| Redmile Group, LLC | 12,957,222 | $10.7 億 | 15.05% | – | – |
| FMR LLC | 8,328,701 | $6.87 億 | 0.06% | – | – |
| Vanguard Group Inc | 7,475,537 | $6.16 億 | 0.02% | – | – |
| BlackRock Inc. | 7,163,487 | $5.91 億 | 0.02% | – | – |
| ARK Investment Management LLC大師方舟投資 | 6,554,546 | $5.40 億 | 1.07% | – | – |
| Casdin Capital, LLC | 3,400,000 | $2.80 億 | 8.35% | – | – |
| Johnson & Johnson Innovation - JJDC, Inc. | 3,379,064 | $2.79 億 | 36.08% | – | – |
| Price T Rowe Associates Inc | 3,149,106 | $2.60 億 | 0.03% | – | – |
| Bellevue Group AG | 2,209,336 | $1.82 億 | 1.93% | – | – |
| State Street Corp | 1,983,196 | $1.64 億 | 0.01% | – | – |
| Janus Henderson Group PLC | 1,900,632 | $1.57 億 | 0.07% | – | – |
| Farallon Capital Management, L.L.C. | 1,900,000 | $1.57 億 | 0.81% | – | – |
| Lone Pine Capital LLC大師孤松資本 | 1,749,284 | $1.44 億 | 0.52% | – | – |
| Darwin Global Management, Ltd. | 1,370,133 | $1.13 億 | 22.12% | – | – |
| Geode Capital Management, LLC | 1,349,312 | $1.11 億 | 0.02% | – | – |
| Victory Capital Management Inc | 1,326,945 | $1.09 億 | 0.11% | – | – |
| Artal Group S.A. | 1,300,000 | $1.07 億 | 2.27% | – | – |
| Morgan Stanley | 1,207,497 | $9,956 萬 | 0.01% | – | – |
| Grosvenor Holdings, L.L.C. | 1,123,576 | $9,264 萬 | 6.81% | – | – |
| Credit Suisse AG | 1,006,607 | $8,299 萬 | 0.06% | – | – |
| Northern Trust Corp | 882,122 | $7,273 萬 | 0.01% | – | – |
| Citadel Advisors LLC | 842,149 | $6,944 萬 | 0.07% | – | – |
| Two Sigma Advisers, LP | 823,900 | $6,793 萬 | 0.19% | – | – |
| Norges Bank | 820,405 | $6,764 萬 | 0.02% | – | – |
| Goldman Sachs Group Inc | 819,542 | $6,757 萬 | 0.02% | – | – |
| Franklin Resources Inc | 757,532 | $6,246 萬 | 0.03% | – | – |
| Jennison Associates LLC | 743,992 | $6,134 萬 | 0.04% | – | – |
| Pictet Asset Management Ltd | 738,982 | $6,093 萬 | 0.07% | – | – |
| JPMorgan Chase & Co | 697,700 | $5,753 萬 | 0.01% | – | – |
| Invesco Ltd. | 677,136 | $5,583 萬 | 0.01% | – | – |
| Two Sigma Investments, LP | 659,583 | $5,438 萬 | 0.17% | – | – |
| Ameriprise Financial Inc | 621,705 | $5,126 萬 | 0.02% | – | – |
| Polaris Venture Management Co. V, L.L.C. | 569,889 | $4,699 萬 | 60.92% | – | – |
| Charles Schwab Investment Management Inc | 564,342 | $4,653 萬 | 0.02% | – | – |
| Sumitomo Mitsui Trust Holdings, Inc. | 561,595 | $4,630 萬 | 0.03% | – | – |
| Nikko Asset Management Americas, Inc. | 561,595 | $4,630 萬 | 0.23% | – | – |
| Nuveen Asset Management, LLC | 459,025 | $3,785 萬 | 0.01% | – | – |
| Amundi Asset Management US, Inc. | 456,699 | $3,766 萬 | 0.03% | – | – |
| Rice Hall James & Associates, LLC | 384,362 | $3,169 萬 | 1.03% | – | – |
| Eversept Partners, LP | 321,760 | $2,653 萬 | 2.17% | – | – |
| DAFNA Capital Management LLC | 314,360 | $2,592 萬 | 6.15% | – | – |
| D. E. Shaw & Co., Inc. | 306,238 | $2,525 萬 | 0.03% | – | – |
| Bank of New York Mellon Corp | 304,340 | $2,509 萬 | 0.01% | – | – |
| Deerfield Management Company, L.P. (Series C) | 304,000 | $2,507 萬 | 0.53% | – | – |
| UBS Asset Management Americas Inc | 299,593 | $2,470 萬 | 0.01% | – | – |
| Candriam Luxembourg S.C.A. | 270,107 | $2,359 萬 | 0.20% | – | – |
| Eagle Asset Management Inc | 287,295 | $2,353 萬 | 0.10% | – | – |
| Ally Bridge Group (NY) LLC | 270,000 | $2,226 萬 | 5.39% | – | – |
| Millennium Management LLC | 257,978 | $2,127 萬 | 0.03% | – | – |
| Westfield Capital Management Co LP | 256,717 | $2,117 萬 | 0.13% | – | – |
