| Wellington Management Group LLP | 8,129,562 | $5.64 億 | 0.10% | – | – |
| Vanguard Group Inc | 5,591,025 | $3.88 億 | 0.01% | – | – |
| BlackRock Inc. | 5,546,617 | $3.85 億 | 0.01% | – | – |
| Avoro Capital Advisors LLC | 4,050,000 | $2.81 億 | 4.85% | – | – |
| Lord, Abbett & Co. LLC | 2,024,848 | $1.41 億 | 0.36% | – | – |
| Alkeon Capital Management LLC | 1,765,169 | $1.22 億 | 0.47% | – | – |
| State Street Corp | 1,748,792 | $1.21 億 | 0.01% | – | – |
| Goldman Sachs Group Inc | 1,079,046 | $7,488 萬 | 0.02% | – | – |
| Geode Capital Management, LLC | 1,022,134 | $7,093 萬 | 0.01% | – | – |
| Alliancebernstein L.P. | 1,009,095 | $7,002 萬 | 0.03% | – | – |
| Pictet Asset Management Ltd | 1,003,434 | $6,963 萬 | 0.08% | – | – |
| Bank of New York Mellon Corp | 937,591 | $6,506 萬 | 0.01% | – | – |
| Avidity Partners Management LP | 898,550 | $6,235 萬 | 1.74% | – | – |
| Holocene Advisors, LP | 854,264 | $5,928 萬 | 0.38% | – | – |
| Farallon Capital Management, L.L.C. | 850,000 | $5,898 萬 | 0.31% | – | – |
| Credit Suisse AG | 826,400 | $5,735 萬 | 0.04% | – | – |
| Northern Trust Corp | 780,191 | $5,414 萬 | 0.01% | – | – |
| Dimensional Fund Advisors LP | 732,583 | $5,083 萬 | 0.02% | – | – |
| ETF Managers Group, LLC | 726,447 | $5,041 萬 | 0.90% | – | – |
| Viking Global Investors LP大師維京全球投資 | 670,912 | $4,656 萬 | 0.14% | – | – |
| Gilder Gagnon Howe & Co LLC | 624,078 | $4,331 萬 | 0.23% | – | – |
| Norges Bank | 596,527 | $4,139 萬 | 0.01% | – | – |
| Perceptive Advisors LLC | 575,007 | $3,990 萬 | 0.53% | – | – |
| Macquarie Group Ltd | 550,851 | $3,822 萬 | 0.05% | – | – |
| Primecap Management Co | 504,090 | $3,498 萬 | 0.02% | – | – |
| Candriam Luxembourg S.C.A. | 432,049 | $3,189 萬 | 0.27% | – | – |
| Nuveen Asset Management, LLC | 420,414 | $2,917 萬 | 0.01% | – | – |
| Charles Schwab Investment Management Inc | 406,955 | $2,824 萬 | 0.01% | – | – |
| Great Point Partners LLC | 375,870 | $2,608 萬 | 5.39% | – | – |
| FMR LLC | 368,357 | $2,556 萬 | 0.00% | – | – |
| First Light Asset Management, LLC | 346,274 | $2,403 萬 | 1.59% | – | – |
| Nicholas Investment Partners, LP | 327,942 | $2,276 萬 | 1.59% | – | – |
| Emerald Advisers, LLC | 327,107 | $2,270 萬 | 0.82% | – | – |
| Marshall Wace North America L.P. | 327,058 | $2,269 萬 | 0.09% | – | – |
| Sectoral Asset Management Inc | 321,659 | $2,232 萬 | 1.69% | – | – |
| Emerald Mutual Fund Advisers Trust | 296,038 | $2,054 萬 | 0.68% | – | – |
| Rice Hall James & Associates, LLC | 287,959 | $1,998 萬 | 0.65% | – | – |
| Arrowstreet Capital, Limited Partnership | 285,115 | $1,978 萬 | 0.03% | – | – |
| Citadel Advisors LLC | 256,724 | $1,781 萬 | 0.02% | – | – |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 252,364 | $1,751 萬 | 0.07% | – | – |
| Laurion Capital Management LP | 252,340 | $1,751 萬 | 0.24% | – | – |
| Great Lakes Advisors, LLC | 251,648 | $1,746 萬 | 0.28% | – | – |
| Handelsbanken Fonder AB | 249,630 | $1,732 萬 | 0.10% | – | – |
| Wells Fargo & Company | 245,481 | $1,703 萬 | 0.00% | – | – |
| Two Sigma Investments, LP | 234,251 | $1,626 萬 | 0.05% | – | – |
| Atika Capital Management LLC | 214,000 | $1,485 萬 | 1.55% | – | – |
| Integral Health Asset Management, LLC | 210,000 | $1,457 萬 | 4.16% | – | – |
| Deutsche Bank AG | 202,745 | $1,407 萬 | 0.01% | – | – |
| Tekla Capital Management LLC | 196,385 | $1,363 萬 | 0.47% | – | – |
| FIL Ltd | 175,093 | $1,215 萬 | 0.01% | – | – |
| Alyeska Investment Group, L.P. | 168,086 | $1,166 萬 | 0.15% | – | – |
