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Relay Therapeutics, Inc.

RLAY
Exchange
Nasdaq
Industry
Biological Products, (No Diagnostic Substances)
SEC CIK
0001812364

In the last 90 days, Relay Therapeutics, Inc. insiders filed 0 open-market purchases and 14 sales; 259 institutions reported holding it in 13F filings for Q2 2026, worth $4.58B in total; Duquesne Family Office is the only superinvestor holding it.

13F holders, Q4 2025

Institutional positions in Relay Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
227
+30 vs. Q3 2025
Shares held
174.1M
+7.90M (+4.8%) vs. Q3 2025
Total value
$1.47B
+$605.0M (+69.8%) vs. Q3 2025
New holders
50
68 more added
Sold out
20
57 more reduced

2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q3 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting RLAY on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2025: 227 institutions
Q1 2021: 137 institutionsQ2 2021: 125 institutionsQ3 2021: 132 institutionsQ4 2021: 131 institutionsQ1 2022: 140 institutionsQ2 2022: 148 institutionsQ3 2022: 162 institutionsQ4 2022: 165 institutionsQ1 2023: 157 institutionsQ2 2023: 161 institutionsQ3 2023: 172 institutionsQ4 2023: 177 institutionsQ1 2024: 189 institutionsQ2 2024: 179 institutionsQ3 2024: 195 institutionsQ4 2024: 200 institutionsQ1 2025: 208 institutionsQ2 2025: 208 institutionsQ3 2025: 199 institutionsQ4 2025: 227 institutionsQ1 2026: 244 institutionsQ2 2026: 259 institutions
Value heldQ4 2025: $1.47B
Q1 2021: $2.96BQ2 2021: $3.26BQ3 2021: $2.89BQ4 2021: $3.41BQ1 2022: $3.38BQ2 2022: $2.02BQ3 2022: $2.76BQ4 2022: $1.91BQ1 2023: $2.16BQ2 2023: $1.64BQ3 2023: $1.10BQ4 2023: $1.40BQ1 2024: $1.10BQ2 2024: $826.8MQ3 2024: $1.16BQ4 2024: $675.8MQ1 2025: $438.1MQ2 2025: $591.8MQ3 2025: $867.4MQ4 2025: $1.47BQ1 2026: $1.83BQ2 2026: $4.58B
Institutions holding RLAY and their total value by quarter
QuarterHoldersValue
Q2 2026259$4.58B
Q1 2026244$1.83B
Q4 2025227$1.47B
Q3 2025199$867.4M
Q2 2025208$591.8M
Q1 2025208$438.1M
Q4 2024200$675.8M
Q3 2024195$1.16B
Q2 2024179$826.8M
Q1 2024189$1.10B
Q4 2023177$1.40B
Q3 2023172$1.10B
Q2 2023161$1.64B
Q1 2023157$2.16B
Q4 2022165$1.91B
Q3 2022162$2.76B
Q2 2022148$2.02B
Q1 2022140$3.38B
Q4 2021131$3.41B
Q3 2021132$2.89B
Q2 2021125$3.26B
Q1 2021137$2.96B

Institutions, Q4 2025

Shares, value and share of portfolio for each institution holding Relay Therapeutics, Inc.; share changes are against Q3 2025.

