| Sep 10, 2026 (view filing)4:49 PM ET | Sep 8 | 2 days | Wang XiaodongDirector, Other: Chair, Scientific Advisory Brd | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −38.3K | $349.10 | −$13.4M | −100.0%0 after | 8 lotsThis row combines 8 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Sep 3, 2026 (view filing)5:17 PM ET | Sep 1 | 2 days | Ball Titus B.Principal Accounting Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −132 | $355.86 | −$47.0K | −100.0%0 after | |
| Aug 27, 2026 (view filing)5:12 PM ET | Aug 25 | 2 days | Wu XiaobinPresident and COO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −280 | $380.00 | −$106.4K | −100.0%0 after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Aug 13, 2026 (view filing)8:54 PM ET | Aug 11 | 2 days | Lee Chan HenrySVP, General Counsel | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −2.67K | $360.00 | −$959.8K | −100.0%0 after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Aug 12, 2026 (view filing)5:53 PM ET | Aug 10-12 | 2 days | Oyler JohnChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −240.8K | $359.12 | −$86.5M | −100.0%0 after | 24 lotsThis row combines 24 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Aug 5, 2026 (view filing)5:15 PM ET | Aug 3 | 2 days | Rosenberg AaronChief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −1.16K | $312.72 | −$361.8K | −100.0%0 after | |
| Aug 3, 2026 (view filing)5:18 PM ET | Jul 30 | 4 days | Lee Chan HenrySVP, General Counsel | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −1.04K | $323.69 | −$337.9K | −100.0%0 after | |
| Jul 24, 2026 (view filing)4:51 PM ET | Jul 22 | 2 days | Lee Chan HenrySVP, General Counsel | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −1.67K | $325.00 | −$542.4K | −100.0%0 after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jul 22, 2026 (view filing)5:03 PM ET | Jul 20-21 | 2 days | Oyler JohnChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −109.7K | $315.28 | −$34.6M | −100.0%0 after | 14 lotsThis row combines 14 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jul 17, 2026 (view filing)5:36 PM ET | Jul 17 | Same day | Oyler JohnChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −64.6K | $312.00 | −$20.2M | −100.0%0 after | 9 lotsThis row combines 9 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jul 17, 2026 (view filing)5:31 PM ET | Jul 15-16 | 2 days | Oyler JohnChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −283.2K | $315.56 | −$89.4M | −100.0%0 after | 17 lotsThis row combines 17 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jul 14, 2026 (view filing)9:26 PM ET | Jul 14 | Same day | Oyler JohnChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −145.9K | $305.95 | −$44.6M | −100.0%0 after | 6 lotsThis row combines 6 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jul 14, 2026 (view filing)9:25 PM ET | Jul 10-13 | 4 days | Oyler JohnChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −60.2K | $303.18 | −$18.3M | −100.0%0 after | 15 lotsThis row combines 15 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jul 10, 2026 (view filing)4:44 PM ET | Jul 8 | 2 days | Lee Chan HenrySVP, General Counsel | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −664 | $302.46 | −$200.8K | −100.0%0 after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jun 25, 2026 (view filing) | Jun 23 | 2 days | Wang LaiPresident, Global Head of R&D | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −1.07K | $276.74 | −$295.6K | −100.0%0 after | |
| Jun 25, 2026 (view filing) | Jun 23 | 2 days | Wu XiaobinPresident and COO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −1.29K | $276.26 | −$356.9K | −100.0%0 after | |
| Jun 25, 2026 (view filing) | Jun 23 | 2 days | Oyler JohnChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −3.41K | $273.78 | −$933.6K | −100.0%0 after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Jun 18, 2026 (view filing) | Jun 16 | 2 days | Lee Chan HenrySVP, General Counsel | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −590 | $265.98 | −$156.9K | −100.0%0 after | |
| Jun 18, 2026 (view filing) | Jun 16 | 2 days | Wang LaiPresident, Global Head of R&D | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −1.17K | $265.39 | −$310.2K | −100.0%0 after | |
| Jun 18, 2026 (view filing) | Jun 16 | 2 days | Wu XiaobinPresident and COO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −1.36K | $266.76 | −$362.0K | −100.0%0 after | |
| Jun 18, 2026 (view filing) | Jun 16 | 2 days | Oyler JohnChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −3.69K | $265.55 | −$980.7K | −100.0%0 after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Jun 15, 2026 (view filing) | Jun 11 | 4 days | Rosenberg AaronChief Financial Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −631 | $257.74 | −$162.6K | −100.0%0 after | |
| Jun 15, 2026 (view filing) | Jun 11 | 4 days | Lee Chan HenrySVP, General Counsel | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −428 | $257.64 | −$110.3K | −100.0%0 after | |
| Jun 15, 2026 (view filing) | Jun 11 | 4 days | Wang LaiPresident, Global Head of R&D | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −756 | $261.00 | −$197.3K | −100.0%0 after | |
| Jun 15, 2026 (view filing) | Jun 11 | 4 days | Wu XiaobinPresident and COO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −626 | $261.20 | −$163.5K | −100.0%0 after | |
| Jun 15, 2026 (view filing) | Jun 11 | 4 days | Ball Titus B.Principal Accounting Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −169 | $257.20 | −$43.5K | −100.0%0 after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jun 15, 2026 (view filing) | Jun 11 | 4 days | Oyler JohnChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −1.95K | $257.24 | −$501.4K | −100.0%0 after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average. |