| Rothschild & Co Asset Management US Inc. | 165,768 | $1,150 萬 | 0.14% | – | – |
| Ameriprise Financial Inc | 163,762 | $1,136 萬 | 0.00% | – | – |
| Asymmetry Capital Management, L.P. | 163,135 | $1,132 萬 | 5.86% | – | – |
| UBS Asset Management Americas Inc | 156,055 | $1,083 萬 | 0.00% | – | – |
| Voya Investment Management LLC | 154,630 | $1,073 萬 | 0.02% | – | – |
| Two Sigma Advisers, LP | 150,193 | $1,042 萬 | 0.03% | – | – |
| AdvisorShares Investments LLC | 149,336 | $1,036 萬 | 1.29% | – | – |
| JPMorgan Chase & Co | 148,258 | $1,029 萬 | 0.00% | – | – |
| Peregrine Capital Management LLC | 146,901 | $1,019 萬 | 0.19% | – | – |
| California Public Employees Retirement System | 141,934 | $984.9 萬 | 0.01% | – | – |
| Swiss National Bank | 132,905 | $922.2 萬 | 0.01% | – | – |
| American Century Companies Inc | 125,535 | $871.1 萬 | 0.01% | – | – |
| Millennium Management LLC | 121,214 | $841.1 萬 | 0.01% | – | – |
| Assenagon Asset Management S.A. | 112,381 | $779.8 萬 | 0.04% | – | – |
| GW&K Investment Management, LLC | 108,803 | $755.0 萬 | 0.07% | – | – |
| Prosight Management, LP | 105,828 | $734.3 萬 | 6.01% | – | – |
| Alps Advisors Inc | 105,229 | $730.2 萬 | 0.07% | – | – |
| Penserra Capital Management LLC | 102,709 | $712.5 萬 | 0.13% | – | – |
| State of Wisconsin Investment Board | 100,748 | $699.1 萬 | 0.01% | – | – |
| Barclays PLC | 97,727 | $678.2 萬 | 0.01% | – | – |
| Sofinnova Investments, Inc. | 91,448 | $634.6 萬 | 0.40% | – | – |
| Rhumbline Advisers | 89,698 | $622.4 萬 | 0.01% | – | – |
| Bank of America Corp | 88,782 | $616.0 萬 | 0.00% | – | – |
| California State Teachers Retirement System | 87,677 | $608.4 萬 | 0.01% | – | – |
| Susquehanna International Group, LLP | 84,759 | $588.1 萬 | 0.01% | – | – |
| Panagora Asset Management Inc | 80,548 | $558.9 萬 | 0.03% | – | – |
| DAFNA Capital Management LLC | 76,715 | $532.3 萬 | 1.26% | – | – |
| Teachers Retirement System of the State of Kentucky | 74,599 | $517.6 萬 | 0.05% | – | – |
| Parametric Portfolio Associates LLC | 73,335 | $508.9 萬 | 0.00% | – | – |
| Thrivent Financial for Lutherans | 70,600 | $489.9 萬 | 0.01% | – | – |
| SEI Investments Co | 64,737 | $455.2 萬 | 0.01% | – | – |
| New York State Common Retirement Fund | 65,317 | $453.2 萬 | 0.01% | – | – |
| Citigroup Inc | 64,847 | $449.9 萬 | 0.00% | – | – |
| Davy Global Fund Management Ltd | 61,166 | $424.4 萬 | 0.75% | – | – |
| Allianz Asset Management GmbH | 60,671 | $421.0 萬 | 0.00% | – | – |
| Rhenman & Partners Asset Management AB | 60,000 | $416.3 萬 | 0.29% | – | – |
| Schroder Investment Management Group | 59,713 | $414.3 萬 | 0.01% | – | – |
| Neuberger Berman Group LLC | 57,726 | $400.6 萬 | 0.00% | – | – |
| Janus Henderson Group PLC | 57,395 | $398.3 萬 | 0.00% | – | – |
| UBS Group AG | 54,432 | $377.7 萬 | 0.00% | – | – |
| Invesco Ltd. | 47,075 | $326.6 萬 | 0.00% | – | – |
| Handelsinvest Investeringsforvaltning | 47,000 | $326.1 萬 | 0.40% | – | – |
| Victory Capital Management Inc | 45,453 | $315.4 萬 | 0.00% | – | – |
| Rafferty Asset Management, LLC | 43,223 | $299.9 萬 | 0.02% | – | – |
| Guggenheim Capital LLC | 40,989 | $284.4 萬 | 0.02% | – | – |
| Legal & General Group Plc | 39,245 | $272.4 萬 | 0.00% | – | – |
| State of New Jersey Common Pension Fund D | 38,660 | $268.3 萬 | 0.01% | – | – |
| Connacht Asset Management LP | 35,008 | $242.9 萬 | 1.91% | – | – |
| American International Group, Inc. | 33,889 | $235.2 萬 | 0.01% | – | – |
