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Pliant Therapeutics, Inc.

PLRX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001746473

No open-market purchases or sales by Pliant Therapeutics, Inc. insiders were filed in the last 90 days; 86 institutions reported holding it in 13F filings for Q2 2026, worth $54.8M in total; no superinvestor holds it.

13F holders, Q4 2025

Institutional positions in Pliant Therapeutics, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
98
+1 vs. Q3 2025
Shares held
46.7M
−3.59M (−7.1%) vs. Q3 2025
Total value
$57.0M
−$17.6M (−23.6%) vs. Q3 2025
New holders
15
30 more added
Sold out
14
34 more reduced

3 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q3 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting PLRX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2025: 98 institutions
Q1 2021: 76 institutionsQ2 2021: 81 institutionsQ3 2021: 77 institutionsQ4 2021: 88 institutionsQ1 2022: 92 institutionsQ2 2022: 88 institutionsQ3 2022: 110 institutionsQ4 2022: 125 institutionsQ1 2023: 143 institutionsQ2 2023: 144 institutionsQ3 2023: 136 institutionsQ4 2023: 134 institutionsQ1 2024: 135 institutionsQ2 2024: 144 institutionsQ3 2024: 151 institutionsQ4 2024: 161 institutionsQ1 2025: 141 institutionsQ2 2025: 114 institutionsQ3 2025: 100 institutionsQ4 2025: 98 institutionsQ1 2026: 91 institutionsQ2 2026: 86 institutions
Value heldQ4 2025: $57.0M
Q1 2021: $1.21BQ2 2021: $893.6MQ3 2021: $512.8MQ4 2021: $416.5MQ1 2022: $222.1MQ2 2022: $241.5MQ3 2022: $948.1MQ4 2022: $864.1MQ1 2023: $1.50BQ2 2023: $1.05BQ3 2023: $1.04BQ4 2023: $1.14BQ1 2024: $971.3MQ2 2024: $687.2MQ3 2024: $710.6MQ4 2024: $852.6MQ1 2025: $78.5MQ2 2025: $59.7MQ3 2025: $74.7MQ4 2025: $57.0MQ1 2026: $62.5MQ2 2026: $54.8M
Institutions holding PLRX and their total value by quarter
QuarterHoldersValue
Q2 202686$54.8M
Q1 202691$62.5M
Q4 202598$57.0M
Q3 2025100$74.7M
Q2 2025114$59.7M
Q1 2025141$78.5M
Q4 2024161$852.6M
Q3 2024151$710.6M
Q2 2024144$687.2M
Q1 2024135$971.3M
Q4 2023134$1.14B
Q3 2023136$1.04B
Q2 2023144$1.05B
Q1 2023143$1.50B
Q4 2022125$864.1M
Q3 2022110$948.1M
Q2 202288$241.5M
Q1 202292$222.1M
Q4 202188$416.5M
Q3 202177$512.8M
Q2 202181$893.6M
Q1 202176$1.21B

Institutions, Q4 2025

Shares, value and share of portfolio for each institution holding Pliant Therapeutics, Inc.; share changes are against Q3 2025.