Institutions holding RLAY in Q4 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Covestor Ltd24$00.00%00.0%Unchanged
Aster Capital Management (DIFC) Ltd10$850.00%+10New
Transamerica Financial Advisors, Inc.13$1100.00%00.0%Unchanged
SRS Capital Advisors, Inc.19$1610.00%−15,038−99.9%Reduced
Clearstead Advisors, LLC34$2850.00%−269−88.8%Reduced
SageView Advisory Group, LLC40$3390.00%+40New
Sunbelt Securities, Inc.52$4400.00%00.0%Unchanged
International Assets Investment Management, LLC93$7870.00%+93New
Your Advocates Ltd., LLP100$8460.00%00.0%Unchanged
Avion Wealth136$1.00K0.00%00.0%Unchanged
Parkside Financial Bank & Trust129$1.09K0.00%00.0%Unchanged
Global Retirement Partners, LLC130$1.10K0.00%00.0%Unchanged
Jones Financial Companies LLLP154$1.30K0.00%00.0%Unchanged
Cornerstone Financial Management LLC162$1.37K0.00%+162New
MAI Capital Management181$1.53K0.00%00.0%Unchanged
Hughes Financial Services, LLC218$1.84K0.00%−7−3.1%Reduced
True Wealth Design, LLC278$2.35K0.00%00.0%Unchanged
Basecamp Wealth Advisors LLC291$2.46K0.00%+291New
Fortitude Family Office, LLC301$2.55K0.00%00.0%Unchanged
GAMMA Investing LLC354$3.00K0.00%+354New
Rockefeller Capital Management L.P.454$3.84K0.00%+454New
Rothschild Investment LLC469$3.97K0.00%+9+2.0%Added
Daiwa Securities Group Inc.486$4.00K0.00%00.0%Unchanged
Versant Capital Management, Inc493$4.17K0.00%00.0%Unchanged
IFP Advisors, Inc576$4.87K0.00%00.0%Unchanged
Comerica Bank664$5.62K0.00%00.0%Unchanged
Keating Financial Advisory Services, Inc.679$5.74K0.00%+679New
CIBC Private Wealth Group, LLC680$5.75K0.00%+680New
Tower Research Capital LLC (TRC)681$5.76K0.00%−7,920−92.1%Reduced
Red Tortoise LLC698$5.91K0.00%00.0%Unchanged
Umb Bank N A735$6.22K0.00%00.0%Unchanged
Webster Bank, N. A.1,000$8.46K0.00%00.0%Unchanged
Parallel Advisors, LLC1,189$10.1K0.00%+15+1.3%Added
Allworth Financial LP1,334$11.3K0.00%−101−7.0%Reduced
SBI Securities Co., Ltd.1,453$12.3K0.00%+447+44.4%Added
BNP PARIBAS ASSET MANAGEMENT Holding S.A.1,769$15.0K0.00%+151+9.3%Added
Nisa Investment Advisors, LLC2,074$17.5K0.00%00.0%Unchanged
Hager Investment Management Services, LLC2,178$18.4K0.01%00.0%Unchanged
EverSource Wealth Advisors, LLC2,211$18.7K0.00%00.0%Unchanged
Signaturefd, LLC3,124$26.4K0.00%00.0%Unchanged
GF Fund Management Co. Ltd.3,406$28.8K0.00%−303−8.2%Reduced
Torren Management, LLC3,544$30.0K0.02%+3,544New
Royal Bank of Canada4,060$35.0K0.00%−216,493−98.2%Reduced
Farther Finance Advisors, LLC4,140$35.0K0.00%+610+17.3%Added
Smartleaf Asset Management LLC4,426$37.0K0.00%+3,287+288.6%Added
Amalgamated Bank4,424$37.0K0.00%+224+5.3%Added
The PNC Financial Services Group, Inc.4,606$39.0K0.00%−48−1.0%Reduced
FNY Investment Advisers, LLC5,000$42.0K0.01%−5,000−50.0%Reduced
US Bancorp5,131$43.4K0.00%00.0%Unchanged
Essential Partners LLC5,346$45.2K0.01%00.0%Unchanged
Public Employees Retirement Association of Colorado5,888$50.0K0.00%00.0%Unchanged
