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SOPHiA GENETICS SA

SOPH
Exchange
Nasdaq
Industry
Services-Computer Processing & Data Preparation
SEC CIK
0001840706

In the last 90 days, SOPHiA GENETICS SA insiders filed 0 open-market purchases and 36 sales; 71 institutions reported holding it in 13F filings for Q2 2026, worth $212.5M in total; Akre Capital Management is the only superinvestor holding it.

13F holders, Q4 2025

Institutional positions in SOPHiA GENETICS SA as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
42
+2 vs. Q3 2025
Shares held
18.3M
+602.4K (+3.4%) vs. Q3 2025
Total value
$85.5M
+$1.22M (+1.4%) vs. Q3 2025
New holders
10
16 more added
Sold out
8
7 more reduced

Compare with Q3 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting SOPH on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2025: 42 institutions
Q1 2021: 0 institutionsQ2 2021: 0 institutionsQ3 2021: 30 institutionsQ4 2021: 32 institutionsQ1 2022: 29 institutionsQ2 2022: 34 institutionsQ3 2022: 34 institutionsQ4 2022: 32 institutionsQ1 2023: 34 institutionsQ2 2023: 35 institutionsQ3 2023: 32 institutionsQ4 2023: 36 institutionsQ1 2024: 32 institutionsQ2 2024: 31 institutionsQ3 2024: 30 institutionsQ4 2024: 36 institutionsQ1 2025: 32 institutionsQ2 2025: 32 institutionsQ3 2025: 40 institutionsQ4 2025: 42 institutionsQ1 2026: 49 institutionsQ2 2026: 71 institutions
Value heldQ4 2025: $85.5M
Q1 2021: $0Q2 2021: $0Q3 2021: $331.5MQ4 2021: $262.5MQ1 2022: $167.5MQ2 2022: $78.1MQ3 2022: $54.6MQ4 2022: $40.1MQ1 2023: $90.9MQ2 2023: $80.2MQ3 2023: $43.2MQ4 2023: $81.2MQ1 2024: $86.3MQ2 2024: $82.1MQ3 2024: $65.2MQ4 2024: $55.5MQ1 2025: $77.2MQ2 2025: $51.2MQ3 2025: $84.3MQ4 2025: $85.5MQ1 2026: $120.4MQ2 2026: $212.5M
Institutions holding SOPH and their total value by quarter
QuarterHoldersValue
Q2 202671$212.5M
Q1 202649$120.4M
Q4 202542$85.5M
Q3 202540$84.3M
Q2 202532$51.2M
Q1 202532$77.2M
Q4 202436$55.5M
Q3 202430$65.2M
Q2 202431$82.1M
Q1 202432$86.3M
Q4 202336$81.2M
Q3 202332$43.2M
Q2 202335$80.2M
Q1 202334$90.9M
Q4 202232$40.1M
Q3 202234$54.6M
Q2 202234$78.1M
Q1 202229$167.5M
Q4 202132$262.5M
Q3 202130$331.5M
Q2 20210$0
Q1 20210$0

Institutions, Q4 2025

Shares, value and share of portfolio for each institution holding SOPHiA GENETICS SA; share changes are against Q3 2025.

Institutions holding SOPH in Q4 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Generation Investment Management LLP6,789,560$31.7M0.22%00.0%Unchanged
Akre Capital Management LLCSuperinvestorAkre Capital Management3,719,140$17.4M0.19%00.0%Unchanged
Banque Pictet & Cie SA2,208,280$10.3M0.10%00.0%Unchanged
Alta Wealth Advisors LLC1,409,160$6.58M2.20%00.0%Unchanged
Principal Financial Group Inc1,399,442$6.54M0.00%+8,230+0.6%Added
Archon Capital Management LLC441,413$2.06M1.17%+14,342+3.4%Added
Royce & Associates LP430,257$2.01M0.02%+430,257New
Pictet & Cie (Europe) SA255,200$1.19M0.02%00.0%Unchanged
1492 Capital Management LLC208,345$973.0K0.37%+208,345New
Edmond de Rothschild Holding S.A.203,334$949.6K0.01%00.0%Unchanged
Federated Hermes, Inc.187,677$876.5K0.00%−22,323−10.6%Reduced
Ensign Peak Advisors, Inc182,414$851.9K0.00%−12,768−6.5%Reduced
Rathbone Brothers plc160,133$747.8K0.00%−2,350−1.4%Reduced
Millennium Management LLC125,458$585.9K0.00%−100,445−44.5%Reduced
Geode Capital Management, LLC92,596$432.4K0.00%+680+0.7%Added
Renaissance Technologies LLC83,000$387.6K0.00%+52,200+169.5%Added
UBS Group AG61,901$289.1K0.00%+46,517+302.4%Added
Morgan Stanley48,047$224.4K0.00%+6,513+15.7%Added
Silverberg Bernstein Capital Management LLC47,815$223.3K0.13%+1,100+2.4%Added
Green Alpha Advisors, LLC45,660$213.2K0.20%+4,444+10.8%Added
Pathstone Holdings, LLC32,203$150.4K0.00%+88+0.3%Added
Susquehanna International Group, LLP30,511$142.5K0.00%+12,032+65.1%Added
Goldman Sachs Group Inc28,660$133.8K0.00%+1,453+5.3%Added
Gsa Capital Partners LLP24,967$117.0K0.01%+12,513+100.5%Added
Polen Capital Management LLC21,738$101.5K0.00%+21,738New
FNY Investment Advisers, LLC16,010$74.0K0.02%−28,695−64.2%Reduced
XTX Topco Ltd11,760$54.9K0.00%+11,760New
Quadrature Capital Ltd11,649$54.4K0.00%+11,649New
Perkins Capital Management Inc10,500$49.0K0.04%+10,500New
Acadian Asset Management LLC5,911$27.0K0.00%+5,911New
Bank of America Corp5,552$25.9K0.00%+5,552New
BlackRock, Inc.5,086$23.8K0.00%00.0%Unchanged
Assetmark, Inc4,687$21.9K0.00%+566+13.7%Added
Zurcher Kantonalbank (Zurich Cantonalbank)3,755$17.5K0.00%−3,172−45.8%Reduced
Compagnie Lombard Odier SCmA1,055$4.93K0.00%00.0%Unchanged
Advisor Group Holdings, Inc.1,000$4.67K0.00%+853+580.3%Added
Royal Bank of Canada600$3.00K0.00%00.0%Unchanged
The PNC Financial Services Group, Inc.370$1.73K0.00%+370New
United Financial Planning Group LLC170$7940.00%+170New
Russell Investments Group, Ltd.59$2760.00%+37+168.2%Added
SBI Securities Co., Ltd.41$1910.00%+40+4,000.0%Added
Simplex Trading, LLC31$1440.00%−995−97.0%Reduced
Dimensional Fund Advisors LP0$00.00%−31,332−100.0%Sold out
Thompson Siegel & Walmsley LLC0$00.00%−29,780−100.0%Sold out
Citadel Advisors LLC0$00.00%−12,320−100.0%Sold out
Squarepoint Ops LLC0$00.00%−10,231−100.0%Sold out
Savvy Advisors, Inc.0$00.00%−10,000−100.0%Sold out
Tower Research Capital LLC (TRC)0$00.00%−491−100.0%Sold out
Principal Securities, Inc.0$00.00%−394−100.0%Sold out
Groupe la Francaise0$00.00%−120−100.0%Sold out