| Voya Investment Management LLC | 238,747 | $1,969 萬 | 0.04% | – | – |
| Bank of America Corp | 220,446 | $1,818 萬 | 0.00% | – | – |
| Principal Financial Group Inc | 213,586 | $1,761 萬 | 0.01% | – | – |
| Wells Fargo & Company | 208,008 | $1,715 萬 | 0.00% | – | – |
| Federated Hermes, Inc. | 199,785 | $1,647 萬 | 0.03% | – | – |
| Ghost Tree Capital, LLC | 185,000 | $1,525 萬 | 4.27% | – | – |
| California Public Employees Retirement System | 180,677 | $1,490 萬 | 0.01% | – | – |
| Wellington Management Group LLP | 180,448 | $1,488 萬 | 0.00% | – | – |
| Deutsche Bank AG | 171,062 | $1,411 萬 | 0.01% | – | – |
| Panagora Asset Management Inc | 162,596 | $1,341 萬 | 0.08% | – | – |
| Swiss National Bank | 159,400 | $1,314 萬 | 0.01% | – | – |
| Tekla Capital Management LLC | 150,343 | $1,240 萬 | 0.43% | – | – |
| Sectoral Asset Management Inc | 142,500 | $1,175 萬 | 0.89% | – | – |
| Alps Advisors Inc | 130,688 | $1,078 萬 | 0.11% | – | – |
| American Century Companies Inc | 129,822 | $1,070 萬 | 0.01% | – | – |
| Alliancebernstein L.P. | 129,170 | $1,065 萬 | 0.00% | – | – |
| Woodline Partners LP | 126,360 | $1,042 萬 | 0.23% | – | – |
| California State Teachers Retirement System | 114,863 | $947.0 萬 | 0.01% | – | – |
| Sphera Funds Management Ltd. | 109,807 | $905.4 萬 | 0.83% | – | – |
| Barclays PLC | 109,779 | $905.1 萬 | 0.01% | – | – |
| State of Wisconsin Investment Board | 106,600 | $878.9 萬 | 0.02% | – | – |
| Guggenheim Capital LLC | 105,930 | $873.4 萬 | 0.06% | – | – |
| Artemis Wealth Advisors, LLC | 100,000 | $824.5 萬 | 1.29% | – | – |
| Bleichroeder LP | 100,000 | $824.5 萬 | 1.39% | – | – |
| Rhumbline Advisers | 89,527 | $738.2 萬 | 0.01% | – | – |
| WCM Investment Management, LLC | 89,424 | $737.3 萬 | 0.02% | – | – |
| TD Asset Management Inc | 88,610 | $730.6 萬 | 0.01% | – | – |
| Parametric Portfolio Associates LLC | 84,777 | $699.0 萬 | 0.00% | – | – |
| Rafferty Asset Management, LLC | 84,775 | $699.0 萬 | 0.05% | – | – |
| New York State Common Retirement Fund | 73,445 | $605.6 萬 | 0.01% | – | – |
| First Trust Advisors LP | 73,208 | $603.6 萬 | 0.01% | – | – |
| Rock Springs Capital Management LP | 70,000 | $577.2 萬 | 0.13% | – | – |
| Bruce & Co., Inc. | 65,000 | $535.9 萬 | 1.00% | – | – |
| Dimensional Fund Advisors LP | 64,762 | $535.7 萬 | 0.00% | – | – |
| Prudential Financial Inc | 64,975 | $535.7 萬 | 0.01% | – | – |
| Connor, Clark & Lunn Investment Management Ltd. | 64,185 | $529.2 萬 | 0.03% | – | – |
| Macquarie Group Ltd | 63,826 | $526.2 萬 | 0.01% | – | – |
| Mutual of America Capital Management LLC | 59,938 | $494.2 萬 | 0.05% | – | – |
| Segall Bryant & Hamill, LLC | 58,888 | $485.4 萬 | 0.05% | – | – |
| Castleark Management LLC | 58,478 | $482.2 萬 | 0.17% | – | – |
| Neuberger Berman Group LLC | 56,683 | $464.3 萬 | 0.00% | – | – |
| Citigroup Inc | 55,665 | $458.9 萬 | 0.00% | – | – |
| Sofinnova Investments, Inc. | 54,795 | $451.8 萬 | 0.28% | – | – |
| Duality Advisers, LP | 52,731 | $434.8 萬 | 0.38% | – | – |
| Legal & General Group Plc | 51,538 | $424.9 萬 | 0.00% | – | – |
| Moore Capital Management, LP | 48,431 | $399.3 萬 | 0.08% | – | – |
| Epiq Partners, LLC | 46,755 | $385.5 萬 | 2.21% | – | – |
| American International Group, Inc. | 46,464 | $383.1 萬 | 0.02% | – | – |
| Schroder Investment Management Group | 45,008 | $371.1 萬 | 0.00% | – | – |
| UBS Group AG | 44,996 | $371.0 萬 | 0.00% | – | – |
