| BlackRock Inc. | 12,901,227 | $8.55 億 | 0.03% | – | – |
| Vanguard Group Inc | 9,601,137 | $6.37 億 | 0.02% | – | – |
| State Street Corp | 3,734,120 | $2.48 億 | 0.01% | – | – |
| Invesco Ltd. | 3,390,909 | $2.25 億 | 0.06% | – | – |
| Johnson & Johnson Innovation - JJDC, Inc. | 3,260,869 | $2.16 億 | 28.01% | – | – |
| JPMorgan Chase & Co | 2,572,922 | $1.71 億 | 0.02% | – | – |
| Geode Capital Management, LLC | 1,756,510 | $1.16 億 | 0.02% | – | – |
| Northern Trust Corp | 1,546,068 | $1.03 億 | 0.02% | – | – |
| Credit Suisse AG | 1,489,716 | $9,878 萬 | 0.07% | – | – |
| FMR LLC | 1,312,051 | $8,700 萬 | 0.01% | – | – |
| Fiera Capital Corp | 1,247,814 | $8,274 萬 | 0.24% | – | – |
| Janus Henderson Group PLC | 1,140,313 | $7,561 萬 | 0.03% | – | – |
| First Manhattan Co | 1,133,246 | $7,515 萬 | 0.32% | – | – |
| Alliancebernstein L.P. | 1,065,997 | $7,069 萬 | 0.03% | – | – |
| Bank of New York Mellon Corp | 1,015,636 | $6,735 萬 | 0.01% | – | – |
| Charles Schwab Investment Management Inc | 960,347 | $6,368 萬 | 0.02% | – | – |
| Bamco Inc | 924,430 | $6,130 萬 | 0.15% | – | – |
| Goldman Sachs Group Inc | 909,250 | $6,029 萬 | 0.02% | – | – |
| Western Financial Corporation | 820,264 | $5,439 萬 | 33.22% | – | – |
| Norges Bank | 716,613 | $4,752 萬 | 0.01% | – | – |
| Eagle Asset Management Inc | 596,918 | $4,004 萬 | 0.18% | – | – |
| Bank of America Corp | 600,866 | $3,984 萬 | 0.00% | – | – |
| First Light Asset Management, LLC | 536,836 | $3,560 萬 | 2.36% | – | – |
| Nuveen Asset Management, LLC | 530,158 | $3,516 萬 | 0.01% | – | – |
| Principal Financial Group Inc | 517,820 | $3,434 萬 | 0.02% | – | – |
| Ameriprise Financial Inc | 493,306 | $3,271 萬 | 0.01% | – | – |
| Deutsche Bank AG | 429,633 | $2,849 萬 | 0.02% | – | – |
| Perceptive Advisors LLC | 409,341 | $2,714 萬 | 0.36% | – | – |
| Aquilo Capital Management, LLC | 407,926 | $2,705 萬 | 7.38% | – | – |
| Citadel Advisors LLC | 407,663 | $2,703 萬 | 0.03% | – | – |
| Wellington Management Group LLP | 389,864 | $2,585 萬 | 0.00% | – | – |
| Morgan Stanley | 377,209 | $2,501 萬 | 0.00% | – | – |
| New York State Common Retirement Fund | 366,822 | $2,432 萬 | 0.03% | – | – |
| Hood River Capital Management LLC | 357,082 | $2,368 萬 | 0.76% | – | – |
| Voloridge Investment Management, LLC | 333,045 | $2,208 萬 | 0.16% | – | – |
| L1 Capital Pty Ltd | 296,024 | $1,963 萬 | 4.93% | – | – |
| Rhumbline Advisers | 288,977 | $1,916 萬 | 0.03% | – | – |
| Legal & General Group Plc | 288,732 | $1,915 萬 | 0.01% | – | – |
| Voya Investment Management LLC | 280,580 | $1,860 萬 | 0.04% | – | – |
| Retirement Systems of Alabama | 268,072 | $1,778 萬 | 0.07% | – | – |
| Wells Fargo & Company | 252,640 | $1,675 萬 | 0.00% | – | – |
| American International Group, Inc. | 249,077 | $1,652 萬 | 0.07% | – | – |
| Renaissance Technologies LLC | 241,600 | $1,602 萬 | 0.02% | – | – |
| Neuberger Berman Group LLC | 244,680 | $1,588 萬 | 0.02% | – | – |
| California Public Employees Retirement System | 224,542 | $1,489 萬 | 0.01% | – | – |
| Barclays PLC | 224,435 | $1,488 萬 | 0.01% | – | – |
| Swiss National Bank | 223,000 | $1,479 萬 | 0.01% | – | – |
| Dimensional Fund Advisors LP | 213,076 | $1,412 萬 | 0.00% | – | – |
| Susquehanna International Group, LLP | 191,448 | $1,270 萬 | 0.02% | – | – |
| Sumitomo Mitsui Trust Holdings, Inc. | 182,704 | $1,212 萬 | 0.01% | – | – |
| Nikko Asset Management Americas, Inc. | 182,704 | $1,212 萬 | 0.06% | – | – |
