| Capital International Investors | 5,578,232 | $3.81 億 | 0.10% | – | – |
| Capital World Investors | 4,739,936 | $3.24 億 | 0.06% | – | – |
| BlackRock Inc. | 3,783,554 | $2.59 億 | 0.01% | – | – |
| Marshall Wace, LLP | 2,776,467 | $1.90 億 | 1.00% | – | – |
| Stifel Financial Corp | 2,564,822 | $1.75 億 | 0.29% | – | – |
| Oracle Investment Management Inc | 2,123,271 | $1.45 億 | 21.80% | – | – |
| RP Management, LLC | 2,111,111 | $1.44 億 | 59.01% | – | – |
| Eventide Asset Management, LLC | 2,015,000 | $1.38 億 | 2.04% | – | – |
| Wellington Management Group LLP | 1,815,354 | $1.24 億 | 0.02% | – | – |
| JPMorgan Chase & Co | 1,754,456 | $1.20 億 | 0.02% | – | – |
| State Street Corp | 1,534,744 | $1.05 億 | 0.01% | – | – |
| Alliancebernstein L.P. | 1,456,559 | $9,956 萬 | 0.04% | – | – |
| Vanguard Group Inc | 1,272,896 | $8,700 萬 | 0.00% | – | – |
| Bank of New York Mellon Corp | 1,187,193 | $8,115 萬 | 0.02% | – | – |
| Wells Fargo & Company | 1,135,210 | $7,759 萬 | 0.02% | – | – |
| FMR LLC | 1,118,224 | $7,643 萬 | 0.01% | – | – |
| Avidity Partners Management LP | 1,049,800 | $7,175 萬 | 2.00% | – | – |
| Armistice Capital, LLC | 1,000,000 | $6,835 萬 | 2.19% | – | – |
| Brown Advisory Inc | 989,688 | $6,764 萬 | 0.12% | – | – |
| Polar Capital Holdings Plc | 861,827 | $5,891 萬 | 0.37% | – | – |
| Kingdon Capital Management, L.L.C. | 860,261 | $5,880 萬 | 9.31% | – | – |
| Knoll Capital Management, LLC | 856,844 | $5,857 萬 | 38.16% | – | – |
| Geode Capital Management, LLC | 816,539 | $5,581 萬 | 0.01% | – | – |
| Pictet Asset Management Ltd | 765,021 | $5,229 萬 | 0.06% | – | – |
| Clearbridge Investments, LLC | 757,340 | $5,176 萬 | 0.04% | – | – |
| Deutsche Bank AG | 726,680 | $4,967 萬 | 0.03% | – | – |
| Janus Henderson Group PLC | 718,040 | $4,908 萬 | 0.02% | – | – |
| Capital International Inc | 583,367 | $3,987 萬 | 0.37% | – | – |
| ARS Investment Partners, LLC | 561,442 | $3,838 萬 | 4.46% | – | – |
| Northern Trust Corp | 540,542 | $3,695 萬 | 0.01% | – | – |
| Thrivent Financial for Lutherans | 496,939 | $3,397 萬 | 0.07% | – | – |
| Glenview Capital Management, LLC | 458,600 | $3,135 萬 | 0.53% | – | – |
| Eagle Asset Management Inc | 403,882 | $2,757 萬 | 0.12% | – | – |
| Norges Bank | 397,939 | $2,720 萬 | 0.01% | – | – |
| Nicholas Investment Partners, LP | 375,654 | $2,568 萬 | 1.79% | – | – |
| Charles Schwab Investment Management Inc | 368,606 | $2,520 萬 | 0.01% | – | – |
| EULAV Asset Management | 345,000 | $2,358 萬 | 0.63% | – | – |
| Hood River Capital Management LLC | 322,087 | $2,202 萬 | 0.71% | – | – |
| Goldman Sachs Group Inc | 303,516 | $2,075 萬 | 0.01% | – | – |
| Handelsbanken Fonder AB | 267,600 | $1,829 萬 | 0.10% | – | – |
| Rice Hall James & Associates, LLC | 264,558 | $1,808 萬 | 0.59% | – | – |
| Gilder Gagnon Howe & Co LLC | 263,420 | $1,801 萬 | 0.10% | – | – |
| C WorldWide Group Holding A/S | 247,498 | $1,692 萬 | 0.17% | – | – |
| Eversept Partners, LP | 242,172 | $1,655 萬 | 1.36% | – | – |
| Compagnie Lombard Odier SCmA | 234,498 | $1,603 萬 | 0.35% | – | – |
| Nuveen Asset Management, LLC | 224,109 | $1,532 萬 | 0.00% | – | – |
| Voya Investment Management LLC | 210,140 | $1,436 萬 | 0.03% | – | – |
| Bank of America Corp | 205,100 | $1,402 萬 | 0.00% | – | – |
| Rhenman & Partners Asset Management AB | 200,419 | $1,370 萬 | 0.96% | – | – |
| Cormorant Asset Management, LP | 200,000 | $1,367 萬 | 0.39% | – | – |
