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Spyre Therapeutics, Inc.

SYRE
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001636282

In the last 90 days, Spyre Therapeutics, Inc. insiders filed 0 open-market purchases and 9 sales; 265 institutions reported holding it in 13F filings for Q2 2026, worth $8.52B in total; no superinvestor holds it.

Open-market trades, last 90 days

Open-market purchases (P) and sales (S) by Spyre Therapeutics, Inc. insiders, counted by Form 4 filing. Trades with a flagged price and duplicate filings are left out.

Open-market buys
0 filings
Open-market sells
9 filings
5 insiders, $13.3M in total
Insiders trading
5
Net value
−$13.3M
Purchases minus sales

Insider roster

Directors, officers and 10% owners who have filed a Form 4 for Spyre Therapeutics, Inc., current and former, most recent filer first. Last reported holding is the position after the last non-derivative trade in their latest filing.

Insider roster for Spyre Therapeutics, Inc.
NameTitleLast reported holdingLast filingFilings, past year
King-Jones HeidySee Remarks2,845Sep 3, 20262
Burrows Scott LChief Financial Officer79,762Sep 3, 20269
Turtle CameronChief Executive Officer552,540Sep 3, 202612
Albers Jeffrey W.Director9,360IndirectAug 10, 20262
Sloan SheldonChief Medical Officer0Jul 2, 20265
Harwin Peter EvanDirector0IndirectJun 23, 20261
Fairmount Healthcare Fund II L.P.Director0IndirectJun 23, 20262
Fairmount Funds Management LLCDirector0IndirectJun 23, 20262
Kiselak TomasDirector0IndirectJun 23, 20262
Henderson Michael ThomasDirector68,606Jun 23, 20264
Stelzer LaurieDirector–May 29, 20261
McKenna Mark C.Director–May 29, 20261
Milligan SandraDirector–May 29, 20261
Fairmount Healthcare Fund L.P.Director, 10% Owner406,038IndirectDec 29, 20230
Fairmount Healthcare Co-Invest L.P.Director, 10% Owner406,038IndirectDec 29, 20230
Magovcevic-Liebisch IvanaDirector–Jun 30, 20230
Cox Russell J.Director–Jun 30, 20230
Lawton Alison FrancesDirector–Jun 30, 20230
Smith Hunter CDirector–Jun 30, 20230
Alspaugh JonathanPresident and CFO165,372Jun 30, 20230
Hanley Jr. Michael ConickChief Business Officer36,200Feb 24, 20230
Kastenmayer James PaulGeneral Counsel–Feb 24, 20230
Neuman Linda LChief Medical Officer–Feb 24, 20230
Goldberg Jeff MarcPresident and CEO–Dec 1, 20220
Souza MarcioDirector90,000Aug 25, 20220
Sloan LeslieChief Operating Officer–Aug 25, 20220
Lawlis V BryanDirector–Jun 9, 20220
Mahatme SandeshDirector–Jun 9, 20220
Shanafelt ArmenDirector150,000Jun 9, 20220
Quinn Anthony G.President & CEO550,540Mar 18, 20220
Weber StevenVP, Controller&Princ Acctg Off–Feb 22, 20220

Insider trades

Each row adds up one type of transaction in one Form 4 filing. Only open-market purchases (P) and sales (S) are shown by default; use the filters to see grants, option exercises and other codes.

