| Sep 24, 2026 (view filing)7:41 PM ET | Sep 22 | 2 days | Newcomb JessicaPrincipal Accounting Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −8.20K | $24.22 | −$198.6K | −12.2%59.1K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Sep 3, 2026 (view filing)4:01 PM ET | Sep 1 | 2 days | Crystal AdamPresident, R&D | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −27.0K | $22.37 | −$603.9K | −18.9%115.7K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Aug 5, 2026 (view filing)4:01 PM ET | Aug 3 | 2 days | Crystal AdamPresident, R&D | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −27.0K | $27.24 | −$735.5K | −18.9%115.7K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jul 2, 2026 (view filing)7:23 PM ET | Jul 1 | 1 day | Crystal AdamPresident, R&D | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −27.0K | $29.59 | −$798.9K | −18.9%115.7K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jun 3, 2026 (view filing) | Jun 1 | 2 days | Crystal AdamPresident, R&D | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −27.0K | $22.88 | −$617.6K | −18.9%115.7K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| May 5, 2026 (view filing) | May 1 | 4 days | Crystal AdamPresident, R&D | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −27.0K | $21.22 | −$573.0K | −18.9%115.7K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 16, 2026 (view filing) | Apr 15 | 1 day | Crystal AdamPresident, R&D | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −38.5K | $25.00 | −$961.5K | −25.5%112.6K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 2, 2026 (view filing) | Apr 1 | 1 day | Crystal AdamPresident, R&D | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −27.0K | $21.20 | −$572.4K | −19.3%112.6K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 27, 2026 (view filing) | Mar 25 | 2 days | Crystal AdamPresident, R&D | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −12.0K | $20.11 | −$241.3K | −9.6%112.6K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 9, 2026 (view filing) | Mar 5 | 4 days | Crystal AdamPresident, R&D | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −20.3K | $15.00 | −$303.8K | −15.2%112.6K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 27, 2026 (view filing) | Feb 25 | 2 days | Crystal AdamPresident, R&D | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −54.3K | $12.77 | −$694.0K | −29.0%132.9K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 4, 2026 (view filing) | Feb 3 | 1 day | Beckman DaniellaChief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −10.3K | $12.27 | −$126.6K | −5.3%184.3K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Feb 4, 2026 (view filing) | Feb 3 | 1 day | Weber BarbaraDirector, Executive Chair | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −30.5K | $12.27 | −$374.4K | −1.8%1.63M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Feb 4, 2026 (view filing) | Feb 3 | 1 day | Crystal AdamPresident, R&D | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −18.5K | $12.27 | −$226.4K | −9.0%187.2K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Oct 27, 2025 (view filing)4:15 PM ET | Oct 23 | 4 days | TRV GP IV, LLC and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −477.4K | $10.15 | −$4.85M | −3.4%13.4M after | |
| Sep 29, 2025 (view filing)4:15 PM ET | Sep 25 | 4 days | TRV GP IV, LLC and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −500.0K | $8.02 | −$4.01M | −3.5%13.9M after | |
| Sep 17, 2025 (view filing)6:06 PM ET | Sep 16 | 1 day | TRV GP IV, LLC and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −363.5K | $7.04 | −$2.56M | −2.5%14.4M after | |
| Sep 9, 2025 (view filing)4:15 PM ET | Sep 5-8 | 4 days | TRV GP IV, LLC and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −729.4K | $7.00 | −$5.11M | −4.7%14.7M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Aug 26, 2025 (view filing)4:15 PM ET | Aug 22 | 4 days | TRV GP IV, LLC and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −302.2K | $7.00 | −$2.12M | −1.9%15.5M after | |
| Aug 21, 2025 (view filing)4:15 PM ET | Aug 19 | 2 days | TRV GP IV, LLC and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.10M | $7.01 | −$7.71M | −6.5%15.8M after | |
| Feb 6, 2025 (view filing) | Feb 4-5 | 2 days | Barry DouglasGeneral Counsel | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −5.33K | $3.07 | −$16.4K | −7.5%66.0K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Feb 6, 2025 (view filing) | Feb 4-5 | 2 days | Beckman DaniellaChief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −8.23K | $3.07 | −$25.3K | −5.2%150.3K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Feb 6, 2025 (view filing) | Feb 4-5 | 2 days | Crystal AdamSee Remarks | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −14.3K | $3.07 | −$43.9K | −8.3%158.2K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Feb 6, 2025 (view filing) | Feb 4-5 | 2 days | Weber BarbaraChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −18.8K | $3.07 | −$57.7K | −1.1%1.62M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Nov 18, 2024 (view filing) | Nov 14-18 | 4 days | Rothenberg MaceDirector | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +20.0K | $3.70 | +$74.0K | +177.8%31.3K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Nov 8, 2024 (view filing) | Nov 6-7 | 2 days | EcoR1 Capital, LLC10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.70M | $3.13 | −$8.45M | −20.3%10.6M after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Nov 7, 2024 (view filing)9:30 PM ET | Nov 6 | 1 day | Davis Aaron I. and 1 otherOther: See remarks | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.08M | $3.14 | −$9.67M | −46.0%3.61M after | |