| Jun 10, 2026 (view filing) | Jun 8 | 2 days | Lee Chan HenrySVP, General Counsel | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −871 | $270.43 | −$235.5K | −100.0%0 after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jun 10, 2026 (view filing) | Jun 8 | 2 days | Wang LaiPresident, Global Head of R&D | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −1.37K | $269.38 | −$368.2K | −100.0%0 after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jun 10, 2026 (view filing) | Jun 8 | 2 days | Wu XiaobinPresident and COO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −1.48K | $269.36 | −$399.7K | −100.0%0 after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jun 10, 2026 (view filing) | Jun 8 | 2 days | Ball Titus B.Principal Accounting Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −136 | $271.33 | −$36.9K | −100.0%0 after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jun 10, 2026 (view filing) | Jun 8 | 2 days | Oyler JohnChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −4.94K | $270.55 | −$1.34M | −100.0%0 after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Jun 3, 2026 (view filing) | Jun 1 | 2 days | Yi QingqingDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −235 | $279.13 | −$65.6K | −100.0%0 after | |
| May 27, 2026 (view filing)4:54 PM ET | May 22 | 5 days | Baker Julian and 5 othersDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase. | −11.0K | $23.82 | −$262.0K | −7.2%142.6K after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average. |
| May 27, 2026 (view filing) | May 22 | 5 days | Dugan MargaretDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −212 | $309.60 | −$65.6K | −100.0%0 after | |
| May 27, 2026 (view filing) | May 22 | 5 days | Riva AlessandroDirector | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −212 | $309.51 | −$65.6K | −100.0%0 after | |
| May 27, 2026 (view filing) | May 22 | 5 days | Sanders Corazon (Corsee) D.Director | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −212 | $309.59 | −$65.6K | −100.0%0 after | |
| May 15, 2026 (view filing) | May 13 | 2 days | Lee Chan HenrySVP, General Counsel | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −332 | $310.72 | −$103.2K | −100.0%0 after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Apr 10, 2026 (view filing) | Apr 8 | 2 days | Lee Chan HenrySVP, General Counsel | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −332 | $311.59 | −$103.4K | −100.0%0 after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Mar 13, 2026 (view filing) | Mar 11 | 2 days | Lee Chan HenrySVP, General Counsel | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −341 | $300.00 | −$102.3K | −100.0%0 after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Feb 6, 2026 (view filing) | Feb 4 | 2 days | Lee Chan HenrySVP, General Counsel | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −1.66K | $349.52 | −$580.2K | −100.0%0 after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Jan 9, 2026 (view filing) | Jan 7 | 2 days | Lee Chan HenrySVP, General Counsel | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −664 | $331.76 | −$220.3K | −100.0%0 after | 10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 17, 2025 (view filing) | Dec 15-16 | 2 days | Oyler JohnChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −100.0K | $306.59 | −$30.7M | −100.0%0 after | 24 lotsThis row combines 24 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 12, 2025 (view filing) | Dec 10-11 | 2 days | Lee Chan HenrySVP, General Counsel | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −664 | $321.64 | −$213.6K | −100.0%0 after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Dec 1, 2025 (view filing) | Nov 26 | 5 days | Sanders Corazon (Corsee) D.Director | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −2.63K | $340.89 | −$895.5K | −100.0%0 after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average. |
| Nov 19, 2025 (view filing) | Nov 17 | 2 days | Wu XiaobinPresident and COO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −3.99K | $380.43 | −$1.52M | −100.0%0 after | 3 lotsThis row combines 3 trades of the same kind from one filing. The price is the value-weighted average. |
| Nov 14, 2025 (view filing) | Nov 12 | 2 days | Lee Chan HenrySVP, General Counsel | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −996 | $349.17 | −$347.8K | −100.0%0 after | 2 lotsThis row combines 2 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Nov 14, 2025 (view filing) | Nov 12-13 | 2 days | Wu XiaobinPresident and COO | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −16.0K | $365.22 | −$5.85M | −100.0%0 after | 10 lotsThis row combines 10 trades of the same kind from one filing. The price is the value-weighted average. |
| Oct 10, 2025 (view filing) | Oct 8 | 2 days | Lee Chan HenrySVP, General Counsel | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −10.7K | $350.40 | −$3.74M | −100.0%0 after | 4 lotsThis row combines 4 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
| Sep 18, 2025 (view filing) | Sep 16 | 2 days | Oyler JohnChief Executive Officer | SSaleThe insider sold shares on the open market or in a private deal. People sell for many reasons, such as paying taxes, diversifying or following a pre-set 10b5-1 plan, so a single sale usually says less than a purchase.American Depositary Shares | −27.8K | $325.71 | −$9.06M | −100.0%0 after | 5 lotsThis row combines 5 trades of the same kind from one filing. The price is the value-weighted average.10b5-1The filer checked the Rule 10b5-1 box: this trade was made under a trading plan set up in advance. |