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
Aug 18, 2021 (view filing)Aug 16-182 daysAlspaugh JonathanChief Financial OfficerPPurchase+40.4K$6.51+$262.7KNew position40.4K after3 lots
Dec 13, 2021 (view filing)Dec 94 daysAlspaugh JonathanChief Financial OfficerPPurchase+50.0K$3.72+$186.0K+123.8%90.4K after
Dec 13, 2021 (view filing)Dec 9-104 daysQuinn Anthony G.President & CEOPPurchase+53.6K$3.71+$199.0K+19.5%328.8K after2 lots
Dec 13, 2021 (view filing)Dec 9-134 daysShanafelt ArmenDirectorPPurchase+150.0K$3.67+$549.9KNew position150.0K after3 lots
Mar 15, 2022 (view filing)Mar 114 daysAlspaugh JonathanChief Financial OfficerPPurchase+75.0K$2.08+$156.0K+83.0%165.4K after
Mar 15, 2022 (view filing)Mar 11-154 daysQuinn Anthony G.President & CEOPPurchase+144.7K$1.94+$280.8K+44.0%473.5K after3 lots
Mar 18, 2022 (view filing)Mar 162 daysQuinn Anthony G.President & CEOPPurchase+80.1K$2.34+$187.4K+17.0%550.5K after
Jun 10, 2022 (view filing)Jun 82 daysHanley Jr. Michael ConickChief Commercial OfficerPPurchase+28.2K$0.71+$20.0K+352.5%36.2K after
Aug 25, 2022 (view filing)Aug 25Same daySouza MarcioDirectorPPurchase+90.0K$0.56+$50.4KNew position90.0K after
Sep 5, 2024 (view filing)Sep 32 daysBurrows Scott LChief Financial OfficerSSale−18.5K$28.17−$522.0K−13.7%116.4K after
Oct 28, 2024 (view filing)Oct 253 daysAlbers Jeffrey W.DirectorSSale−300$36.43−$10.9K−0.9%34.1K after10b5-1
Nov 8, 2024 (view filing)Nov 62 daysAlbers Jeffrey W.DirectorSSale−6.70K$36.76−$246.3K−19.7%27.4K after10b5-1
Sep 3, 2025 (view filing)Sep 21 dayBurrows Scott LChief Financial OfficerSSale−18.4K$16.26−$299.6K−15.8%98.0K after
Nov 5, 2025 (view filing)Nov 32 daysTurtle CameronChief Executive OfficerSSale−45.0K$23.33−$1.05M−6.0%701.9K after2 lots10b5-1
Dec 3, 2025 (view filing)Dec 12 daysTurtle CameronChief Executive OfficerSSale−15.0K$29.02−$435.4K−2.1%686.9K after2 lots10b5-1
Jan 6, 2026 (view filing)Jan 24 daysTurtle CameronChief Executive OfficerSSale−15.0K$30.68−$460.1K−2.2%671.9K after3 lots10b5-1
Feb 4, 2026 (view filing)Feb 22 daysTurtle CameronChief Executive OfficerSSale−15.0K$32.80−$492.0K−2.2%657.5K after2 lots10b5-1
Mar 3, 2026 (view filing)Mar 21 dayTurtle CameronChief Executive OfficerSSale−15.0K$42.19−$632.9K−2.3%642.5K after2 lots10b5-1
Mar 3, 2026 (view filing)Mar 3Same dayBurrows Scott LChief Financial OfficerSSale−2.50K$40.65−$101.6K−2.5%98.0K after2 lots10b5-1
Apr 3, 2026 (view filing)Apr 12 daysSloan SheldonChief Medical OfficerSSale−7.96K$50.00−$397.9K−100.0%0 after10b5-1
Apr 3, 2026 (view filing)Apr 12 daysTurtle CameronChief Executive OfficerSSale−15.0K$49.33−$739.9K−2.3%627.5K after2 lots10b5-1
Apr 3, 2026 (view filing)Apr 12 daysBurrows Scott LChief Financial OfficerSSale−7.50K$49.34−$370.1K−7.1%98.0K after2 lots10b5-1
May 1, 2026 (view filing)May 1Same dayTurtle CameronChief Executive OfficerSSale−15.0K$71.37−$1.07M−2.4%612.5K after6 lots10b5-1
May 1, 2026 (view filing)May 1Same dayBurrows Scott LChief Financial OfficerSSale−12.5K$71.37−$892.1K−11.3%98.0K after10b5-1
May 1, 2026 (view filing)May 1Same daySloan SheldonChief Medical OfficerSSale−78.3K$71.50−$5.60M−100.0%0 after7 lots10b5-1
May 8, 2026 (view filing)May 8Same dayHenderson Michael ThomasDirectorSSale−80.0K$74.40−$5.95M−47.4%88.6K after4 lots10b5-1
Jun 3, 2026 (view filing)Jun 12 daysBurrows Scott LChief Financial OfficerSSale−7.50K$71.06−$532.9K−7.1%98.0K after3 lots10b5-1
Jun 3, 2026 (view filing)Jun 12 daysTurtle CameronChief Executive OfficerSSale−15.0K$70.43−$1.06M−2.4%597.5K after3 lots10b5-1
Jun 3, 2026 (view filing)Jun 3Same daySloan SheldonChief Medical OfficerSSale−8.33K$75.00−$625.0K−100.0%0 after10b5-1
Jun 23, 2026 (view filing)Jun 221 dayHenderson Michael ThomasDirectorSSale−20.0K$100.00−$2.00M−22.6%68.6K after10b5-1
Jun 23, 2026 (view filing)9:56 PM ETJun 23Same dayHarwin Peter Evan and 3 othersDirectorSSale−4.68M$85.31−$399.7M−100.0%0 after
Jun 26, 2026 (view filing)Jun 251 dayBurrows Scott LChief Financial OfficerSSale−15.0K$87.13−$1.31M−13.3%98.0K after2 lots
Jul 2, 2026 (view filing)9:32 PM ETJul 11 dayTurtle CameronChief Executive OfficerSSale−15.0K$87.69−$1.32M−2.5%582.5K after3 lots10b5-1
Jul 2, 2026 (view filing)9:33 PM ETJul 11 daySloan SheldonChief Medical OfficerSSale−8.33K$87.70−$730.9K−100.0%0 after2 lots10b5-1
Jul 2, 2026 (view filing)9:33 PM ETJul 11 dayBurrows Scott LChief Financial OfficerSSale−7.50K$87.74−$658.0K−7.1%98.0K after2 lots10b5-1
Aug 5, 2026 (view filing)9:31 PM ETAug 32 daysTurtle CameronChief Executive OfficerSSale−15.0K$95.51−$1.43M−2.6%567.5K after5 lots10b5-1
Aug 5, 2026 (view filing)9:32 PM ETAug 32 daysBurrows Scott LChief Financial OfficerSSale−7.50K$95.57−$716.8K−7.1%98.0K after3 lots10b5-1
Aug 10, 2026 (view filing)9:31 PM ETAug 73 daysAlbers Jeffrey W.DirectorSSale−5.00K$104.47−$522.4K−100.0%0 after10b5-1
Aug 10, 2026 (view filing)9:31 PM ETAug 73 daysAlbers Jeffrey W.DirectorSSale−18.0K$104.55−$1.88M−65.8%9.36K after2 lots10b5-1
Sep 3, 2026 (view filing)9:33 PM ETSep 12 daysTurtle CameronChief Executive OfficerSSale−15.0K$87.29−$1.31M−2.6%552.5K after4 lots10b5-1
Sep 3, 2026 (view filing)9:33 PM ETSep 1-22 daysBurrows Scott LChief Financial OfficerSSale−25.7K$88.75−$2.28M−24.4%79.8K after5 lots10b5-1
Sep 3, 2026 (view filing)9:34 PM ETSep 1-22 daysKing-Jones HeidySee RemarksSSale−28.4K$87.35−$2.48M−90.9%2.85K after5 lots10b5-1