| Vanguard Group Inc | 4,999,523 | $3.40 億 | 0.01% | – | – |
| ARK Investment Management LLC大師方舟投資 | 4,460,824 | $3.04 億 | 0.60% | – | – |
| Fred Alger Management, LLC | 4,106,310 | $2.80 億 | 0.73% | – | – |
| BlackRock Inc. | 4,099,418 | $2.79 億 | 0.01% | – | – |
| Invesco Ltd. | 3,004,056 | $2.05 億 | 0.05% | – | – |
| State Street Corp | 1,664,206 | $1.13 億 | 0.01% | – | – |
| Waddell & Reed Financial Inc | 1,527,424 | $1.04 億 | 0.21% | – | – |
| Clearbridge Investments, LLC | 1,508,384 | $1.03 億 | 0.08% | – | – |
| Matrix Capital Management Company, LP | 1,439,000 | $9,798 萬 | 1.13% | – | – |
| D. E. Shaw & Co., Inc. | 1,215,931 | $8,279 萬 | 0.10% | – | – |
| First Light Asset Management, LLC | 1,212,677 | $8,257 萬 | 5.47% | – | – |
| Casdin Capital, LLC | 1,193,335 | $8,125 萬 | 2.42% | – | – |
| Credit Suisse AG | 1,167,258 | $7,948 萬 | 0.06% | – | – |
| Lord, Abbett & Co. LLC | 1,109,131 | $7,552 萬 | 0.19% | – | – |
| Geode Capital Management, LLC | 866,747 | $5,902 萬 | 0.01% | – | – |
| Sumitomo Mitsui Trust Holdings, Inc. | 820,146 | $5,584 萬 | 0.03% | – | – |
| Gagnon Securities LLC | 819,265 | $5,578 萬 | 8.49% | – | – |
| Nikko Asset Management Americas, Inc. | 816,812 | $5,562 萬 | 0.27% | – | – |
| Price T Rowe Associates Inc | 802,826 | $5,466 萬 | 0.01% | – | – |
| Goldman Sachs Group Inc | 761,673 | $5,186 萬 | 0.02% | – | – |
| Bamco Inc | 737,229 | $5,020 萬 | 0.12% | – | – |
| Northern Trust Corp | 728,325 | $4,959 萬 | 0.01% | – | – |
| Nuveen Asset Management, LLC | 496,300 | $3,379 萬 | 0.01% | – | – |
| Blue Water Life Science Advisors, LLC | 491,516 | $3,347 萬 | 16.35% | – | – |
| Next Century Growth Investors LLC | 480,241 | $3,270 萬 | 2.49% | – | – |
| Granite Investment Partners, LLC | 469,274 | $3,195 萬 | 1.06% | – | – |
| Wells Fargo & Company | 434,223 | $2,957 萬 | 0.01% | – | – |
| Two Sigma Investments, LP | 390,082 | $2,656 萬 | 0.08% | – | – |
| Charles Schwab Investment Management Inc | 386,640 | $2,633 萬 | 0.01% | – | – |
| Balyasny Asset Management LLC | 383,964 | $2,614 萬 | 0.16% | – | – |
| Norges Bank | 363,071 | $2,472 萬 | 0.01% | – | – |
| Eagle Asset Management Inc | 340,983 | $2,401 萬 | 0.11% | – | – |
| William Blair Investment Management, LLC | 346,366 | $2,358 萬 | 0.08% | – | – |
| Gagnon Advisors, LLC | 344,886 | $2,348 萬 | 9.67% | – | – |
| Two Sigma Advisers, LP | 333,900 | $2,274 萬 | 0.06% | – | – |
| FMR LLC | 326,967 | $2,226 萬 | 0.00% | – | – |
| ArrowMark Colorado Holdings LLC | 309,863 | $2,110 萬 | 0.16% | – | – |
| UBS Asset Management Americas Inc | 305,110 | $2,077 萬 | 0.01% | – | – |
| Bank of New York Mellon Corp | 297,283 | $2,024 萬 | 0.00% | – | – |
| Royce & Associates LP | 279,620 | $1,904 萬 | 0.13% | – | – |
| Kornitzer Capital Management Inc | 267,979 | $1,825 萬 | 0.29% | – | – |
| Hitchwood Capital Management LP | 250,000 | $1,702 萬 | 0.61% | – | – |
| Redwood Investments, LLC | 202,182 | $1,377 萬 | 1.21% | – | – |
| Bellevue Group AG | 190,371 | $1,296 萬 | 0.14% | – | – |
| Silvercrest Asset Management Group LLC | 179,499 | $1,222 萬 | 0.08% | – | – |
| G2 Investment Partners Management LLC | 160,205 | $1,091 萬 | 1.75% | – | – |
| Ziegler Capital Management, LLC | 159,892 | $1,089 萬 | 0.34% | – | – |
| Zweig-DiMenna Associates LLC | 148,553 | $1,012 萬 | 0.71% | – | – |
| Bank of America Corp | 144,497 | $983.9 萬 | 0.00% | – | – |
| Morgan Stanley | 137,764 | $938.1 萬 | 0.00% | – | – |