Institutions holding PLRX in Q4 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Tang Capital Management LLC6,143,132$7.49M0.37%+139,686+2.3%Added
Blue Owl Capital Holdings LP2,969,199$3.62M1.12%00.0%Unchanged
Vanguard Group Inc2,818,241$3.44M0.00%+42,303+1.5%Added
Citadel Advisors LLC2,583,332$3.15M0.00%+243,864+10.4%Added
Acadian Asset Management LLC2,364,669$2.88M0.00%−4,873−0.2%Reduced
Woodline Partners LP2,026,191$2.47M0.01%−2,478,626−55.0%Reduced
Monaco Asset Management SAM1,938,747$2.37M0.70%+1,116,054+135.7%Added
Redmile Group, LLC1,616,228$1.97M0.15%+24,533+1.5%Added
Prosight Management, LP1,555,744$1.90M0.39%+1,535,257+7,493.8%Added
BML Capital Management, LLC1,546,137$1.89M1.67%+1,546,137New
Two Sigma Advisers, LP1,245,600$1.52M0.00%+173,100+16.1%Added
JPMorgan Chase & Co1,212,875$1.48M0.00%−917,614−43.1%Reduced
Marshall Wace, LLP1,080,128$1.32M0.00%+780,667+260.7%Added
BlackRock, Inc.1,073,272$1.31M0.00%−347,591−24.5%Reduced
UBS Group AG1,062,615$1.30M0.00%−259,402−19.6%Reduced
Renaissance Technologies LLC1,045,818$1.28M0.00%+34,016+3.4%Added
Centiva Capital, LP1,000,000$1.22M0.07%+1,000,000New
Two Sigma Investments, LP953,293$1.16M0.00%+170,038+21.7%Added
Peapod Lane Capital LLC886,374$1.08M0.92%−210,654−19.2%Reduced
Eversept Partners, LP842,023$1.03M0.06%+17,429+2.1%Added
Bank of America Corp711,777$868.4K0.00%+3,721+0.5%Added
Jane Street Group, LLC653,774$797.6K0.00%+273,447+71.9%Added
Gsa Capital Partners LLP623,698$761.0K0.07%+462,814+287.7%Added
Geode Capital Management, LLC592,696$723.4K0.00%+5,287+0.9%Added
Jacobs Levy Equity Management, Inc556,938$679.5K0.00%+189,825+51.7%Added
Morgan Stanley548,962$669.7K0.00%−2,958,326−84.3%Reduced
XTX Topco Ltd545,016$664.9K0.02%+78,032+16.7%Added
Bessemer Group Inc532,079$649.0K0.00%00.0%Unchanged
Millennium Management LLC408,831$498.8K0.00%−128,506−23.9%Reduced
Connor, Clark & Lunn Investment Management Ltd.371,951$453.8K0.00%+347,611+1,428.1%Added
Bridgeway Capital Management, LLC321,530$392.3K0.01%+239,230+290.7%Added
Torno Capital, LLC320,000$390.4K0.17%+189,084+144.4%Added
SEI Investments Co297,291$362.7K0.00%00.0%Unchanged
ArrowMark Colorado Holdings LLC281,189$343.1K0.01%00.0%Unchanged
Goldman Sachs Group Inc276,866$337.8K0.00%−278,210−50.1%Reduced
Seven Fleet Capital Management LP276,500$337.3K0.23%+276,500New
Laurion Capital Management LP257,400$314.0K0.02%+257,400New
State Street Corp253,418$309.2K0.00%−416−0.2%Reduced
Nano Cap New Millennium Growth Fund L P235,000$286.7K0.24%+235,000New
Stonepine Capital Management, LLC230,050$280.7K0.22%−59,187−20.5%Reduced
Rangeley Capital, LLC225,000$274.5K0.24%+164,780+273.6%Added
HighMark Wealth Management LLC170,924$208.5K0.08%−48,076−22.0%Reduced
Rice Hall James & Associates, LLC147,705$180.2K0.01%+2,862+2.0%Added
Diadema Partners LP144,914$176.8K0.11%+144,914New
Northern Trust Corp123,273$150.4K0.00%−13,227−9.7%Reduced
Dimensional Fund Advisors LP121,756$148.5K0.00%−29,917−19.7%Reduced
Advisor Group Holdings, Inc.114,971$140.3K0.00%−10,405−8.3%Reduced