| Candriam Luxembourg S.C.A. | 163,958 | $1,208 萬 | 0.10% | – | – |
| Farallon Capital Management, L.L.C. | 172,454 | $1,144 萬 | 0.06% | – | – |
| Manufacturers Life Insurance Company, The | 171,673 | $1,138 萬 | 0.01% | – | – |
| Mutual of America Capital Management LLC | 168,640 | $1,118 萬 | 0.12% | – | – |
| California State Teachers Retirement System | 154,410 | $1,024 萬 | 0.01% | – | – |
| State of Wisconsin Investment Board | 137,800 | $913.8 萬 | 0.02% | – | – |
| Vivo Capital, LLC | 137,411 | $911.2 萬 | 0.32% | – | – |
| Tekla Capital Management LLC | 132,886 | $881.2 萬 | 0.30% | – | – |
| New York State Teachers Retirement System | 128,972 | $855.2 萬 | 0.02% | – | – |
| Cetera Investment Advisers | 113,788 | $754.5 萬 | 0.15% | – | – |
| Mirae Asset Global Investments Co., Ltd. | 113,659 | $753.7 萬 | 0.03% | – | – |
| Parametric Portfolio Associates LLC | 109,868 | $728.5 萬 | 0.00% | – | – |
| Thrivent Financial for Lutherans | 109,434 | $725.7 萬 | 0.02% | – | – |
| Acuta Capital Partners, LLC | 108,000 | $716.1 萬 | 2.58% | – | – |
| Ensign Peak Advisors, Inc | 106,466 | $706.0 萬 | 0.02% | – | – |
| CWM, LLC | 82,196 | $680.7 萬 | 0.05% | – | – |
| Two Sigma Advisers, LP | 99,800 | $661.8 萬 | 0.02% | – | – |
| Citigroup Inc | 97,871 | $649.0 萬 | 0.01% | – | – |
| UBS Asset Management Americas Inc | 91,461 | $606.5 萬 | 0.00% | – | – |
| MetLife Investment Management | 91,401 | $606.1 萬 | 0.06% | – | – |
| Russell Investments Group, Ltd. | 89,642 | $594.2 萬 | 0.01% | – | – |
| Oak Ridge Investments LLC | 85,320 | $565.7 萬 | 0.53% | – | – |
| WCM Investment Management, LLC | 84,049 | $557.3 萬 | 0.02% | – | – |
| King Luther Capital Management Corp | 80,985 | $537.0 萬 | 0.03% | – | – |
| Texas Permanent School Fund | 77,542 | $514.2 萬 | 0.06% | – | – |
| Federated Hermes, Inc. | 75,528 | $500.9 萬 | 0.01% | – | – |
| Evolutionary Tree Capital Management, LLC | 72,948 | $483.7 萬 | 2.86% | – | – |
| UBS Group AG | 71,941 | $477.1 萬 | 0.00% | – | – |
| Royal Bank of Canada | 71,098 | $471.5 萬 | 0.00% | – | – |
| Parkman Healthcare Partners LLC | 70,089 | $464.8 萬 | 1.12% | – | – |
| Prudential Financial Inc | 69,086 | $458.1 萬 | 0.01% | – | – |
| Group One Trading, L.P. | 67,366 | $446.7 萬 | 0.10% | – | – |
| Castleark Management LLC | 67,165 | $445.4 萬 | 0.16% | – | – |
| Tygh Capital Management, Inc. | 63,947 | $424.0 萬 | 0.60% | – | – |
| Comerica Bank | 57,640 | $412.6 萬 | 0.02% | – | – |
| Jefferies Group LLC | 61,423 | $407.3 萬 | 0.10% | – | – |
| State of New Jersey Common Pension Fund D | 61,097 | $405.1 萬 | 0.01% | – | – |
| Schroder Investment Management Group | 56,599 | $375.3 萬 | 0.00% | – | – |
| SG Americas Securities, LLC | 55,033 | $364.9 萬 | 0.02% | – | – |
| Guggenheim Capital LLC | 53,765 | $356.5 萬 | 0.02% | – | – |
| Two Sigma Investments, LP | 51,862 | $343.9 萬 | 0.01% | – | – |
| Nomura Holdings Inc | 51,588 | $342.6 萬 | 0.02% | – | – |
| Price T Rowe Associates Inc | 50,997 | $338.2 萬 | 0.00% | – | – |
| ProShare Advisors LLC | 49,731 | $329.8 萬 | 0.01% | – | – |
| ClariVest Asset Management LLC | 49,690 | $329.5 萬 | 0.12% | – | – |
| Victory Capital Management Inc | 48,359 | $320.7 萬 | 0.00% | – | – |
| Macquarie Group Ltd | 47,311 | $313.7 萬 | 0.00% | – | – |
| Rafferty Asset Management, LLC | 45,792 | $303.6 萬 | 0.02% | – | – |
| Metropolitan Life Insurance Co | 44,268 | $293.5 萬 | 0.04% | – | – |