| Woodline Partners LP | 188,256 | $1,287 萬 | 0.29% | – | – |
| Principal Financial Group Inc | 187,870 | $1,284 萬 | 0.01% | – | – |
| American Century Companies Inc | 186,029 | $1,272 萬 | 0.01% | – | – |
| International Biotechnology Trust PLC | 176,400 | $1,206 萬 | 3.19% | – | – |
| Pier Capital, LLC | 162,934 | $1,114 萬 | 1.06% | – | – |
| Samlyn Capital, LLC | 154,706 | $1,057 萬 | 0.16% | – | – |
| Price T Rowe Associates Inc | 154,547 | $1,056 萬 | 0.00% | – | – |
| Bamco Inc | 146,000 | $997.9 萬 | 0.02% | – | – |
| D. E. Shaw & Co., Inc. | 138,335 | $945.5 萬 | 0.01% | – | – |
| Two Sigma Investments, LP | 136,605 | $933.7 萬 | 0.03% | – | – |
| Ardsley Advisory Partners LP | 135,550 | $926.5 萬 | 1.62% | – | – |
| Novo Holdings A/S | 128,300 | $876.9 萬 | 0.36% | – | – |
| Skandinaviska Enskilda Banken AB (publ) | 119,536 | $817.0 萬 | 0.05% | – | – |
| Swiss National Bank | 116,500 | $796.3 萬 | 0.01% | – | – |
| GW&K Investment Management, LLC | 105,712 | $722.5 萬 | 0.07% | – | – |
| California Public Employees Retirement System | 105,334 | $720.0 萬 | 0.01% | – | – |
| Monashee Investment Management LLC | 100,000 | $683.5 萬 | 1.05% | – | – |
| Hennion & Walsh Asset Management, Inc. | 97,498 | $666.4 萬 | 0.40% | – | – |
| DAFNA Capital Management LLC | 93,600 | $639.8 萬 | 1.52% | – | – |
| Tudor Investment Corp Et Al | 92,658 | $633.3 萬 | 0.14% | – | – |
| Cinctive Capital Management LP | 90,450 | $618.2 萬 | 0.39% | – | – |
| Weiss Multi-Strategy Advisers LLC | 88,711 | $606.3 萬 | 0.14% | – | – |
| Caas Capital Management LP | 86,985 | $594.5 萬 | 0.18% | – | – |
| Putnam Investments LLC | 80,270 | $548.7 萬 | 0.01% | – | – |
| WCM Investment Management, LLC | 78,942 | $539.6 萬 | 0.01% | – | – |
| Mutual of America Capital Management LLC | 78,063 | $533.6 萬 | 0.06% | – | – |
| California State Teachers Retirement System | 77,648 | $530.7 萬 | 0.01% | – | – |
| Susquehanna International Group, LLP | 73,056 | $499.3 萬 | 0.01% | – | – |
| Adage Capital Partners GP, L.L.C. | 70,000 | $478.5 萬 | 0.01% | – | – |
| Citigroup Inc | 67,163 | $459.0 萬 | 0.00% | – | – |
| Capital Bank & Trust Co | 67,154 | $459.0 萬 | 0.05% | – | – |
| Ensign Peak Advisors, Inc | 65,808 | $449.8 萬 | 0.01% | – | – |
| State of Wisconsin Investment Board | 64,800 | $442.9 萬 | 0.01% | – | – |
| Candriam Luxembourg S.C.A. | 49,067 | $404.0 萬 | 0.03% | – | – |
| L & S Advisors Inc | 58,811 | $402.0 萬 | 0.46% | – | – |
| New York State Common Retirement Fund | 54,607 | $373.2 萬 | 0.00% | – | – |
| Schroder Investment Management Group | 53,928 | $368.6 萬 | 0.00% | – | – |
| Millennium Management LLC | 53,616 | $366.5 萬 | 0.01% | – | – |
| UBS Asset Management Americas Inc | 52,103 | $356.2 萬 | 0.00% | – | – |
| Rhumbline Advisers | 51,877 | $354.6 萬 | 0.00% | – | – |
| Ameriprise Financial Inc | 51,171 | $349.8 萬 | 0.00% | – | – |
| Silverarc Capital Management, LLC | 50,089 | $342.4 萬 | 1.92% | – | – |
| Nwi Management LP | 50,000 | $341.8 萬 | 0.32% | – | – |
| Handelsinvest Investeringsforvaltning | 50,000 | $341.8 萬 | 0.42% | – | – |
| Atika Capital Management LLC | 47,000 | $321.2 萬 | 0.33% | – | – |
| Fiera Capital Corp | 45,153 | $308.6 萬 | 0.01% | – | – |
| AXA S.A. | 45,116 | $308.4 萬 | 0.01% | – | – |
| General American Investors Co Inc | 45,000 | $307.6 萬 | 0.29% | – | – |
| Symmetry Investments LP | 45,001 | $307.6 萬 | 0.99% | – | – |
| Citadel Advisors LLC | 43,922 | $300.2 萬 | 0.00% | – | – |
