204,817 | $3,127 萬 | 0.02% | – | – |
| PFM Health Sciences, LP | 204,344 | $3,119 萬 | 1.09% | – | – |
| Dimensional Fund Advisors LP | 201,819 | $3,085 萬 | 0.01% | – | – |
| Rock Springs Capital Management LP | 200,000 | $3,053 萬 | 0.67% | – | – |
| Raymond James & Associates | 196,880 | $3,005 萬 | 0.03% | – | – |
| Aristotle Atlantic Partners, LLC | 190,868 | $2,914 萬 | 2.13% | – | – |
| Barclays PLC | 185,337 | $2,829 萬 | 0.03% | – | – |
| Blue Water Life Science Advisors, LLC | 185,330 | $2,829 萬 | 13.82% | – | – |
| La Financiere de L'Echiquier | 181,199 | $2,766 萬 | 1.12% | – | – |
| California Public Employees Retirement System | 175,154 | $2,674 萬 | 0.02% | – | – |
| Swiss National Bank | 171,300 | $2,615 萬 | 0.02% | – | – |
| New York State Common Retirement Fund | 168,844 | $2,577 萬 | 0.03% | – | – |
| Tekla Capital Management LLC | 158,727 | $2,423 萬 | 0.83% | – | – |
| Nicholas Investment Partners, LP | 154,507 | $2,359 萬 | 1.64% | – | – |
| Sumitomo Mitsui Trust Holdings, Inc. | 148,614 | $2,269 萬 | 0.01% | – | – |
| Nikko Asset Management Americas, Inc. | 148,614 | $2,269 萬 | 0.11% | – | – |
| Eaton Vance Management | 148,477 | $2,267 萬 | 0.03% | – | – |
| Van Eck Associates Corp | 148,301 | $2,264 萬 | 0.06% | – | – |
| California State Teachers Retirement System | 147,493 | $2,252 萬 | 0.03% | – | – |
| Primecap Management Co | 140,952 | $2,152 萬 | 0.02% | – | – |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 126,782 | $1,935 萬 | 0.08% | – | – |
| Two Sigma Investments, LP | 120,956 | $1,846 萬 | 0.06% | – | – |
| Parametric Portfolio Associates LLC | 116,055 | $1,772 萬 | 0.01% | – | – |
| Adalta Capital Management LLC | 107,145 | $1,636 萬 | 9.44% | – | – |
| Pura Vida Investments, LLC | 103,908 | $1,586 萬 | 1.10% | – | – |
| UBS Asset Management Americas Inc | 101,538 | $1,550 萬 | 0.01% | – | – |
| State Board of Administration of Florida Retirement System | 101,291 | $1,546 萬 | 0.03% | – | – |
| Kornitzer Capital Management Inc | 101,140 | $1,544 萬 | 0.25% | – | – |
| Carnegie Capital Asset Management, LLC | 100,205 | $1,530 萬 | 0.64% | – | – |
| Fuller & Thaler Asset Management, Inc. | 100,156 | $1,529 萬 | 0.11% | – | – |
| Federated Hermes, Inc. | 100,000 | $1,527 萬 | 0.03% | – | – |
| Iron Triangle Partners LP | 100,000 | $1,527 萬 | 1.94% | – | – |
| AXA S.A. | 99,461 | $1,518 萬 | 0.05% | – | – |
| Great Lakes Advisors, LLC | 95,278 | $1,454 萬 | 0.23% | – | – |
| Moore Capital Management, LP | 90,369 | $1,380 萬 | 0.27% | – | – |
| Graticule Asia Macro Advisors LLC | 89,380 | $1,364 萬 | 2.30% | – | – |
| Atika Capital Management LLC | 87,600 | $1,337 萬 | 1.39% | – | – |
