| BlackRock Inc. | 16,241,775 | $1.65 億 | 0.00% | – | – |
| Baker Bros. Advisors LP | 12,710,818 | $1.29 億 | 0.56% | – | – |
| Vanguard Group Inc | 9,700,067 | $9,865 萬 | 0.00% | – | – |
| Sarissa Capital Management LP | 7,637,700 | $7,768 萬 | 7.45% | – | – |
| State Street Corp | 7,308,816 | $7,433 萬 | 0.00% | – | – |
| HealthCor Management, L.P. | 4,886,440 | $4,970 萬 | 1.85% | – | – |
| Artisan Partners Limited Partnership | 3,025,606 | $3,077 萬 | 0.04% | – | – |
| Geode Capital Management, LLC | 2,990,523 | $3,041 萬 | 0.00% | – | – |
| Deerfield Management Company, L.P. (Series C) | 2,605,380 | $2,650 萬 | 0.56% | – | – |
| Nuveen Asset Management, LLC | 2,504,355 | $2,547 萬 | 0.01% | – | – |
| Oracle Investment Management Inc | 2,367,670 | $2,408 萬 | 3.62% | – | – |
| Goldman Sachs Group Inc | 2,170,590 | $2,208 萬 | 0.01% | – | – |
| Susquehanna International Group, LLP | 2,094,445 | $2,130 萬 | 0.03% | – | – |
| Northern Trust Corp | 1,952,128 | $1,985 萬 | 0.00% | – | – |
| Stifel Financial Corp | 1,850,354 | $1,882 萬 | 0.03% | – | – |
| Adage Capital Partners GP, L.L.C. | 1,800,000 | $1,831 萬 | 0.04% | – | – |
| Invesco Ltd. | 1,433,838 | $1,458 萬 | 0.00% | – | – |
| Bank of America Corp | 1,349,133 | $1,372 萬 | 0.00% | – | – |
| Charles Schwab Investment Management Inc | 1,206,966 | $1,228 萬 | 0.00% | – | – |
| Marshall Wace North America L.P. | 865,538 | $880.3 萬 | 0.04% | – | – |
| Burrage Capital Management LLC | 864,916 | $879.6 萬 | 7.13% | – | – |
| Citadel Advisors LLC | 807,612 | $821.3 萬 | 0.01% | – | – |
| FMR LLC | 806,386 | $820.1 萬 | 0.00% | – | – |
| Bain Capital Public Equity Management II, LLC | 718,730 | $730.9 萬 | 0.30% | – | – |
| Bank of New York Mellon Corp | 714,901 | $727.0 萬 | 0.00% | – | – |
| Victory Capital Management Inc | 685,484 | $697.1 萬 | 0.01% | – | – |
| Ghost Tree Capital, LLC | 500,000 | $508.5 萬 | 1.42% | – | – |
| Lisanti Capital Growth, LLC | 472,520 | $480.6 萬 | 0.62% | – | – |
| North Star Investment Management Corp. | 435,790 | $443.2 萬 | 0.42% | – | – |
| Granahan Investment Management Inc | 429,902 | $437.2 萬 | 0.09% | – | – |
| Swiss National Bank | 403,468 | $410.3 萬 | 0.00% | – | – |
| Integral Health Asset Management, LLC | 400,000 | $406.8 萬 | 1.16% | – | – |
| Jane Street Group, LLC | 392,073 | $398.8 萬 | 0.01% | – | – |
| Advisor Group Holdings, Inc. | 388,697 | $395.3 萬 | 0.01% | – | – |
| Sofinnova Investments, Inc. | 378,774 | $385.2 萬 | 0.24% | – | – |
| Citigroup Inc | 362,165 | $368.3 萬 | 0.00% | – | – |
| California Public Employees Retirement System | 359,300 | $365.4 萬 | 0.00% | – | – |
| State of Wisconsin Investment Board | 268,900 | $273.5 萬 | 0.01% | – | – |
| Rhumbline Advisers | 266,467 | $271.0 萬 | 0.00% | – | – |
| California State Teachers Retirement System | 266,359 | $270.9 萬 | 0.00% | – | – |
| Rafferty Asset Management, LLC | 263,584 | $268.1 萬 | 0.02% | – | – |
| Morgan Stanley | 257,207 | $261.6 萬 | 0.00% | – | – |
| Parkman Healthcare Partners LLC | 244,680 | $248.8 萬 | 0.60% | – | – |
| Credit Suisse AG | 236,047 | $240.0 萬 | 0.00% | – | – |
| Barclays PLC | 235,293 | $239.3 萬 | 0.00% | – | – |
| UBS Asset Management Americas Inc | 233,413 | $237.4 萬 | 0.00% | – | – |
| Two Sigma Advisers, LP | 224,212 | $228.0 萬 | 0.01% | – | – |
| New York State Common Retirement Fund | 211,950 | $215.6 萬 | 0.00% | – | – |
| Gilder Gagnon Howe & Co LLC | 211,407 | $215.0 萬 | 0.01% | – | – |
