| Aug 13, 2026 (view filing)9:00 PM ET | Aug 11 | 2 days | Wagner Heidi LDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −7.00K | $6.01 | −$42.1K | −13.5%44.9K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Aug 13, 2026 (view filing)9:00 PM ET | Aug 12 | 1 day | Rawcliffe AdrianDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −12.7K | $5.29 | −$67.2K | −100.0%0 after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Aug 13, 2026 (view filing)9:00 PM ET | Aug 11 | 2 days | Takanashi KenDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.86K | $6.01 | −$23.2K | −16.1%20.1K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Aug 13, 2026 (view filing)9:00 PM ET | Aug 11 | 2 days | Tan Aik NaDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −432 | $6.01 | −$2.60K | −1.7%25.0K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 30, 2026 (view filing)8:30 PM ET | Mar 26-30 | 4 days | RA Capital Healthcare Fund LP and 3 othersDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +8.77M | $6.23 | +$54.6M | +48.2%27.0M after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average. |
| Feb 27, 2026 (view filing) | Feb 26 | 1 day | Francis ChrisSee Remarks | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −33.2K | $15.05 | −$499.5K | −34.9%61.9K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 11, 2026 (view filing) | Feb 9 | 2 days | Moran KyleChief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.59K | $13.45 | −$48.3K | −2.6%134.4K after | |
| Feb 11, 2026 (view filing) | Feb 9 | 2 days | Bolno PaulPresident and CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.5K | $13.45 | −$141.0K | −3.7%275.5K after | |
| Feb 11, 2026 (view filing) | Feb 9 | 2 days | Francis ChrisSee Remarks | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.88K | $13.45 | −$25.3K | −3.0%61.9K after | |
| Feb 11, 2026 (view filing) | Feb 9 | 2 days | Vargeese ChandraSee Remarks | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.23K | $13.45 | −$43.4K | −0.8%408.2K after | |
| Jan 6, 2026 (view filing) | Jan 2 | 4 days | Francis ChrisSee Remarks | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −9.38K | $16.03 | −$150.3K | −27.3%25.0K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 15, 2025 (view filing) | Dec 11 | 4 days | GlaxoSmithKline PLC10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +1.47M | $19.00 | +$27.9M | +8.8%18.2M after | |
| Dec 10, 2025 (view filing) | Dec 8 | 2 days | Rawcliffe AdrianDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −42.0K | $15.00 | −$630.0K | −76.8%12.7K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 10, 2025 (view filing) | Dec 8 | 2 days | Wagner Heidi LDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −14.0K | $13.50 | −$189.0K | −23.8%44.9K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 10, 2025 (view filing) | Dec 8 | 2 days | Henry Christian ODirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −93.4K | $14.65 | −$1.37M | −88.0%12.7K after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 10, 2025 (view filing) | Dec 8 | 2 days | Tan Aik NaDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −134.2K | $13.58 | −$1.82M | −84.1%25.4K after | 8 lotsThis row combines 8 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 10, 2025 (view filing) | Dec 8 | 2 days | Verdine Gregory L.Director | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −20.0K | $13.47 | −$269.5K | −6.8%275.2K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 10, 2025 (view filing) | Dec 8 | 2 days | Francis ChrisSee Remarks | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −441.0K | $14.58 | −$6.43M | −94.6%25.0K after | 9 lotsThis row combines 9 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 10, 2025 (view filing) | Dec 8-9 | 2 days | Moran KyleChief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −260.0K | $15.78 | −$4.10M | −74.2%90.4K after | 6 lotsThis row combines 6 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 10, 2025 (view filing) | Dec 8 | 2 days | Corrigan MarkDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −16.1K | $13.49 | −$217.3K | −35.9%28.8K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Nov 14, 2025 (view filing)6:14 PM ET | Nov 13 | 1 day | RA Capital Healthcare Fund LP and 3 othersDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +1.00K | $6.69 | +$6.69K | 0.0%18.2M after | |
| Nov 14, 2025 (view filing) | Nov 13 | 1 day | Rawcliffe AdrianDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −16.1K | $6.79 | −$109.4K | −55.9%12.7K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Aug 26, 2025 (view filing) | Aug 22 | 4 days | Verdine Gregory L.Director | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.0K | $10.00 | −$100.0K | −3.4%285.2K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Aug 26, 2025 (view filing) | Aug 22 | 4 days | Bolno PaulPresident and CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −217.4K | $10.10 | −$2.20M | −64.2%121.0K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Aug 19, 2025 (view filing) | Aug 15 | 4 days | Tan Aik NaDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −21.0K | $9.25 | −$194.3K | −34.2%40.4K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Aug 13, 2025 (view filing) | Aug 13 | Same day | Henry Christian ODirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −9.67K | $8.81 | −$85.2K | −24.6%29.6K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Aug 7, 2025 (view filing) | Aug 5 | 2 days | Takanashi KenDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −4.87K | $8.75 | −$42.6K | −0.1%5.72M after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Aug 7, 2025 (view filing) | Aug 5 | 2 days | Tan Aik NaDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.13K | $8.75 | −$9.86K | −7.0%15.0K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jun 13, 2025 (view filing) | Jun 13 | Same day | Verdine Gregory L.Director | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −30.0K | $6.95 | −$208.5K | −9.6%282.5K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 21, 2025 (view filing) | Mar 20 | 1 day | Henry Christian ODirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.5K | $9.77 | −$102.6K | −39.5%16.1K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 7, 2025 (view filing) | Mar 7 | Same day | Bolno PaulPresident and CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −169.0K | $9.57 | −$1.62M | −33.3%338.4K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Nov 27, 2024 (view filing) | Nov 25 | 2 days | Bolno PaulPresident and CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −50.0K | $15.00 | −$750.0K | −18.7%217.4K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Nov 15, 2024 (view filing) | Nov 15 | Same day | Bolno PaulPresident and CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −51.2K | $14.32 | −$733.7K | −19.1%217.4K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Nov 13, 2024 (view filing) | Nov 8 | 5 days | Francis ChrisSee Remarks | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −36.0K | $16.00 | −$576.0K | −100.0%0 after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Oct 18, 2024 (view filing) | Oct 16 | 2 days | Francis ChrisSee Remarks | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −208.8K | $13.67 | −$2.86M | −100.0%0 after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Oct 18, 2024 (view filing) | Oct 16 | 2 days | Bolno PaulPresident and CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −90.5K | $15.00 | −$1.36M | −25.2%268.6K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Oct 1, 2024 (view filing) | Sep 27 | 4 days | GlaxoSmithKline PLC10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +2.79M | $8.00 | +$22.3M | +20.0%16.8M after | |
| Sep 27, 2024 (view filing) | Sep 25 | 2 days | Moran KyleChief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −17.1K | $9.00 | −$154.3K | −46.4%19.8K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Aug 23, 2024 (view filing) | Aug 21 | 2 days | Bolno PaulPresident and CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −48.4K | $5.78 | −$279.6K | −11.9%359.1K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 5, 2024 (view filing) | Apr 3 | 2 days | Moran KyleChief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −15.6K | $6.17 | −$96.4K | −31.5%33.9K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jan 30, 2024 (view filing) | Dec 7, 2023 | 54 daysLateFiled more than 2 business days after the trade (the Form 4 deadline). A few cases, such as trades a broker makes under a 10b5-1 plan, have a longer deadline, so this flag comes from the dates alone and does not mean a rule was broken. | GlaxoSmithKline PLC10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +3.30M | $5.00 | +$16.5M | +30.9%14.0M after | |
| Jan 17, 2024 (view filing)7:06 PM ET | Dec 11, 2023 | 37 days | RA Capital Healthcare Fund LP and 3 othersDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +1.00M | $5.00 | +$5.00M | +5.8%18.2M after | AmendedAn amended filing (for example Form 4/A or 13F-HR/A) that corrects or adds to an earlier filing. |
| Aug 23, 2023 (view filing) | Aug 23 | Same day | Moran KyleChief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −37.1K | $4.75 | −$176.0K | −44.6%46.1K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 17, 2023 (view filing) | Feb 16 | 1 day | Vargeese ChandraSee Remarks | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.2K | $4.03 | −$41.3K | −8.8%106.6K after | |
| Feb 17, 2023 (view filing) | Feb 16 | 1 day | Bolno PaulPresident and CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −29.4K | $4.04 | −$118.8K | −6.7%407.4K after | |
| Feb 17, 2023 (view filing) | Feb 16 | 1 day | Francis ChrisSee Remarks | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.3K | $4.03 | −$41.3K | −11.4%79.7K after | |
| Feb 17, 2023 (view filing) | Feb 16 | 1 day | Moran KyleChief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −9.73K | $4.04 | −$39.3K | −10.9%79.8K after | |
| Jun 21, 2022 (view filing)4:33 PM ET | Jun 16 | 5 days | RA Capital Healthcare Fund LP and 3 othersDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +9.48M | $2.15 | +$20.4M | +122.8%17.2M after | |
| Jun 21, 2022 (view filing)4:33 PM ET | Jun 16 | 5 days | RA Capital Healthcare Fund LP and 3 othersDirector, 10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +7.09M | $2.15 | +$15.3M | –7.09M after | DerivativeA trade in a derivative security (option, warrant, restricted stock unit and so on). The value is the derivative's own price times the quantity. |
| May 6, 2022 (view filing) | May 5 | 1 day | Vargeese ChandraSee Remarks | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −16.7K | $1.72 | −$28.7K | −13.1%111.1K after | |
