| Mar 14, 2025 (view filing) | Mar 12 | 2 days | Koehler MariaEVP, CHIEF MEDICAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −3.60K | $1.14 | −$4.10K | −1.6%227.8K after | |
| Mar 14, 2025 (view filing) | Mar 12 | 2 days | Zinda MichaelEVP, CHIEF SCIENTIFIC OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −5.61K | $1.14 | −$6.40K | −6.5%80.3K after | |
| Mar 14, 2025 (view filing) | Mar 12 | 2 days | Forte SteveEVP, CHIEF FINANCIAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −6.88K | $1.14 | −$7.85K | −11.2%54.8K after | |
| Mar 14, 2025 (view filing) | Mar 12 | 2 days | Segal Lloyd MitchellPRESIDENT AND CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −21.2K | $1.14 | −$24.1K | −14.5%124.4K after | |
| Apr 1, 2024 (view filing) | Mar 28-Apr 1 | 4 days | Segal Lloyd MitchellPRESIDENT AND CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −5.14K | $4.62 | −$23.8K | −4.6%107.6K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 1, 2024 (view filing) | Mar 28-Apr 1 | 4 days | Forte SteveEVP, CHIEF FINANCIAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.61K | $4.62 | −$7.45K | −3.5%44.8K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 1, 2024 (view filing) | Mar 28-Apr 1 | 4 days | Zinda MichaelEVP, CHIEF SCIENTIFIC OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −860 | $4.65 | −$4.00K | −1.2%71.9K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 1, 2024 (view filing) | Mar 28-Apr 1 | 4 days | Koehler MariaEVP, CHIEF MEDICAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −800 | $4.65 | −$3.72K | −0.3%231.4K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 27, 2024 (view filing) | Mar 25-27 | 2 days | Forte SteveEVP, CHIEF FINANCIAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −2.48K | $4.67 | −$11.6K | −5.5%42.2K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 27, 2024 (view filing) | Mar 25-27 | 2 days | Zinda MichaelEVP, CHIEF SCIENTIFIC OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.35K | $4.67 | −$6.30K | −1.8%72.8K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 27, 2024 (view filing) | Mar 25-27 | 2 days | Koehler MariaEVP, CHIEF MEDICAL OFFICER | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.50K | $4.67 | −$7.00K | −0.6%232.2K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 27, 2024 (view filing) | Mar 25-27 | 2 days | Segal Lloyd MitchellPRESIDENT AND CEO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −7.95K | $4.69 | −$37.3K | −8.7%83.9K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Nov 17, 2023 (view filing)4:54 PM ET | Nov 15-16 | 2 days | Biotechnology Value Fund L P and 9 others10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in.Common Shares, no par value | +1.23M | $5.09 | +$6.25M | New position548.9K after | 6 lotsThis row combines 6 trades of the same kind from one filing. The price is the value-weighted average. |
| Nov 3, 2023 (view filing)5:37 PM ET | Nov 2 | 1 day | Biotechnology Value Fund L P and 9 others10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in.Common Shares, no par value | +783.7K | $3.60 | +$2.82M | New position485.1K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Jun 9, 2023 (view filing) | Jun 7 | 2 days | Zinda MichaelEVP, Chief Scientific Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −6.40K | $12.03 | −$77.0K | −9.2%63.0K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jun 9, 2023 (view filing) | Jun 8 | 1 day | Zinda MichaelEVP, Chief Scientific Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | +2.87K | $12.02 | +$34.5K | +5.0%60.1K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jun 7, 2023 (view filing) | Jun 6 | 1 day | Zinda MichaelEVP, Chief Scientific Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −1.20K | $12.04 | −$14.4K | −1.7%69.4K after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 13, 2022 (view filing) | Dec 9 | 4 days | Jerel DavisDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −250.0K | $16.00 | −$4.00M | −10.7%2.09M after | |
| Jun 15, 2022 (view filing)6:15 PM ET | Jun 13 | 2 days | Biotechnology Value Fund L P and 9 others10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in.Common Shares, no par value | +149.2K | $12.73 | +$1.90M | +56.6%412.6K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Jun 7, 2022 (view filing)4:37 PM ET | Jun 3 | 4 days | Versant Vantage I, L.P. and 2 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −750.0K | $12.25 | −$9.19M | −87.1%111.5K after | 5 lotsThis row combines 5 trades of the same kind from one filing. The price is the value-weighted average.Duplicate filingThe same trade also appears in an earlier filing, for example when the same people file twice or a fund and its partners each report it. Rankings and totals count only the earliest copy. |
| Jun 7, 2022 (view filing)4:36 PM ET | Jun 3 | 4 days | Versant Affiliates Fund V, L.P. and 9 others10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −750.0K | $12.25 | −$9.19M | −87.1%111.5K after | 5 lotsThis row combines 5 trades of the same kind from one filing. The price is the value-weighted average. |
| Jun 7, 2022 (view filing) | Jun 3 | 4 days | Jerel DavisDirector, 10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −750.0K | $12.25 | −$9.19M | −87.1%111.5K after | 5 lotsThis row combines 5 trades of the same kind from one filing. The price is the value-weighted average. |
| Jun 6, 2022 (view filing)6:14 PM ET | Jun 2-6 | 4 days | Biotechnology Value Fund L P and 9 others10% Owner | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in.Common Shares, no par value | +1.84M | $11.90 | +$21.9M | New position406.4K after | 9 lotsThis row combines 9 trades of the same kind from one filing. The price is the value-weighted average. |
| May 20, 2022 (view filing)6:09 PM ET | May 18 | 2 days | Biotechnology Value Fund L P and 9 othersOther: See Explanation of Responses | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in.Common Shares, no par value | +420.0K | $8.50 | +$3.57M | New position313.4K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Mar 16, 2022 (view filing) | Mar 15 | 1 day | Zinda MichaelEVP, Chief Science Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −533 | $11.30 | −$6.02K | −1.1%46.0K after | |