| Nordea Investment Management AB | 135,517 | $908.2 萬 | 0.01% | – | – |
| California Public Employees Retirement System | 128,301 | $873.6 萬 | 0.01% | – | – |
| Lisanti Capital Growth, LLC | 116,530 | $793.5 萬 | 1.02% | – | – |
| Azimuth Capital Management LLC | 114,997 | $783.0 萬 | 0.37% | – | – |
| JPMorgan Chase & Co | 107,794 | $733.9 萬 | 0.00% | – | – |
| Swiss National Bank | 107,000 | $728.6 萬 | 0.00% | – | – |
| Mirae Asset Global Investments Co., Ltd. | 106,906 | $727.9 萬 | 0.03% | – | – |
| Pembroke Management, LTD | 106,208 | $723.2 萬 | 0.60% | – | – |
| Perkins Capital Management Inc | 106,142 | $722.7 萬 | 4.18% | – | – |
| Raymond James & Associates | 104,159 | $709.2 萬 | 0.01% | – | – |
| Deutsche Bank AG | 101,476 | $691.0 萬 | 0.00% | – | – |
| Dimensional Fund Advisors LP | 101,195 | $689.5 萬 | 0.00% | – | – |
| Scout Investments, Inc. | 99,539 | $677.8 萬 | 0.10% | – | – |
| Premier Fund Managers Ltd | 96,308 | $606.1 萬 | 0.23% | – | – |
| New York State Common Retirement Fund | 87,419 | $595.2 萬 | 0.01% | – | – |
| Altium Capital Management LP | 81,284 | $553.5 萬 | 1.54% | – | – |
| Barclays PLC | 77,308 | $526.4 萬 | 0.01% | – | – |
| Legal & General Group Plc | 76,202 | $518.8 萬 | 0.00% | – | – |
| Citadel Advisors LLC | 76,105 | $518.2 萬 | 0.01% | – | – |
| California State Teachers Retirement System | 75,733 | $515.7 萬 | 0.01% | – | – |
| State of Wisconsin Investment Board | 72,300 | $492.3 萬 | 0.01% | – | – |
| First Trust Advisors LP | 71,942 | $489.9 萬 | 0.01% | – | – |
| Citigroup Inc | 71,439 | $486.4 萬 | 0.00% | – | – |
| Prudential Financial Inc | 70,361 | $479.1 萬 | 0.01% | – | – |
| Alliancebernstein L.P. | 67,542 | $459.9 萬 | 0.00% | – | – |
| Tiaa, FSB | 66,515 | $452.9 萬 | 0.02% | – | – |
| Oberweis Asset Management Inc | 65,840 | $448.3 萬 | 0.92% | – | – |
| Mutual of America Capital Management LLC | 63,911 | $435.2 萬 | 0.05% | – | – |
| Parametric Portfolio Associates LLC | 63,620 | $433.2 萬 | 0.00% | – | – |
| Voloridge Investment Management, LLC | 62,013 | $422.2 萬 | 0.03% | – | – |
| PDT Partners, LLC | 61,550 | $419.1 萬 | 0.30% | – | – |
| Neuberger Berman Group LLC | 61,272 | $417.2 萬 | 0.00% | – | – |
| AWM Investment Company, Inc. | 57,000 | $388.1 萬 | 0.43% | – | – |
| Raymond James Financial Services Advisors, Inc. | 56,771 | $386.6 萬 | 0.01% | – | – |
| Cubist Systematic Strategies, LLC | 56,438 | $384.3 萬 | 0.05% | – | – |
| Rhumbline Advisers | 55,691 | $379.2 萬 | 0.01% | – | – |
| Ameriprise Financial Inc | 55,542 | $378.2 萬 | 0.00% | – | – |
| Millennium Management LLC | 53,608 | $365.0 萬 | 0.01% | – | – |
| Victory Capital Management Inc | 52,866 | $360.0 萬 | 0.00% | – | – |
| Russell Investments Group, Ltd. | 50,844 | $345.9 萬 | 0.01% | – | – |
| Royal Bank of Canada | 50,302 | $342.5 萬 | 0.00% | – | – |
| Gabelli Funds LLC | 50,156 | $341.5 萬 | 0.02% | – | – |
| Rafferty Asset Management, LLC | 49,343 | $336.0 萬 | 0.02% | – | – |
| Bluefin Capital Management, LLC | 47,960 | $326.6 萬 | 0.17% | – | – |
| Calamos Advisors LLC | 45,320 | $308.6 萬 | 0.02% | – | – |
| Federated Hermes, Inc. | 43,681 | $297.4 萬 | 0.01% | – | – |
| Exchange Traded Concepts, LLC | 43,016 | $292.9 萬 | 0.11% | – | – |
| King Luther Capital Management Corp | 41,760 | $284.3 萬 | 0.02% | – | – |
| Zacks Investment Management | 40,140 | $273.3 萬 | 0.05% | – | – |
| Jane Street Group, LLC | 39,990 | $272.3 萬 | 0.01% | – | – |
