| BlackRock Inc. | 11,927,444 | $2.77 億 | 0.01% | – | – |
| Vanguard Group Inc | 4,899,174 | $1.14 億 | 0.00% | – | – |
| State Street Corp | 4,141,970 | $9,634 萬 | 0.01% | – | – |
| FMR LLC | 3,841,703 | $8,936 萬 | 0.01% | – | – |
| Driehaus Capital Management LLC | 3,235,638 | $7,526 萬 | 1.11% | – | – |
| Marshall Wace North America L.P. | 2,700,123 | $6,281 萬 | 0.26% | – | – |
| Polar Capital Holdings Plc | 2,671,884 | $6,215 萬 | 0.39% | – | – |
| Wasatch Advisors Inc | 2,609,751 | $6,070 萬 | 0.27% | – | – |
| Deerfield Management Company, L.P. (Series C) | 2,561,000 | $5,957 萬 | 1.25% | – | – |
| Farallon Capital Management, L.L.C. | 2,500,000 | $5,815 萬 | 0.30% | – | – |
| Boxer Capital, LLC | 2,100,000 | $4,885 萬 | 1.66% | – | – |
| RTW Investments, LP | 2,000,000 | $4,652 萬 | 0.73% | – | – |
| Adage Capital Partners GP, L.L.C. | 1,550,000 | $3,605 萬 | 0.07% | – | – |
| PFM Health Sciences, LP | 1,536,373 | $3,574 萬 | 1.24% | – | – |
| Geode Capital Management, LLC | 1,158,128 | $2,694 萬 | 0.00% | – | – |
| Wellington Management Group LLP | 996,277 | $2,317 萬 | 0.00% | – | – |
| Two Sigma Advisers, LP | 975,300 | $2,269 萬 | 0.06% | – | – |
| Millennium Management LLC | 920,775 | $2,142 萬 | 0.03% | – | – |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 906,722 | $2,109 萬 | 0.09% | – | – |
| Foresite Capital Management IV, LLC | 881,901 | $2,051 萬 | 2.46% | – | – |
| RP Management, LLC | 875,656 | $2,037 萬 | 8.33% | – | – |
| Northern Trust Corp | 810,181 | $1,884 萬 | 0.00% | – | – |
| Goldman Sachs Group Inc | 805,288 | $1,873 萬 | 0.01% | – | – |
| Morgan Stanley | 703,217 | $1,636 萬 | 0.00% | – | – |
| Vivo Capital, LLC | 700,000 | $1,628 萬 | 0.57% | – | – |
| Integral Health Asset Management, LLC | 700,000 | $1,628 萬 | 4.65% | – | – |
| Logos Global Management LP | 700,000 | $1,628 萬 | 1.59% | – | – |
| Bank of New York Mellon Corp | 687,162 | $1,598 萬 | 0.00% | – | – |
| Caas Capital Management LP | 671,382 | $1,562 萬 | 0.47% | – | – |
| Opaleye Management Inc. | 580,000 | $1,349 萬 | 1.98% | – | – |
| Two Sigma Investments, LP | 546,215 | $1,271 萬 | 0.04% | – | – |
| Principal Financial Group Inc | 517,719 | $1,204 萬 | 0.01% | – | – |
| Charles Schwab Investment Management Inc | 473,519 | $1,102 萬 | 0.00% | – | – |
| HealthCor Management, L.P. | 462,500 | $1,076 萬 | 0.40% | – | – |
| Peregrine Capital Management LLC | 446,554 | $1,039 萬 | 0.19% | – | – |
| Invesco Ltd. | 420,512 | $978.1 萬 | 0.00% | – | – |
| Pictet Asset Management Ltd | 419,853 | $976.6 萬 | 0.01% | – | – |
| Sofinnova Investments, Inc. | 389,720 | $906.5 萬 | 0.57% | – | – |
| Point72 Asset Management, L.P. | 374,600 | $871.3 萬 | 0.04% | – | – |
| Alliancebernstein L.P. | 362,324 | $842.8 萬 | 0.00% | – | – |
| CM Management, LLC | 325,000 | $756.0 萬 | 5.62% | – | – |
| Pinnacle Associates Ltd | 324,299 | $754.3 萬 | 0.14% | – | – |
| Candriam Luxembourg S.C.A. | 375,853 | $750.2 萬 | 0.06% | – | – |
| Citadel Advisors LLC | 321,716 | $748.3 萬 | 0.01% | – | – |
| Ameriprise Financial Inc | 316,029 | $735.2 萬 | 0.00% | – | – |
| Nuveen Asset Management, LLC | 295,866 | $688.1 萬 | 0.00% | – | – |
| South Dakota Investment Council | 278,017 | $646.7 萬 | 0.11% | – | – |
| Marshall Wace, LLP | 273,906 | $637.1 萬 | 0.03% | – | – |
| Burrage Capital Management LLC | 244,673 | $569.1 萬 | 4.61% | – | – |
| Assenagon Asset Management S.A. | 231,032 | $537.4 萬 | 0.03% | – | – |
| HHLR Advisors, Ltd.大師高瓴 HHLR | 230,718 | $536.7 萬 | 0.05% | – | – |
