| NEA Management Company, LLC | 13,633,582 | $9,025 萬 | 2.04% | – | – |
| Ra Capital Management, L.P. | 6,077,294 | $4,023 萬 | 0.61% | – | – |
| BlackRock Inc. | 5,982,776 | $3,961 萬 | 0.00% | – | – |
| Rock Springs Capital Management LP | 5,176,561 | $3,427 萬 | 0.75% | – | – |
| Adage Capital Partners GP, L.L.C. | 4,254,892 | $2,817 萬 | 0.06% | – | – |
| Vanguard Group Inc | 3,975,938 | $2,632 萬 | 0.00% | – | – |
| State Street Corp | 3,765,222 | $2,493 萬 | 0.00% | – | – |
| Redmile Group, LLC | 3,514,100 | $2,326 萬 | 0.33% | – | – |
| Marshall Wace, LLP | 3,107,735 | $2,057 萬 | 0.11% | – | – |
| 683 Capital Management, LLC | 2,799,307 | $1,853 萬 | 1.20% | – | – |
| Deerfield Management Company, L.P. (Series C) | 2,561,554 | $1,696 萬 | 0.36% | – | – |
| Price T Rowe Associates Inc | 2,469,243 | $1,635 萬 | 0.00% | – | – |
| Thrivent Financial for Lutherans | 2,434,929 | $1,612 萬 | 0.04% | – | – |
| Dimensional Fund Advisors LP | 2,070,375 | $1,371 萬 | 0.00% | – | – |
| Pekin Hardy Strauss, Inc. | 1,636,730 | $1,084 萬 | 1.71% | – | – |
| Candriam Luxembourg S.C.A. | 1,372,217 | $852.8 萬 | 0.07% | – | – |
| Geode Capital Management, LLC | 1,285,322 | $850.8 萬 | 0.00% | – | – |
| Orchard Capital Managment, LLC | 1,227,465 | $812.6 萬 | 2.56% | – | – |
| Ikarian Capital, LLC | 1,030,436 | $682.1 萬 | 1.02% | – | – |
| Jacobs Levy Equity Management, Inc | 997,946 | $660.6 萬 | 0.05% | – | – |
| Prudential Financial Inc | 928,305 | $614.6 萬 | 0.01% | – | – |
| Voya Investment Management LLC | 903,061 | $597.9 萬 | 0.01% | – | – |
| Northern Trust Corp | 824,853 | $546.0 萬 | 0.00% | – | – |
| Kennedy Capital Management, Inc. | 812,605 | $537.9 萬 | 0.11% | – | – |
| Two Sigma Advisers, LP | 722,000 | $478.0 萬 | 0.01% | – | – |
| Sio Capital Management, LLC | 720,621 | $477.1 萬 | 1.00% | – | – |
| Millennium Management LLC | 706,173 | $467.5 萬 | 0.01% | – | – |
| Two Sigma Investments, LP | 674,373 | $446.4 萬 | 0.01% | – | – |
| Assenagon Asset Management S.A. | 672,905 | $445.5 萬 | 0.02% | – | – |
| Tekla Capital Management LLC | 607,698 | $402.3 萬 | 0.14% | – | – |
| Deutsche Bank AG | 558,893 | $370.0 萬 | 0.00% | – | – |
| Janus Henderson Group PLC | 542,251 | $358.7 萬 | 0.00% | – | – |
| Renaissance Technologies LLC | 499,273 | $330.5 萬 | 0.00% | – | – |
| Goldman Sachs Group Inc | 486,285 | $321.9 萬 | 0.00% | – | – |
| D. E. Shaw & Co., Inc. | 457,489 | $302.9 萬 | 0.00% | – | – |
| Bailard, Inc. | 353,000 | $233.7 萬 | 0.09% | – | – |
| Nuveen Asset Management, LLC | 339,763 | $224.9 萬 | 0.00% | – | – |
| Bank of New York Mellon Corp | 287,345 | $190.3 萬 | 0.00% | – | – |
| Allianz Asset Management GmbH | 273,150 | $180.9 萬 | 0.00% | – | – |
| Citigroup Inc | 242,220 | $160.3 萬 | 0.00% | – | – |
| Charles Schwab Investment Management Inc | 241,697 | $160.1 萬 | 0.00% | – | – |
| Susquehanna International Group, LLP | 223,286 | $147.8 萬 | 0.00% | – | – |
| Letko, Brosseau & Associates Inc | 172,300 | $114.1 萬 | 0.02% | – | – |
| Rafferty Asset Management, LLC | 166,592 | $110.3 萬 | 0.01% | – | – |
| California Public Employees Retirement System | 148,600 | $98.4 萬 | 0.00% | – | – |
| Swiss National Bank | 134,100 | $88.8 萬 | 0.00% | – | – |
| Boothbay Fund Management, LLC | 120,603 | $79.8 萬 | 0.04% | – | – |
| California State Teachers Retirement System | 111,711 | $74.0 萬 | 0.00% | – | – |
| Principal Financial Group Inc | 101,451 | $67.2 萬 | 0.00% | – | – |