Invesco Ltd.113,934$139.0K0.00%+6,838+6.4%Added
Hennion & Walsh Asset Management, Inc.113,383$138.3K0.00%+15,349+15.7%Added
Bond & Devick Financial Network, Inc.100,160$122.2K0.03%00.0%Unchanged
Squarepoint Ops LLC99,018$120.8K0.00%+65,176+192.6%Added
Quadrature Capital Ltd97,891$119.4K0.00%+60,296+160.4%Added
Kotler Kevin93,000$113.5K0.08%+93,000New
Algert Global LLC84,452$103.0K0.00%−19,930−19.1%Reduced
ADAR1 Capital Management, LLC73,819$90.1K0.01%+73,819New
Canada Pension Plan Investment Board61,400$74.9K0.00%+61,400New
Federated Hermes, Inc.59,495$72.6K0.00%+4,199+7.6%Added
Deeter Investments LLP48,025$58.6K0.01%+48,025New
Point72 Asset Management, L.P.46,537$56.8K0.00%−4,291,857−98.9%Reduced
Simplex Trading, LLC45,912$56.0K0.00%+32,923+253.5%Added
Persistent Asset Partners Ltd38,831$47.4K0.02%+38,831New
Susquehanna International Group, LLP34,201$41.7K0.00%−39,753−53.8%Reduced
HRT Financial LP32,205$39.0K0.00%+32,205New
Engineers Gate Manager LP30,544$37.3K0.00%+7,056+30.0%Added
Tudor Investment Corp Et Al29,729$36.3K0.00%00.0%Unchanged
JustInvest LLC26,237$32.0K0.00%−8,506−24.5%Reduced
Blackstone Group Inc.22,206$27.1K0.00%00.0%Unchanged
Bronte Capital Management Pty Ltd.18,613$22.7K0.00%+18,613New
Universal- Beteiligungs- und Servicegesellschaft mbH18,065$22.0K0.00%00.0%Unchanged
Bank of New York Mellon Corp15,824$19.3K0.00%−109−0.7%Reduced
Group One Trading, L.P.15,790$19.3K0.00%+12,669+405.9%Added
Qube Research & Technologies Ltd15,425$18.8K0.00%−34,090−68.8%Reduced
SG Americas Securities, LLC12,261$15.0K0.00%−4,522−26.9%Reduced
Quest Partners LLC11,716$14.3K0.00%00.0%Unchanged
Fiduciary Trust Co11,620$14.2K0.00%00.0%Unchanged
Barclays PLC10,584$12.9K0.00%−358,972−97.1%Reduced
Rhumbline Advisers2,379$2.90K0.00%00.0%Unchanged
FMR LLC1,934$2.36K0.00%−3,040−61.1%Reduced
Royal Bank of Canada1,185$2.00K0.00%−14,990−92.7%Reduced
Fortitude Family Office, LLC1,278$1.56K0.00%00.0%Unchanged
The PNC Financial Services Group, Inc.978$1.19K0.00%−6−0.6%Reduced
Rockefeller Capital Management L.P.660$8050.00%−425−39.2%Reduced
BNP Paribas Arbitrage, SA657$8020.00%−181,699−99.6%Reduced
Russell Investments Group, Ltd.542$6610.00%−864−61.5%Reduced
Bare Financial Services, Inc413$5040.00%+413New
MAI Capital Management400$4880.00%00.0%Unchanged
SBI Securities Co., Ltd.320$3900.00%00.0%Unchanged
Cornerstone Financial Management LLC319$3890.00%+319New
Wells Fargo & Company50$610.00%00.0%Unchanged
Truvestments Capital LLC50$610.00%00.0%Unchanged
Zurcher Kantonalbank (Zurich Cantonalbank)36$440.00%−570−94.1%Reduced
Comerica Bank6$70.00%−8−57.1%Reduced
Farther Finance Advisors, LLC5$60.00%00.0%Unchanged
Global Retirement Partners, LLC4$50.00%00.0%Unchanged
Caitong International Asset Management Co., Ltd1$10.00%−2,046−100.0%Reduced
CWM, LLC391$00.00%−266−40.5%Reduced
Covestor Ltd45$00.00%−1−2.2%Reduced
DekaBank Deutsche Girozentrale40,000––00.0%Unchanged
Great Point Partners LLC0$00.00%−850,000−100.0%Sold out
Voleon Capital Management LP0$00.00%−149,041−100.0%Sold out