| Rhumbline Advisers | 203,217 | $472.7 萬 | 0.01% | – | – |
| Legal & General Group Plc | 201,926 | $469.7 萬 | 0.00% | – | – |
| Citigroup Inc | 186,746 | $434.4 萬 | 0.00% | – | – |
| Parametric Portfolio Associates LLC | 166,605 | $387.5 萬 | 0.00% | – | – |
| Ensign Peak Advisors, Inc | 165,545 | $385.1 萬 | 0.01% | – | – |
| Mirador Capital Partners LP | 149,084 | $346.8 萬 | 0.89% | – | – |
| Bank of America Corp | 148,753 | $346.0 萬 | 0.00% | – | – |
| Rafferty Asset Management, LLC | 146,001 | $339.6 萬 | 0.02% | – | – |
| Public Sector Pension Investment Board | 145,932 | $339.4 萬 | 0.02% | – | – |
| Swiss National Bank | 145,500 | $338.4 萬 | 0.00% | – | – |
| Barclays PLC | 135,887 | $316.3 萬 | 0.00% | – | – |
| California Public Employees Retirement System | 135,000 | $314.0 萬 | 0.00% | – | – |
| Alps Advisors Inc | 128,652 | $299.2 萬 | 0.03% | – | – |
| Ikarian Capital, LLC | 127,000 | $295.4 萬 | 0.44% | – | – |
| New York State Teachers Retirement System | 125,465 | $291.8 萬 | 0.01% | – | – |
| Palo Alto Investors LP | 123,686 | $287.7 萬 | 0.16% | – | – |
| Credit Suisse AG | 121,608 | $282.9 萬 | 0.00% | – | – |
| Lazard Asset Management LLC | 114,478 | $266.2 萬 | 0.00% | – | – |
| State of Wisconsin Investment Board | 104,900 | $244.0 萬 | 0.01% | – | – |
| State of New Jersey Common Pension Fund D | 103,762 | $241.4 萬 | 0.01% | – | – |
| Altium Capital Management LP | 103,262 | $240.2 萬 | 0.67% | – | – |
| California State Teachers Retirement System | 100,063 | $232.7 萬 | 0.00% | – | – |
| Russell Investments Group, Ltd. | 92,737 | $215.5 萬 | 0.00% | – | – |
| D. E. Shaw & Co., Inc. | 92,247 | $214.6 萬 | 0.00% | – | – |
| UBS Group AG | 88,254 | $205.3 萬 | 0.00% | – | – |
| Wells Fargo & Company | 82,058 | $190.9 萬 | 0.00% | – | – |
| Cubist Systematic Strategies, LLC | 81,635 | $189.9 萬 | 0.02% | – | – |
| Comerica Bank | 71,630 | $189.7 萬 | 0.01% | – | – |
| Bain Capital Public Equity Management II, LLC | 81,366 | $189.3 萬 | 0.08% | – | – |
| Prudential Financial Inc | 80,815 | $188.0 萬 | 0.00% | – | – |
| Employees Retirement System of Texas | 75,358 | $175.3 萬 | 0.02% | – | – |
| Macquarie Group Ltd | 74,759 | $173.9 萬 | 0.00% | – | – |
| Ironwood Investment Management LLC | 69,188 | $160.9 萬 | 0.85% | – | – |
| Public Employees Retirement System of Ohio | 66,629 | $155.0 萬 | 0.01% | – | – |
| UBS Asset Management Americas Inc | 63,417 | $147.5 萬 | 0.00% | – | – |
| Great West Life Assurance Co | 61,067 | $141.9 萬 | 0.00% | – | – |
| New York State Common Retirement Fund | 60,200 | $140.0 萬 | 0.00% | – | – |
| Thrivent Financial for Lutherans | 58,415 | $135.9 萬 | 0.00% | – | – |
| Maven Securities LTD | 57,441 | $132.9 萬 | 0.12% | – | – |
| Commonwealth of Pennsylvania Public School Empls Retrmt Sys | 54,841 | $127.6 萬 | 0.02% | – | – |
| Susquehanna International Group, LLP | 54,487 | $126.7 萬 | 0.00% | – | – |
| ExodusPoint Capital Management, LP | 53,486 | $124.4 萬 | 0.03% | – | – |
| Texas Permanent School Fund | 53,127 | $123.6 萬 | 0.02% | – | – |
| First Trust Advisors LP | 49,288 | $114.6 萬 | 0.00% | – | – |
| State of Alaska, Department of Revenue | 47,970 | $111.5 萬 | 0.01% | – | – |
| Tudor Investment Corp Et Al | 45,792 | $106.5 萬 | 0.02% | – | – |
| American International Group, Inc. | 44,584 | $103.7 萬 | 0.00% | – | – |
| Deutsche Bank AG | 44,478 | $103.4 萬 | 0.00% | – | – |
| State of Tennessee, Treasury Department | 42,288 | $98.4 萬 | 0.00% | – | – |