| DG Capital Management, LLC | 203,337 | $206.8 萬 | 0.52% | – | – |
| Alliancebernstein L.P. | 203,220 | $206.7 萬 | 0.00% | – | – |
| Wells Fargo & Company | 201,799 | $205.2 萬 | 0.00% | – | – |
| UBS Group AG | 189,416 | $192.6 萬 | 0.00% | – | – |
| Marshall Wace, LLP | 182,905 | $186.0 萬 | 0.01% | – | – |
| Norges Bank | 171,351 | $174.3 萬 | 0.00% | – | – |
| Platinum Investment Management Ltd | 168,715 | $171.6 萬 | 0.04% | – | – |
| JPMorgan Chase & Co | 163,968 | $166.8 萬 | 0.00% | – | – |
| E. Ohman J:or Asset Management AB | 144,100 | $146.5 萬 | 0.05% | – | – |
| Deutsche Bank AG | 129,321 | $131.6 萬 | 0.00% | – | – |
| Group One Trading, L.P. | 123,699 | $125.8 萬 | 0.03% | – | – |
| Commonwealth Equity Services, LLC | 123,459 | $125.5 萬 | 0.00% | – | – |
| Personal Cfo Solutions, LLC | 121,678 | $123.7 萬 | 0.27% | – | – |
| American International Group, Inc. | 102,952 | $104.7 萬 | 0.00% | – | – |
| Parametric Portfolio Associates LLC | 101,189 | $102.9 萬 | 0.00% | – | – |
| State of New Jersey Common Pension Fund D | 100,000 | $101.7 萬 | 0.00% | – | – |
| Graticule Asia Macro Advisors LLC | 100,000 | $101.7 萬 | 0.17% | – | – |
| Manufacturers Life Insurance Company, The | 99,064 | $100.7 萬 | 0.00% | – | – |
| Price T Rowe Associates Inc | 95,990 | $97.6 萬 | 0.00% | – | – |
| Wolverine Trading, LLC | 95,902 | $95.8 萬 | 0.02% | – | – |
| Gsa Capital Partners LLP | 80,197 | $81.6 萬 | 0.14% | – | – |
| Voya Investment Management LLC | 77,630 | $78.9 萬 | 0.00% | – | – |
| Principal Financial Group Inc | 72,741 | $74.0 萬 | 0.00% | – | – |
| ProShare Advisors LLC | 71,674 | $72.9 萬 | 0.00% | – | – |
| SG Americas Securities, LLC | 68,533 | $69.7 萬 | 0.00% | – | – |
| MetLife Investment Management | 68,180 | $69.3 萬 | 0.01% | – | – |
| State Board of Administration of Florida Retirement System | 67,748 | $68.9 萬 | 0.00% | – | – |
| Renaissance Technologies LLC | 67,470 | $68.6 萬 | 0.00% | – | – |
| DekaBank Deutsche Girozentrale | 65,265 | $64.3 萬 | 0.00% | – | – |
| AQR Capital Management LLC | 61,386 | $62.4 萬 | 0.00% | – | – |
| Tower Research Capital LLC (TRC) | 61,104 | $62.2 萬 | 0.01% | – | – |
| D. E. Shaw & Co., Inc. | 60,803 | $61.8 萬 | 0.00% | – | – |
| ClariVest Asset Management LLC | 60,000 | $61.1 萬 | 0.02% | – | – |
| Bank of Montreal | 57,849 | $60.1 萬 | 0.00% | – | – |
| Two Sigma Investments, LP | 58,369 | $59.4 萬 | 0.00% | – | – |
| Tudor Investment Corp Et Al | 57,917 | $58.9 萬 | 0.01% | – | – |
| Blueshift Asset Management, LLC | 57,655 | $58.6 萬 | 0.06% | – | – |
| Squarepoint Ops LLC | 56,770 | $57.7 萬 | 0.01% | – | – |
| Quantitative Systematic Strategies LLC | 55,047 | $56.0 萬 | 0.09% | – | – |
| ETF Managers Group, LLC | 54,272 | $54.2 萬 | 0.01% | – | – |
| Grimes & Company, Inc. | 51,762 | $52.6 萬 | 0.03% | – | – |
| Arizona State Retirement System | 51,399 | $52.3 萬 | 0.00% | – | – |
| Ameriprise Financial Inc | 50,334 | $51.2 萬 | 0.00% | – | – |
| Edge Wealth Management LLC | 50,000 | $50.9 萬 | 0.11% | – | – |
| Legal & General Group Plc | 49,572 | $50.4 萬 | 0.00% | – | – |
| Cambridge Investment Research Advisors, Inc. | 48,309 | $49.1 萬 | 0.00% | – | – |
| Metropolitan Life Insurance Co | 47,985 | $48.8 萬 | 0.01% | – | – |
| Qube Research & Technologies Ltd | 46,252 | $47.0 萬 | 0.01% | – | – |
| First Hawaiian Bank | 44,620 | $45.4 萬 | 0.02% | – | – |
| Assenagon Asset Management S.A. | 44,469 | $45.2 萬 | 0.00% | – | – |
| Royal Bank of Canada | 42,784 | $43.5 萬 | 0.00% | – | – |