| Jan 21, 2022 (view filing)5:12 PM ET | Jan 19 | 2 days | Biotechnology Value Fund L P and 9 othersOther: See Explanation of Responses | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in.Common Shares, no par value | +998.0K | $14.10 | +$14.1M | New position307.6K after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Nov 18, 2021 (view filing) | Nov 16 | 2 days | Civik ThomasDirector | PPurchaseThe insider bought shares with their own money, on the open market or in a private deal (for example, a company's private placement). This is the code investors watch most closely: it is money the insider chose to put in. | +7.50K | $28.08 | +$210.6K | New position7.50K after | |
| Nov 17, 2021 (view filing) | Nov 15 | 2 days | Zinda MichaelEVP, Chief Science Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −20.0K | $27.33 | −$546.6K | −97.4%533 after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Sep 8, 2021 (view filing)6:18 PM ET | Sep 3-7 | 5 days | OrbiMed Advisors LLC and 2 othersDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −8.08K | $33.99 | −$274.8K | −7.8%96.2K after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average.Duplicate filingThe same trade also appears in an earlier filing, for example when the same people file twice or a fund and its partners each report it. Rankings and totals count only the earliest copy. |
| Sep 8, 2021 (view filing) | Sep 3-7 | 5 days | Bonita David PDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −8.08K | $33.99 | −$274.8K | −7.8%96.2K after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average. |
| Sep 2, 2021 (view filing)8:27 PM ET | Aug 31-Sep 2 | 2 days | OrbiMed Advisors LLC and 2 othersDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −37.9K | $34.08 | −$1.29M | −28.2%96.4K after | 6 lotsThis row combines 6 trades of the same kind from one filing. The price is the value-weighted average.Duplicate filingThe same trade also appears in an earlier filing, for example when the same people file twice or a fund and its partners each report it. Rankings and totals count only the earliest copy. |
| Sep 2, 2021 (view filing) | Aug 31-Sep 2 | 2 days | Bonita David PDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −37.9K | $34.08 | −$1.29M | −28.2%96.4K after | 6 lotsThis row combines 6 trades of the same kind from one filing. The price is the value-weighted average. |
| Aug 30, 2021 (view filing)6:37 PM ET | Aug 26-30 | 4 days | OrbiMed Advisors LLC and 2 othersDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −18.1K | $34.07 | −$615.7K | −15.6%97.5K after | 6 lotsThis row combines 6 trades of the same kind from one filing. The price is the value-weighted average.Duplicate filingThe same trade also appears in an earlier filing, for example when the same people file twice or a fund and its partners each report it. Rankings and totals count only the earliest copy. |
| Aug 30, 2021 (view filing) | Aug 26-30 | 4 days | Bonita David PDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −18.1K | $34.07 | −$615.7K | −15.6%97.5K after | 6 lotsThis row combines 6 trades of the same kind from one filing. The price is the value-weighted average. |
| Aug 25, 2021 (view filing)8:43 PM ET | Aug 23-25 | 2 days | OrbiMed Advisors LLC and 2 othersDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −18.2K | $34.17 | −$622.4K | −15.7%98.1K after | 6 lotsThis row combines 6 trades of the same kind from one filing. The price is the value-weighted average.Duplicate filingThe same trade also appears in an earlier filing, for example when the same people file twice or a fund and its partners each report it. Rankings and totals count only the earliest copy. |
| Aug 25, 2021 (view filing) | Aug 23-25 | 2 days | Bonita David PDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −18.2K | $34.17 | −$622.4K | −15.7%98.1K after | 6 lotsThis row combines 6 trades of the same kind from one filing. The price is the value-weighted average. |
| Aug 25, 2021 (view filing) | Aug 17-18 | 8 daysLateFiled more than 2 business days after the trade (the Form 4 deadline). A few cases, such as trades a broker makes under a 10b5-1 plan, have a longer deadline, so this flag comes from the dates alone and does not mean a rule was broken. | Bonita David PDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −20.3K | $34.10 | −$693.2K | −17.1%98.6K after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average.Duplicate filingThe same trade also appears in an earlier filing, for example when the same people file twice or a fund and its partners each report it. Rankings and totals count only the earliest copy. |
| Aug 20, 2021 (view filing) | Aug 16 | 4 daysLateFiled more than 2 business days after the trade (the Form 4 deadline). A few cases, such as trades a broker makes under a 10b5-1 plan, have a longer deadline, so this flag comes from the dates alone and does not mean a rule was broken. | Zinda MichaelEVP, Chief Science Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −15.0K | $33.99 | −$509.9K | −42.2%20.5K after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Aug 19, 2021 (view filing)8:55 PM ET | Aug 17-18 | 2 days | OrbiMed Advisors LLC and 2 othersDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −20.3K | $34.10 | −$693.2K | −17.1%98.6K after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average.Duplicate filingThe same trade also appears in an earlier filing, for example when the same people file twice or a fund and its partners each report it. Rankings and totals count only the earliest copy. |
| Aug 19, 2021 (view filing) | Aug 17-18 | 2 days | Bonita David PDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −20.3K | $34.10 | −$693.2K | −17.1%98.6K after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average. |
| Jul 13, 2021 (view filing) | Jul 9-12 | 4 days | Foley ToddDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −27.4K | $33.55 | −$917.7K | −1.2%2.24M after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Jul 13, 2021 (view filing) | Jul 9-12 | 4 days | Gadicke Ansbert10% Owner | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −62.1K | $33.55 | −$2.08M | −1.6%3.88M after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