| Oct 28, 2024 (view filing)6:59 AM ET | Oct 25 | 3 days | Davis Aaron I. and 1 otherOther: See remarks. | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −633.0K | $6.87 | −$4.35M | −8.6%6.69M after | |
| Oct 23, 2024 (view filing)9:31 PM ET | Oct 21-22 | 2 days | Davis Aaron I. and 1 otherOther: See remarks | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −875.0K | $6.97 | −$6.10M | −10.7%7.32M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Sep 17, 2024 (view filing)4:48 PM ET | Sep 13 | 4 days | TRV GP IV, LLC and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −67.4K | $10.53 | −$709.8K | −0.4%16.9M after | |
| Sep 9, 2024 (view filing)7:19 PM ET | Sep 5 | 4 days | TRV GP IV, LLC and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −75.0K | $11.56 | −$867.1K | −0.4%16.9M after | |
| Sep 4, 2024 (view filing)8:42 PM ET | Aug 30 | 5 days | TRV GP IV, LLC and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −175.0K | $11.60 | −$2.03M | −1.0%17.0M after | |
| Aug 29, 2024 (view filing)4:40 PM ET | Aug 27 | 2 days | TRV GP IV, LLC and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −25.0K | $11.55 | −$288.7K | −0.1%17.2M after | |
| Aug 20, 2024 (view filing)5:59 PM ET | Aug 16-19 | 4 days | TRV GP IV, LLC and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −285.0K | $9.95 | −$2.84M | −1.6%17.2M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Aug 1, 2024 (view filing)5:51 PM ET | Jul 30-Aug 1 | 2 days | TRV GP IV, LLC and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −235.0K | $9.86 | −$2.32M | −1.3%17.5M after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Jul 30, 2024 (view filing)4:15 PM ET | Jul 26 | 4 days | TRV GP IV, LLC and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −50.0K | $9.84 | −$491.9K | −0.3%17.7M after | |
| Jul 26, 2024 (view filing)4:15 PM ET | Jul 24-25 | 2 days | TRV GP IV, LLC and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −300.6K | $9.83 | −$2.96M | −1.7%17.8M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jul 24, 2024 (view filing)4:15 PM ET | Jul 22-23 | 2 days | TRV GP IV, LLC and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −387.7K | $9.78 | −$3.79M | −2.1%18.1M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jul 22, 2024 (view filing)4:15 PM ET | Jul 18 | 4 days | TRV GP IV, LLC and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −191.5K | $9.81 | −$1.88M | −1.0%18.5M after | |
| Jul 18, 2024 (view filing)4:15 PM ET | Jul 17 | 1 day | TRV GP IV, LLC and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −550.2K | $9.79 | −$5.39M | −2.9%18.7M after | |
| Jul 2, 2024 (view filing)8:56 PM ET | Jun 28-Jul 2 | 4 days | Davis Aaron I. and 1 otherOther: See remarks | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −234.7K | $8.76 | −$2.06M | −68.3%108.8K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Jun 7, 2024 (view filing)9:14 PM ET | Jun 6-7 | 1 day | Davis Aaron I. and 1 otherOther: See remarks | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −140.0K | $7.04 | −$985.9K | −29.0%343.5K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jun 7, 2024 (view filing) | Jun 5 | 2 days | Calhoun Lesley AnnDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | +5.00K | $7.21 | +$36.0K | +400.0%6.25K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| May 3, 2024 (view filing)9:34 PM ET | May 1-3 | 2 days | Davis Aaron I. and 1 otherOther: See remarks | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −210.0K | $7.53 | −$1.58M | −30.3%483.5K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Feb 21, 2024 (view filing)5:52 PM ET | Feb 20 | 1 day | TRV GP IV, LLC and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −162.5K | $12.00 | −$1.95M | −0.8%19.2M after | |
| Feb 8, 2024 (view filing) | Feb 6-7 | 2 days | Weber BarbaraChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −9.14K | $12.59 | −$115.0K | −0.6%1.54M after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Feb 8, 2024 (view filing) | Feb 6-7 | 2 days | Barry DouglasGeneral Counsel | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.78K | $12.59 | −$34.9K | −5.9%44.0K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Feb 8, 2024 (view filing) | Feb 6-7 | 2 days | Beckman DaniellaChief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.73K | $12.59 | −$46.9K | −2.7%132.4K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Feb 8, 2024 (view filing) | Feb 6-7 | 2 days | Crystal AdamSee Remarks | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −8.37K | $12.59 | −$105.4K | −6.5%119.5K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Nov 2, 2023 (view filing) | Nov 1 | 1 day | Crystal AdamSee Remarks | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −7.51K | $8.39 | −$63.0K | −8.5%81.3K after | |
