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Talphera, Inc.

TLPH
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001427925

No open-market purchases or sales by Talphera, Inc. insiders were filed in the last 90 days; 50 institutions reported holding it in 13F filings for Q2 2026, worth $24.6M in total; no superinvestor holds it.

13F holders, Q4 2025

Institutional positions in Talphera, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
38
+4 vs. Q3 2025
Shares held
20.9M
+3.09M (+17.4%) vs. Q3 2025
Total value
$23.8M
+$7.91M (+49.8%) vs. Q3 2025
New holders
10
11 more added
Sold out
6
6 more reduced

Compare with Q3 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting TLPH on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2025: 38 institutions
Q1 2021: 82 institutionsQ2 2021: 71 institutionsQ3 2021: 57 institutionsQ4 2021: 58 institutionsQ1 2022: 56 institutionsQ2 2022: 60 institutionsQ3 2022: 56 institutionsQ4 2022: 37 institutionsQ1 2023: 32 institutionsQ2 2023: 27 institutionsQ3 2023: 31 institutionsQ4 2023: 33 institutionsQ1 2024: 31 institutionsQ2 2024: 30 institutionsQ3 2024: 29 institutionsQ4 2024: 35 institutionsQ1 2025: 32 institutionsQ2 2025: 32 institutionsQ3 2025: 34 institutionsQ4 2025: 38 institutionsQ1 2026: 45 institutionsQ2 2026: 50 institutions
Value heldQ4 2025: $23.8M
Q1 2021: $61.6MQ2 2021: $34.8MQ3 2021: $20.5MQ4 2021: $16.8MQ1 2022: $5.66MQ2 2022: $4.18MQ3 2022: $3.81MQ4 2022: $3.29MQ1 2023: $720.9KQ2 2023: $1.17MQ3 2023: $1.88MQ4 2023: $2.42MQ1 2024: $4.56MQ2 2024: $3.87MQ3 2024: $3.58MQ4 2024: $2.14MQ1 2025: $2.74MQ2 2025: $2.43MQ3 2025: $15.9MQ4 2025: $23.8MQ1 2026: $16.3MQ2 2026: $24.6M
Institutions holding TLPH and their total value by quarter
QuarterHoldersValue
Q2 202650$24.6M
Q1 202645$16.3M
Q4 202538$23.8M
Q3 202534$15.9M
Q2 202532$2.43M
Q1 202532$2.74M
Q4 202435$2.14M
Q3 202429$3.58M
Q2 202430$3.87M
Q1 202431$4.56M
Q4 202333$2.42M
Q3 202331$1.88M
Q2 202327$1.17M
Q1 202332$720.9K
Q4 202237$3.29M
Q3 202256$3.81M
Q2 202260$4.18M
Q1 202256$5.66M
Q4 202158$16.8M
Q3 202157$20.5M
Q2 202171$34.8M
Q1 202182$61.6M

Institutions, Q4 2025

Shares, value and share of portfolio for each institution holding Talphera, Inc.; share changes are against Q3 2025.

Institutions holding TLPH in Q4 2025
InstitutionSharesValue% of portfolioChange in sharesAction
AIGH Capital Management LLC4,661,502$5.31M1.57%+206,957+4.6%Added
Rock Springs Capital Management LP3,589,186$4.09M0.21%00.0%Unchanged
Rosalind Advisors, Inc.3,579,273$4.08M1.56%−806,484−18.4%Reduced
Nantahala Capital Management, LLC3,492,519$3.98M0.24%00.0%Unchanged
Empery Asset Management, LP1,333,497$1.52M1.34%+1,333,497New
Bleichroeder LP881,166$1.00M0.18%00.0%Unchanged
Vanguard Group Inc663,677$756.6K0.00%+377,448+131.9%Added
Dauntless Investment Group, LLC579,320$660.4K2.43%+479,320+479.3%Added
Cantor Fitzgerald, L. P.577,490$658.3K0.02%+577,490New
Geode Capital Management, LLC342,987$391.1K0.00%+177,294+107.0%Added
Renaissance Technologies LLC257,380$293.4K0.00%+207,166+412.6%Added
Diadema Partners LP136,923$156.1K0.09%+136,923New
BlackRock, Inc.91,548$104.4K0.00%00.0%Unchanged
Simplex Trading, LLC85,799$97.8K0.00%+84,572+6,892.6%Added
Jane Street Group, LLC84,938$96.8K0.00%+84,938New
Values First Advisors, Inc.81,208$92.6K0.05%−16,674−17.0%Reduced
Citadel Advisors LLC76,445$87.1K0.00%+76,445New
Mariner, LLC58,000$66.1K0.00%+33,000+132.0%Added
Group One Trading, L.P.57,173$65.2K0.00%+26,758+88.0%Added
Susquehanna International Group, LLP56,432$64.3K0.00%+56,432New
Northern Trust Corp52,580$59.9K0.00%+41,689+382.8%Added
Persistent Asset Partners Ltd36,630$41.8K0.02%+36,630New
Two Sigma Investments, LP24,588$28.0K0.00%+24,588New
State Street Corp22,182$25.3K0.00%00.0%Unchanged
Gsa Capital Partners LLP20,973$24.0K0.00%+20,973New
Onyx Bridge Wealth Group LLC11,500$13.1K0.00%00.0%Unchanged
UBS Group AG6,818$7.77K0.00%−20,832−75.3%Reduced
MAI Capital Management3,314$3.78K0.00%00.0%Unchanged
Tower Research Capital LLC (TRC)2,801$3.19K0.00%−3,360−54.5%Reduced
Wells Fargo & Company983$1.12K0.00%+500+103.5%Added
Bank of America Corp335$3820.00%+159+90.3%Added
Silicon Valley Capital Partners137$1560.00%00.0%Unchanged
BNP Paribas Arbitrage, SA136$1550.00%00.0%Unchanged
SRS Capital Advisors, Inc.81$920.00%+81New
SBI Securities Co., Ltd.78$890.00%−175−69.2%Reduced
Global Retirement Partners, LLC23$260.00%−50−68.5%Reduced
Morgan Stanley10$110.00%00.0%Unchanged
Dogwood Wealth Management LLC10$110.00%00.0%Unchanged
Virtu Financial LLC0$00.00%−32,811−100.0%Sold out
PFG Investments, LLC0$00.00%−10,000−100.0%Sold out
Sterling Capital Management LLC0$00.00%−2,000−100.0%Sold out
GWM Advisors LLC0$00.00%−500−100.0%Sold out
Advisor Group Holdings, Inc.0$00.00%−26−100.0%Sold out
Citigroup Inc0$00.00%−1−100.0%Sold out