| State of Wisconsin Investment Board | 99,700 | $66.0 萬 | 0.00% | – | – |
| UBS Group AG | 97,302 | $64.4 萬 | 0.00% | – | – |
| FMR LLC | 97,094 | $64.3 萬 | 0.00% | – | – |
| Integral Health Asset Management, LLC | 95,000 | $62.9 萬 | 0.18% | – | – |
| Pictet Asset Management Ltd | 94,822 | $62.8 萬 | 0.00% | – | – |
| TD Asset Management Inc | 89,278 | $59.1 萬 | 0.00% | – | – |
| Rhumbline Advisers | 85,145 | $56.4 萬 | 0.00% | – | – |
| UBS Asset Management Americas Inc | 74,800 | $49.5 萬 | 0.00% | – | – |
| Russell Investments Group, Ltd. | 72,514 | $47.8 萬 | 0.00% | – | – |
| Alliancebernstein L.P. | 63,900 | $42.3 萬 | 0.00% | – | – |
| Barclays PLC | 62,731 | $41.5 萬 | 0.00% | – | – |
| Personal Cfo Solutions, LLC | 60,000 | $39.7 萬 | 0.09% | – | – |
| Bank of America Corp | 58,846 | $39.0 萬 | 0.00% | – | – |
| New York State Common Retirement Fund | 56,400 | $37.3 萬 | 0.00% | – | – |
| Citadel Advisors LLC | 54,644 | $36.2 萬 | 0.00% | – | – |
| Cubist Systematic Strategies, LLC | 52,195 | $34.6 萬 | 0.00% | – | – |
| Parametric Portfolio Associates LLC | 51,998 | $34.4 萬 | 0.00% | – | – |
| Los Angeles Capital Management LLC | 51,034 | $33.8 萬 | 0.00% | – | – |
| Copernicus Capital Management, LLC | 50,000 | $33.1 萬 | 5.35% | – | – |
| Rothschild Investment Corp | 46,700 | $30.9 萬 | 0.03% | – | – |
| Manufacturers Life Insurance Company, The | 46,506 | $30.8 萬 | 0.00% | – | – |
| Silverarc Capital Management, LLC | 45,000 | $29.8 萬 | 0.17% | – | – |
| Virtus ETF Advisers LLC | 43,649 | $28.9 萬 | 0.12% | – | – |
| Credit Suisse AG | 43,463 | $28.8 萬 | 0.00% | – | – |
| American International Group, Inc. | 43,147 | $28.6 萬 | 0.00% | – | – |
| Martingale Asset Management L P | 34,536 | $22.9 萬 | 0.00% | – | – |
| ProShare Advisors LLC | 32,269 | $21.4 萬 | 0.00% | – | – |
| Gsa Capital Partners LLP | 30,122 | $19.9 萬 | 0.03% | – | – |
| JPMorgan Chase & Co | 27,879 | $18.5 萬 | 0.00% | – | – |
| DekaBank Deutsche Girozentrale | 30,000 | $18.4 萬 | 0.00% | – | – |
| HN Saltoro Capital, LP | 27,764 | $18.4 萬 | 0.15% | – | – |
| Jane Street Group, LLC | 26,034 | $17.2 萬 | 0.00% | – | – |
| Blair William & Co | 25,100 | $16.6 萬 | 0.00% | – | – |
| Tower Research Capital LLC (TRC) | 20,181 | $13.4 萬 | 0.00% | – | – |
| BNP Paribas Arbitrage, SA | 18,419 | $12.2 萬 | 0.00% | – | – |
| Virtu Financial LLC | 17,471 | $11.6 萬 | 0.01% | – | – |
| Arizona State Retirement System | 17,076 | $11.3 萬 | 0.00% | – | – |
| XTX Topco Ltd | 17,072 | $11.3 萬 | 0.05% | – | – |
| Invesco Ltd. | 16,779 | $11.1 萬 | 0.00% | – | – |
| State Board of Administration of Florida Retirement System | 16,695 | $11.1 萬 | 0.00% | – | – |
| SG Americas Securities, LLC | 15,911 | $10.5 萬 | 0.00% | – | – |
| Cambridge Investment Research Advisors, Inc. | 14,400 | $9.50 萬 | 0.00% | – | – |
| MetLife Investment Management | 13,865 | $9.18 萬 | 0.00% | – | – |
| Morgan Stanley | 13,317 | $8.80 萬 | 0.00% | – | – |
| Victory Capital Management Inc | 12,661 | $8.40 萬 | 0.00% | – | – |
| Metropolitan Life Insurance Co | 12,055 | $7.98 萬 | 0.00% | – | – |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 11,980 | $7.90 萬 | 0.00% | – | – |
| Legal & General Group Plc | 11,075 | $7.30 萬 | 0.00% | – | – |
| STRS Ohio | 11,120 | $7.30 萬 | 0.00% | – | – |
| Bank of Montreal | 11,084 | $7.30 萬 | 0.00% | – | – |
| Brinker Capital Investments, LLC | 11,016 | $7.30 萬 | 0.00% | – | – |