Sterling Capital Management LLC8,116$68.7K0.00%−1,021−11.2%Reduced
Mirae Asset Global Investments Co., Ltd.8,422$71.3K0.00%+1,757+26.4%Added
Great West Life Assurance Co8,624$73.0K0.00%00.0%Unchanged
Plante Moran Financial Advisors, LLC8,764$74.1K0.00%+6,764+338.2%Added
Steward Partners Investment Advisory, LLC8,900$75.3K0.00%+800+9.9%Added
Portland Investment Counsel Inc.10,000$84.6K0.03%00.0%Unchanged
DRW Securities, LLC10,127$85.7K0.01%−24,472−70.7%Reduced
Buckingham Strategic Partners10,665$90.2K0.00%−260−2.4%Reduced
Xponance, Inc.11,002$93.1K0.00%+666+6.4%Added
Ameritas Investment Partners, Inc.11,180$94.6K0.00%−1,550−12.2%Reduced
49 Wealth Management, LLC11,401$96.5K0.01%−1,700−13.0%Reduced
Opal Capital LLC11,401$98.6K0.02%+11,401New
Quadrant Capital Group LLC11,791$99.8K0.00%00.0%Unchanged
Duncan Williams Asset Management, LLC11,763$99.9K0.02%+11,763New
Russell Investments Group, Ltd.12,462$105.4K0.00%+23+0.2%Added
EP Wealth Advisors, LLC12,502$105.8K0.00%+12,502New
J. Goldman & Co LP12,551$106.2K0.00%+12,551New
Mercer Global Advisors Inc12,838$108.6K0.00%−217−1.7%Reduced
Virginia Retirement Systems Et Al12,900$109.1K0.00%+12,900New
Abel Hall, LLC12,984$109.8K0.03%+1,809+16.2%Added
Caitong International Asset Management Co., Ltd13,639$115.4K0.03%+13,639New
Victory Capital Management Inc15,016$127.0K0.00%+24+0.2%Added
Pictet Asset Management Holding SA15,052$127.3K0.00%+15,052New
Winton Group Ltd16,000$135.4K0.00%+16,000New
AssuredPartners Investment Advisors, LLC16,123$136.4K0.02%+16,123New
Quantinno Capital Management LP17,277$146.2K0.00%+4,904+39.6%Added
Colony Group, LLC17,333$146.6K0.00%+17,333New
Teacher Retirement System of Texas17,473$147.8K0.00%−11,395−39.5%Reduced
BNP Paribas Arbitrage, SA20,004$169.2K0.00%−12,238−38.0%Reduced
Merit Financial Group, LLC20,485$173.3K0.00%−29−0.1%Reduced
Callan Family Office, LLC20,531$173.7K0.00%+20,531New
Cerity Partners LLC21,046$178.0K0.00%−195−0.9%Reduced
Erste Asset Management GmbH23,100$194.3K0.00%00.0%Unchanged
Graham Capital Management, L.P.23,126$195.6K0.01%+23,126New
Voya Investment Management LLC24,575$207.9K0.00%00.0%Unchanged
KLP Kapitalforvaltning AS24,700$209.0K0.00%00.0%Unchanged
Pallas Capital Advisors LLC25,120$212.5K0.01%+20+0.1%Added
SEI Investments Co25,630$216.8K0.00%00.0%Unchanged
State Board of Administration of Florida Retirement System25,807$218.3K0.00%00.0%Unchanged
Blueshift Asset Management, LLC26,814$226.8K0.07%+26,814New
Skopos Labs, Inc.27,141$228.3K0.01%−70,806−72.3%Reduced
JustInvest LLC27,587$233.4K0.00%−284−1.0%Reduced
Fiduciary Trust Co27,971$236.6K0.00%00.0%Unchanged
China Universal Asset Management Co., Ltd.28,243$238.9K0.02%−1,978−6.5%Reduced
PDT Partners, LLC28,906$244.5K0.02%−24,731−46.1%Reduced
Group One Trading, L.P.28,952$244.9K0.01%+17,283+148.1%Added
VARCOV Co.29,289$247.8K0.10%+29,289New
HRT Financial LP30,645$259.0K0.00%−167,061−84.5%Reduced
Citigroup Inc30,930$261.7K0.00%+16,616+116.1%Added